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Sexual dimorphism of G protein-coupled receptor signaling in the brain

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Neural Regeneration Research 2024年第8期19卷 1635-1636页

作者： Sara Aljoudi Hamdan Hamdan Khaled S.abd-Elrahman Department of Physiology and Immunology College of Medicine and Health SciencesKhalifa UniversityAbu DhabiUnited Arab Emirates Healthcare Engineering Innovation Center(HEIC) Khalifa UniversityAbu DhabiUnited Arab Emirates Department of Anesthesiology Pharmacology and Therapeuticsand Djavad Mowafaghian Center for Brain HealthUniversity of British ColumbiaVancouverBCCanada Department of Pharmacology and Therapeutics College of Medicine and Health ScienceKhalifa UniversityAbu DhabiUnited Arab Emirates Department of Pharmacology and Toxicology Faculty of PharmacyAlexandria UniversityAlexandriaEgypt

G protein-coupled receptors(GPCRs)represent the most substantial family of membrane receptors that are targeted by *** and Drug Administration-approved *** of the preclinical research to understand the pharmacology of... 详细信息

关键词： drugs clinical targeted

Perception beyond sight:Investigating the cognitive maps of congenitally blind individuals in urban environments

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Frontiers of Architectural Research 2024年第4期13卷 809-821页

作者： Anwar Ibrahim Hikmat HAli Zainab mahmoud College of Architecture and Design Jordan University of Science and TechnologyIrbidJordan College of Engineering and Architecture Al Yamamah UniversityRiyadhKSA

This study explores the challenges faced by congenitally blind individuals in navigating urban ***,this research investigates the factors that contribute to the construction of city mental mapping for individuals who are born ***-one congenitally blind individuals from the University of Jordan were asked to define and describe specific elements of the city based on their personal experiences and ***,participants were guided through two urban paths:familiar and *** participants were asked to complete a survey regarding their experiences during the *** collected data was analyzed by using thematic *** results revealed that congenitally blind individuals construct their mental image of the city by using their three senses of touching,hearing,and smelling,as well as their safety and *** mental image consists of five key elements:links,reference points,areas,separators,and *** the small size of the study sample and the specificity of the context,the results of this study will tremendously help planners in designing highly inclusive urban *** characteristics that can be recognized by the blinds will enhance their accessibility of urban spaces,encourage independent mobility,increase the quality of life and social inclusion for them.

关键词： Mental map City image Congenital blind Cognitive mapping Environmental perception

Anthropogenic mineral generation and its potential resource supply:The case of niobium

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Science China Earth Sciences 2024年第8期67卷 2583-2591页

作者： Xianlai ZENG Moisés Gómez mahmoud BAKRY Yong GENG Jinhui LI School of Environment Tsinghua UniversityBeijing 100084China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200030China

The strategy of carbon neutrality is reshaping the global landscape of resource flow and *** the final sink of geological minerals,the proliferated anthropogenic minerals,also called secondary resources,play an increasingly important role in resource supply *** is a critical metal that lacks full concern for its *** fundamental principle of niobium circularity is to recycle and maintain the material as close to the manufacturing process as *** we estimate the niobium-containing applications lost at their end-of-life,underscoring the imperative to minimize such ***,we elucidate the extraction processes for scrap and alloy quantities throughout the industry's *** from anticipated waste generated by the majority of niobium applications,a forecast indicates a potential loss of approximately 168 kt by 2090 in the absence of ***,with a recycling efficiency of 90%for niobium,the projected loss diminishes to approximately 16 *** delve into the significance of niobium's circular economy and explore various aspects that demand further investigation for a seamless transition from linear to circular practices.

