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Association of mitochondrial dysfunction and,lipid metabolism with type 2diabetes mellitus:A review of literature

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Frontiers in Biology 2018年第6期13卷 406-417页

作者： Karimeh Haghani Pouyan Asadi gholamreza Taheripak Ali Noori-Zadeh Shahram Darabi Salar Bakhtiyari Department of Clinical Biochemistry Faculty of MedicineIlam University of Medical SciencesIlamIran Medical Cellular &Molecular Research Center Golestan University of Medical SciencesGorgan1ran Department of Clinical Biochemistry School of Medicine1ran University of Medical SciencesTehran1ran Department of Clinical Biochemistry Faculty of Paramedicine1lain University of Medical Sciencesllam1ran Cellular and Molecular Research Center Qazvin University of Medical ScienceQazvin1ran

Diabetes mellitus (DM) is one of the most prevalent chronic diseases, and its prevalence continues to increase globally. The impact of mitochondrial dysfunction and lipid metabolism on diabetes mellitus and insulin resistance (IR) has been implicated in several previous reports; however, the results of studies are confusing despite four decades of study. This review has evaluated updated understanding of the role of mitochondrial dysfunction and lipid metabolism on type 2 diabetes, and found that mitochondrial dysfunction and lipid metabolism disorder induce the dysregulation of liver and pancreatic beta cells, insulin resistance, and type 2 diabetes. Mitochondrial dysfunction and lipid metabolism induce metabolic dysregulation and finally increasing the possibility of diabetes.

关键词： Insulin resistance Type 2 diabetes Mitochondrial dysfunction Lipid metabolism

基于粘聚区模型的电阻点焊搭接失效模拟（英文）

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Journal of Central South University 2018年第11期25卷 2567-2577页

作者： Mohammad Ali Saeimi SADIGH gholamreza MARAMI Bahman PAYGOZAR Department of Mechanical Engineering Azarbaijan Shahid Madani University Department of Mechanical Engineering University of Tabriz

本文主要研究电阻点焊(RSW)连接薄壁单搭接头在拉伸载荷作用下的断裂过程。对3组不同节点结构的搭接头进行试验,以获得接头的拉伸性能。为了模拟焊接接头的拉伸行为,首先采用二维轴对称有限元模型计算焊接过程中产生的残余应力,然后将... 详细信息

本文主要研究电阻点焊(RSW)连接薄壁单搭接头在拉伸载荷作用下的断裂过程。对3组不同节点结构的搭接头进行试验,以获得接头的拉伸性能。为了模拟焊接接头的拉伸行为,首先采用二维轴对称有限元模型计算焊接过程中产生的残余应力,然后将结果转化为三维模型作为预应力。在此基础上,采用粘聚区模型(CZM)对拉伸载荷作用下模型中的断裂进行数值模拟。采用拉皮法和剪切搭接法提取粘聚区参数。用于模拟单搭接点焊试样的变形和失效的结果表明,在模拟变形和断裂载荷时,考虑残余应力的影响对保证预测结果的准确性是必要的。

关键词：点焊断裂残余应力粘聚区

Galerkin法研究磁场和热辐射作用下的非牛顿纳米流体在垂直平板间的流动和自然对流换热特性（英文）

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Journal of Central South University 2019年第5期26卷 1294-1305页

作者： Peyman MAGHSOUDI gholamreza SHAHRIARI Hamed RASAM Sadegh SADEGHI School of Engineering University of TehranTehran ***Iran School of Engineering Iran University of Science and TechnologyTehran ***Iran

研究了在磁场和热辐射作用下,非牛顿纳米流体在两个无限大的垂直平板间流动的自然对流换热和流动特性。首先,采用相似变换法,将偏微分形式的动量和能量守恒方程转化为特殊边界条件下的非线性常微分方程组。应用Galerkin方法(GM),获得非... 详细信息

研究了在磁场和热辐射作用下,非牛顿纳米流体在两个无限大的垂直平板间流动的自然对流换热和流动特性。首先,采用相似变换法,将偏微分形式的动量和能量守恒方程转化为特殊边界条件下的非线性常微分方程组。应用Galerkin方法(GM),获得非线性常微分方程组的解析解,并给出了非线性常微分方程组的数值解。对比分析解析解和数值解,验证了模型的准确性、精度和可靠性。最后,综合考虑了磁场、辐射参数和纳米流体体积分数等参数对速度、摩擦阻力系数和Nusselt数分布的影响。结果表明,随着磁力作用的增大,速度场、摩擦阻力系数和热性能下降。辐射参数虽然对增强的速度场影响不大,但降低了摩擦阻力系和Nusselt数的影响。

关键词：非牛顿流体纳米流体流动 Galerkin法磁场辐射

Wound healing potential of Althaea officinalis flower mucilage in rabbit full thickness wounds

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亚太热带生物医学杂志：英文版 2015年第11期5卷 937-943页

