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电刺激小脑顶核下调缺血心肌炎性细胞因子基因表达

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科技导报 2006年第4期24卷 86-90页

作者：张润峰李霞陈运贞唐克新马国中黄宣银罗再贵冯瑾同济大学管理科学与工程博士后流动站上海200092 复旦大学医学院生理与病理生理学系上海200032 重庆医科大学附属第一医院心内科重庆400016 四川省绵阳市第三人民医院四川绵阳621000

探讨预先电刺激小脑顶核(FNS)对心肌梗死(MI)大鼠心肌炎性细胞因子基因表达的干预作用。分别采用小脑顶核电刺激或小脑顶核毁损(FNL)技术及左冠状动脉前降支(LAD)结扎法建立大鼠实验模型。实验分组:①MI组,单纯结扎LAD;②FNS+MI组,即先F... 详细信息

探讨预先电刺激小脑顶核(FNS)对心肌梗死(MI)大鼠心肌炎性细胞因子基因表达的干预作用。分别采用小脑顶核电刺激或小脑顶核毁损(FNL)技术及左冠状动脉前降支(LAD)结扎法建立大鼠实验模型。实验分组:①MI组,单纯结扎LAD;②FNS+MI组,即先FNS,后结扎LAD组;③FNL+FNS+MI组,即毁损小脑顶核后电刺激小脑顶核部位,再行LAD结扎组;④假手术组(Sham组),仅在LAD下穿线不结扎。各组按结扎LAD后的时程又随机分为1、7、21d3个时间点进行研究。应用逆转录聚合酶链反应法检测(RT-PCR)心肌梗死区(iz)与非梗死区(Niz)肿瘤坏死因子α(TNF-α)、白介素1β(IL-1β)、白介素6(IL-6)mRNA的表达,结果发现,MI后TNF-α、IL-β和IL-6mRNA表达不论在iz还是Niz均明显增加,其中以冠状动脉结扎后第7d最明显。经FNS预处理后,上述细胞因子在MI后各时间点的表达明显下降;提前毁损小脑顶核后再给予电刺激则无以上作用。研究证实,FNS可下调炎性细胞因子TNF-α、IL-1β、IL-6mRNA的表达。因此,FNS很可能发展成一种使MI患者受益的防治方法。

关键词：小脑顶核电刺激心肌梗死炎性细胞因子

Reconstruction of Cherenkov image bymultiple telescopes of LHAASO-WFCTA

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Radiation Detection Technology and Methods 2022年第4期6卷 544-557页

作者： F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi J.T.Cai Zhe Cao Zhen Cao J.Chang J.F.Chang E.S.Chen Liang Chen Liang Chen Long Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen Y.Chen H.L.Cheng N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.D’Ettorre Piazzoli B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu Ddella Volpe K.K.Duan J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng X.T.Feng Y.L.Feng B.Gao C.D.Gao L.Q.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu F.L.Guo J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu Q.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang W.H.Huang X.T.Huang X.Y.Huang Y.Huang Z.C.Huang X.L.Ji H.Y.Jia K.Jia K.Jiang Z.J.Jiang M.Jin M.M.Kang T.Ke D.Kuleshov K.Levochkin B.B.Li Cheng Li Cong Li F.Li H.B.Li H.C.Li H.Y.Li J.Li Jian Li Jie Li K.Li WLLi XRLi Xin Li Xin Li YZLi Zhe Li Zhuo Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.Liu Y.N.Liu W.J.Long R.Lu Q.Luo H.K.Lv B.Q.ma L.L.ma X.H.ma J.R.mao A.masood Z.Min W.Mitthumsiri Y.C.Nan Z.W.Ou B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi Y.Q.Qi B.Q.Qiao J.J.Qin D.Ruffolo A.Sáiz C.Y.Shao L.Shao O.Shchegolev X.D.Sheng J.Y.Shi H.C.Song Yu.V.Stenkin V.Stepanov Y.Su Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.Wang R.N.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu X.F.Wu Y.S.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang D.X.Xiao G.Xiao G.G.Xin Y.L.Xin Y.Xing Z.Xiong D.L.Xu R.X.Xu L.Xue D.H.Yan J.Z.Yan C.W.Yang F.F.Yang H.W.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang F.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang L.X.Zhang Li Zhang Lu Zhang P.F.Zhang P.P.Zhang R.Zhang S.B.Zhang S.R.Zhang S. Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2DublinIreland max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina Key Laboratory of Dark matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and Astronomy(Zhuhai)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000China School of Physics(Guangzhou) Sun Yat-sen UniversityGuangzhou 510275GuangdongChina Dipartimento di Fisica.dell’Universitàdi Napoli“Federico II” Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of Physics and Astronomy Yunnan UniversityKunming 650091YunnanChina Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève

