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腹针联合常规针刺治疗腰椎间盘突出症的临床观察

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光明中医 2018年第18期33卷 2712-2714页

作者：郑丽芬繁峙县人民医院康复科山西繁峙034300

目的探析腰椎间盘突出症患者应用腹针联合常规针刺治疗的临床效果。方法将2016年4月—2017年8月来我院治疗的86例腰椎间盘突出症患者选为研究对象,依照随机数字表法分为2组,即对照组(43例)、试验组(43例)。对照组患者应用常规针刺治疗,... 详细信息

目的探析腰椎间盘突出症患者应用腹针联合常规针刺治疗的临床效果。方法将2016年4月—2017年8月来我院治疗的86例腰椎间盘突出症患者选为研究对象,依照随机数字表法分为2组,即对照组(43例)、试验组(43例)。对照组患者应用常规针刺治疗,试验组患者在对照组基础上联合腹针治疗,对2组患者临床疗效、生活质量及不良事件发生情况进行统计比较。结果试验组临床总有效率明显高于对照组,数据分别为95.35%、79.07%,有统计学差异(P<0.05)。试验组躯体功能、心理功能、社会功能、物质生活评分明显高于对照组,有统计学差异(P<0.05)。试验组不良事件发生率明显低于对照组,数据分别为6.98%、23.26%,有统计学差异(P<0.05)。结论腰椎间盘突出症患者应用腹针联合常规针刺治疗的临床效果更加显著,不仅可以提高患者生活质量,还可以减少不良事件的发生,值得在临床中广泛应用与推广。

关键词：腰痛腰椎间盘突出症常规针刺腹针

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鹅及家鸽血红蛋白的肽链与其末端结构

四川大学学报(自然科学版) 1965年第1期 123-135页

作者：曾仲奎徐泽纹四川大学生化专业毕业学生

各类动物血红蛋白的化学结构的研究,近年来有了迅速的进展。诸如血红蛋白的分离、结构的测定及其比较生物化学等各方面,均已提出不少评论或报导。在鸟类血红蛋白的研究中,首由Saha等报导把鸡、珠鸡(Guinea fowl)、鸽、鸭等鸟类的血红蛋... 详细信息

各类动物血红蛋白的化学结构的研究,近年来有了迅速的进展。诸如血红蛋白的分离、结构的测定及其比较生物化学等各方面,均已提出不少评论或报导。在鸟类血红蛋白的研究中,首由Saha等报导把鸡、珠鸡(Guinea fowl)、鸽、鸭等鸟类的血红蛋白的纸电泳行为;而Matsuda对鸡的血红蛋白进行了柱层析纯化、肽链的裂解、与游离的α—氨基端结构的研究。但对其它鸟类血红蛋白的化学结构的研究;迄今的报导甚少。

关键词：珠蛋白血红蛋白 DnP 层析谱肽链家鸽鹁鸽

C3G contributes to platelet activation and aggregation by regulating major signaling pathways

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2103-2117页

作者： Sara Gutiérrez-Herrero Cristina Fernández-Infante Luis Hernández-Cano Sara Ortiz-Rivero Carlos Guijas Víctor Martín-Granado JoséRamón González-Porras Jesús Balsinde Almudena Porras Carmen Guerrero Instituto de Biología Molecular y Celular del Cáncer(IMBCC) University of Salamanca-CSICSalamancaSpain Instituto de Investigación Biomédica de Salamanca(IBSAL) SalamancaSpain Instituto de Biología y Genética Molecular(IBGM) Consejo Superior de Investigaciones Científicas(CSIC)University of ValladolidValladolidSpain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) MadridSpain Departamento de Hematologiá Hospital Universitario de Salamanca(HUS)SalamancaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaComplutense University of Madrid.Instituto de Investigación Sanitaria del Hospital Clínico San Carlos(IdISSC)MadridSpain Departamento de Medicina University of SalamancaSalamancaSpain

C3G is a GEF(guanine nucleotide exchange factor)for Rap GTPases,among which the isoform Rap1b is an essential protein in platelet *** transgenic mouse models with platelet-specific overexpression of C3G or mutant C3GΔCat,we have unveiled a new function of C3G in regulating the hemostatic function of platelets through its participation in the thrombin-PKCRap1b pathway.C3G also plays important roles in angiogenesis,tumor growth,and metastasis through its regulation of the platelet *** addition,C3G contributes to megakaryopoiesis and ***,we used a platelet-specific C3G-KO mouse model to further support the role of C3G in hemostasis.C3G-KO platelets showed a significant delay in platelet activation and aggregation as a consequence of the defective activation of Rap1,which resulted in decreased thrombus formation in ***,we explored the contribution of C3G-Rap1b to platelet signaling pathways triggered by thrombin,PMA or ADP,in the referenced transgenic mouse model,through the use of a battery of specific *** found that platelet C3G is phosphorylated at Tyr504 by a mechanism involving *** phosphorylation was shown to be positively regulated by ERKs through their inhibition of the tyrosine phosphatase ***,C3G participates in the ADP-P2Y12-PI3K-Rap1b pathway and is a mediator of thrombin-TXA2 ***,it inhibits the synthesis of TXA2 through cPLA2 *** together,our data reveal the critical role of C3G in the main pathways leading to platelet activation and aggregation through the regulation of Rap1b.