作者： Robab Valizadeh Ali Asghar Hemmati gholamreza Houshmand Sara Bayat Mohammad Bahadoram Department of Pharmacology and Toxicology Herbal Research CenterPharmacy SchoolAhvaz Jundishapur University of Medical Sciences Medical Student Research Committee Ahvaz Jundishapur University of Medical Sciences

Objective: To evaluate and practically demonstrate the in fluence of Althaea officinalis flower mucilage as a plant known in Iran's and other Middle Eastern countries' traditional medicine for its wound healing ***: Animals were divided into 6 groups of 5 cases including a non-treated group as the negative control group receiving no treatment, a group treated with eucerin as the positive control group, a phenytoin 1% group as a standard group treated topically with phenytoin 1% hand-made ointment, and treatment groups treated with hand-made Althaea officinalis flower mucilage(AFM) ointment in a eucerin base with different concentrations(5%, 10%, 15%).Results: Among the treatment groups, the AFM 15% ointment showed the best *** healing duration was reduced by the surface application of these groups. Wound closure was completed on Days 14 and 15 in the AFM 15% ointment and phenytoin 1%groups, respectively. No significant difference was observed in healing period between these ***: In conclusion, AFM 15% ointment was found to reduce wound healing time without any significant difference with the phenytoin 1% ointment. The authors suggest increased AFM effectiveness in when combined with phenytoin or other effectual plants.

关键词： Wound Antibacterial Skin Mucilage Althaea flower R

Effect of royal jelly on in vitro fertilization and early embryo development following nicotine treatment in adult female rats

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Asian pacific Journal of Reproduction 2021年第3期10卷 121-126页

作者： Zhila Khodabandeh Vahid Nejati Ali Shalizar-Jalali gholamreza Najafi Fatemeh Rahmani Department of Biology Faculty of ScienceUrmia UniversityUrmiaIran Department of Veterinary Basic Sciences Faculty of Veterinary MedicineUrmia UniversityUrmiaIran

Objective:To scrutinize the protective role of royal jelly as an antioxidant on nicotine-induced changes in malondialdehyde(MDA)level,p53 expression,in vitro fertilization(IVF)rate,and early embryo development in adult female ***:A total of 56 adult female Wistar rats were divided into 8 groups(n=7 in each group).Group 1 served as an untreated control group,group 2,3 and 4 received nicotine at a dose of 0.50,1.00 and 2.00 mg/kg respectively,group 5 received royal jelly at a dose of 100.00 mg/kg,and group 6,7 and 8 received 0.50,1.00 and 2.00 mg/kg nicotine,respectively,with 100.00 mg/kg body weight royal *** and royal jelly were administered daily for 49 days in the experimental groups intra-peritoneally and orally,*** the end of the experimental period,p53 expression,IVF rate and early embryo development as well as MDA concentration were ***:The IVF rate,number of cumulus oocytes,two-cell embryos and blastocysts decreased in the nicotine-treated groups in a dose-dependent *** addition,p53 mRNA expression and MDA levels increased in the nicotine-treated *** jelly co-administration led to partial improvement in the aforementioned ***:Royal jelly may have a repro-protective effect in nicotine-administered female rats in terms of its anti-oxidant and anti-apoptotic properties.

关键词： Fertility Nicotine Ovary Rat Royal jelly In vitro fertilization Embryo development

Scientific and technical aspects of yogurt fortification:A review

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Food Science and Human Wellness 2015年第1期4卷 1-8页

作者： Hadi Hashemi Gahruie Mohammad Hadi Eskandari gholamreza Mesbahi Mohammad Amin Hanifpour Department of Food Science and Technology College of AgricultureShiraz UniversityShirazIran Fars Pegah Dairy Company ShirazIran

Food fortification is one of the most important processes for improvement of the nutrients quality and quantity in *** can be a very cost effective public health *** to the high consumption rate of dairy products such as yogurt,fortification of these products will effectively reduce or prevent diseases associated with nutritional *** aim of this investigation is to study the technical aspects involved in production of different types of fortified yogurts and their role in disease prevention and correction of *** this paper,firstly,fortification is defined and the main reasons behind carrying out this process are presented and then yogurt production process and a variety of minerals,vitamins,and functional ingredients which are used in the process are briefly discussed.©2015 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Yogurt fortification Minerals Vitamins Fiber

Examination of the Level of Heavy Metals in Wastewater of Bandar Abbas Wastewater Treatment Plant

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Open Journal of Ecology 2016年第2期6卷 55-61页

作者： gholamreza Mansourri Mehrzad Madani Science in Environmental Engineering Islamic Azad University Tehran Iran

One of the main environmental pollutants is heavy metals. Due to extensive usage in industry, these metals enter biological cycle rapidly and contaminated water and soil resources rapidly. In this work, lead, copper, zinc and chromium of Bandar Abbas wastewater are examined. For this research, nine stations were set for measurement in urban level in Bandar Abbas and sampling of aforesaid metals was performed in fall and winter 2006 in these stations. After extraction and preparation operations using APDC-MIBK, samples were measured using flame atomic absorption system. According to results, concentrate of studied metals was lower than allowable standard value set by Iran environmental protection organization for agricultural purposes and sewage to ground level waters. In addition, efficiency of Bandar Abbas wastewater treatment plant to remove these metals is 40% - 70% from which highest removal is for zinc as much as 71.1% and lowest level is for copper as much as 40.5%. However, copper level was higher than allowable level for agricultural purposes in spring and summer (0.21 mg/L and 0.23 mg/L, respectively) and lower in fall and winter (0.103 mg/L and 0.098 mg/L, respectively). Furthermore, changes in concentration of metals in these stations in various seasons were measured and analyzed using one-way variance analysis and simultaneous effects of time and place on measured variables were analyzed using two-way variance analysis.

