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Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients

World Journal of Gastroenterology 2018年第29期24卷 3293-3301页

作者： Svein Oskar Frigstad Marte Lie Hoivik Jorgen Jahnsen Milada Cvancarova Tore Grimstad Ingrid Prytz Berset gert Huppertz-Hauss Oistein Hovde Tomm Bernklev Bjorn Moum Lars-Petter Jelsness-Jorgensen Department of Medicine Vestre Viken Baeum HospitalGjettum 1346Norway Department of Gastroenterology Ostfold Hospital KalnesGralum 1714Norway Department of Health Sciences Ostfold University CollegeHalden 1757Norway Department of Gastroenterology Stavanger University HospitalStavanger 4068Norway Department of Research Otfold Hospital KalnesGralum 1714Norway Department of Gastroenterology Oslo University HospitalOslo 0424Norway Department of Gastroenterology Akershus University HospitalLorenskog 1478Norway Faculty of Health Sciences Oslo Metropolitan UniversityOslo 0130Norway Department of Medicine Alesund Hospital TrustAlesund 6026Norway Department of Gastroenterology Telemark Hospital TrustSkien 3710Norway Department of Medicine Innlandet Hospital TrustGjovik 2819Norway Department of Research and Development Vestfold Hospital TrustTonsberg 3103Norway

AIM To investigate if vitamin D deficiency is associated with fatigue in patients with inflammatory bowel disease(IBD).METHODS IBD patients were recruited from nine hospitals in the southeastern and western regions of Norway to participate in a multicenter cross-sectional study lasting from March 2013 to April 2014. Data were collected by interviews, from medical records and laboratory tests. The Fatigue Questionnaire(FQ) was used to measure fatigue. Linear and logistic regression models were applied to explore the possible association between vitamin D deficiency and total fatigue scores and chronic fatigue, respectively. The analyses were adjusted for age, gender, disease activity, depressive symptoms and sleep *** In total, 405 patients were included in the analyses, of which 227(56%) had Crohn's disease(CD) and 178(44%) had ulcerative colitis(UC). Vitamin D deficiency(< 50 nmol/L) was present in half(203/405) of the patients. Chronic fatigue was reported by 116(29%) of all included patients with substantial fatigue reported by 194(48%). Vitamin D levels were neither associated with total fatigue nor with chronic fatigue. Higher total fatigue scores and chronic fatigue were both associated with increased disease activity scores in patients with UC and CD, but not with increased CRP or fecal calprotectin. In UC patients, female gender was associated with fatigue in the univariate analysis, but no such difference was found when adjusted for elevated disease activity scores. Sleep disturbance and more depressive symptoms were associated with total fatigue scores in both UC and CD patients, but with chronic fatigue only in CD *** In this study, no significant association between fatigue and vitamin D deficiency in IBD patients was revealed.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Fatigue Chronic fatigue Vitamin D deficiency

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污泥作为污水厂内碳源的水解特性及工艺选择

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中国给水排水 2011年第22期27卷 30-35页

作者：刘智晓 Sille Bendix Larsen gert Petersen 马宝玲首创爱华天津市政环境工程有限公司天津300191 EnviDan Denmark

随着各地污水厂出水水质对氮、磷要求的日益提高,强化脱氮除磷成为必然要求,但是我国多数污水厂由于多种原因导致进水碳源不足,尤其是进水SCOD、VFAs的匮乏,直接影响了生物脱氮除磷的效率,甚至不得已采用人工投加外碳源脱氮或者化学除... 详细信息

随着各地污水厂出水水质对氮、磷要求的日益提高,强化脱氮除磷成为必然要求,但是我国多数污水厂由于多种原因导致进水碳源不足,尤其是进水SCOD、VFAs的匮乏,直接影响了生物脱氮除磷的效率,甚至不得已采用人工投加外碳源脱氮或者化学除磷方式以满足严格的出水氮、磷要求,但这无疑大大提高了污水厂的产泥率及运行成本。充分挖掘污水厂的"内碳源",利用污泥水解产生VFAs,不仅能有效提高除磷脱氮效率,而且可以降低污水厂的污泥产量,是可持续的资源化技术。比较了初沉污泥和活性污泥的水解特性差异,介绍了污泥水解工艺的常用构型及参数选择,以及国内外一些成功的实施案例。

