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Predictors of survival in autoimmune liver disease overlap syndromes

World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph Wendy cheng Simon Hazeldine Briohny W Smith gerry c macquillan Michael c Wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BAcKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBc)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSc)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBc,27%AIH-PSc).There was no significant difference in survival between AIH-PBc and *** was a significant predictor of liver-related mortality(Pc(n=14)but not AIH-PSc(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBc patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's c-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBc *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

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Effect of airplane transport of donor livers on post-liver transplantation survival

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World Journal of Gastroenterology 2016年第41期22卷 9154-9161页

作者： Yi Huang gerry macquillan Leon A Adams George Garas Megan collins Albert Nwaba Linjun Mou Max K Bulsara Luc Delriviere Gary P Jeffrey School of Medicine and Pharmacology University of Western Australia Western Australian Liver Transplantation Service Sir Charles Gairdner Hospital Institute of Health Research University of Notre Dame

AIM To evaluate the effect of long haul airplane transport of donor livers on post-transplant outcomes. METHODS A retrospective cohort study of patients who received a liver transplantation was performed in Perth, Australia from 1992 to 2012. Donor and recipient characteristics information were extracted from Western Australian liver transplantation service database. Patients were followed up for a mean of six years. Patient and graft survival were evaluated and compared between patients who received a local donor liver and those who received an airplane transported donor liver. Predictors of survival were determined by univariate and multivariate analysis using cox *** One hundred and ninety-three patients received alocal donor liver and 93 patients received an airplane transported donor liver. Airplane transported livers had a significantly lower alanine transaminase(mean: 45 U/L vs 84 U/L, P = 0.035), higher donor risk index(mean: 1.88 vs 1.42, P cold ischemic time(cIT)(mean: 10.1 h vs 6.4 h, P correlation between cIT and transport distance(r2 = 0.29, P cance for graft loss(HR = 1.92, 95%cI: 1.16-3.17). One year graft survival was 0.88 for those with a local liver and was 0.71 for those with an airplane transported liver. One year graft loss was due to primary graft non-function or associated with preservation injury in 20.8% of recipients of an airplane transported liver compared with 4.6% in those with a local liver(P = 0.027). cONcLUSION Airplane transport of donor livers was independently associated with reduced graft survival following liver transplantation.

关键词： Airplane transportation cold ischemic time Graft survival Donor location Organ damage

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Improved Hepascore in hepatitis c predicts reversal in risk of adverse outcome

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World Journal of Hepatology 2017年第19期9卷 850-856页

作者： Angus W Jeffrey Yi Huang W Bastiaan de Boer Leon A Adams gerry macquillan David Speers John Joseph Gary P Jeffrey School of Medicine University of Notre Dame School of Medicine and Pharmacology University of Western Australia Department of Hepatology Sir Charles Gairdner Hospital Department of Anatomical Pathology Path West QEII Medical Centre Department of Microbiology Path West QEII Medical Centre Department of Biochemistry Path West QEII Medical Centre

AIM To establish if serial Hepascore tests(referred to as delta Hepascore) in those with chronic hepatitis c(cHc) correlate with the increase and/or decrease in risk of liver related *** Three hundred and forty-six cHc patients who had two Hepascore tests performed were studied. During 1944 patient years follow-up 28(8.1%) reached an endpoint. The Hepascore is a serum test that provides clinically useful data regarding the stage of liver fibrosis andsubsequent clinical outcomes in chronic liver *** Patients with a baseline Hepascore > 0.75 had a significantly increased rate of reaching a composite endpoint consisting of hepatocellular carcinoma, liver death, and/or decompensation(P core > 0.75, a subsequent improved Hepascore showed a significantly decreased risk for the composite endpoint(P = 0.004). There were no negative outcomes in those with a stable or improved delta Hepascore. The minimum time between tests that was found to give a statically significant result was in those greater than one year(P = 0.03).cONcLUSION In conclusion, Hepascore is an accurate predictor of liver related mortality and liver related morbidity in cHc patients. Of note, we have found that there is a decreased risk of mortality and morbidity in cHc patients when the patient has an improving delta Hepascore. Repeat Hepascore tests, when performed at a minimum one-year interval, may be of value in routine clinical practice to predict liver related clinical outcomes and to guide patient management.

