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颗粒尺寸及倾角对渗流水压力分布的影响研究

采矿与安全工程学报 2021年第3期38卷 592-601页

作者：韩流舒继森尚涛杨国宇陈涛李胤达 gerson.s.v.tovele 中国矿业大学矿业工程学院江苏徐州221116

为了研究颗粒尺寸及渗流倾角对水压力分布的影响规律,基于水力学基本原理,推导出了结构面渐进贯通过程中的静水压力以及多孔介质连续渗流过程中的渗透力计算方法,揭示了颗粒结构、倾角与水压力的函数关系。设计单因素渗流试验方案,分别... 详细信息

为了研究颗粒尺寸及渗流倾角对水压力分布的影响规律,基于水力学基本原理,推导出了结构面渐进贯通过程中的静水压力以及多孔介质连续渗流过程中的渗透力计算方法,揭示了颗粒结构、倾角与水压力的函数关系。设计单因素渗流试验方案,分别以颗粒尺寸和渗流倾角为自变量,以压力水头为因变量,进行了9组循环渗流试验,测定了沿程压力水头。结果表明:渗透力未改变石子、中沙的颗粒排布结构,造成了细沙渗流路径上13^(#)水头管位置出现流沙沉降。沿程压力水头在石子、中沙内部分别呈"直角三角形"和"等腰三角形"分布,在细沙内部则呈现连续增长+骤降+水平波动+连续下降的分布规律。峰值压力水头分别出现在石子渗流路径的终点、中沙渗流路径的中点,以及细沙压力水头骤降区的起点。石子、中沙渗流的峰值压力水头△h_(max)与β,sinβ均符合良好的线性关系,细沙渗流的峰值压力水头与倾角符合二次函数关系。散体介质过流断面与底板出水孔透水能力的相对大小是决定压力水头峰值和分布规律的关键因素。

关键词：颗粒尺寸倾角渗流试验水压力分布规律

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排土场散体软岩重塑物理力学参数研究

采矿与安全工程学报 2019年第4期36卷 820-826页

作者：韩流舒继森尚涛陈树召 gerson.s.v.T 中国矿业大学矿业工程学院

为了研究蒙东地区露天矿软岩散体物料重塑进程中的物理力学参数变化规律,依据该地区露天矿不同的排土作业方式,分析了堆载压力叠加方式,设计了分级加载和连续加载2种软岩重塑试验方案,提供了具体的试验步骤进行重塑试样的制备,对软岩重... 详细信息

为了研究蒙东地区露天矿软岩散体物料重塑进程中的物理力学参数变化规律,依据该地区露天矿不同的排土作业方式,分析了堆载压力叠加方式,设计了分级加载和连续加载2种软岩重塑试验方案,提供了具体的试验步骤进行重塑试样的制备,对软岩重塑试样的物理力学强度进行了测定,结果表明:重塑岩样的孔隙比随着重塑压力的增大呈负指数规律递减,密度随着重塑压力的增大呈幂函数增长,含水率随重塑压力的增大呈对数关系递减;重塑岩样的黏聚力随重塑压力的增大呈二次函数规律增长,增长的速度逐渐下降;而内摩擦角不受重塑压力的影响。

关键词：排土场软岩重塑物理力学参数试验设计变化规律

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Fine mapping of genomic regions associated with female fertility in Nellore beef cattle based on sequence variants from segregating sires

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Journal of Animal science and Biotechnology 2020年第2期11卷 303-315页

作者： gerson A.Oliveira Júnior Daniel J.A.santos Aline s.M.Cesar solomon A.Boison Ricardo v.ventura Bruno C.Perez JoséF.Garcia JoséBento s.Ferraz Dorian J.Garrick Department of veterinary Medicine University of São Paulo(USP)Faculty of Animal Science and Food EngineerPirassunungaSPBrazil Department of Animal Bioscience Center for Genetic Improvement of LivestockUniversity of GuelphGuelphONCanada Department of Animal and Avian sciences University of MarylandCollege ParkMarylandUSA Department of Animal science University of São Paulo(USP)PiracicabaSPBrazil Department of sustainable Agricultural systems University of Natural Resources and Life SciencesViennaAustria Department of Animal Nutrition and Production School of Veterinary Medicine and Animal ScienceUniversity of São Paulo(USP)PirassunungaBrazil Department of support Production and Animal HealthSchool of Veterinary MedicineSão Paulo State University(Unesp)AraçatubaSPBrazil school of Agriculture Massey UniversityRuakura Ag CentreHamiltonNew Zealand