关键词：初沉污泥活性污泥侧流水解发酵强化生物除磷 RBCOD VFAs

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Statins markedly potentiate aminopeptidase inhibitor activity against(drug-resistant)human acute myeloid leukemia cells

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Cancer Drug Resistance 2023年第3期6卷 430-446页

作者： Gerrit Jansen Marjon Al Yehuda G.Assaraf Sarah Kammerer Johan van Meerloo gert J.Ossenkoppele Jacqueline Cloos Godefridus J.Peters Department of Rheumatology and Clinical Immunology Amsterdam Rheumatology and immunology CenterAmsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands The Fred Wyszkowsky Cancer Research Laboratory Faculty of BiologyThe Technion-Israel Institute of TechnologyHaifa 3200003Israel Department of Medical Oncology Amsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands Institute of Biotechnology Molecular Cell BiologyBrandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Department of Hematology Amsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands Department of Biochemistry Medical University of GdanskGdansk 80-210Poland

Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and -resistant acute myeloid leukemia (AML) ***: U937 cells and their sublines with low and high levels of acquired resistance to (6S)-[(R)-2-((S)-Hydroxy-hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]-3,3 dimethyl-butyric acid cyclopentyl ester (CHR2863), an APi prodrug, served as main AML cell line models. Drug combination effects were assessed with CHR2863 and in vitro non-toxic concentrations of various statins upon cell growth inhibition, cell cycle effects, and apoptosis induction. Mechanistic studies involved analysis of Rheb prenylation required for mTOR ***: A strong synergy of CHR2863 with the statins simvastatin, fluvastatin, lovastatin, and pravastatin was demonstrated in U937 cells and two CHR2863-resistant sublines. This potent synergy between simvastatin and CHR2863 was also observed with a series of other human AML cell lines (e.g., THP1, MV4-11, and KG1), but not with acute lymphocytic leukemia or multiple solid tumor cell lines. This synergistic activity was: (i) specific for APis (e.g., CHR2863 and Bestatin), rather than for other cytotoxic agents;and (ii) corroborated by enhanced induction of apoptosis and cell cycle arrest which increased the sub-G1 fraction. Consistently, statin potentiation of CHR2863 activity was abrogated by co-administration of mevalonate and/or farnesyl pyrophosphate, suggesting the involvement of protein prenylation;this was experimentally confirmed by impaired Rheb prenylation by ***: These novel findings suggest that the combined inhibitory effect of impaired Rheb prenylation and CHR2863-dependent mTOR inhibition instigates a potent synergistic inhibition of statins and APis on human AML cells.

关键词： Aminopeptidase statins mevalonate pathway carboxyl esterase Rheb mTOR

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中国的低碳转型与生态现代化

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中国人口·资源与环境 2012年第9期22卷 15-19页

作者：刘文玲王灿 Spaargaren gert Mol Arthur P J 清华大学环境学院北京100084 瓦赫宁根大学环境政策系

生态现代化理论探讨了国家在社会体制、经济发展和社会思想意识形态等方面的生态化转向,为政府、企业以及非政府团体和个人在面对环境问题时应该如何做出调整提供了一种新的思路。本文综述了生态现代化理论的核心思想和基本要素,并探讨... 详细信息

