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Tailoring thermoelectric properties of Zr(0.43)Hf(0.57)NiSn half-Heusler compound by defect engineering

Rare Metals 2020年第6期39卷 659-670页

作者： Krzysztof Galazka Wenjie Xie Sascha Populoh Myriam H.Aguirre Songhak Yoon gesine b.ttner Anke Weidenkaff Institute of Plasma Physics and Laser Microfusion Warsaw 01-497Poland Department of Materials Science Technische Universitat DarmstadtDarmstadt 64287Germany Laboratory for Solid State Chemistry and Catalysis EmpaDlibendorf 8600Switzerland Instituto de Nanociencia de Aragon Universidad de ZaragozaSaragossa 50018Spain Departamento de Fisica de la Materia Condensada Universidad de ZaragozaSaragossa 50009Spain Laboratorio de Microscopias Avanzadas Universidad de ZaragozaSaragossa 50018Spain Fraunhofer Research Institution for Materials Recycling and Resource Strategies IWKS Hanau 63457Germany

The thermoelectric transport properties of Zr0.43Hf0.57 NiSn half-Heusler compounds were investigated for samples sintered with different spark plasma sintering(SPS)periods:8,32 and 72 *** means of scanning transmission electron microscopy with a highangular annular dark-field detector(STEM-HAADF),it was found that sintering time affected the defect concentration,namely the amount of Ni interstitial atoms,and created locally ordered inclusions of full-Heusler *** structural information,phase composition and electrical transport properties could be consistently explained by the assumption that Ni interstitials give rise to an impurity band situated about 100 meV below the bottom of the conduction band via a self-doping *** impurity band was found to merge with the conduction band for the sample with intermediate SPS *** effect was ascribed to the gradual dissolution of full-Heusler phase inclusions and production of interstitial Ni defects,which eventually vanished for the sample with the longest sintering *** was demonstrated that the modification of the density of states near the edge of the conduction band and enhanced overall charge carrier concentration provided by defect engineering led to overall 26%increase in the thermoelectric figure of merit(ZT)with respect to the other samples.

关键词： Thermoelectric Half-Heusler Interstitial Defect engineering

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Taking out the garbage:cathepsin D and calcineurin in neurodegeneration

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Neural Regeneration Research 2017年第11期12卷 1776-1779页

作者： Andreas Aufschnaiter Verena Kohler Sabrina b.ttner Institute of Molecular biosciences University of GrazHumboldtstraBe 508010 GrazAustria Department of Molecular biosciences The Wenner-Gren InstituteStockholm UniversitySvante Arrheniusvag 20C106 91 StockholmSweden

Cellular homeostasis requires a tightly controlled balance between protein synthesis, folding and degradation. Especially long-lived, post-mitotic cells such as neurons depend on an efficient proteostasis system to maintain cellular health over decades. Thus, a functional decline of processes contributing to protein degradation such as autophagy and general lysosomal proteolytic capacity is connected to several age-associated neurodegenerative disorders, including Parkinson＇s, Alzheimer＇s and Huntington＇s diseases. These so called proteinopathies are characterized by the accumulation and misfolding of distinct proteins, subsequently driving cellular demise. We recently linked efficient lysosomal protein breakdown via the protease cathep- sin D to the Ca2＋/calmodulin-dependent phosphatase calcineurin. In a yeast model for Parkinson＇s disease, functional calcineurin was required for proper trafficking of cathepsin D to the lysosome and for recycling of its endosomal sorting receptor to allow further rounds of shuttling. Here, we discuss these findings in relation to present knowledge about the involvement of cathepsin D in proteinopathies in general and a possible connection between this protease, calcineurin signalling and endosomal sorting in particular. As dysregulation of Ca2＋ homeostasis as well as lysosomal impairment is connected to a plethora of neurode- generative disorders, this novel interplay might very well impact pathologies beyond Parkinson＇s disease.