关键词： Urban Wastewater Bandar Abbas Heavy Metals Treatment Plant

Dual effects of 3,4-methylenedioxymethamphetamine (ecstasy) on survival and apoptosis of primary hippocampal neurons

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Neural Regeneration Research 2009年第12期4卷 1068-1072页

作者： Abolfazl Azami Parichehr Pasbakhsh Mohammad Akbari Mohammad Barbarestani Mohammadhosein Ghahremani Mohammadali Shokrgozar Ali Mandegary Amir Kiani gholamreza Hassanzadeh Department of Anatomy School of MedicineTehran University of Medical Sciences Department of Toxicology-Pharmacology Faculty of PharmacyTehran University of Medical Sciences National Cell Bank of Iran Pasteur Institute of Iran School of Pharmacy Kermanshah University of Medical Scences

BACKGROUND： 3, 4-methylenedioxymethamphetamine （MDMA, also known as ＂ecstasy＂） has been shown to exhibit neurotoxic effects on the hippocampus. However, exposure to sub-lethal insults of MDMA has been reported to result in neuroprotection. OBJECTIVE： To investigate the effects of MDMA on hippocampal neuronal viability, caspase-3 activity, and mRNA expression of the N-methyI-D-aspartate （NMDA） receptor 2B （NR2B） subunit. DESIGN, TIME AND SETTING： A cytological, in vitro experiment was performed at the Department of Anatomy, School of Medicine, and Department of Toxicology-Pharmacology, Faculty of Pharmacy Tehran University of Medical Sciences in 2008. MATERIALS： MDMA was extracted from ecstasy tablets, which were kindly supplied by the Pharmacology-Toxicology Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Iran. METHODS： Hippocampal neurons were isolated from Wistar rats at gestational day 18. Following primary culture, hippocampal neuronal viability was detected by MTT assay. Varying concentrations of MDMA （100-5 000 μmol/L） were used to determine lethal concentration 50 （LC50）, which was around 1 500 μmol/L. Five concentrations of MDMA below 1 500 μmol/L （100, 200, 400, 800, and 1 050 μmol/L） were used for the remaining experiments. After 24 hours of MDMA treatment, NR2B mRNA expression was detected by RT-PCR, and caspase-3 relative activity was determined by colorimetric assay. MAIN OUTCOME MEASURES： Hippocampal neuronal viability, caspase-3 activity, and NR2B mRNA expression. RESULTS： MDMA-induced neurotoxicity in hippocampal neuronal cultures was dose-dependent. In high concentrations （1 000-5 000μmol/L） of MDMA, neuronal viability was decreased. However, with a 500 μmol/L dose of MDMA, neuronal viability was significantly increased （P 〈 0.01）. Low concentrations of MDMA （200 and 400μmol/L） significantly decreased caspase-3 activity （P 〈 0.01）, whereas high concentrations of MDMA significantly increased caspase-3 activity （P 〈 0.01）. NR2B

关键词： 3, 4-methylenedioxymethamphetamine ecstasy apoptosis N-methyI-D-aspartate neuronal culture

圆柱形壳体内牛顿型纳米流体的自然对流传热的实验研究（英文）

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Chinese Journal of Chemical Engineering 2015年第8期23卷 1266-1274页

作者： Hamid Moradi Bahamin Bazooyar Ahmad Moheb Seyed gholamreza Etemad Department of Chemical Engineering Isfahan University of Technology Ahvaz Faculty of Petroleum Engineering Petroleum University of Technology

This study characterizes and optimizes natural convection heat transfer of two Newtonian Al2O3 and Ti O2/water nano fluids in a cylindrical enclosure. Nusselt number(Nu) of nano fluids in relation to Rayleigh number(Ra) for different concentrations of nano fluids is investigated at different con figurations and orientations of the *** show that adding nanoparticles to water has a negligible or even adverse in fluence upon natural convection heat transfer of water: only a slight increase in natural convection heat transfer of Al2O3/water is observed,while natural convection heat transfer for TiO2/water nano fluid is inferior to that for the base fluid. Results also reveal that at low Ra, the likelihood of enhancement in natural convection heat transfer is more than at high Ra: at low Ra, inclination angle, aspect ratio of the enclosure and nanoparticle concentration in fluence natural convection heat transfer more pronouncedly than that in high Ra.

关键词：自然对流换热纳米流体圆筒形外壳优化牛顿自然对流传热纳米粒子