Introduction One of main scientiﬁc goals of the Large High Altitude Air Shower Observatory(LHAASO)is to accurately measure the energy spectra of different cosmic ray compositions around the‘knee’*** Wide Field-of-View(FoV)Cherenkov Telescope Array(WFCTA),which is one of the main detectors of LHAASO and has 18 telescopes,is built to achieve this *** telescopes are put together and point to connected directions for a larger *** Telescopes are deployed spatially as close as possible,but due to their own size,the distance between two adjacent telescopes is about 10 ***,the Cherenkov lateral distribution and the parallax between the two telescopes should be considered in the event building process for images crossing over the boundaries of FoVs of the *** event building method for Cherenkov images measured by multiple telescopes of WFCTA is *** performance of the shower measurements using the combined images is evaluated by comparing with showers that are fully contained by a virtual telescope in *** and conclusion It is proved that the developed event building process can help to increase the FoV of WFCTA by 30%while maintaining the same reconstruction quality,compared to the separate telescope reconstruction method.

关键词： method directions conclusion

A dynamic range extension system for LHAASOWCDA-1

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Radiation Detection Technology and Methods 2021年第4期5卷 520-530页

作者： F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volpe B.D’Ettorre Piazzoli X.J.Dong J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.H.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huang W.H.Huang X.T.Huang Y.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li C.Li F.Li H.B.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv B.Q.ma L.L.ma X.H.ma J.R.mao A.masood W.Mitthumsiri T.Montaruli Y.C.Nan B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhai 519000GuangdongChina School of Physical Science and Technology Guangxi UniversityNanning 530004GuangxiChina Hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001HenanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Key Laboratory of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237ShandongChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina School of Physics

Purpose The main scientific goal of LHAASO-WCDA is to survey gamma-ray sources with energy from 100 GeV to 30 *** observe high-energy shower events,especially to measure the energy spectrum of cosmic rays from 100 TeV to 10 PeV,a dynamic range extension system(WCDA++)is designed to use a 1.5-inch PMT with a dynamic range of four orders of magnitude for each cell in *** The dynamic range is extended by using these PMTs to measure the effective charge density in the core region of air shower events,which is an important parameter for identifying the composition of primary *** and Conclusion The system has been running for more than one *** this paper,the details of the design and performance of WCDA++are presented.

关键词： LHAASO-WCDA WCDA++ Water Cherenkov detector Performance

Line-of-shower trigger method to lower energy threshold for GRB detection using LHAASO-WCDA

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Radiation Detection Technology and Methods 2021年第4期5卷 531-541页

