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Rice melatonin deficiency causes premature leaf senescence via DNA methylation regulation

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The Crop Journal 2024年第3期12卷 721-731页

作者： Yue Lu Ahmed gharib Rujia Chen Hanyao Wang Tianyun Tao Zhihao Zuo Qing Bu Yanze Su Yaoqing Li Yanmo Luo Hamdi F.El-Mowafi Zhichao Wang Qianfeng Huang Shuting Wang Yang Xu Pengcheng Li Chenwu Xu Zefeng Yang Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education Agriculture College of Yangzhou UniversityYangzhou 225009JiangsuChina Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Jiangsu Key Laboratory of Crop Genetics and PhysiologyYangzhou UniversityYangzhou 225009JiangsuChina National Institute of Laser Enhanced Sciences(NILES) Cairo UniversityGiza 12613Egypt Rice research Department Field Crops Research InstituteAgricultural Research CenterSakhaKafr El-Sheikh 33717Egypt

In a study of DNA methylation changes in melatonin-deficient rice mutants,mutant plants showed premature leaf senescence during grain-filling and reduced grain *** deficiency led to transcriptional reprogramming,especially of genes involved in chlorophyll and carbon metabolism,redox regulation,and transcriptional regulation,during dark-induced leaf *** of mCG and mCHG in the melatonin-deficient rice mutants was associated with the expression change of both protein-coding genes and transposable element-related *** in gene expression and DNA methylation in the melatonin-deficient mutants were compensated by exogenous application of melatonin.A decreased S-adenosyl-L-methionine level may have contributed to the DNA methylation variations in rice mutants of melatonin deficiency under dark conditions.

关键词： Melatonin Premature leaf senescence Rice DNA methylation Epigenetic regulation

Quality of life and aging

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Life research 2024年第3期7卷 1-1页

作者： Masoud gharib Vahid Rashedi Department of rehabilitation Faculty of Paramedical SciencesMazandaran University of Medical SciencesSariIran Iranian research Center on Aging Department of AgingUniversity of Social Welfare and Rehabilitation SciencesTehranIran

The aging population has far-reaching implications for health,significantly influencing medical care and health *** to the World Health Organization(WHO),by 2030,one in six people worldwide will be aged 60 years or ***,the population of individuals aged 60 and older is projected to increase from 1 billion in 2020 to 1.4 billion in *** 2050,this population is expected to double,reaching 2.1 ***,the number of people aged 80 years and older is anticipated to triple between 2020 and 2050,reaching 426 million[1].This demographic shift toward older adults,known as population aging,initially began in high-income countries but has now extended to low and middle-income *** 2050,approximately two-thirds of the world’s population aged 60 and older will reside in these *** effects of this aging population pose significant challenges for human health,necessitating substantial societal adjustments[2].

关键词： demographic income reaching

Preparation,characterization and application of CuCrO_2/ZnO photocatalysts for the reduction of Cr(VI)

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Journal of Environmental Sciences 2012年第12期24卷 2173-2179页

作者： Wahiba Ketir gharib re.hila Mohamed Trari Abdelatif Amrane Technical and Scientific research Centre of Physico-Chemical Analysis BP 248RP 16004AlgiersAlgeria Laboratory of Storage and Valorisation of renewable Energies Faculty of ChemistryBP 3216111 AlgiersAlgeria Equipe Chimie et Ingenierie des Procede-UMR CNRS 6226 E.N.S.C.R.-Avenue de General Leclerc-CS 50837-35708 Rennes Cedex 7France

The delafossite CuCrO2 elaborated by sol-gel from 40 nm diameter colloid is optically active in the visible region. It is characterized physically and photoelectrochemically. The microstrncture is fairly homogenous with a mean crystallite size of ca. 2 Ixm. The optical gap （1.30 eV）, determined from the diffuse reflectance, is well suited to the sunlight spectrum. The Mott Schottky plot is characteristic of P-type conductivity with a flat band potential of-0.26 VscE. As application, the photoreduction of chromate is successfully achieved in air-equilibrated suspension CuCrO2/ZnO （1/1）. CuCrO2 is photoactivated by visible light and the electrons in the conduction band （-1.34 VscE） are injected to ZnO. In the presence of salicylic acid, a conversion of Cr（VI） to Cr（III） of 57% is obtained under optimal conditions （pH 3 at 25~C, 5x 10-4 mol/L） because of the HCrO4- dark adsorption onto ZnO （4HCrO4- ＋ 3C7H603 ＋ 1802 ＋ 16H~ 4Cr3＋＋ 21CO2 ＋ 19H20, AGO = -557 kcal/mol）. Prolonged illumination is accompanied by a deceleration in the photoactivity owing to the competitive water reduction, an issue of energetic concern. The hetero-system exhibits self sensitization for hydrogen production with an evolution rate of 149 Ixmol/（hr.g）.

