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Biomedical and Environmental Sciences 2023年第10期36卷 996-998页

作者： Minji Kim Wonyoung Cho Jinseok lee Yong Sung Choi Seung geun Yeo Young Joo lee Sang Youl Rhee Chanyang Min Dong Keon Yon Center for Digital Health Medical Science Research InstituteKyung Hee University Medical CenterKyung Hee University College of MedicineSeoulSouth Korea Department of Regulatory Science Kyung Hee UniversitySeoulSouth Korea Department of Biomedical Engineering Kyung Hee UniversityYonginSouth Korea Department of Pediatrics Kyung Hee University Medical CenterKyung Hee University College of MedicineSeoulSouth Korea Department of Otolaryngology-Head&Neck Surgery Kyung Hee University Medical CenterKyung Hee University College of MedicineSeoulSouth Korea Department of Obstetrics and Gynecology Kyung Hee University College of MedicineSeoulSouth Korea Department of Endocrinology and Metabolism Kyung Hee University College of MedicineSeoulKorea

Both cigarette and e-cigarette use cause respiratory tract damage and related health outcomes,and potentially increase the risk of coronavirus disease 2019(COVID-19)-related symptoms[1].Since the COVID-19 pandemic,loc... 详细信息

关键词： respiratory damage legal

Locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of colon

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Chinese Journal of Cancer Research 2013年第6期25卷 777-780页

作者： Ok-Jun lee Seok-Joong Yun Wun-Jae Kim Song-Yi Choi Ho-Chang lee Hyung-geun Song Sung-Nam Lim Ki-Hyeong lee Seung-Taik Kim Hye-Suk Han Department of Pathology College of MedicineChungbuk National University Department of Urology College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University

Apocrine carcinoma is a rare malignant adnexal neoplasm. The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-old man with a history of surgical resection due to sigmoid colon cancer and penile metastasis two years prior to this study presented with a nodule at the left penile base. He underwent a wide local resection of the penile mass under a suggested preoperative diagnosis of extra-mammary Paget＇s disease （EMPD） associated with previous sigmoid colon cancer. However, the previously and currently resected penile masses were identified as primary apocrine carcinoma upon hematoxylin and eosin （H＆E） staining and immunohistochemical staining. Although the incidence is extremely rare, both clinicians and pathologists should be alert to the possibility of synchronous double primary apocrine carcinoma in cancer patients with malignant cutaneous lesions.

关键词： Apocrine glands carcinoma colon cancer penis

Dual-frequency piezoelectric micromachined ultrasound transducer based on polarization switching in ferroelectric thin films

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Microsystems & Nanoengineering 2023年第5期9卷 233-243页

作者： Jin Soo Park Soo Young Jung Dong Hun Kim Jung Ho Park Ho Won Jang Tae geun Kim Seung-Hyub Baek Byung Chul lee Bionics Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Center for Electronic Materials Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul 02792Republic of Korea KHU-KIST Department of Converging Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea

Due to its additional frequency response,dual-frequency ultrasound has advantages over conventional ultrasound,which operates at a specific frequency ***,a tunable frequency from a single transducer enables sonographers to achieve ultrasound images with a large detection area and high *** facilitates the availability of more advanced techniques that simultaneously require low-and high-frequency ultrasounds,such as harmonic imaging and image-guided *** this study,we present a novel method for dual-frequency ultrasound generation from a ferroelectric piezoelectric micromachined ultrasound transducer(PMUT).Uniformly designed transducer arrays can be used for both deep low-resolution imaging and shallow high-resolution *** switch the ultrasound frequency,the only requirement is to tune a DC bias to control the polarization state of the ferroelectric *** vibration of the PMUT membrane strongly depends on the polarization state,producing low-and high-frequency ultrasounds from a single excitation *** strategy for dual-frequency ultrasounds meets the requirement for either multielectrode configurations or heterodesigned elements,which are integrated into an ***,this technique significantly reduces the design complexity of transducer arrays and their associated driving circuits.

