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顺铂和可调强度(IMRT)扩大野放疗(EFRT)同时应用治疗宫颈癌的可行性

世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 47-47页

作者： gerszten k. Colonello k. Heron D.E. 马超 Department of Radiation Oncology Centre AvenuePittsburghPA 15232United States

Objectives.:To assess the acute tolerance of delivering concurrent cisplatin and extended field radiotherapy (EFRT) using intensity-modulated radiotherapy technique (IMRT) for cancer of the cervix. Methods.:All patients receiving definitive treatment for cervical cancer were treated with EFRT using IMRT technique and concurrent cisplatin. The treatment volume included the cervix,uterus,parametria,presacral space,upper vagina,pelvic,common iliac,and paraaortic nodes to the top of L1. All regions received 45 Gy (25 fractions) with a simultaneous boost to involved nodes (55 Gy/25 fractions). Patients were assessed weekly for toxicity and response. Results.:Twenty-two consecutive patients underwent treatment. All patients completed the prescribed course of EFRT. Median treatment length was 39.5 days (range 36-53). Treatment breaks of 2 and 3 days were required for bone marrow toxicity in 2 patients. The final week of chemotherapy was held in 2 patients because of neutropenia. No patient suffered acute or subacute grade 3 or 4 GI or GU toxicity. Conclusion.:In this clinical study,an IMRT technique was used to successfully deliver EFRT with concurrent chemosensitization for cervical cancer. The technique was associated with an acceptable acute toxicity without signi- ficant treatment protraction. This new role for IMRT merits further evaluation with larger patient numbers and longer follow-up.

关键词：扩大野放疗 EFRT IMRT 子宫旁组织急性毒性反应前间隙骨髓毒性中性粒细胞

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维普期刊数据库

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局灶性晚期外阴癌术前放、化疗

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 35-35页

作者： gerszten k Selvaraj R.N kelley J Faul C 朱亮 Department of Radiation Oncology University of Pittsburgh Cancer Institute UPMC Cancer Pavillon (POB II) 5150 Centre Avenue Pittsburgh PA 15232 United States

A twice daily (BID) radiation treatment schedule (interval of 4- 6 h) delivered concurrent with chemotherapy for advanced or critically located carcinoma of the vulva was modeled on the schema developed by the Gynecology Oncology Group (GOG). Inguinal nodes were included in the treatment fields even if clinically negative. This review analyzed the outcomes using this approach. Methods. A retrospective review was conducted of the records of 18 patients with vulvar cancer. Patients were treated with a modified GOG schema using 5- fluorouracil (5FU) and cisplatin with BID radiation treatments during the first and last weeks of treatment and seven daily radiation treatments in between. The regional nodes and primary tumor were prescribed 44.6 Gy. Resection of the primary tumor bed and inguinal dissection was planned at 4- 6 weeks post-treatment. Clinical and pathological responses as well as locoregional control and toxicity were assessed. Results. All patients responded. There were 13/18 complete clinical responses (cCR), of whom 12 remained NED at 25 months. Of the five partial clinical response (cPR) patients, two have suffered local recurrences, despite surgical resection in one and electron boost in the other. All patients developed a desquamative perineal skin reaction necessitating a mean treatment break of 15 days. No severe hematological toxicity was encountered, and only one patient had grade 3 small bowel toxicity. One patient required surgical debridement for groin wound breakdown. Conclusion. The use of BID chemoradiation resulted in complete or partial responses in all cases. Post-treatment groin dissection can be performed without significant post-operative complications.

关键词：腹股沟淋巴结局部淋巴结尿嘧啶毒性反应妇科肿瘤原发瘤临床反应会阴皮肤原发肿瘤临床病理

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肺动脉高压患者脂肪酸代谢异常与右心室脂毒性的关系

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中华高血压杂志 2016年第4期24卷 399-399页

作者： Brittain EL Talati M Fessel JP Zhu H Penner N Calcutt MW West J Funke M Lewis GD gerszten RE Hamid R Pugh ME Austin ED Newman JH Hemnes AR 刘莉叶鹏

肺动脉高压（pulmonary arterial hypertension,PAH）中右心衰竭的机制尚未完全阐明。在PAH动物实验模型中发现脂肪酸代谢异常,然而,还没有研究针对人类PAH的全身和心肌脂肪酸代谢情况进行分析。方法与结果：获取人类血液和右心室组织,... 详细信息

肺动脉高压（pulmonary arterial hypertension,PAH）中右心衰竭的机制尚未完全阐明。在PAH动物实验模型中发现脂肪酸代谢异常,然而,还没有研究针对人类PAH的全身和心肌脂肪酸代谢情况进行分析。方法与结果：获取人类血液和右心室组织,应用无创成像检测PAH患者及对照人群脂肪酸代谢途径不同阶段的特点。与对照组比较,PAH患者循环游离脂肪酸和长链酰基肉碱水平升高;右心室长链脂肪酸增加,长链酰基肉碱显著减少。

关键词：脂肪酸代谢长链酰基肉碱肺动脉高压右心室脂毒性长链脂肪酸动物实验模型右心衰竭三酰甘油水平脂肪变性

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