关键词： C3G platelet activation

基于TESPAR和LS-SVM算法的滚动轴承退化趋势预测

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煤矿机械 2017年第8期38卷 18-20页

作者：陈龙谭继文姜晓瑜青岛理工大学山东青岛266520

在分析了滚动轴承退化趋势预测是实现滚动轴承预防维护关键的基础上,提出了基于时间编码信号处理与识别(TESPAR)和最小二乘支持向量机(LS-SVM)相结合的滚动轴承性能退化趋势预测新方法。将通过TESPAR提取的性能退化特征集输入到LS-SVM... 详细信息

在分析了滚动轴承退化趋势预测是实现滚动轴承预防维护关键的基础上,提出了基于时间编码信号处理与识别(TESPAR)和最小二乘支持向量机(LS-SVM)相结合的滚动轴承性能退化趋势预测新方法。将通过TESPAR提取的性能退化特征集输入到LS-SVM中完成了滚动轴承的性能退化趋势预测,最后通过实例验证了所提出方法的有效性。

关键词：滚动轴承 TESPAR LS-SVM 退化趋势预测

Gastroenteritis in an adult female revealing hemolytic uremic syndrome: case report

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World Journal of Gastroenterology 2018年第6期24卷 763-766页

作者： Paulina Chinchilla-López Vania Cruz-Ramón Oscar Ramírez-Pérez nahum Méndez-Sánchez Liver Research Unit Medica Sur Clinic and Foundation

nowadays acute gastroenteritis infection caused by Escherichia coli(E. coli) O157:H7 is frequently associated with hemolytic uremic syndrome(hus), which usually developed after prodromal diarrhea that is often bloody. The abdominal pain accompanied by failure kidney is a suspicious symptom to develop this disorder. Their pathological characteristic is vascular damage which manifested as arteriolar and capillary thrombosis with abnormalities in the endothelium and vessel walls. The major etiological agent of hus is enterohemorragic(E coli) strain belonging to serotype O157:H7. The lack of papers about hus associated to gastroenteritis lead us to report this case for explain the symptoms that are uncommon. Furthermore, this report provides some strategies to suspect and make an early diagnosis, besides treatment approach to improving outcomes and prognosis for patients with this disorder.

关键词： Gastroenteritis Gastrointestinal hemorrhage Hemolytic-uremic syndrome Escherichia coli O157 Shiga-toxigenic Escherichia coli

盐酸美金刚联合奥氮平治疗阿尔茨海默病伴精神行为症状的临床研究

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中国临床药理学杂志 2017年第12期33卷 1113-1115,1119页

作者：杨永秀赵明学陈斌华齐若兵罗烈岚杭州市第七人民医院老年科杭州310013

目的观察盐酸美金刚联合奥氮平治疗阿尔茨海默病(AD)伴精神行为症状(BPSD)的临床疗效及安全性。方法将176例阿尔茨海默病患者随机分为对照组89例和试验组87例。对照组予以口服盐酸美金刚,第1周每日5 mg,第2周每日10 mg,第3周每日15 mg,... 详细信息

目的观察盐酸美金刚联合奥氮平治疗阿尔茨海默病(AD)伴精神行为症状(BPSD)的临床疗效及安全性。方法将176例阿尔茨海默病患者随机分为对照组89例和试验组87例。对照组予以口服盐酸美金刚,第1周每日5 mg,第2周每日10 mg,第3周每日15 mg,从第4周开始每日20 mg维持治疗;试验组在对照组盐酸美金刚治疗基础上,予以加用奥氮平,每日2.5 mg,每晚口服,最大剂量每日10 mg;2组患者一个疗程为2周,共治疗6个疗程。比较2组患者的临床疗效、日常生活能力量表(ADL)、神经精神症状问卷(nPI-1,nPI-2)评分,以及药物不良反应发生率。结果治疗后,试验组和对照组的总有效率分别为90.70%(78/86例)和75.29%(64/85例),差异有统计学意义(PnPI-1评分分别为(25.18±4.17),(23.02±3.98),(20.51±3.65),(17.85±3.08),(16.56±2.95)分;nPI-2评分分别为(46.86±4.65),(45.78±4.62),(43.53±4.24),(40.53±4.31),(38.91±4.27)分;ADL评分分别为(44.34±4.59),(44.25±4.53),(42.85±4.01),(40.30±3.98),(39.21±3.48)分。对照组nPI-1评分分别为(25.27±4.23),(24.67±4.12),(23.68±3.98),(21.36±3.57),(19.92±3.24)分;nPI-2评分分别为和(46.56±4.72),(46.31±4.51),(45.82±4.42),(43.21±4.37),(42.74±4.33)分;ADL评分分别为(43.62±4.61),(43.36±4.49),(43.08±4.25),(42.18±4.31),(41.27±4.29)分。第2,4,8周,试验组与对照组的nPI-1,nPI-2,ADL差异均有统计学意义(P0.05)。结论盐酸美金刚联合奥氮平治疗阿尔茨海默病伴精神行为症状的疗效优于单用盐酸美金刚,且不增加药物不良反应的发生率。

