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Platelet counts to spleen diameter ratio:A promising noninvasive tool for predicting esophageal varices in cirrhosis patients

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World Journal of Hepatology 2024年第10期16卷 1177-1187页

作者： getnet yigzaw mossie Abdulsemed Mohammed Nur Zekarias Seifu Ayalew Gebeyehu Tessema Azibte Kaleb Assefa Berhane Department of Internal Medicine Addis Ababa UniversityAddis Ababa 1000Ethiopia Division of Gastroenterology and Hepatology Department of Internal MedicineCollege of Health SciencesAddis Ababa UniversityAddis Ababa 1000Ethiopia Department of General Medicine Adera Medical and Surgical CenterAddis Ababa 1000Ethiopia

BACKGROUND Liver cirrhosis is the end stage of progressive liver fibrosis as a consequence of chronic liver inflammation,wherein the standard hepatic architecture is replaced by regenerative hepatic nodules,which eventually lead to liver *** without any symptoms is referred to as compensated *** such as ascites,variceal bleeding,and hepatic encephalopathy indicate the onset of decompensated *** varices are the hallmark of clini-cally significant portal *** To determine the accuracy of the platelet count-to-spleen diameter(PC/SD)ratio to evaluate esophageal varices(EV)in patients with *** This retrospective observational study was conducted at Tikur Anbessa Specia-lized Hospital and Adera Medical Center from January 1,2019,to December 30,*** were collected via chart review and direct patient interviews using structured *** data were exported to the SPSS software version 26 for analysis and clearance.A receiver operating characteristic curve was plotted for splenic diameter,platelet count,and PC/SD ratio to obtain sensitivity,speci-ficity,positive predictive value,negative predictive value,positive likelihood ratio,and negative likelihood *** Of the 140 participants,67%were *** B(38%)was the most common cause of cirrhosis,followed by cryptogenic cirrhosis(28%)and hepatitis C(16%).Approximately 83.6%of the participants had endoscopic evidence of EV,whereas 51.1%had gastric *** cirrhosis and PC were associated with the presence of EV with adjusted odds ratios of 12.63(95%CI:3.16-67.58,P=0.001)and 0.14(95%CI:0.037-0.52,P=0.004),respectively.A PC/SD ratio<1119 had a sensitivity of 86.32%and specificity of 70%with area under the curve of 0.835(95%CI:0.736-0.934,P<0.001).CONCLUSION A PC/SD ratio<1119 predicts EV in patients with *** is a valuable,noninvasive tool for EV risk assess-ment in resource-limited settings.

关键词： Cirrhosis,Esophageal varices,Portal hypertension Platelet count Splenic diameter

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