关键词： neurodegeneration Parkinson’s disease α-synuclein cathepsin D calcineurin retromer yeast lysosome endosomal sorting

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Comment on “Evidence for Mesoproterozoic collision,deep burial and rapid exhumation of garbenschiefer in the Namaqua Front,South Africa” by Valby Van Schijndel,David ***,Robert Anczkiewicz,Anders Schersten,Geoscience Frontiers,Volume 11,Issue 2,Pag

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Geoscience Frontiers 2020年第5期11卷 1889-1894页

作者： Steffen H.b.ttner Department of Geology Rhodes University6139Makhanda(Grahamstown)South Africa

In their recent publication Van Schijndel et al.(2020) present new age data and P-T analysis from the eastern margin of the Namaqua Sector of the Namaqua Natal Metamorphic *** authors claim to provide evidence for the... 详细信息

关键词： Province. burial eastern

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Giant cavernous hemangioma of the liver with satellite nodules:Aspects on tumour/tissue interface:A case report

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World Journal of Hepatology 2023年第5期15卷 707-714页

作者： Anne Kristin Fischer Karl Tobias Erich beckurts Reinhard b.ttner Uta Drebber Institute of Pathology University of CologneKöln 50937North Rhine WestphaliaGermany Visceral Surgery Severinsklösterchen Hospital CologneCologne 50678North Rhine WestphaliaGermany Institute of Pathology University Hospital of CologneCologne 50937North Rhine WestphaliaGermany

bACKGROUND Giant hepatic cavernous hemangioma with multiple satellite nodules is a rare subtype of hepatic cavernous hemangioma,the most common vascular liver *** report on a tumor with unusual histologic features:(1)Finger-like infiltration pattern;(2)lack of encapsulation;(3)blurred tumor/liver interface;and(4)massive satellitosis-referring to the article“Hepatic cavernous hemangioma:underrecognized associated histologic features”.CASE SUMMARY A 60-year-old man presented with increasing uncharacteristic abdominal discomfort and mildly elevated blood parameters of acute *** revealed an unclear,giant liver tumor of the left liver lobe.A massive vascular tumor with extensive satellitosis broadly infiltrating the adjacent liver parenchyma was resected via hemihepatectomy of segmentsⅡ/Ⅲ.Histopathological diagnosis was giant hepatic cavernous hemangioma with multiple satellite nodules,featuring unusual characteristics hardly portrayed in the ***,this particular morphology can explain the difficult pre-and perioperative diagnosis of a vascular liver tumor that is usually readily identifiable by modern imaging *** This case emphasizes the exact histological workup of tumor and tumor-induced parenchyma changes in radiologically unclassifiable liver tumors.

关键词： diagnosis hemangioma elevated

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Adaptive-optical 3D microscopy for microfluidic multiphase flows

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Light(Advanced Manufacturing) 2024年第3期5卷 105-119页

作者： Clemens bilsing Erik Nützenadel Sebastian burgmann Jürgen Czarske Lars b.ttner Laboratory of Measurement and Sensor System Techniques TUD Dresden University of Technology01069 DresdenGermany Chair of Fluid Mechanics Bergische Universitát Wuppertal42119 WuppertalGermany bIOLAS Laboratory of Measurement and Sensor System Techniques01069 DresdenGermany

Measurements based on optical microscopy can be severely impaired if the access exhibits variations of the refractive *** the case of fluctuating liquid-gas boundaries,refraction introduces dynamical aberrations that increase the measurement *** is prevalent at multiphase flows(***,film flows)that occur in many technical applications as for example in coating and cleaning processes and the water management in fuel *** this paper,we present a novel approach based on adaptive optics for correcting the dynamical aberrations in real time and thus reducing the measurement *** shape of the fluctuating water-air interface is sampled with a reflecting light beam(Fresnel Guide Star)and a Hartmann-Shack sensor which makes it possible to correct its influence with a deformable mirror in a closed ***-dimensional flow measurements are achieved by using a double-helix point spread *** measure the flow inside a sessile,oscillating 50-μl droplet on an opaque gas diffusion layer for fuel cells and show that the temporally varying refraction at the droplet surface causes a systematic underestimation of the flow field magnitude corresponding to the first droplet eigenmode which plays a major role in their detachment *** demonstrate that the adaptive optics correction is able to reduce this systematic ***,the adaptive optics system can pave the way to a deeper understanding of water droplet formation and detachment which can help to improve the efficiency of fuels cells.

关键词： Double-Helix point spread function Adaptive optics Particle tracking velocimetry Aberration correction Depth-resolving microscopy Closed-loop control

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Planet新标准德语强化教程

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2011年

作者： (德)Siegfried b.ttner (德)Gabriele Kopp

本书按主题划分为四个单元，即：我和你、学校和学习、业余时间、在家，每个单元主题包括四篇短文。

ISBN: (纸本)9787513512732

本书按主题划分为四个单元，即：我和你、学校和学习、业余时间、在家，每个单元主题包括四篇短文。

关键词：德语

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Experimental small bowel preservation using Polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan-ketoglutarate solution?