Background:Impaired fertility in cattle limits the efficiency of livestock production *** the genetic architecture of fertility traits would facilitate their improvement by *** this study,we characterized sNP chip haplotypes at QTL blocks then used whole-genome sequencing to fine map genomic regions associated with reproduction in a population of Nellore(Bos indicus)***:The dataset comprised of 1337 heifers genotyped using a Geneseek®Genomic Profiler panel(74677 sNPs),representing the daughters from 78 *** performing marker quality control,64800 sNPs were *** carried by each sire at six previously identified QTL on BTAs 5,14 and 18 for heifer pregnancy and BTAs 8,11 and 22 for antral follicle count were constructed using findhap *** significance of the contrasts between the effects of every two paternally-inherited haplotype alleles were used to identify sires that were heterozygous at each ***-genome sequencing data localized to the haplotypes from six sires and 20 other ancestors were used to identify sequence variants that were concordant with the haplotype *** analyses were applied to these variants using KEGG and MesH ***:A total of six(BTA 5),six(BTA 14)and five(BTA 18)sires were heterozygous for heifer pregnancy QTL whereas six(BTA 8),fourteen(BTA 11),and five(BTA 22)sires were heterozygous for number of antral follicles’*** to inadequate representation of many haplotype alleles in the sequenced animals,fine mapping analysis could only be reliably performed for the QTL on BTA 5 and 14,which had 641 and 3733 concordant candidate sequence variants,*** KEGG“Circadian rhythm”and“Neurotrophin signaling pathway”were significantly associated with the genes in the QTL on BTA 5 whereas 32 MesH terms were associated with the QTL on BTA *** the concordant sequence variants,0.2%and 0.3%were classified as missense variants for BTAs 5 and 14,respe

关键词： Antral follicles Causal variants Haplotype Heifer pregnancy WGs

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Novel polysaccharide-protein conjugates provide an immunogenic 13-valent pneumococcal conjugate vaccine for ***

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synthetic and systems Biotechnology 2017年第1期2卷 49-58页

作者： Allison E.B.Turner Jonas E.gerson Helen Y.so Daniel J.Krasznai Adrienne J.st.Hilaire Donald F.gerson vaccine Research and Development PnuVax Incorporated Headquarters134 Albert St.KingstonOntarioK7L 3V2Canada vaccine Research and Development PnuVax Incorporated Laboratories6000 Royalmount Ave.MontrealQuebecH4P 2T1Canada

Pneumonia remains the single leading cause of childhood death *** the commercial availability of multiple pneumococcal conjugate vaccines(PCvs),high dosage cost and supply shortages prevent PCv delivery to much of the developing *** current work presents high-yield pneumococcal conjugates that are immunogenic in animals and suitable for use in human vaccine *** 13-valent pneumococcal conjugate vaccine(PCv-13)investigated in this research incorporated serotypes 1,3,4,5,6A,6B,7F,9v,14,18C,19A,19F,and *** polysaccharides(PnPss)and CRM197 carrier protein were produced and purified in-house,and used to prepare PnPs-CRM conjugates using unique,cyanide-free,in vacuo glycation conjugation *** vitro characterization confirmed the generation of higher molecular weight PnPs-CRM conjugates low in free *** vivo animal studies were performed to compare Pnuvax's PCv-13 to the commercially available PCv-13,Prevnar®13(Pfizer,UsA).A boost dose was provided to all groups post-dose 1 at t?14 ***-dose 2 results at t?28 days showed that all 13 serotypes in Pnuvax's PCv-13 were *** serotype IgG GMCs demonstrated that Pnuvax's PCv-13 is immunogenic for all 13 serotypes,with 10 of the 13 serotypes statistically the same or higher than Prevnar®13 post-dose *** a result,the novel polysaccharideprotein conjugates developed in this work are highly promising for use in human PCv *** in vacuo conjugation technique applied in this work could also be readily adapted to develop many other conjugate vaccines.

关键词： Pneumonia vaccine development PCv Pneumococcal conjugate vaccine Polysaccharide Carrier protein In vacuo glycation

Chemical Profile of the sulphated saponins from the starfish Luidia senegalensis Collected as by-Catch Fauna in Brazilian Coast

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Natural Products and Bioprospecting 2018年第2期8卷 83-89页

作者： Marcelo Marucci Pereira Tangerina Julia Pizarro Cesario gerson Rodrigues Raggi Pereira Tania Marcia Costa Wagner Cotroni valenti Wagner vilegas UNEsP-Univ Estadual Paulista Coastal campus of Sao VicentePraca Infante Dom Henrique s/nSao VicenteSP 11330-900Brazil Chemistry Institute Sao Paulo State University-UNESPAraraquara CampusProf.Francisco Degni55SPAraraquara 14800-060Brazil

The by-catch fauna of the shrimp fishery includes a number of marine invertebrates that are discarded because they do not have commercial *** order to try to add some value to these materials,we analyzed the chemical composition of the starfish Luidia senegalensis collected in the Brazilian coast as a consequence of the trawling fishery *** order to access their chemical composition,we used a combination of solid phase extraction(sPE)followed by ultra-high performance liquid chromatography coupled to electrospray ionization ion trap tandem mass spectrometry(UPLC-EsI-IT-Msn).Luidia sene-galensis contains asterosaponins,which are sulphated glycosilated steroids,containing five and six sugar moieties,in addition to *** study helped us to support the presence of important and potentially bioactive compounds in invertebrates associated to the by-catch fauna of the shrimp fishery,using a fast and efficient method.

关键词： Luidia senegalensis By-catch fauna Asterosaponins UPLC-Ms