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Adult neurogenesis:a real hope or a delusion?

Neural Regeneration Research 2024年第1期19卷 6-15页

作者： ghulam Hussain Rabia Akram Haseeb Anwar Faiqa Sajid Tehreem Iman Hyung Soo Han Chand Raza Jose-Luis Gonzalez De Aguilar Neurochemicalbiology and Genetics Laboratory(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan Department of Physiology School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea Department of Zoology Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSERM U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neurogenesis,the process of creating new neurons,involves the coordinated division,migration,and differentiation of neural stem *** process is restricted to neurogenic niches located in two distinct areas of the brain:the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle,where new neurons are generated and then migrate to the olfactory *** has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem ***,recent years have seen tremendous progress in our understanding of adult brain neurogenesis,bridging the knowledge gap between embryonic and adult ***,we discuss the current status of adult brain neurogenesis in light of what we know about neural stem *** this notion,we talk about the importance of intra cellular signaling molecules in mobilizing endogenous neural stem cell prolife *** on the current understanding,we can declare that these molecules play a role in targeting neurogenesis in the mature ***,to achieve this goal,we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints,which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.

关键词： adult neurogenesis aging brain-derived neurotrophic factor dentate gyrus hippocampus neural stem cells neurotrophic factors Notch oxidative stress stem cells subgranular zone

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Smart tailoring of molecular catalysts:Mounting approach to oxygen reduction reaction

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Journal of Materials Science & Technology 2024年第1期168卷 169-184页

作者： Anuj Kumar Mohd Ubaidullah Guoxin Zhang Jasvinder Kaur Saira Ajmal Mudassir Hasan Krishna Kumar Yadav Hafiz M.Adeel Sharif Ram K.Gupta ghulam Yasin Nano-Technology Research Laboratory Department of ChemistryGLA UniversityMathuraUttar Pradesh 281406India Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdaoShandong 266590China Institute for Advanced Study Shenzhen UniversityShenzhenGuangdong 518060China Department of Chemistry Kansas Polymer Research CenterPittsburg State UniversityPittsburgKS 66762United States Faculty of Science and Technology Madhyanchal Professional UniversityRatibadBhopal 462044India Environmental and Atmospheric Sciences Research Group Scientific Research CenterAl-Ayen UniversityThi-QarNasiriyah 64001Iraq Department of Chemical Engineering King Khalid University Saudi Arabia Department of Chemistry School of SciencesIFTM UniversityMoradabadUttar Pradesh 244102India Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan 523808China School of Environment and Civil Engineering Dongguan University of TechnologyDongguanGuangdong 523808China

Efficient electrocatalytic rupture of energy-rich molecules(H_(2)and O_(2))is a green approach for gener-ating clean energy for modern *** this context,porphyry-type molecular electrocatalysts act intelligently toward oxygen reduction reaction(ORR),a fundamental process in fuel cells,due to their redox-rich chemistry,which involves core metal ions and macrocyclic *** concerned scientific community has tried many times to correlate the ORR intermediates with their formation kinetics and simplify the associated multi H+/e-stages during the ORR process,constructing several volcano plots be-tween catalytic Tafel data,turnover frequencies,and overpotentials for many *** the fact that many review articles on molecular electrocatalysts for ORR have been published,understanding the strategic implications and molecular catalyst intelligence towards homogenous ORR has been poorly *** review examined the relationships between volcano plots of current *** parameters and the Sabatier principle in order to explain the intelligence of molecular electrocatalysts and approaches for their creation,as well as the difficulties and potential prospects of molecular *** facts distinguish this review from previously published articles and will pique the scien-tific community’s interest in avoiding trial-and-error procedures for catalyst creation while also allowing for more exact evaluations of the molecular catalyst’s performance.