关键词： piezoelectric ferroelectric enable

Phase-controlled synthesis of thermally stable nitrogen-doped carbon supported iron catalysts for highly efficient Fischer-Tropsch synthesis

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Nano Research 2019年第10期12卷 2568-2575页

作者： Jin Hee lee Hack-Keun lee Dong Hyun Chun Hyunkyung Choi geun Bae Rhim Min Hye Youn Heondo Jeong Shin Wook Kang Jung-ll Yang Heon Jung Chui Sung Kim Ji Chan Park Clean Fuel Laboratory Korea Institute of Energy ResearchDaejeon 34129Republic of Korea Department of Chemical Engineering University of SeoulSeoul 02504Republic of Korea Advanced Energy and System Technology University of Science and TechnologyDaejeon 34113Republic of Korea Department of Physics Kookmin UniversitySeoul 02707Republic of Korea

Iron-based nan oparticles with un iform and high particle dispersi on,which are supported on carb on structures,have been used for various ***,their preparation still suffers from complicated synthesis involving multiple steps and from the high price of precursors and solve *** the prese nt work,a new carbon en capsulated iron-carbide nano particle supported on n itroge rvdoped porous carbon(Fe5C2@C/NPC)structure was *** was made using a simple solid-state reaction with sequential thermal ***5C2@C/NPC is a highly active and stable catalyst for the high-temperature Fischer-Tropsch synthesis *** showed very high hydrocarbon productivity(4.71 gHc gcat^-1·h^-1)with high CO conversions(up to 96%).

关键词： iron-carbide one-pot synthesis nitrogen-doped graphene Fischer-Tropsch synthesis Mdssbauer spectroscopy

Clinical implications of neutrophil-to-lymphocyte ratio and MDSC kinetics in gastric cancer patients treated with ramucirumab plus paclitaxel

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Chinese Journal of Cancer Research 2020年第5期32卷 621-630页

作者： Hyung-Don Kim Min-Hee Ryu Sangsoon Yoon Young-Soon Na Meesun Moon Hyungeun lee Hyung geun Song Yoon-Koo Kang Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Asan Institute for Life Science Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea DiNonA Inc Seoul 05505Korea

Objective: We aimed to investigate the prognostic value of neutrophil-to-lymphocyte ratio(NLR) and myeloidderived suppressor cells(MDSCs) in gastric cancer patients treated with second-line ramucirumab plus ***: A total of 116 patients with advanced or metastatic gastric cancer who receive ramucirumab plus paclitaxel were prospectively enrolled. Fresh blood samples were collected before and after treatment, and flow cytometry was performed to assess the proportions of monocytic(m MDSCs) and granulocytic MDSCs(g MDSCs).Results: Median age was 58 years and 71(61.2%) patients were male. A baseline NLR≥2.94 was associated with significantly poorer progression-free survival(PFS) and overall survival(OS) vs. an NLR<2.94(P=0.011 and P=0.002, respectively). In multivariate analysis, an NLR≥2.94 was independently associated with poorer PFS[hazard ratio(HR)=1.58;95% confidence interval(95% CI): 1.01-2.49, P=0.046] and OS(HR=1.77;95% CI:1.04-3.04, P=0.036). While m MDSC counts did not significantly change following two cycles of therapy(P=0.530),g MDSC counts decreased significantly after two treatment cycles(P=0.025) but tended to increase in patients with progressive disease after two treatment cycles(P=0.098). A progressive increase in g MDSC counts(≥44%) was associated with a significantly shorter PFS and OS vs. a g MDSC count increase <44%(P=0.001 and P=0.003,respectively).Conclusions: The baseline NLR may help guide clinical decisions during ramucirumab plus paclitaxel therapy for gastric cancer. Our g MDSC kinetics data warrant further clinical validation and mechanistic investigation.

