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New therapeutic approaches for type 1 diabetes:Disease-modifying therapies

World Journal of Diabetes 2022年第10期13卷 835-850页

作者： geza nagy Tekla Evelin Szekely Aniko Somogyi Magdolna Herold Zoltan Herold Department of Internal Medicine and Hematology Semmelweis UniversityBudapest H-1088Hungary Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest H-1083Hungary

It has been 100 years since the first successful clinical use of insulin, yet it remains the only treatment option for type 1 diabetes mellitus(T1DM) patients. Advances in diabetes care, such as insulin analogue therapies and new devices, including continuous glucose monitoring with continuous subcutaneous insulin infusion have improved the quality of life of patients but have no impact on the pathogenesis of the disease. They do not eliminate long-term complications and require several lifestyle sacrifices. A more ideal future therapy for T1DM, instead of supplementing the insufficient hormone production(a consequence of β-cell destruction), would also aim to stop or slow down the destructive autoimmune process. The discovery of the autoimmune nature of type 1 diabetes mellitus has presented several targets by which disease progression may be altered. The goal of disease-modifying therapies is to target autoimmune mechanisms and prevent β-cell destruction. T1DM patients with better β-cell function have better glycemic control, reduced incidence of long-term complications and hypoglycemic episodes. Unfortunately, at the time symptomatic T1DM is diagnosed, most of the insulin secreting β cells are usually lost. Therefore, to maximize the salvageable β-cell mass by disease-modifying therapies, detecting autoimmune markers in an early, optimally presymptomatic phase of T1DM is of great importance. Diseasemodifying therapies, such as immuno-and regenerative therapies are expected to take a relevant place in diabetology. The aim of this article was to provide a brief insight into the pathogenesis and course of T1DM and present the current state of disease-modifying therapeutic interventions that may impact future diabetes treatment.

关键词： Type 1 diabetes Mesenchymal stem cell Immunotherapy Islet cells Autoimmunity Regenerative medicine

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Segmented trust assessment in autonomous vehicles via eye-tracking

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2024年第2期7卷 151-161页

作者： Miklós Lukovics Szabolcs Prónay Barbara nagy Faculty of Economics and Business Administration University of SzegedSzeged H-6726Hungary

Previous studies have identified trust as one of the key factors in the technology acceptance of autonomousvehicles. As these studies mostly investigated the population in general, little is known about segment-specific ***, the widely used survey methods are less able to capture the deeper forms of trust—which neuroscientificmethods are much better suited to capture. The main objective of our research is to study trust as one of the key factors oftechnology acceptance related to autonomous vehicles by using neuroscientific methods for specific consumer ***-time eye-tracking tests were applied to a sample of 113 participants, combined with a posttest self-report. The testswere carried out under laboratory conditions during which our subjects watched videos recorded with the internal camerasof autonomous vehicles. Based on the fixation count, total fixation duration, and pupil dilation, we empirically verified thatthe trust level of all five identified segments is relatively low, while the trust level of the “traditional rejecting” segment is thelowest. An increase in trust level can be shown if the subjects receive extra information about the journey. Anotherimportant finding is that the self-reported trust level is not always congruent with the eye-tracking analysis results;therefore,combined approaches can lead to greater measurement validity.

关键词： autonomous vehicles(AVs) technology acceptance trust eye-tracking

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Hydrodynamic function and spring constant calibration of FluidFM micropipette cantilevers

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Microsystems & Nanoengineering 2024年第1期10卷 277-286页

作者： Attila Bonyár Ágoston G.nagy Hans Gunstheimer Gotthold Fläschner Robert Horvath Department of Electronics Technology Faculty of Electrical Engineering and InformaticsBudapest University of Technology and EconomicsBudapestHungary Nanobiosensorics Laboratory Institute of Technical Physics and Materials ScienceCentre for Energy ResearchHUN-RENBudapestHungary Nanosurf AG Gräubernstrasse 12CH-4410 LiestalSwitzerland