生态现代化理论探讨了国家在社会体制、经济发展和社会思想意识形态等方面的生态化转向,为政府、企业以及非政府团体和个人在面对环境问题时应该如何做出调整提供了一种新的思路。本文综述了生态现代化理论的核心思想和基本要素,并探讨了该理论发展过程中的主要争论。考虑目前国内经济的发展动态和发展低碳经济的迫切需求,这一理论对推动我国经济的低碳转型有着重要的借鉴意义。尤其是该理论发展过程中关于生产与消费的讨论,更为探讨发展低碳经济的核心定位等问题提供了参考。结合生态现代化观点和争论,本文提出我国经济的低碳转型,需要从尤其强调生产端导向的碳减排向同时兼顾上下游并重视消费者作用的战略思路转变;经济变革同时强调制度变革,转变行政命令控制为主的规制格局,促进多角色的参与;作为生产的微观主体,企业需强调以保护生态为己任的机构和管理改革,长远的发展更需要构建一种生产者与消费者之间有效衔接的消费导向战略。这些转变都将有利地推动中国经济的低碳现代化。

关键词：生态现代化低碳转型生产导向消费者战略

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低碳源条件下利用侧流活性污泥水解技术强化生物脱氮除磷

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给水排水 2013年第1期39卷 53-57页

作者：刘智晓 gert Petersen 张伟 Alexander Grossmann 詹卫东首创爱华天津市政环境工程有限公司天津300191 EnviDan A/S 2770 KastrupDenmark Lund Institute of Technology Lund 北京首创股份有限公司北京100028

污水水质特性是决定生物脱氮除磷工艺处理效能的关键性影响因素,尤其是进水中可快速降解有机物(rbCOD)及挥发性脂肪酸(VFA)浓度与N、P浓度比值的高低,直接制约了N、P的去除效率,补加外部碳源往往成为污水处理厂迫不得已的选择,但是外部... 详细信息

污水水质特性是决定生物脱氮除磷工艺处理效能的关键性影响因素,尤其是进水中可快速降解有机物(rbCOD)及挥发性脂肪酸(VFA)浓度与N、P浓度比值的高低,直接制约了N、P的去除效率,补加外部碳源往往成为污水处理厂迫不得已的选择,但是外部商业碳源会导致高昂的运行费用及其他运行问题。近十年来,充分挖掘优先利用污水处理厂内碳源技术在国外得到发展和应用。介绍了回流活性污泥(RAS)进行水解补充碳源的技术优势及工艺选择,就采用RAS侧流水解发酵在国内某厂实施技术示范项目进行了介绍,以期为国内在开发活性污泥可持续性利用技术方面提供借鉴。

关键词：活性污泥污泥水解可快速降解有机物挥发性脂肪酸生物脱氮除磷内碳源

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The role of radiation therapy and particle therapy in renal cell carcinoma: current evidence and future perspectives

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 775-784页

作者： Charlien Berghen Maarten Albersen Robin De Roover Kato Rans Benoit Beuselinck KarelDecaestecker Kenneth Poels Francois-Xavier Otte Steven Joniau Karin Haustermans gert De Meerleer Department of Radiation Oncology University Hospitals LeuvenLeuven 3000Belgium Department of Urology University Hospitals LeuvenLeuven 3000Belgium Department of General Medical Oncology University Hospitals LeuvenLeuven Cancer Instituteand Laboratory of experimental OncologyDepartment of OncologyCatholic University LeuvenLeuven 3000Belgium Department of Urology Ghent University HospitalLeuven 3000Belgium Department of Radiation Oncology Institut Jules BordetBrussels 1000Belgium

For both primary and metastatic renal cell carcinoma(RCC),treatment with stereotactic body radiotherapy(SBRT)has found its way into clinical *** a non-invasive outpatient procedure,SBRT requires only a few visits to the radiation department and may be of interest for the elderly or,in the case of primary RCC,for patients who are not considered surgical candidates due to technical limitations,medical comorbidities,or in the event that the maintenance of kidney function is *** the treatment landscape of oligometastatic RCC,SBRT shows promise in eradicating metastatic disease and delaying the initiation of systemic *** advancements in the planning and administration of radiation treatment and improvements in movement management allow irradiating the tumor and/or metastatic lesions with very high doses in few fractions while maximally sparing the surrounding organs at risk,thus minimizing *** that context,the increasing availability of particle therapy,such as proton beam radiotherapy or carbon ion radiotherapy,could further optimize the delivery of radiation treatment in order to reduce toxicity and improve outcome.