关键词： chronic Prognosis Direct acting antivirals Serum Hepatitis c

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Environmental Enrichment

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上海实验动物科学 2002年第2期22卷 73-77页

作者： gerry c Bantin B&KUniversalLimitedc/oSIPPR/BKLabAnimalLimited779LaoHuMinRoad

本文是英国 BK公司总裁 Gc Bantin教授在 2 0 0 2年 5月上海国际实验动物科学研讨会上关于实验动物环境优化的专题发言。中国已加入 WTO,动物福利问题已引起国内各界人士的重视和关注 ,Bantin教授的文章或可作为参考和借鉴。

关键词：实验动物环境优化动物福利

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Munc18/SNARE proteins’ regulation of exocytosis in guinea pig duodenal Brunner’s gland acini

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World Journal of Gastroenterology 2008年第15期14卷 2314-2322页

作者： Laura I cosen-Binker gerry P Morris Stephen Vanner Herbert Y Gaisano Department of Medicine University of Toronto Toronto Ontario M5S 1A8 Canada Gastrointestinal Diseases Research Unit Queen's University Kingston Ontario KL7 5G2 Canada

AIM: To examine the molecular mechanism of exocytosis in the Brunner’s gland acinar cell. METHODS: We used a submucosal preparation of guinea pig duodenal Brunner’s gland acini to visualize the dilation of the ductal lumen in response to cholinergic stimulus. We correlated this to electron microscopy to determine the extent of exocytosis of the mucin-filled vesicles. We then examined the behavior of SNARE and interacting Munc18 proteins by confocal microscopy. RESULTS: One and 6 μmol/L carbachol evoked a dose- dependent dilation of Brunner’s gland acini lumen, which correlated to the massive exocytosis of mucin. Munc18c and its cognate SNARE proteins Syntaxin-4 and SNAP-23 were localized to the apical plasma membrane, and upon cholinergic stimulation, Munc18c was displaced into the cytosol leaving Syntaxin-4 and SNAP-23 intact. cONcLUSION: Physiologic cholinergic stimulation induces Munc18c displacement from the Brunner’s gland acinar apical plasma membrane, which enables apical membrane Syntaxin-4 and SNAP-23 to form a SNARE complex with mucin-filled vesicle SNARE proteins to affect exocytosis.

关键词： Apical exocytosis Brunner's gland acini Munc18c Syntaxin-4 carbachol

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Flash flood modeling in the data-poor basin:A case study in Matina River Basin

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Tropical cyclone Research and Review 2021年第2期10卷 87-95页

作者： Rhonalyn V.Macalalad Shichao Xu Roy A.Badilla Socrates F.Paat Bema c.Tajones Yangbo chen gerry Bagtasa Philippine Atmospheric Geophysical and Astronomical Services AdministrationDepartment of Science and TechnologyQuezon CityPhilippines School of Geography and Planning Sun Yat-Sen UniversityGuangzhouChina Institute of Environmental Science and Meteorology University of the PhilippinesQuezon CityPhilippines

Forecasting flooding hazards is a very effective non-engineering measure for flood ***,the commonly used forecasting method in simulating flash flood events is through a watershed hydrological *** Asia-Pacific countries like the Philippines are prone to frequent hydrometeorological hazards such as tropical cyclones,resulting in frequent heavy rainfall ***,most rivers in the many basins lack water flow observation data,which makes it challenging to use lumped and data-driven models for flash flood *** the continuous progress of remote sensing(RS)and geographic information system(GIS)techniques,the physically-based distributed hydrological model(PBDHMs)has rapidly *** can directly determine the model parameters according to the underlying surface characteristics from remotely-sensed data,which makes it possible for flood forecasting in areas with little to virtually no *** this study,the Matina River basin in Davao city was selected as a case study in simulating a small data-poor basin in the *** Liuxihe model was used to formulate a forecasting scheme and simulated the past flash flood *** results show that there is a good correspondence between the past heavy rainfall events and their corresponding simulated river *** results conform to the hydrological regularities,which can be used for flood forecasting and can serve as a baseline for the development of a flood forecasting system in the rivers of Davao city and elsewhere.