Fluidic force microscopy(FluidFM)fuses the force sensitivity of atomic force microscopy with the manipulation capabilities of microfluidics by using microfabricated cantilevers with embedded fluidic *** innovation initiated new research and development directions in biology,biophysics,and material *** acquire reliable and reproducible data,the calibration of the force sensor is ***,the hollow FluidFM cantilevers contain a row of parallel pillars inside a rectangular *** precise spring constant calibration of the internally structured cantilever is far from trivial,and existing methods generally assume simplifications that are not applicable to these special types of *** addition,the Sader method,which is currently implemented by the FluidFM community,relies on the precise measurement of the quality factor,which renders the calibration of the spring constant sensitive to *** this study,the hydrodynamic function of these special types of hollow cantilevers was experimentally determined with different *** on the hydrodynamic function,a novel spring constant calibration method was adapted,which relied only on the two resonance frequencies of the cantilever,measured in air and in a *** on these results,our proposed method can be successfully used for the reliable,noise-free calibration of hollow FluidFM cantilevers.

关键词： spring cantilever function

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Spatial relationship of tertiary lymphoid structures and tumor-associated neutrophils in bladder cancer and prognostic potential for anti-PD-L1 immunotherapy

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Cancer Communications 2024年第4期44卷 499-503页

作者： Xuechun Wang Anna Juncker-Jensen Gang Huang Mate Levente nagy Xuemin Lu Liang Cheng Xin Lu Department of Biological Sciences Boler-Parseghian Center for Rare and Neglected DiseasesHarper Cancer Research InstituteUniversity of Notre DameNotre DameINUSA NeoGenomics Laboratories Inc.Aliso ViejoCAUSA Department of Pathology and Laboratory Medicine Brown University Warren Alpert Medical SchoolLifespan Academic Medical CenterLegorreta Cancer Center at Brown UniversityProvidenceRIUSA Tumor Microenvironment and Metastasis Program Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolisINUSA

Dear Editor,Tertiary lymphoid structures(TLSs)are organized clus-ters of immune cells found in non-lymphoid tissues of chronic inflammation,including solid tumors[1].High endothelial venules(HEVs)positive for peripheral node addressin(PNAd)are present in TLSs and may pro-vide highway entry for ***-residing TLSs may be formed by the concerted actions of cytokines and chemokines,a finding supported by the relation between a 12-chemokine signature and TLSs[2].

关键词： bladder lymphoid inflammation

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In-situ study of the microstructure evolution during tension of a Mg-Y-Zn-Al alloy processed by rapidly solidified ribbon consolidation technique

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Journal of Magnesium and Alloys 2024年第5期12卷 2024-2040页

作者： Jeno Gubicza Kristián Máthis Péter nagy Péter Jenei Zoltán Hegedus Andrea Farkas Jozef Vesely Shin-ichi Inoue Daria Drozdenko Yoshihito Kawamura Department of Materials Physics Faculty of ScienceEotvos Loránd UniversityPázmány P.sétány 1/ABudapest H-1117Hungary Department of Physics of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 Praha 2Czech Republic Deutsches Elektronen-Synchrotron DESY Notkestr.85Hamburg 22603Germany Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg-Y-Zn-Al alloys processed by rapidly solidified ribbon consolidation(RSRC)technique exhibit an exceptional mechanical performance indicating promising application *** material has a bimodal microstructure consisting of fine recrystallized and coarse non-recrystallized grains with solute-rich stacking faults forming cluster arranged layers(CALs)and nanoplates(CANaPs),or complete long period stacking ordered(LPSO)*** order to reveal the deformation mechanisms,in-situ synchrotron X-ray diffraction line profile analysis was employed for a detailed study of the dislocation arrangement created during tension in Mg-0.9%Zn-2.05%Y-0.15%Al(at%)*** uncovering the effect of the initial microstructure on the mechanical performance,additional samples were obtained by annealing of the as-consolidated specimen at 300 and 400℃ for 2 *** heat treatment at 300℃ had no significant effect on the initial microstructure,its evolution during tension and,thus,the overall deformation behavior under tensile *** the other hand,annealing at 400℃ resulted in a significant increase of the recrystallized grains fraction and a decrease of the dislocation density,leading to only minor degradation of the mechanical *** maximum dislocation density at the failure of the samples corresponding to the plastic strain of 10-25% was estimated to be about 16-20×10^(14)m^(-2).The diffraction profile analysis indicated that most dislocations formed during tension were of non-basal and pyramidal types,what was also in agreement with the Schmid factor values revealed independently from orientation *** was also shown that the dislocation-induced Taylor hardening was much lower below the plastic strain of 3% than above this value,which was explained by a model of the interaction between prismatic dislocations and CANaPs/LPSO plates.