关键词： delafossite CuCrO2, chromate photoreduction ZnO hydrogen

Outpatient insulin use in type 2 diabetes mellitus and acute respiratory distress syndrome outcomes:A retrospective cohort study

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World Journal of Clinical Cases 2024年第17期12卷 2966-2975页

作者： Georges Khattar Samer Asmar Laurence Aoun Fares Saliba Shaza Almardini Saif Abu Baker Catherine Hong Carolla El Chamieh Fadi Haddadin Toni Habib Omar Mourad Zeina Morcos Fatema Arafa Jonathan Mina Khalil El gharib Mohammad Aldalahmeh Salman Khan Elie Bou Sanayeh Department of Medicine Holy Spirit University of KaslikJounieh 00000Lebanon Department of Internal Medicine Staten Island University HospitalStaten IslandNY 10305United States Public Heath and Biostatistics Independent ResearchBeirut 0000Lebanon Department of Medicine Lebanese UniversityBeirut 00000Lebanon Department of Medicine University of BalamandBeirut 00000Lebanon Department of Medicine Lebanese American UniversityBeirut 00000Lebanon Department of Medicine Northwell Health Staten Island University HospitalNew YorkNY 10305United States

BACKGROUND The impact of type 2 diabetes mellitus(T2DM)on acute respiratory distress syndrome(ARDS)is debatable.T2DM was suspected to reduce the risk and complications of ***,during coronavirus disease 2019(COVID-19),T2DM predisposed patients to ARDS,especially those who were on insulin at *** evaluate the impact of outpatient insulin use in T2DM patients on non-COVID-19 ARDS *** We conducted a retrospective cohort analysis using the Nationwide Inpatient Sample *** patients diagnosed with ARDS were stratified into insulin-dependent diabetes mellitus(DM)(IDDM)and non-insulindependent DM(NIDDM)*** applying exclusion criteria and matching over 20 variables,we compared cohorts for mortality,duration of mechanical ventilation,incidence of acute kidney injury(AKI),length of stay(LOS),hospitalization costs,and other clinical *** Following 1:1 propensity score matching,the analysis included 274 patients in each ***,no statistically significant differences emerged between the IDDM and NIDDM groups in terms of mortality rates(32.8%vs 31.0%,P=0.520),median hospital LOS(10 d,P=0.537),requirement for mechanical ventilation,incidence rates of sepsis,pneumonia or AKI,median total hospitalization costs,or patient disposition upon *** Compared to alternative anti-diabetic medications,outpatient insulin treatment does not appear to exert an independent influence on in-hospital morbidity or mortality in diabetic patients with non-COVID-19 ARDS.

关键词： Acute respiratory distress syndrome Type 2 diabetes mellitus Insulin Length of stay Mortality Endotracheal intubation Acute kidney injury Coronavirus disease 2019

Novel Synthesis of Barbiturates

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Chinese Journal of Chemistry 2007年第3期25卷 382-384页

作者： ASHNAGAR Alamdar gharib NASERI Nahid SHEERI Behrang School of Pharmacy Ahwaz Jundi Shapour University of Medical Sciences Ahwaz 61739-44871 Iran Ahwaz Faculty of Petroleum Engineering Petroleum University of Technology Ahwaz 61739-44871 Iran

Knovenagel reaction of barbituric acid with different aldehydes were used to synthesize new barbiturates. This is a novel method which can be used to synthsis various types of new generation of barbiturates which are ... 详细信息

关键词： barbiturate barbituric acid Knovenagel reaction 5-(indol-3-ylmethylidene)barbituric acid 5-(thien-2-ylmethylidee)barbituric acid

Isolation and Identification of the Major Chemical Components Found in the Upper Parts of Teucrium Pofium Plants Grown in Khuzestan Province of Iran

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Chinese Journal of Chemistry 2007年第8期25卷 1171-1173页

作者： ASHNAGAR Alamdar gharib NASERI Nahid FOROOZANFAR Shahla School of Pharmacy Ahwaz Jundi Shapour University of Medical Sciences Ahwaz Iran Ahwaz Faculty of Petroleum Engineering Petroleum University of Technology Ahwaz Iran

Teucrium polium is a dwarf sub-shrub usually 30-60 cm high with many branches, which is fairly distributed throughout Iran, with its flowering being season mainly from April to July. The plant was collected during its flowering season in Baghmalek region in the North-East of Khuzestan province, Iran. After the identification of the genus, species and variety of the plant, the dried whole plant （flowers, fruits and the leaves） was steam distilled with different methods. The isolated essential oil was dried over anhydrous sodium sulphate and stored at 4-6 ℃. Analysis of the essential oil was carried out by GC-MS technique. At least 10 major components were identified （3-carene/α-pinene, β-phellandrene, limonene, germacrene, β-bourbonene, β-caryophylene, γ-muurolene, γ-elemene, spathulenol, β-eudesmol）（totally 97.02%）. Also, successive TLC and column chromatography of the essential oil resulted in the separation of four fractions. Based upon 1^H NMR, IR and mass spectra, the fractions with Rf=0.12 and 0.93 were determined as gualol and a mixture of α-pinene, β-phellandrene and limonene, respectively.