关键词： Niobium Anthropogenic mineral Circular economy Recycling Sustainability

Efficient energy harvesting from PV Panel with reinforced hydrophilic nano-materials for eco-buildings

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Energy and Built Environment

Energy and Built Environment 2024年第3期5卷 393-403页

作者： Ahmed Elnozahy Heba abd-Elbary Farag K.Abo-Elyousr Department of Electrical Engineering Faculty of EngineeringAssiut UniversityAssiut 71516Egypt

The main target of this research is to allow solar PV to contribute economically to an on-grid energy-efficient building where the dust accumulation is a significant ***-cleaning coatings such as hydrophobic or hy-drophilic materials have recently been introduced to reduce dust deposition on building-integrated PV(BIPV)*** hydrophilic Nano-coated material is examined as a solution to decrease the impact of the dust on the BIPV panels and harvest more solar *** impartial comparison of the BIPV panels performance under natu-ral dust conditions,manual cleaning,and hydrophilic nanomaterial coating is *** an exhaustive and qualitative experimental analysis,the anti-reflection and anti-static properties of the utilized Nano-coated material are *** experimental results show that the hydrophilic Nano-coated material significantly improves the gathered maximum output power by 18%compared to the manually wiped *** calculated efficiencies of the Nano-coated,manual cleaning,and dusty panels are 11%,9%,and 6%,respectively,which highlights the futureproofing of the Nano-coated solar *** to the dusty panels,the ecological and economical results show that the BIPV carbon emissions are desirably dropped by 11%while using Nano-coated PV panels and the payback period is reduced to 3.9 years,which is approximately 12.8%faster.

关键词： Hydrophilic Self-cleaning BIPV panels Nano-coating Techno-economic

Hydrogen Permeation Characteristics of Pd-CuMembrane in Plasma Membrane Reactor

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Energy Engineering 2024年第2期121卷 259-272页

作者： Muhd Hadi Iskandar abd Razak Motoki Tsuda YukioHayakawa Shinji Kambara Graduate School of Engineering Gifu UniversityGifu501-1193Japan

Hydrogen is an alternative energy source that has the potential to replace fossil *** of the hydrogen applications is as a material for Polymer Electrolyte Membrane Fuel Cells(PEMFC)in fuel cell ***-purity hydrogen can be obtained using a hydrogen separation membrane to prevent unwanted contaminants from potentially harming the PEMFC *** this study,we fabricated a plasma membrane reactor and investigated the permeation performance of a hydrogen separation membrane in a plasma membrane reactor utilizing atmospheric pressure *** result showed the hydrogen permeation rate increasing with time as reactor temperature is increased through joule *** decreasing the gap length of the reactor from 2 to 1 mm,the hydrogen permeation rate increases by up to 40%.The hydrogen permeation rate increases by 30%when pressure is applied to the plasma membrane reactor by up to 100 kPa.

关键词： Hydrogen energy hydrogen separation membrane atmospheric pressure plasma

Hybrid Model of Power Transformer Fault Classification Using C-set and MFCM – MCSVM

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 672-685页

作者： Ali abdo Hongshun Liu Yousif mahmoud Hongru Zhang Ying Sun Qingquan Li Jian Guo Shandong Provincial Key Laboratory of UHV Transmission Technology and Equipment School of Electrical EngineeringShandong UniversityJinan 250061China

This paper aims to increase the diagnosis accuracy of the fault classification of power transformers by introducing a new off-line hybrid model based on a combination subset of the et method(C-set)&modified fuzzy C-mean algorithm(MFCM)and the optimizable multiclass-SVM(MCSVM).The innovation in this paper is shown in terms of solving the predicaments of outliers,boundary proportion,and unequal data existing in both traditional and intelligence *** into consideration the closeness of dissolved gas analysis(DGA)data,the C-set method is implemented to subset the DGA data samples based on their type of faults within unrepeated ***,the MFCM is used for removing outliers from DGA samples by combining highly similar data for every subset within the same cluster to obtain the optimized training data(OTD)*** is also used to minimize dimensionality of DGA samples and the uncertainty of transformer condition *** that,the optimized MCSVM is trained by using the(OTD).The proposed model diagnosis accuracy is 93.3%.The obtained results indicate that our model significantly improves the fault identification accuracy in power transformers when compared with other conventional and intelligence models.