关键词： Electrocatalysis Molecular catalysts Oxygen reduction reaction Sabatier principle

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Systematic Review:Load Balancing in Cloud Computing by Using Metaheuristic Based Dynamic Algorithms

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Intelligent Automation & Soft Computing 2024年第3期39卷 437-476页

作者： Darakhshan Syed ghulam Muhammad Safdar Rizvi Department of Computer Science Bahria UniversityKarachi CampusKarachiPakistan

Cloud Computing has the ability to provide on-demand access to a shared resource *** has completely changed the way businesses are managed,implement applications,and provide *** rise in popularity has led to a significant increase in the user demand for ***,in cloud environments efficient load balancing is essential to ensure optimal performance and resource *** systematic review targets a detailed description of load balancing techniques including static and dynamic load balancing ***,metaheuristic-based dynamic load balancing algorithms are identified as the optimal solution in case of increased *** a cloud-based context,this paper describes load balancing measurements,including the benefits and drawbacks associated with the selected load balancing *** also summarizes the algorithms based on implementation,time complexity,adaptability,associated issue(s),and targeted QoS ***,the analysis evaluates the tools and instruments utilized in each investigated ***,comparative analysis among static,traditional dynamic and metaheuristic algorithms based on response time by using the CloudSim simulation tool is also ***,the key open problems and potential directions for the state-of-the-art metaheuristic-based approaches are also addressed.

关键词： Cloud computing load balancing metaheuristic algorithm dynamic algorithm load balancer QoS

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Rare earth based MgPm_(2)X_(4)(X=S,Se) spinel chalcogenides for spintronic and thermoelectric applications

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Journal of Rare Earths 2024年第8期42卷 1577-1585,I0006页

作者： Tariq M.Al-Daraghmeh Omar zayed ghulam M.Mustafa Taharh Zelai Bisma Younas Hind Albalawi S.Bouzgarrou Othman Hakami Q.Mahmood Khaild I.Hussein Basic Sciences Department King Abdullah Ⅱ School of EngineeringPrincess Sumaya University For TechnologyP.O.Box 1438Al-jubaiha11941AmmanJordan Department of Physics Division of Science&TechnologyUniversity of EducationLahorePakistan Department of Physics Faculty of ScienceJazan University JazanSaudi Arabia Department of Physics The University of LahoreLahorePakistan Department of Physics College of SciencesPrincess Nourah bint Abdulrahman University(PNU)P.O.Box 84428Riyadh11671Saudi Arabia Department of Physics College of ScienceQassim UniversityPo.64BuraidahSaudi Arabia Laboratoire de Microelectronique et Instrumentation(UR 03/13-04) Faculte des Sciences de MonastirAvenue de I'Environnement 5000MonastirTunisia Department of Chemistry Faculty of ScienceJazan University JazanSaudi Arabia Basic&Applied Scientific Research Center Department of PhysicsCollege of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia Department of Radiological Sciences College of Applied Medical SciencesKing Khalid UniversityAbha61421Saudi Arabia

In current report,the structural,magnetic,and thermoelectric properties of RE doped MgPm_(2)X_(4)(X=S,Se) spinels were *** energy difference in ferromagnetic and antiferromagnetic states reveals the stability of MgPm_(2)(S/Se)_(4) in the ferromagnetic *** co mputation of enthalpy of formation also ascertains thermodynamic stability of crystal ***-dependent band structure and density of states analysis reveal ferromagnetic semiconducting character showing different electronic behavior in both spin *** room temperature ferromagnetism,spin polarization and Curie temperature are estimated from exchange energies *** addition,exchange constants(N_(0)α and N_(0)β),exchange energy Δ_(x)(pd),crystal ifeld energy,and double exchange mechanism were studied to explore the magnetic ***,the electrical conductivity,thermal conductivity,Seebeck co-efficient,and power factor show effect on electrons spin and their potential for thermoelectric devices.

关键词： Rare earth elements Spintronic applications Thermoelectric effects Exchange energies

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Combined Application of Biostimulants and EDTA Improved Wheat Productivity under Cadmium Stress

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1647-1665页

作者： Abida Aziz Shafiqa Bano Mubshar Hussain Muhammad Farooq Azhar ghulam Yasin Naila Hadayat Iqra Arooj Abeer Hashem Ajay Kumar Elsayed Fathi Abd_Allah Qamar uz zaman Department of Botany The Women UniversityMultan54500Pakistan Institute of Agronomy Bahauddin Zakariya UniversityMultan60800Pakistan Department of Forestry and Range Management Bahauddin Zakariya UniversityMultan60800Pakistan Department of Botany Division of Science&TechnologyUniversity of EducationLahore54770Pakistan Department of Microbiology&Molecular Genetics The Women UniversityMultan54500Pakistan Botany and Microbiology Department College of ScienceKing Saud UniversityRiyadh201313Saudi Arabia Amity Institute of Biotechnology Amity UniversityNoida201313India Plant Production Department College of Food and Agricultural SciencesKing Saud UniversityRiyadh11451Saudi Arabia School of Agriculture Yunnan UniversityKunmingYunan650504China Department of Environmental Sciences The University of LahoreLahore54590Pakistan