关键词： teucrium polium labiatae germander α-pinene β-phellandrene limonene guaiol GC-mass analysis

Comparison of the effects of high-intensity interval and moderate-intensity continuous training on inflammatory markers,cardiorespiratory fitness,and quality of life in breast cancer patients

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Journal of Sport and Health Science 2023年第6期12卷 674-689,F0003页

作者： Amin Isanejad Somayeh Nazari Behroz gharib Ali Ghanbari Motlagh Immunoregulation research Center Shahed UniversityTehran ***Iran Department of Exercise Physiology Sport Sciences Research InstituteTehran ***Iran Department of Physical Education and Sport Sciences Faculty of Human SciencesShahed UniversityTehran ***Iran Oncology Department Naft HospitalTehran ***Iran Cancer research Center Shahid Beheshti University of Medical SciencesTehran ***Iran

Background:As the effectiveness of breast cancer treatment has improved,a growing number of long-term breast cancer survivors are seeking help for unique health *** patients may be at increased risk of cardiovascular disease due to the side effects of *** positive impact of most types of exercise has been repeatedly reported in people with cancer,but the most effective exercise approaches for maximum beneficial adaptations remain ***,this study aimed to compare the effects of high-intensity interval training(HIIT)and moderate-intensity continuous training(MICT) on inflammatory indices,adipokines,metabolic markers,body composition,cardiorespiratory fitness,and quality of life in breast cancer patients during adjuvant endocrine ***:Thirty non-metastatic breast cancer patients during adjuvant endocrine therapy who had been treated with chemotherapy and/or radiotherapy were recruited from Iran and randomized to HIIT,MICT,or control groups for a supervised exercise intervention that took place 3 times a week for 12 *** training intensity was determed based on the peak oxygen uptake(VO2peak),and the volume of training was matched in HIIT and MICT based on the *** composition,functional capacity,cardiorespiratory fitness,metabolic indices,sex hormones,adipokines,and inflammatory markers were assessed before and after the ***:The VO2peakincreased by 16.8% in the HIIT group in comparison to baseline values(mean difference=3.61 mL/kg/min).HIIT significantly improved the VO2peakcompared to control(mean difference=3.609 mL/kg/min) and MICT(mean differences=2.974 mL/kg/min)*** HIIT(mean difference=9.172 mg/dL) and MICT(mean difference=7.879 mg/dL) interventions significantly increased highdensity lipoprotein cholesterol levels compared to the control *** analysis of covariance showed that physical well-being significantly improved in MICT compared to control group(mean difference=3.268)

关键词： Breast cancer Cardiorespiratory fitness HIIT Inflammation MICTTagedAPTARAEnd

Influence of sex and rearing method on performance and flock uniformity in broilers-implications for research settings

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Animal Nutrition 2023年第1期12卷 276-283页

作者： Ashley England Kosar gharib-Naseri Sarbast KKheravii Shu-Biao Wu School of Environmental and Rural Science University of New EnglandArmidaleNSW2351Australia

Male and female broiler chickens differ in their growth performance,carcass part weights and nutrient *** potential reasons for these differences have been explored by looking at differences in nutrient digestibility,nutrient transporter gene expression as well as gut microbiota populations between male and female *** have shown that male broilers have higher crude protein requirements compared to female *** expression of monosaccharide and amino acid transporters show conflicting results as expression depends on the interactions between sex and bird age and breed as well as which tissue is *** in microbiota populations between the genders were reported which may contribute towards performance differences,however research in this area is *** differences observed between the sexes contribute to increased variation in nutrition trials,and the potential to rear birds as equally mixed-sex becomes an option to reduce the variation introduced by the sex *** in rearing options obviously would only be feasible provided a quick,practical and cost-effective method of sexing birds is available,a topic that is also discussed in this review.

关键词： Sex effect Chicken Gut microbiota Nutrient transporter gene expression Sexing method

The influence of microwave irradiation on rocks for microwaveassisted underground excavation

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Journal of Rock Mechanics and Geotechnical Engineering 2016年第1期8卷 1-15页

作者： Ferri Hassani Pejman M.Nekoovaght Nima gharib Department of Mining and Material Engineering McGill University

Demand is growing for explosive-free rock breakage systems for civil and mining engineering, and space industry applications. This paper highlights the work being undertaken in the Geomechanics Laboratory of Mc Gill University to make a real application of microwave-assisted mechanical rock breakage to fullface tunneling machines and drilling. Comprehensive laboratory tests investigated the effect of microwave radiation on temperature profiles and strength reduction in hard rocks(norite, granite, and basalt)for a range of exposure times and microwave power levels. The heating rate on the surface of the rock specimens linearly decreased with distance between the sample and the microwave antenna, regardless of microwave power level and exposure time. Tensile and uniaxial compressive strengths were reduced with increasing exposure time and power level. Scanning electron micrographs(SEMs) highlighted fracture development in treated basalt. It was concluded that the microwave power level has a strong positive influence on the amount of heat damage induced to the rock surface. Numerical simulations of electric field intensity and wave propagation conducted with COMSOL Multiphysics~ software generated temperature profiles that were in close agreement with experimental results.

关键词： Microwaves Crack density Microwave-assisted tunnel boring Rock breakage