关键词： Particle therapy proton therapy carbon ion radiation therapy

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Species diversity and chemotype analysis of Fusarium from Chinese barley

Species diversity and chemotype analysis of Fusarium from Ch...

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中国植物病理学会2006年学术年会

作者： Theo van der Lee Cees Waalwijk gert Kema Plant Research International BV Biointeractions and Plant Health6700AA Wageningenthe Netherlands Plant Research International BV Biointeractions and Plant Health6700AA Wageningenthe Netherlands Plant Research International BV Biointeractions and Plant Health6700AA Wageningenthe Netherlands

＜正＞China is an increasing stakeholder in the barley/malt/beer chain, both as producer as well as consumer. Fusarium is a major problem in wheat and barley due to the production of mycotoxins, and malt/beer producers have a zero tolerance for mycotoxins. We therefore monitored the presence of Fusarium species during the growing season of 2005. We performed hierarchical sampling of

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专用指令集处理器设计的架构性研究

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中国集成电路 2013年第10期22卷 41-43,49页

作者： gert Goossens Target Compiler Technologies

今日的半导体行业受到快速增长的智能消费设备市场的推动。这些产品具有功能丰富，多感官，无线互联，永久在线，以及绿色环保的特征。传统的SoC设计方法是基于一个或多个嵌入式微处理器内核（如ARM）的运用，辅之以硬连线加速器。

关键词：专用指令集处理器设计方法架构微处理器内核半导体行业设备市场无线互联绿色环保

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Identification of habitat requirements of farmland birds based on a hierarchical structured monitoring scheme

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Chinese Birds 2013年第4期4卷 265-280页

作者： Jrg HOFFMANN Udo WITTCHEN Ulrich STACHOW gert BERGER 德国战略与技术评价研究所栽培植物联邦研究中心德国土地利用系统研究所莱布尼兹农业景观研究中心

Agricultural landscapes are essential for the conservation of biodiversity. Nevertheless, a negative trend continues to be observed in many rural areas for the most prominent indicator species group, the farmland birds. However, clear cause-effect relationships are rarely reported and sometimes difficult to deduce, especially from monitoring data which are based only on the detection of species and counts of the numbers of individuals. Because the identification of habitat preferences is a precondition for farmland bird biodiversity conservation efforts, a monitoring scheme for the simultaneous collection and analysis of bird and land use data was developed and tested. In order to assign the occurrence of bird species to land characteristics at various spatial scales and different land use and crop types, we applied a hierarchical structured sampling design. The spatial scales were ‘agricultural landscape', ‘agricultural landscape types', ‘field crops and other habitats' and ‘vegetation structures'. These scales were integrated with a novel concept, the ‘habitat matrix'(HM). This method was applied to farmland breeding bird abundances on 29 plots, each 1 km2 in size, by the use of the territory mapping method. The same plots were enlarged by a 100 m buffer and the sizes and location of habitats documented. Vegetation height, coverage and density were also recorded for all crop fields in the study area. We propose that this monitoring method facilitates the identification of scale dependent relationships between farmland bird habitat characteristics and bird abundance. This is demonstrated by the farmland bird species Corn Bunting(Emberiza calandra), Skylark(Alauda arvensis), and Whinchat(Saxicola rubetra). The breeding territories of these species reveal large differences within the various spatial scales ‘agricultural landscape', ‘agricultural landscape types' and ‘field crops'. Throughout the breeding season the abundances varied, dependent on the field crop and t

关键词： farmland birds hierarchical monitoring scheme agricultural landscape vegetation structures habitat matrix biodiversity

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可充电电池技术和充电方法

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电子产品世界 2004年第9A期11卷 111-114页

作者： gert Helles Maxim公司

电池的应用从来没有像现在这么广泛.电池正在变得更小、更轻,在单位容积内可容纳更多能量.电池发展的主要驱动力来自便携装置(移动电话,膝上电脑,摄录像机,MP3播放机)的发展.

关键词：摄录像机可充电电池 MP3播放机移动电话充电方法驱动力便携装置容积

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