Wheat(Triticum aestivum L.)exhibits a greater capacity for cadmium(Cd)absorption compared to other cereal crops,leading to elevated daily Cd intake,and posing a signiﬁcant threat to public *** the mitigation of Cd stress in sustainable and environmentally friendly way,a pot study was designed by using exogenous application of various biostimulants,i.e.,Nigella sativa and Ocimum sanctum extracts:0%,10%,and 20%in combination with the chelating agent ethylenediaminetetraacetic acid(EDTA)using 0 and 5 mg kg^(-1) under various levels of Cd stress(i.e.,0,5,10,and 15 mg kg^(-1) soil).Results revealed that Cd stress signiﬁcantly reduced the seed emergence,growth,root,and allometric characters and yield-related parameters of wheat *** most observable reduc-tion was documented in wheat plants exposed to a higher Cd concentration(15 mg kg^(-1)),followed by the lower Cd level(control).The combined application of bio-stimulants and EDTA minimized the negative impacts of Cd *** highest increase in seedling emergence(5.44%),leaf area(50.60%),number of tillers(31.02%),grain yield per plant(24.28%),biological yield(13.97%),and decrease in Cd levels in grains(40%)was noticed where 20%foliar application of *** and 10%of *** biostimulants were done using 5 mg kg^(-1) of soil-applied *** intervention demonstrated a notable reduction in Cd-induced negative effects,highlighting the potential of these substances in promoting sustainable wheat cultivation in contaminated ***,it is an eco-friendly and approachable method at theﬁeld level able to ensure food safety.

关键词： Abiotic stress allometric characters antioxidant activity crop yield seed emergence grain yield

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The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways

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Food Science and Human Wellness 2024年

作者： Hong Duan Wei Wang Shu Li Han Li ghulam Jilany Khan Fawang Liu Kefeng Zhai Lili Li Zhaojun Wei General Clinical Research Center， Anhui Wanbei Coal-Electricity Group General Hospital Department of Pharmacology and Therapeutics， Faculty of Pharmacy， University of Central Punjab College of Biological and Food Engineering， Anhui Polytechnic University School of Biological and Food Engineering， Engineering Research Center for Development and High Value Utilization of Genuine Medicinal Materials in North Anhui Province， Suzhou University School of Food and Biological Engineering， Hefei University of Technology

Corona Virus Disease 2019 (COVID-19) has brought the new challenges to scientific research. Isodon suzhouensis has good anti-inflammatory and antioxidant stress effects， which is considered as a potential treatment for COVID-19. The possibility for the treatment of COVID-19 with suzhouensis and its potential mechanism of action were explored by employing molecular docking and network pharmacology. Network pharmacology and molecular docking were used to screen drug targets， and Lipopolysaccharide (LPS) induced RAW264.7 and NR8383 cells inflammation model was used for experimental verification. Collectively a total of 209 possible linkages against 18 chemical components from suzhouensis and 1194 COVID-19 related targets were selected. Among these， 164 common targets were obtained from the intersection of suzhouensis and COVID-19. GO and KEGG enriched 582 function targets and 87 target proteins pathways， respectively. The results from molecular docking studies revealed that rutin， vitexin， isoquercitrin and quercetin had significant binding ability with SARS-CoV-23CLpro and ACE2. In vitro studies showed that Isodon suzhouensis extract (ISE) may inhibit the activation of PI3K/Akt pathway and the expression level of downstream pro-inflammatory factors by inhibiting the activation of EGFR in RAW264.7 cells induced by LPS. In addition， ISE was able to inhibit the activation of TLR4/NF-κB signaling pathway in NR8383 cells exposed to LPS. Overall， the network pharmacology and in vitro studies conclude that active components from suzhouensis have strong therapeutic potential against COVID-19 through multi-target， multi-pathway dimensions and can be a promising candidate against COVID-19.