作者： F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi H.Cai J.T.Cai Z.Cao Z.Cao J.Chang J.F.Chang X.C.Chan B.M.Chen J.Chen L.Chen L.Chen L.Chen M.J.Chen M.L.Chen Q.H.Chen S.H.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Chen Y.D.Chen S.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu D.della Volpe B.D’Ettorre Piazzoli X.J.Don J.H.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fan C.F.Feng L.Feng S.H.Fen Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Gen G.H.Gong Q.B.Gou M.H.Gu J.G.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han H.H.He H.N.He J.C.He S.L.He X.B.He Y.He M.Heller Y.K.Hor C.Hou X.Hou H.B.Hu S.Hu S.C.Hu X.J.Hu D.H.Huang Q.L.Huan W.H.Huang X.T.Huang Z.C.Huang F.Ji X.L.Ji H.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li C.Li F.Li H.B.Li H.C.Li H.Y.Li J.Li K.Li W.L.Li X.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu H.Liu H.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu H.K.Lv B.Q.ma L.L.ma X.H.ma J.R.mao A.masood W.Mitthumsiri T.Montaruli Y.C.Nan B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Shen J.R.Shi H.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.H.T.Tam Z.B.Tang W.W.Tian B.D.Wan C.Wang H.Wang H.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wan R.N.Wang W.Wang W.Wang X.G.Wang X.J.Wan X.Y.Wang Y.D.Wan Y.J.Wan Y.P.Wang Z.Wang Z.Wang Z.H.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu H.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao H.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.H.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yan R.Z.Yang S.B.Yang Y.H.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang H.M.Zhang H.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhan X.Zhang X.P.Zhan Y.Zhan Y.Zhang Y.F.Zhang Y.L.Zhan B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou H.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G. Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics BeijingChina University of Science and Technology of China Hefei 230026AnhuiChina Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Physics Peking UniversityBeijing 100871China Center for Astrophysics Guangzhou UniversityGuangzhou 510006GuangdongChina School of Physics and Astronomy&School of Physics(Guangzhou) Sun Yat-sen UniversityZhuhai 519000GuangdongChina School of Physical Science and Technology Guangxi UniversityNanning 530004GuangxiChina Hebei Normal University Shijiazhuang 050024HebeiChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001HenanChina School of Astronomy and Space Science Nanjing UniversityNanjing 210023JiangsuChina Key Laboratory of Dark matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023JiangsuChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237ShandongChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031SichuanChina College of Physics Sichuan UniversityChengdu 610065SichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina School of Physic

Purpose Observation of high energy and very high emission from Gamma Ray Bursts(GRBs)is crucial to study the gigantic explosion and the underline *** a large field-of-view and almost full duty cycle,the Water Cherenkov Detector Array(WCDA),a sub-array of the Large High Altitude Air Shower Observatory(LHAASO),is appropriate to monitor the very high energy emission from unpredictable transients such as *** Nevertheless,the main issue for an extensive air shower array is the high energy threshold which limits the horizon of the *** address this issue a new trigger method is developed in this article to lower the energy threshold of WCDA for GRB *** The proposed method significantly improves the detection efficiency of WCDA for gamma-rays around the GRB direction at 10-300 *** sensitivity of the WCDA for GRB detection with the new trigger method is *** achieved sensitivity of the quarter WCDA array above 10 GeV is comparable with that of *** data analysis process and corresponding fluence upper limit for GRB 190719C is presented as an example.

关键词： LHAASO WCDA GRB

gha预激化疗方案对难治性急性髓系白血病和骨髓增生异常综合征的疗效及其与共刺激分子B7.1表达的关系

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中国实验血液学杂志 2008年第5期16卷 1002-1005页

作者：陈银霞马肖容张王刚刘捷曹星梅何爱丽西安交通大学医学院第二附属医院血液内科陕西西安710004

本研究探讨G-CSF联合高三尖杉酯碱(homoharringtonine)和小剂量阿糖胞苷(cytarabine,Ara-C)的gha预激化疗方案治疗难治性急性髓系白血病(AML)和骨髓增生异常综合征(MDS)的临床疗效和不良反应,寻求高效低毒的新型化疗方案,探索其与共刺... 详细信息

本研究探讨G-CSF联合高三尖杉酯碱(homoharringtonine)和小剂量阿糖胞苷(cytarabine,Ara-C)的gha预激化疗方案治疗难治性急性髓系白血病(AML)和骨髓增生异常综合征(MDS)的临床疗效和不良反应,寻求高效低毒的新型化疗方案,探索其与共刺激分子B7.1的关系。应用gha标准预激化疗方案G-CSF[200μg/(m2·d)皮下注射,第1-14天];高三尖杉酯碱[1mg/(m2·d)静脉点滴,第1-14天];阿糖胞苷[10mg/m2,皮下注射,每12小时1次,第1-14天]治疗79例难治性急性髓系白血病和21例骨髓增生异常综合征,与传统ma方案化疗组比较,观察临床疗效和不良反应、治疗相关死亡率并随访。应用免疫荧光法检测各组肿瘤细胞上共刺激分子B7.1的表达并与临床疗效比较。结果表明:gha预激化疗治疗后难治性AML缓解率60.7%(完全缓解率43%,部分缓解率17.7%),治疗MDS有效率52.4%。粒细胞缺乏发生率25%,平均持续时间3.5天。重症感染发生率3%,无严重出血、消化道反应,心、肝、肾功能损害轻微,患者均痊愈。治疗相关死亡率为零。AML-M2组、AML-M5组完全缓解率较高(60.9%,61.9%),最长持续缓解期已4年。各组肿瘤细胞上共刺激分子B7.1表达阳性率差异较大(0%-66.7%),正常对照组为0,AML-M2组和AML-M5组明显高于其它AML组和正常对照组,且表达率与预激化疗疗效呈正相关。结论:gha预激化疗方案治疗难治性急性髓系白血病和骨髓增生异常综合征疗效肯定,不良反应较轻,无严重毒副作用和治疗相关死亡率,无病生存期长,是高效低毒的新型化疗方案。肿瘤细胞上共刺激分子B7.1表达可能与预激化疗疗效有关,其机理尚需进一步研究。