关键词： Mg-Zn-Y-Al alloy Long period stacking ordered(LPSO)phase Cluster arranged nanoplates(CANaPs) Annealing Tension Dislocation density Hardening

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A Proposed Approach for Measuring Maturity Level of Software Delivery

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Journal of Software Engineering and Applications 2024年第5期17卷 228-245页

作者： Osama Hassan Mansour Atef Raslan nagy Ramadan Faculty of Postgraduate Studies for Statistical Research Cairo University Cairo Egypt

Software delivery is vital for modern organizations, driving innovation and competitiveness. Measuring an organization’s maturity in software delivery is crucial for efficiency and quality. The Capability Maturity Model (CMM) framework provides a roadmap for improvement but assessing an organization’s CMM Level is challenging. This paper offers a quantitative approach tailored to the CMM framework, using Goal-Question-Metric (GQM) frame-works for each key process area (KPA). These frameworks include metrics and questions to compute maturity scores effectively. The study also refines practices into questions for a thorough assessment. The result is an Analysis Matrix that calculates weighted scores and an overall maturity score. This approach helps organizations assess and enhance their software delivery processes systematically, aiming for improved practices and growth.

关键词： CMM CMMI Software Delivery Maturity KPAs GQM Practices

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Proton irradiation-induced cracking and microstructural defects in UN and (U,Zr)N composite fuels

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Journal of Materiomics 2024年第4期10卷 906-918页

作者： Elina Charatsidou Maria Giamouridou Andrea Fazi Gyula nagy Diogo Ribeiro Costa Sarmad Naim Katea Mikael Jolkkonen Gunnar Westin Mattias Thuvander Daniel Primetzhofer Pär Olsson KTH Royal Institute of Technology StockholmSweden Chalmers University of Technology GothenburgSweden Uppsala University UppsalaSweden Westinghouse Electric Sweden AB VästeråsSweden Höganäs Sweden AB HöganäsSweden

Proton irradiation with a primary ion energy of 2 MeV was used to simulate radiation damage in UN and(U,Zr)N fuel *** pellets,nominally at room temperature,were irradiated to peak levels of 0.1,1,10 dpa and 100.0 dpa resulting in a peak hydrogen concentration of at most 90 at.%.Microstructure and mechanical properties of the samples were investigated and compared before and after *** irradiation induced an increase in hardness,whereas a decrease in Young’s modulus was observed for both *** characterization revealed irradiation-induced cracking,initiated in the bulk of the material,where the peak damage was deposited,propagating towards the ***,transmission electron microscopy was used to study irradiation *** loops and fringes were identified and observed to increase in density with increasing dose *** high density of irradiation defects and hydrogen implanted are proposed as the main cause of swelling and consequent sample cracking,leading simultaneously to increased hardening and a decrease in Young's modulus.

