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Prognostic factors in patients with advanced cholangiocarcinoma: Role of surgery, chemotherapy and body mass index

World Journal of Gastroenterology 2008年第20期14卷 3224-3230页

作者： Mirna H Farhat Ali I Shamseddine Ayman N Tawil ghina berjawi Charif Sidani Wael Shamseddeen Kassem A Barada Division of Hematology-Oncology Department of Internal Medicine American University of Beirut Medical Center Department of Pathology American Universityof Beirut Medical Center Department of Radiology American University of Beirut Medical Center Department of Public health American University of Beirut Medical Center Division of Gastroenterology Departmentof Internal Medicine American University of Beirut MedicalCenter

AIM： To study the factors that may affect survival of cholangiocarcinoma in Lebanon. METHODS： A retrospective review of the medical records of 55 patients diagnosed with cholangio- carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. RJ^SULTS： The median survival of all patients was 8.57 mo （0.03-105.2）. Univariate analysis showed that low bilirubin level （〈 10 mg/dL）, radical surgery and chemotherapy administration were significantly associated with better survival （P = 0.012, 0.038 and 0.038, respectively）, in subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly （17.0 mo vs 3.5 mo, P = 0.001）. Multivariate analysis identified only low bilirubin level 〈 10 mg/dL and chemotherapy administration as independent predictors associated with better survival （P 〈 0.05）. CONCLUSION： Our data show that palliative and postoperative chemotherapy as well as a bilirubin level 〈 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma.

关键词： Cholangiocarcinoma Biliary tract cancer Chemotherapy Bilirubin Prognosis

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Deep Morphea in an Immunosuppressed Patient With Anti-U1RNP Myositis:A Case Report

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International Journal of Dermatology and Venereology 2024年第2期7卷 111-114页

作者： Ahmad berjawi Laure L.Irani Jinane R.El Khoury Department of Dermatology Gilbert and Rose Marie Chagoury School of MedicineLebanese American UniversityBeirut 1100Lebanon Department of Rheumatology Division of Internal MedicineGilbert and Rose Marie Chagoury School of MedicineLebanese American University Medical CenterBeirut 1100Lebanon

Introduction:Morphea is an inflammatory skin disease characterized by skin thickening due to increased collagen deposition in the dermis or subcutaneous ***-U1RNP myositis is a newly described entity characterized by myositis,arthritis,interstitial lung disease,and Raynaud *** present a case of a unique combination of deep morphea in a patient with anti-U1RNP *** presentation:A 64-year-old male with 5-year history of proximal muscle weakness,polyarthritis,Raynaud phenomenon,and dyspnea on multiple immunosuppressives presented with localized infiltrated,tight,and hyperpigmented plaques over the posterior thighs and mid-to-lower back developing over the last 2 years and limiting his *** workup revealed a positive ANA,anti-U1RNP antibody,anti-Jo1 antibody,and anti-Ro52 *** workup showed restrictive lung disease,kidney disease,and *** was diagnosed with anti-U1RNP *** biopsy of the back lesion showed deep ***:Association of deep morphea with anti-U1RNP myositis is not described prior in the *** of morphea is challenging since the patient is already on immunosuppressive *** patient failed methotrexate prior and is currently on Mycophenolate mofetil and Deflazacort which are reported as potential treatment for ***,physical therapy plus topical Tacrolimus were suggested as an initial measure to preserve the range of motion of his posterior thighs and *** is a case of progressive deep morphea developing in a patient with a unique autoimmune profile on immunosuppressive ***:Anti-U1RNP myositis is a challenging diagnosis and should be always thought of in patients with positive anti-U1RNP,myositis,interstitial lung disease,arthritis,kidney disease,and Raynaud ***,deep morphea treatment in immunosuppressed patients is challenging and different measures should be considered.

关键词： deep morphea immunosuppression anti-U1RNP myositis case report

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伴有苗勒管发育不全的腹股沟卵巢:病例报道及文献回顾

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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 32-32页

作者： Bazi T. berjawi G. Seoud M. 朱亮 Department of Obstetrics and Gynecology American University Beirut Medical Center Beirut Lebanon Dr.

Objective: To report on a patient with Mü llerian agenesis (MA) and inguinal ovaries and to reviewthe pertinent literature. Design: Case report and literature review. Setting: Clinical. Patient(s): A 12- year-old girl. Intervention(s): Magnetic resonance imaging, review of prior ovarian biopsies, karyotyping. Main Outcome Measure(s): Accuracy of diagnosis and preservation of ovarian function. Result(s): A 12- year-old girl with MA and bilateral inguinal ovaries is reported. An exhaustive review of the English literature on this rare association revealed only seven other well-documented such cases. Management of this condition involves reduction of the ovaries into the pelvis. Conclusion(s): The association of MA and bilateral inguinal ovaries is rare and possibly underreported. Ideal management consists of surgical reduction of the gonads into the pelvic cavity as soon as they are discovered, to decrease the risk of ovarian torsion and loss of ovarian function.

关键词：苗勒管发育不全卵巢扭转文献回顾双侧腹股沟并发疾病染色体核型分析活检切片外科手术英文

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