关键词：预激化疗急性髓系白血病骨髓增生异常综合征 B7.1

Flux variations of cosmic ray air showers detected by LHAASO-KM2A during a thunderstorm on June 10,2021

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Chinese Physics C 2023年第1期47卷 193-203页

作者： F.Aharonian 安琪阿西克古白立新白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹喆曹臻常进常劲帆陈恩生陈良陈亮陈龙陈明君陈玛丽陈素弘陈松战陈天禄陈学健陈阳程皓麟程宁程耀东崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 段凯凯樊军辉范一中范志香方军方堃冯存峰封莉冯少辉丰晓婷冯有亮高博高川东高林青高启高卫高伟康葛茂茂耿利斯龚光华苟全补顾旻皓郭福来郭俊广郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何思乐何新波何钰 M.Heller 贺远强侯超侯贤胡红波胡铨胡森胡世聪呼晓军黄代绘黄文昊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜泽军金敏康明铭柯通 D.Kuleshov 李兵兵李澄李骢李飞李海波李会财李华阳李军李剑李捷李凯李文龙李秀荣李昕李新李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘佳松刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农龙文杰鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣 A.masood 闵振 W.Mitthumsiri 南云程区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz 邵澄宇邵琅 O.Shchegolev 盛祥东石京燕宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐泽波田文武王博东王超王辉王洪光王建成王界双王利苹王玲玉王冉王润娜王为王祥高王祥玉王阳王玉东王岩谨王亚平王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁新薛良闫大海颜景志杨朝文杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮曾宗康查敏翟徐徐张彬彬张丰张海明张恒英张建立张丽霞张力张路张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张月雷张毅张勇赵兵赵静赵雷赵立志赵世平郑福郑应周斌周浩周佳能周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center of Sciences Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduSichuanChina Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China College of Physics Sichuan UniversityChengdu 610065China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Key Laboratory of Dark matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of Education850000 LhasaTibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Hebei Normal University Shijiazhuang 050024China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen University519000 Zhuhai&510275 GuangzhouGuangdongChina Dipartimento di Fisica.dell’Universitàdi Napoli"Federico II" Complesso Universitario di Monte Sant’Angelovia Cinthia80126 NapoliItaly School of Physics and Astronomy Yunnan UniversityKunming 650091China D´epartement de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China Depar

The Large High Altitude Air Shower Observatory(LHAASO)has three sub-arrays,KM2A,WCDA,and *** flux variations of cosmic ray air showers were studied by analyzing the KM2A data during a thunderstorm on June 10,*** number of shower events that meet the trigger conditions increases significantly in atmospheric electric fields,with a maximum fractional increase of 20%.The variations in trigger rates(increases or decreases)were found to be strongly dependent on the primary zenith *** flux of secondary particles increased significantly,following a trend similar to that of shower *** better understand the observed behavior,Monte Carlo simulations were performed with CORSIKA and G4KM2A(a code based on GEANT4).We found that the experimental data(in saturated negative fields)were in good agreement with the simulations,assuming the presence of a uniform electric field of-700 V/cm with a thickness of 1500 m in the atmosphere above the observation *** to the acceleration/deceleration by the atmospheric electric field,the number of secondary particles with energy above the detector threshold was modified,resulting in the changes in shower detection rate.

关键词： thunderstorm cosmic rays extensive air showers LHAASO-KM2A