关键词： Combination subset of set(C-set)method modified fuzzy C-means(MFCM) optimizable multiclass-SVM(MCSVM) optimized training data(OTD)

Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

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Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： Manal abd El-Salam Marwa Mohamed Anwar Rasha mahmoud Gouda Naglaa Abou El Fattah Nadia Youssef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and Methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status

Electrospun Aloe Vera Extract Loaded Polycaprolactone Scaffold for Biomedical Applications:A Promising Candidate for Corneal Stromal Regeneration

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Journal of Bionic Engineering 2024年第4期21卷 1949-1959页

作者： Amin Orash mahmoud Salehi Mohammad Rafienia Narsimha Mamidi Saeed Heidari Keshel Alireza Baradaran-Rafii Department of Chemistry and Nanotechnology School of Engineering and ScienceTecnologico de MonterreyMonterreyNuevo Leon64849Mexico Biosensor Research Center Isfahan University of Medical SciencesIsfahan81746-73461Iran Wisconsin Center for NanoBioSystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWisconsin53705USA Medical Nanotechnology Research Center Shahid Beheshti University of Medical SciencesTehran19857-17443Iran Department of Ophthalmology Ophthalmic Research CenterLabbafinejad Medical CenterShahid Beheshti University of Medical SciencesTehran19395-4631Iran Department of Ophthalmology Morsani College of MedicineUniversity of South FloridaTampaFL33612USA Department of Tissue Engineering and Applied Cell Science School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehran19857-17443Iran

Corneal diseases,the second leading cause of global vision loss affecting over 10.5 million people,underscores the unmet demand for corneal tissue *** the scarcity of fresh donor corneas and the associated risks of immune rejection,corneal tissue engineering becomes *** nanofibrous scaffolds that mimic the natural corneal structure is crucial for creating transparent and mechanically robust corneal equivalents in tissue ***,Aloe Vera Extract(AVE)/Polycaprolactone(PCL)nanofibrous scaffolds were primed using *** electrospun AVE/PCL fibers exhibit a smooth,bead-free morphology with a mean diameter of approximately 340±95 nm and appropriate light *** measurements reveal Young’s modulus and ultimate tensile strength values of around 3.34 MPa and 4.58 MPa,respectively,within the range of stromal *** addition,cell viability of AVE/PCL fibers was measured against Human Stromal Keratocyte Cells(HSKCs),and improved cell viability was *** cell-fiber interactions were investigated using scanning electron *** conclusion,the incorporation of Aloe Vera Extract enhances the mechanical,optical,hydrophilic,and biological properties of PCL fibers,positioning PCL/AVE fiber scaffolds as promising candidates for corneal stromal regeneration.

关键词： Corneal stromal regeneration Aloe vera extract Polycaprolactone Electrospinning

Source Camera Identification Algorithm Based on Multi-Scale Feature Fusion

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Computers, Materials & Continua 2024年第8期80卷 3047-3065页

作者： Jianfeng Lu Caijin Li Xiangye Huang Chen Cui mahmoud Emam School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China Shangyu Institute of Science and Engineering Hangzhou Dianzi UniversityShaoxing312300China Key Laboratory of Public Security Information Application Based on Big-Data Architecture Ministry of Public SecurityZhejiang Police CollegeHangzhou310000China Faculty of Artificial Intelligence Menoufia UniversityShebin El-Koom32511Egypt

The widespread availability of digital multimedia data has led to a new challenge in digital *** source camera identification algorithms usually rely on various traces in the capturing ***,these traces have become increasingly difficult to extract due to wide availability of various image processing *** Neural Networks(CNN)-based algorithms have demonstrated good discriminative capabilities for different brands and even different models of camera ***,their performances is not ideal in case of distinguishing between individual devices of the same model,because cameras of the same model typically use the same optical lens,image sensor,and image processing algorithms,that result in minimal overall *** this paper,we propose a camera forensics algorithm based on multi-scale feature fusion to address these *** proposed algorithm extracts different local features from feature maps of different scales and then fuses them to obtain a comprehensive feature *** representation is then fed into a subsequent camera fingerprint classification *** upon the Swin-T network,we utilize Transformer Blocks and Graph Convolutional Network(GCN)modules to fuse multi-scale features from different stages of the backbone ***,we conduct experiments on established datasets to demonstrate the feasibility and effectiveness of the proposed approach.

关键词： Source camera identification camera forensics convolutional neural network feature fusion transformer block graph convolutional network