关键词： Gastric cancer ramucirumab plus paclitaxel neutrophil-to-lymphocyte ratio myeloid-derived suppressor cells

Endoscopic resection of sparganosis presenting as colon submucosal tumor: A case report

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World Journal of Gastroenterology 2016年第19期22卷 4776-4780页

作者： Joong Keun Kim Dong Hoon Baek Bong Eun lee Gwang Ha Kim geun Am Song Do Youn Park Division of Gastroenterology Departments of Internal Medicine Pusan National University School of Medicine and Biomedical Research Institute Pusan National University Hospital Department of Pathology Pusan National University School of Medicine and Biomedical Research Institute Pusan National University Hospital

Human sparganosis is a rare parasitic disease caused by infection with the tapeworm Sparganum, the migrating plerocercoid(second stage) larva of Spirometra species. Sparganosis usually involves subcutaneous tissues and/or muscles of various parts of the body, but involvement of other sites such as the brain, eye, peritoneopleural cavity, urinary track, scrotum, and abdominal viscera has also been documented. Infections caused by sparganum have a worldwide distribution but are most common in Southeast Asia such as China, Japan, and South Korea. Rectal sparganosis is an uncommon disease but should be considered in the differential diagnosis of unusual and suspicious rectal submucosal tumors. We report a case of rectal sparganosis presenting as rectal submucosal tumor. We performed endoscopic submucosal dissection of the rectal submucosal tumor. The sparganosis was confirmed based on the presence of calcospherules in the submucosal layer on histological examination. Moreover, the result of the immunoglobulin G antibody test for sparganosis was positive but became negative after endoscopic submucosal dissection. Though rare, rectal sparganosis should be considered in the differential diagnosis of rectal submucosal tumor-like lesions. This case suggests that physicians should make effort to exclude sparganosis through careful diagnostic approaches, including detailed history taking and serological tests for parasites. In this report, we aimed to highlight the clinical presentation of Sparganum infection as a rectal submucosal tumor.

关键词： Rectum Submucosal tumor Sparganosis Sparganum Parasite disease

Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy

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Microsystems & Nanoengineering 2020年第1期6卷 796-805页

作者： Jong Min lee Ji Wook Choi Christian D.Ahrberg Hyung Woo Choi Jang Ho Ha Seok Gyu Mun Sung Joon Mo Bong geun Chung Department of Mechanical Engineering Sogang UniversitySeoulKorea Division of Chemical Industry Yeungnam University CollegeDaeguRepublic of Korea Research Center Sogang UniversitySeoulKorea Department of Biomedical Engineering Sogang UniversitySeoulKorea

Despite their simplicity,monolayer cell cultures are not able to accurately predict drug behavior in vivo due to their inability to accurately mimic cell-cell and cell-matrix *** contrast,cell spheroids are able to reproduce these interactions and thus would be a viable tool for testing drug ***,the generation of homogenous and reproducible cell spheroids on a large scale is a labor intensive and slow process compared to monolayer cell ***,we present a droplet-based microfluidic device for the automated,large-scale generation of homogenous cell spheroids in a uniform *** the microfluidic system,the size of the spheroids can be tuned to between 100 and 130μm with generation frequencies of 70 *** demonstrated the photothermal therapy(PTT)application of brain tumor spheroids generated by the microfluidic device using a reduced graphene oxide-branched polyethyleneimine-polyethylene glycol(rGO-BPEI-PEG)nanocomposite as the PTT ***,we generated uniformly sized neural stem cell(NSC)-derived neurospheres in the droplet-based microfluidic *** also confirmed that the neurites were regulated by ***,this droplet-based microfluidic device could be a powerful tool for photothermal therapy and drug screening applications.

