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Hepatoprotective and antioxidant activity of methanolic extract of flowers of Nerium oleander against CCl_4-induced liver injury in rats

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Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 677-685页

作者： Kumar Gaurav Singhal ghanshyam das gupta Pharmacology & Toxicology Research Lab Department of PharmacologyASBASJSM College of PharmacyBelaRopar-140111PunjabIndia ASBASJSM College of Pharmacy BelaRopar-140111PunjabIndia

Objective:To investigate the antioxidant and hepatoproteetive activity of methanolic flower extract of Nerium oleander against CCl4—induced hepatotoxicity in ***:In vitro antioxidant activity of methanolic extract of dowers of Nerium oleander（MENO-F） was evaluated by various assays,including reducing power,lipid ***,superoxide anion,hydroxyl radicals and metal *** hepatoproteetive and in vivo antioxidant activity of MENO-F were evaluated against CCl4-induced hepatic damage in *** MENO-F at dose of 100.200 and 400 mg/kg were administered orally once daily for seven *** enzymatic levels of serum glutamate oxaloacetate transaminase（AST）,serum glutamate pyruvate transaminase（ALT）,serum alkaline phosphatase（ALP） and total bilirubin were estimated along with estimation of superoxide dismutase（SOD） and malondialdehvde（MDA） levels in liver *** histopathological examination of the liver sections was carried out to support the induction of hepalotoxicity and hepatoproteetive ***:The extract showed potent activities on reducing power,lipid *** anion,hydroxyl radical and metal *** substantially elevated serum enzymatic levels of AST,*** and total bilirubin were found to he restored towards normalization significantly by the MENO-F in a dose dependent manner with maximum hepatoprotection at 400 mg/kg dose *** histopathological observations supported the biochemical evidences of *** level of SOD and decreased level of MDA further strengthen the hepatoproteetive observations. The results of the present study strongly reveal that MENO-F has potent antioxidant activity and hepatoproteetive activity against CCl4—induced hepatic damage in experimental animals.

关键词： Hepatoprotective Antioxidant Carbon tetrachloride Nerium oleander Silymarin

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Image Segmentation Based on Block Level and Hybrid Directional Local Extrema

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Computers, Materials & Continua 2022年第2期70卷 3939-3954页

作者： ghanshyam Raghuwanshi Yogesh gupta Deepak Sinwar Dilbag Singh Usman Tariq Muhammad Attique Kuntha Pin Yunyoung Nam Manipal University Jaipur Jaipur302026India BMLMunjal University GurugramIndia Bennett University Greater NoidaIndia College of Computer Engineering and Sciences Prince Sattam Bin Abdulaziz UniversityAl-KhrajSaudi Arabia Department of Computer Science HITEC University TaxilaTaxilaPakistan Department of ICT Convergence Soonchunhyang UniversityAsan 31538Korea Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea

In the recent decade,the digitalization of various tasks has added great flexibility to human lifestyle and has changed daily routine activities of *** segmentation is a key step in *** plays a key role in almost all areas of image processing,and various approaches have been proposed for image *** this paper,a novel approach is proposed for image segmentation using a nonuniform adaptive ***-based image segmentation along with a directional binary pattern generated a better segmented *** adaptive mask of 8×8 was circulated over the pixels whose bit value was 1 in the generated directional binary *** was performed in three phases:first,an image was divided into sub-images or image chunks;next,the image patches were taken as input,and an adaptive threshold was generated;and finally the image chunks were processed separately by convolving the adaptive mask on the image *** and Laplacian of Gaussian algorithms along with directional extrema patterns provided a double check for boundary *** proposed approach was tested on chunks of varying sizes,and after multiple iterations,it was found that a block size of 8×8 performs better than other chunks or block *** accuracy of the segmentation technique was measured in terms of the count of ill regions,which were extracted after the segmentation process.

关键词： Image segmentation HDEP block-level processing adaptive threshold

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Validation of Vesical Imaging Reporting and Data System score for the diagnosis of muscle-invasive bladder cancer: A prospective cross-sectional study

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Asian Journal of Urology 2022年第4期9卷 467-472页

作者： Kumawat ghanshyam Vyas Nachiket Sharma Govind Priyadarshi Shivam gupta Bhagwan Sahay Singla Mohit Kumar Ashok Department of Urology Sawai Man Singh Medical College and HospitalJaipurRajasthanIndia

Objective:Vesical Imaging Reporting and Data System(VIRADS)score was developed to standardize the reporting and staging of bladder tumors on pre-operative multiparametric magnetic resonance *** helps in avoiding unnecessary repeat transurethral resection of bladder tumor in high-risk non-muscle-invasive bladder cancer *** study was done to determine the validity of VIRADS score prospectively for the diagnosis of muscleinvasive bladder ***:This study was conducted from March 2019 to March 2020 at Sawai Man Singh Medical College and Hospital,Jaipur,Rajasthan,*** admitted with the provisional diagnosis of bladder tumor were included as *** these patients underwent a 3 Tesla mpMRI to obtain a VIRADS score before they underwent transurethral resection of bladder tumor and these data were analyzed to evaluate the correlation of pre-operative VIRADS score with mus-cle invasiveness of the tumor in final biopsy ***:A cut-off of VIRADS≥4 for prediction of detrusor muscle invasion yielded a sensitivity of 79.4%,specificity of 94.2%,positive predictive value of 90.0%,negative predictive value of 87.5%,and diagnostic accuracy of 86.4%.A cut off of VIRADS≥3 for prediction of detrusor muscle invasion yielded a sensitivity of 91.2%,specificity of 78.8%,positive predictive value of 73.8%,negative predictive value of 93.2%,and accuracy of 83.7%.The receiver operating curve showed the area under the curve to be 0.922(95%confidence interval:0.862e0.983).Conclusion:VIRADS score appears to be an excellent and effective pre-operative radiological tool for the prediction of detrusor muscle invasion in bladder cancer.

关键词： Vesical Imaging Reporting and Data System Bladder tumor Multiparametric magnetic resonance imaging Detrusor invasion

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