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World Journal of Gastroenterology 2007年第27期13卷 3684-3691页

作者： Lai Wei Koichiro Hata benedict Marie Doorschodt Reinhard b.ttner Thomas Minor René H Tolba House of Experimental Therapy University of Bonn 53105 Bonn Germany Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Surgical Laboratory Academic Medical Center 1105 AZ Amsterdam The Netherlands Institute of Pathology University of Bonn 53105 Bonn Germany Surgical Research Division Department of Surgery University of Bonn 53105 Bonn Germany

AIM: To evaluate the potential of Polysol, a newly developed preservation solution, in cold storage of small bowel grafts, compared with the current standards, University of Wisconsin solution (UW), Celsior and histidine-tryptophan-ketoglutarate solution (HTK). METHODS: Male Wistar rats were used as donors. Small bowels were retrieved, flushed and then stored in the respective 4 solutions for 18 h at 4℃. Functional integrity of the grafts was evaluated by isolated reperfusion with oxygenated Krebs-Henseleit buffer at 37℃ for 30 min in all 4 groups. RESULTS: Polysol preservation exhibited the highest tissue ATP concentration and the lowest release of LDH. Malondialdehyde, an index for tissue lipid peroxidation, was also the lowest in Polysol. Tissue oxygen consumption was significantly higher in Polysol than in the others. Of interest, UW-storage promoted 10-fold higher apoptosis than in the others. Moreover, electron microscopy revealed that the mucosal villi/micro-villi formation and the cell organelles, including mitochondria, were both significantly better preserved in Polysol, while deleterious alterations were apparent in the others, most notably in UW. Although Celsior and HTK exhibited the better trend of results than UW in some parameters, but could not reach the over-all superiority to ***: Cold storage using Polysol resulted in significantly better integrity and function of small bowel grafts than UW. Hence, Polysol may be a novel alternative for the small bowel preservation.

关键词： Small bowel transplantation Ischemia/reperfusion Cold storage Polysol University of Wisconsin solution Histidine-tryptophan-ketoglutarate solution Celsior

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一路随行的安全标签

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流程工业 2009年第20期 70-71页

作者： Sandra b.ttner 德国Wolke Inks& Printers有限公司

Tracking＆Tracing（追踪与追溯）技术解决方案现已在药品生产企业中得到了广泛的认可。而由此带来的大量数据信息可以经济可靠地记录在小巧的2D矩阵代码标签中。

关键词：安全标签药品生产企业数据信息

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Article 95:真正为每个人创造平等条件了吗?

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中国涂料 2015年第11期30卷 74-75页

作者： Gabi b.ttner

在生物杀灭剂法规中,Article 95或许不是最具争议的条款,但自2013年9月新法规执行以来,该条款备受关注,并引发业界极大争论。然而,这并非是陈述部分引起的,而是由于过渡期到2015年9月1日终止而引起。

关键词：活性物质市场竞争 Article 95 竞争条件供应链参考资料搭便车者申请费官方机构联合申请

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临床化学——历史发展、现状与今后任务

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德国医学 1995年第2期12卷 84-86页

作者： J.b.ttner 吴远 Institut für Klinische Chemie der Medizinischen Hochschule Konstanty-Gutschow-Straβe 8D-30625 HannoverGermany 同济医科大学附属同济医院

临床化学的一个主导思想是基于这样的认识,即人体组织的某些现象可用化学方法识别,而且对疾病有诊断价值。这种“化学标志”具有与其他临床症状和体征同样的价值。第一个临床实验室在法国建立。十九世纪,有关血液和尿液成分以及其他机... 详细信息

临床化学的一个主导思想是基于这样的认识,即人体组织的某些现象可用化学方法识别,而且对疾病有诊断价值。这种“化学标志”具有与其他临床症状和体征同样的价值。第一个临床实验室在法国建立。十九世纪,有关血液和尿液成分以及其他机体物质可以应用的分析方法得到了发展。1840年在德语国家临床化学作为一门学科独立出来。在德国,临床实验室大多与内科建立起密切的关系,20世纪临床化学的发展受到了来自美国的冲击。新兴的生物化学取代了病理学在医学理论上的主导地位,使得现代自然科学与临床医学关系更为密切。

关键词：临床化学实验室现状展望

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