关键词： fluid viable simplicity

Primary needle-knife fistulotomy for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis:Importance of the endoscopist’s expertise level

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World Journal of Clinical Cases 2021年第17期9卷 4166-4177页

作者： Sung Yong Han Dong Hoon Baek Dong Uk Kim Chang Joon Park Young Joo Park Moon Won lee geun Am Song Division of Gastroenterology and Hepatology Internal Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Needle-knife fistulotomy(NKF)is used as a rescue technique for difficult ***,the data are limited regarding the use of NKF for primary biliary cannulation,especially when performed by *** To assess the effectiveness and safety of primary NKF for biliary cannulation,and the role of the endoscopist’s expertise level(beginner vs expert).METHODS We retrospectively evaluated the records of 542 patients with naïve prominent bulging papilla and no history of pancreatitis,who underwent bile duct cannulation at a tertiary referral *** patients were categorized according to the endoscopist’s expertise level and the technique used for bile duct *** assessed the rates of successful cannulation and adverse *** The baseline characteristics did not differ between the experienced and lessexperienced *** incidence rate of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP)was significantly affected by the endoscopist’s expertise level in patients who received conventional cannulation with sphincterotomy(8.9%vs 3.4%for beginner vs expert,P=0.039),but not in those who received *** the multivariable analysis,a lower expertise level of the biliary endoscopist(P=0.037)and longer total procedure time(P=0.026)were significant risk factor of PEP in patients who received conventional cannulation with sphincterotomy but only total procedure time(P=0.004)was significant risk factor of PEP in those who received *** Primary NKF was effective and safe in patients with prominent and bulging ampulla,even when performed by less-experienced *** need to confirm which level of endoscopist’s experience is needed for primary NKF through prospective randomized study.

关键词： Needle-knife fistulotomy Primary biliary cannulation Endoscopic retrograde cholangiopancreatography Expertise levels Pancreatitis

Acute distal common bile duct angle is risk factor for postendoscopic retrograde cholangiopancreatography pancreatitis in beginner endoscopist

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World Journal of Clinical Cases 2020年第1期8卷 20-28页

作者： Sung Yong Han Dong Uk Kim Moon Won lee Young Joo Park Dong Hoon Baek Gwang Ha Kim geun Am Song Division of Gastroenterology Department of Internal Medicine and Biomedical Research Institute Pusan National University Hospital

BACKGROUND Post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP)is a critical and poorly managed complication of ERCP. Endoscopists need to understand the risk factors for PEP. However, the majority of studies investigating ERCP-related risk factors have included well-trained endoscopists,with the issue of endoscopist experience on PEP incidence not having been systematically *** To explore the risk factors for PEP in beginner endoscopists without *** We performed a retrospective analysis of 293 patients, with na?ve papilla and no history of pancreatitis, treated using bile duct cannulation. Patients were classified according to the endoscopist’s experience(beginner vs expert). The angle of the distal common bile duct(CBD) was measured as the angle between the lower wall of the bile duct and a vertical line extending to the lower wall of the bile duct on coronal view computed *** After propensity matching, there were no differences between patients treated by the expert and beginner endoscopist with regard to age, sex, mean bile duct dilatation, and ratio of benign disease. The distal CBD angle was classified as acute(> 30o) or obtuse(≤ 30o), based on the mean angle of 29.9o for the group. An acute distal CBD angle was a significant risk factor for PEP for beginner(P =0.049), but not *** For beginner endoscopists first performing unsupervised ERCP, cases with an obtuse distal CBD angle may be more appropriate to lower the risk of PEP.

关键词： Common bile duct angle Endoscopic retrograde cholangiopancreatography Novice learner Pancreatitis Risk factor Begginer endoscopist

Magnifying endoscopy of gastric epithelial dysplasia based on the morphologic characteristics

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World Journal of Gastroenterology 2014年第42期20卷 15771-15779页

作者： Hwa Mi Kang Gwang Ha Kim Do Youn Park Hong Ryeol Cheong Dong Hoon Baek Bong Eun lee geun Am Song Department of Internal Medicine Busan Adeventist Hospital Department of Internal Medicine Pusan National University School of Medicine Department of Pathology Pusan National University School of Medicine

AIM: To investigate the difference in magnifying endoscopic findings of gastric epithelial dysplasias (GEDs) according to the morphologic characteristics.

关键词： Stomach Dysplasia Narrow band imaging Magnifying endoscopy Mucin