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电化学分析方法在中药质量控制中的研究进展

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分析化学 2024年第1期52卷 22-34页

作者：潘彦冰 Awais IHSAN 施敏马雯雯 ghulam murt.za 胡克菲李竣黄先菊程寒中南民族大学药学院伊斯兰堡COMSATS大学生物科技学院伊斯兰堡COMSATS大学药学院元莱健康产品(武汉)有限公司国家中医药管理局民族药学三级实验室

中药质量控制是保证中药现代化、产业化以及国际化的核心问题。与其它分析方法相比，电化学分析法具有灵敏度高、检测速度快和成本低等优点，是中药质量控制的重要手段，具有广阔的发展前景。本文综述了近年来电化学方法在中药质量控制... 详细信息

中药质量控制是保证中药现代化、产业化以及国际化的核心问题。与其它分析方法相比，电化学分析法具有灵敏度高、检测速度快和成本低等优点，是中药质量控制的重要手段，具有广阔的发展前景。本文综述了近年来电化学方法在中药质量控制方面的研究进展，介绍了电化学指纹图谱技术在中药鉴别方面的研究概况，着重归纳了电化学技术在分析中药有效成分和有害物质中的应用，包括黄酮类、生物碱类、醌类、苷类、重金属和农药残留等，并展望了电化学方法在中药质量控制领域的发展前景。

关键词：电化学方法指纹图谱中药质量控制评述

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Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice

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Zoological Research 2024年第5期45卷 1073-1087页

作者： Jing-Wei Ye Tanveer Abbas Jian-Teng Zhou Jing Chen Meng-Lei Yang Xiong-Heng Huang Huan Zhang Hui Ma Ao Ma Bo Xu ghulam murt.za Qing-Hua Shi Bao-Lu Shi Division of Reproduction and Genetics First Affiliated Hospital of University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at MicroscaleSchool of Basic Medical SciencesDivision of Life Sciences and MedicineBiomedical Sciences and Health Laboratory of Anhui ProvinceInstitute of Health and MedicineHefei Comprehensive National Science CenterUniversity of Science and Technology of ChinaHefeiAnhui 230026China Institute of Andrology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China

Infertility represents a significant health concern,with sperm quantity and quality being crucial determinants of male ***(OAT)is characterized by reduced sperm motility,lower sperm concentration,and morphological abnormalities in sperm heads and *** variants in several genes have been implicated in OAT,its genetic etiologies and pathogenetic mechanisms remain inadequately *** this study,we identified a homozygous nonsense mutation(c.916C>T,***306*)in the coiled-coil domain containing 146(CCDC146)gene in an infertile male patient with *** mutation resulted in the production of a truncated CCDC146 protein(amino acids 1-305),retaining only two out of five coiled-coil *** validate the pathogenicity of the CCDC146 mutation,we generated a mouse model(Ccdc146^(mut/mut))with a similar mutation to that of the ***,the Ccdc146mut/mut mice exhibited infertility,characterized by significantly reduced sperm counts,diminished motility,and multiple defects in sperm heads and ***,the levels of axonemal proteins,including DNAH17,DNAH1,and SPAG6,were significantly reduced in the sperm of Ccdc146^(mut/mut) ***,both human and mouse CCDC146 interacted with intraflagellar transport protein 20(IFT20),but this interaction was lost in the mutated versions,leading to the degradation of *** study identified a novel deleterious homozygous nonsense mutation in CCDC146 that causes male infertility,potentially by disrupting axonemal protein *** findings offer valuable insights for genetic counseling and understanding the mechanisms underlying CCDC146 mutant-associated infertility in human males.

关键词： Oligoasthenoteratozoospermia Human infertility Sperm flagellum CCDC146 Intraflagellar transport IFT20

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上海崇明东滩湿地潮滩梯度下芦苇种群动态分析

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生态与农村环境学报 2024年第5期40卷 657-664页

作者：王虓李德志计阳晴李羚菱 Rasool Samreen ghulam Tehreem Rafique 王莹陈婧华东师范大学生态与环境科学学院上海200241 华东师范大学上海市城市化生态过程与生态恢复重点实验室上海200241 崇明生态研究院上海202162 自然资源部大都市区国土空间生态修复工程技术创新中心上海200062