关键词：盐酸美金刚奥氮平阿尔茨海默病精神行为症状

A Possible Hypoallergenic Cereal in Wheat Food Allergy and Baker’s Asthma

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American Journal of Plant Sciences 2012年第12期3卷 1779-1781页

作者： Alicia Armentia Sara Martín Araceli Diaz-Perales Arantxa Palacín Leticia Tordesillas Manuel Herrero Blanca Martín-Armentia Allergy Section IEN UMDAI Hospital Universitario Rio Hortega de Valladolid Valladolid Spain Departamento de Biotecnología ETS Ingenieros Agrónomos Madrid Spain Pediatrics Service Hospital Universitario Rio Hortega Valladolid Spain

Background: Wheat is a potent allergen source and is one of the causes of baker’s asthma and food allergy. The best strategy for managing food hypersensitivity involves strict avoidance of the trigger. However, wheat is quite difficult to avoid. Several alternative strategies for the treatment of food allergy are under study. Spelt is a possible hypoallergenic crop that may be tried in patients with wheat allergy. Methods: We have evaluated the allergenic IgE hypersensitivity mediated by spelt in wheat allergic patients. Overall, 66 patients who suffered from baker’s asthma or food allergy (45 males and 21 females, mean age 28.6 ± 12.9 years) were included. We have also compared its reactivity with standard- ized extracts from wheat and with purified non-specific lipid transfer proteins from wheat (Tri a 14) and from peach (Pru p 3). Immunodetection with spelt and common bread wheat extracts (Triticum aestivum, cultivar Astral) was per- formed. Fresh wheat and spelt grain extracts were used both for oral and bronchial challenge and skin tests. Specific IgE detection to different cereals was performed using the Immuno CAP System (Phadia, Uppsala, Sweden). The bronchial challenge was positive with wheat Astral in 44 (67%) patients, all of them suffered from asthma. Thirteen (29.54%) of these 44 patients had negative the challenge with spelt. The oral challenge with wheat Astral was positive in 22 (33%) patients with wheat food allergy, and the same test was positive in only in 6 of them with spelt (27.3%). The diagnostic yield (sensitivity, specificity and predictive values) of routine tests in determining spelt allergy by specific positive challenge responses was determined. Prick tests for spelt versus positive challenge tests had a good sensitivity (94%, 86.5 - 99.4;95%CI) and specificity (86%, 84 - 90;95% CI) for the diagnosis of spelt allergy. Immunodetection detected minor differences among different extracts. Conclusion: In summary, the prick test and bronchial

关键词： Spelt Wheat Allergy Food Allergy Low Allergenic Plant Culture

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崂山猪染色体组型的研究

莱阳农学院学报 1989年第1期6卷 52-56页

作者：周克年王喜凤莱阳农学院牧医系莱阳农学院牧医系

本实验利用骨髓直接制片的方法,观察分析了崂山猪的染色体组型。结果表明,崂山猪二倍体细胞染色体数2n=38。其中18对常染色体可分成 A、B、C 三组。A 组8对,为中部着丝点染色体;B 组4对,为亚中部着丝点染色体;C 组6对,为端部着丝点染色... 详细信息

本实验利用骨髓直接制片的方法,观察分析了崂山猪的染色体组型。结果表明,崂山猪二倍体细胞染色体数2n=38。其中18对常染色体可分成 A、B、C 三组。A 组8对,为中部着丝点染色体;B 组4对,为亚中部着丝点染色体;C 组6对,为端部着丝点染色体。性染色体1对,为 XY 型,属中部着丝点染色体。染色体总臂数为64。

关键词：染色体组型崂山猪猪

光电监测英仙座一个亮蓝致密反射星云的照明星

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天文学报 1984年第2期 136-141页

作者：初毓桦赵昭旺王毕中国科学院紫金山天文台中国科学院云南天文台

本文报道了对英仙座一颗亮蓝致密反射星云的照明星所进行的三色光电监测。从1983年2月4/5夜的观测得知,这个天体仍有明显变光,但变幅已较1979年的为小。2月5/6夜观测到的光起伏,已和校验星的观测误差相近,由此推测,在近几年内,这个天体... 详细信息

本文报道了对英仙座一颗亮蓝致密反射星云的照明星所进行的三色光电监测。从1983年2月4/5夜的观测得知,这个天体仍有明显变光,但变幅已较1979年的为小。2月5/6夜观测到的光起伏,已和校验星的观测误差相近,由此推测,在近几年内,这个天体的中央星可能出现气壳活动的稳定期。

关键词：英仙座光电监测英仙星座反射星云尘埃星云致密亮蓝