关键词： Typhoon Flash flood Liuxihe model

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EFFEcTS OF cORDYcEPS SINENSIS ON MURINE T LYMPHOcYTE SUBSETS

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中华医学杂志(英文版) 1991年第1期104卷 4-8页

作者： chen Guo-zhen chen Guo-lin Sun Tsieh gerry c. Hsieh Joan M. Henshall Institute of combined Western and Traditional chinese Medicine Hunan Medical University Changsha 410078 The clinical Laboratory of North Shore Hospital Cornell University NY USA

It was shown by flow cytometry analysis that crystalized preparation of cordyceps sinensis (cs-cr) caused significant elevation of the number of T helper cells and Lyt-1 /Lyt-2 (T helper to T suppressor cell) ratio both in peripheral blood and the treated mice spleen. The spleen weight, phagocyte counts and phagocytic activity were also elevated in the treated group. In addition, cs-cr could protect T helper cells from the immnnosuppressive effects of prednisolone acetate and cyclophosphamide. These results further substantiate the fact that cs-cr is an immunoregulator/biological response modifier of cellular immunity and may be potentially useful in handling immunodeficient or immunosuppressed patients.

关键词： cELLS MOUSE

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介入心脏病学知识(一) 经皮介入电生理学

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英国医学杂志中文版 2005年第1期8卷 47-51页

作者： gerry c Kaye 唐恺

20世纪80年代以前，心脏电生理检查主要通过药物手段来验证某些心律失常的产生机制(mechanism)，以便指导药物治疗。后来，人们认识到抗心律失常药有其自身的缺陷，因而大力开展了非药物治疗技术，其中最突出的是射频消融和植入型除颤器。

关键词：介入心脏病学经皮电生理学心脏电生理检查植入型除颤器抗心律失常药非药物治疗知识技术手段

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介入心脏病学基本知识(二)——治疗心动过速的植入型装置

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英国医学杂志中文版 2005年第2期8卷 110-113页

作者： Timothy Houghton gerry c Kaye 唐恺

对心动过速的起搏治疗已经获得成功。它在治疗室上性心动过速(室上速）片面的表现尤其引人瞩目，而用起搏来终止室性心动过速（室速）则一直较为困难。但随着人们对室性心律失常机理（mechanism）的认识，加之起搏器功能的日益完善．最... 详细信息

对心动过速的起搏治疗已经获得成功。它在治疗室上性心动过速(室上速）片面的表现尤其引人瞩目，而用起搏来终止室性心动过速（室速）则一直较为困难。但随着人们对室性心律失常机理（mechanism）的认识，加之起搏器功能的日益完善．最终使心腔内起搏与心腔内电击技术结合到了一起，从而使植入型心律转复除颤器(implaniable cardioverter defibrillalors，IcD)得以问世。

关键词：介入心脏病学植入型心律转复除颤器室上性心动过速装置知识室性心动过速室性心律失常起搏治疗心腔内室上速起搏器

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气候变化和人类活动对天山北坡净初级生产力变化的影响

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农业工程学报 2020年第20期36卷 195-202页

作者：尹小君祝宏辉 Gao gerry 高军郭丽洁王娇娇石河子大学信息科学与技术学院石河子832000 石河子大学经济与管理学院石河子832000 圣何塞州立大学计算机工程系加州95192 安徽四创电子股份有限公司合肥230000

天山北坡是中国农牧业发展基地,也是“一带一路”开发重点区域。气候变化和人类活动是影响天山北坡净初级生产力(Net Primary Productivity,NPP)的2个重要因素,定量评估气候变化和人类活动对天山北坡草场可持续性利用具有重要意义。该... 详细信息

天山北坡是中国农牧业发展基地,也是“一带一路”开发重点区域。气候变化和人类活动是影响天山北坡净初级生产力(Net Primary Productivity,NPP)的2个重要因素,定量评估气候变化和人类活动对天山北坡草场可持续性利用具有重要意义。该研究采用MODIS c6遥感数据、气象数据和野外实测数据,分析2004-2015年气候变化和人类活动对天山北坡NPP变化的影响。结果表明:2004-2015年天山北坡实际净初级生产力(Actual Net Primary Productivity,NPPA)介于128.67~170.49 g/(m^2·a)之间,总体呈现增加趋势;西部区域NPPA年均值最高,天山北坡NPPA的主要供给区是中西部区域。天山北坡不同区域年均温度及降水量呈现明显差异,降水对NPPA的影响大于温度。同时,人类活动对NPP的影响(Human Activities on Net Primary Productivity,NPPH),总体上由负作用逐渐向正作用转变,正作用增强区域主要分布在奇台县、木垒县和天山北坡东部部分地区,负作用逐渐增强区域主要分布在奎屯市及乌苏市部分地区。

关键词：遥感气候变化 NPP 人类活动天山北坡 MODIS c6

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