芦苇(Phragmites australis)是崇明东滩湿地潮间带的优势种,具有良好的水土保持与净化功能。芦苇种群主要在中、高潮滩呈带状分布,但在低潮滩也有小斑块状分布。作为典型根茎型克隆植物的芦苇种群,在盐沼湿地不同潮滩表现出怎样的种群... 详细信息

芦苇(Phragmites australis)是崇明东滩湿地潮间带的优势种,具有良好的水土保持与净化功能。芦苇种群主要在中、高潮滩呈带状分布,但在低潮滩也有小斑块状分布。作为典型根茎型克隆植物的芦苇种群,在盐沼湿地不同潮滩表现出怎样的种群动态特征,进而反映出怎样的差异化的适应能力,值得深入研究。以分布在崇明东滩湿地低、中、高3个潮滩上的芦苇种群为研究对象,全程定位追踪起始于4、6月的同生群在整个生长季的生长、发育过程,并定量分析它们的动态生命表、生存曲线、生存率和累积死亡率,系统揭示分布于3个潮滩的芦苇种群典型动态特征。结果表明:(1)起始于4月的处于低、中、高3个潮滩上的芦苇同生群,其生存曲线存在差异,它们分别趋近于Deevey-Ⅰ型、Deevey-Ⅱ型和Ⅲ型的过渡型,以及Deevey-Ⅰ型和Ⅱ型的过渡型;(2)起始于6月的处于低、中潮滩上的芦苇同生群,其生存曲线呈现出与4月同生群相似的特征,高潮滩同生群则由Deevey-Ⅰ型和Ⅱ型的过渡型转变成Deevey-Ⅱ型和Ⅲ型的过渡型;(3)经综合分析,高潮滩芦苇同生群稳定性最强,低潮滩同生群相对不稳定,中潮滩同生群在生长初期不稳定而在生长中后期趋于稳定;(4)基于上述研究结果,针对东滩湿地沿潮滩梯度分布的芦苇种群的保育与管理提出了合理建议。

关键词：崇明东滩湿地芦苇动态生命表种群动态

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Influence of Microorganisms Effective against Basal Rot and on Agronomic Parameters of Onion [Allium cepa L. (Amaryllidaceae)]

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Journal of Agricultural Chemistry and Environment 2024年第3期13卷 282-299页

作者： Henriette Doukahonon Guigui Bi zaï Pacôme zaouli Alain Serge Coulibaly Juliette Ky Dedi Training and Research Unit of Sciences of Nature Laboratory of Biology and Improvement of Plant Production Nangui Abrogoua University Abidjan Cte dIvoire Department of Plant Biology Training and Research Unit (UFR) of Biological Sciences Peleforo Gon Coulibaly University Korhogo Cte dIvoire

Onions are a horticultural crop of great economic, dietary and medicinal importance, and are highly prized by the Ivorian population. However, production remains low, due to a number of constraints, including parasitic attacks. The most frequent is fusariosis caused by Fusarium sp., a pathogen that causes enormous damage to onion crops. Faced with these attacks, chemical control appears to be ineffective, with consequences for human health and the environment. This is why the search for effective alternative methods that respect the environment and human health is so necessary. It is in this context that this study was carried out, with the general aim of controlling fusarium wilt in onion crops, with a view to improving onion production in Ivory Coast through the use of effective microorganisms. The experimental set-up used for this purpose was a fisher block with complete randomization, comprising three replicates. A fungal spore concentration of 106 spore/mL of Fusarium sp., three doses (1%;2.5% and 5% v/v) of EM and one dose of a chemical fungicide (30 mL/16L) were tested on young onion plants. Each block consisted of nine sub-plots with nine treatments. Health parameters (incidence and severity) and agronomic parameters (growth and yield) were assessed. Microbiological analysis of the EM revealed the presence of nine morphotypes of Trichoderma sp., Aspergillus clavatus, Aspergillus flavus, Aspergillus sp., Penicillium sp., Rhizopus sp., lactic acid bacteria of the Bacillus family and the yeast Saccharomyces cerevisiae. Field experimentation showed that the 5% EM microbial solution reduced the incidence and severity of fusariosis compared with the chemical fungicide, and proved to be the best. This dose reduced yield losses by 7.14%, while improving onion growth and yield by over 5%. The results demonstrated the ability of the EM solution to effectively control the causal agent of basal rot in onion crops.

关键词： Basal Rot Effective Microorganisms (EM) Fusarium sp. Onion

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