关键词： Proton irradiation Uranium nitride Spark plasma sintering Irradiation induced cracking Simulated burn-up structure Composite nuclear fuels

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Behavior of transporting pipeline sections without and with hydrogen exposure based on full-scale tests

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China Welding 2024年第3期33卷 14-24页

作者： Nóra nagy János Lukács Institute of Materials Science and Technology Faculty of Mechanical Engineering and InformaticsUniversity of MiskolcMiskolc 3515Hungary

Pipeline transport of hydrogen is one of today’s economic and environmental *** order to find safe and reliable applic-ation of both existing gas and build new pipelines,it is essential to carry out tests on full-scale pipeline section,including the potentially more dangerous places than the main pipe,the girth *** the investigations,pipeline sections of P355NH steel with girth welds were prepared and exposed to pure hydrogen at twice the maximum allowable operating pressure for 41 ***,full-scale burst tests were carried out and specimens were cut and prepared from the typical locations of the failed pipeline sections for mechanical,and macro-and microstructural *** results obtained were evaluated and compared with data from previous full-scale tests on pipeline sections without hydrogen *** results showed differences in the behavior of pipeline sections loaded in different ways,with differ-ent characteristics of the materials and the welded joints,both in the cases without hydrogen exposure and in the cases exposed to hydrogen.

关键词： gas transporting pipeline full-scale pipeline test complex loading condition hydrogen exposure safety factor

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The Implementation of Ray Tracing Algorithm with OpenMP Parallelization

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Journal of Computer and Communications 2024年第1期12卷 120-130页

作者： Noor Alnasser Raghad Alabssi Batool Faran Latifah Alessa Naya nagy College of Computer Science and IT Imam Abdulrahman Bin Faisal University Dammam Kingdom of Saudi Arabia

Ray tracing is a computer graphics method that renders images realistically. As the name suggests, this technique primarily traces the path of light rays interacting with objects in a scene [1], permitting the calculation of lighting and reflecting impact [2]. As ray tracing is a time-consuming process, the need for parallelization to solve this problem arises. One downside of this solution is the existence of race conditions. In this work, we explore and experiment with a different, well-known solution for this race condition. Starting with the introduction and the background section, a brief overview of the topic is followed by a detailed part of how the race conditions may occur in the case of the ray tracing algorithm. Continuing with the methods and results section, we have used OpenMP to parallelize the Ray tracing algorithm with the different compiler directives critical, atomic, and first-private. Hence, it concluded that both critical and atomic are not efficient solutions to produce a good-quality picture, but first-private succeeded in producing a high-quality picture.

关键词： Parallelization Ray Tracing Parallel Computer Architecture OpenMP

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Parallel Image Processing: Taking Grayscale Conversion Using OpenMP as an Example

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Journal of Computer and Communications 2024年第2期12卷 1-10页

作者： Bayan AlHumaidan Shahad Alghofaily Maitha Al Qhahtani Sara Oudah Naya nagy Department of Computer Science College of Computer Science & Information Technology Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia

In recent years, the widespread adoption of parallel computing, especially in multi-core processors and high-performance computing environments, ushered in a new era of efficiency and speed. This trend was particularly noteworthy in the field of image processing, which witnessed significant advancements. This parallel computing project explored the field of parallel image processing, with a focus on the grayscale conversion of colorful images. Our approach involved integrating OpenMP into our framework for parallelization to execute a critical image processing task: grayscale conversion. By using OpenMP, we strategically enhanced the overall performance of the conversion process by distributing the workload across multiple threads. The primary objectives of our project revolved around optimizing computation time and improving overall efficiency, particularly in the task of grayscale conversion of colorful images. Utilizing OpenMP for concurrent processing across multiple cores significantly reduced execution times through the effective distribution of tasks among these cores. The speedup values for various image sizes highlighted the efficacy of parallel processing, especially for large images. However, a detailed examination revealed a potential decline in parallelization efficiency with an increasing number of cores. This underscored the importance of a carefully optimized parallelization strategy, considering factors like load balancing and minimizing communication overhead. Despite challenges, the overall scalability and efficiency achieved with parallel image processing underscored OpenMP’s effectiveness in accelerating image manipulation tasks.

关键词： Parallel Computing Image Processing OpenMP Parallel Programming High Performance Computing GPU (Graphic Processing Unit)

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