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Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population

World Journal of Gastroenterology 2008年第20期14卷 3183-3187页

作者： Muhammed Hadithi Marcel Cazemier gerrit a meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven Department of Gastroenterology VUmcUniversity Medical Center Department of Pathology VUmc University MedicalCenter

AIM： To describe the characteristics of Dutch patients with *** bowel disease （IBD） first diagnosed above 60 years of age-a disease also known as old-age colitis （OAC） and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease （SCAD）. METHODS： A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS： Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 （50） [median age 82 years （range 64-101）; 25 male （42%）] were identified. These patients were diagnosed with ulcerative colitis （n = 37, 61%）, Crohn＇s disease （n = 14, 24%）, and indeterminate colitis （n = 8, 15%）. Remission was induced in 40 （68%） patients within a median interval of 6 mo （range 1-21） and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five （8%） patients. CONCLUSION： OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical features suggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli.

关键词： Inflammatory bowel disease Old-age colitis Segmental colitis

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Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： Manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian Rausch Esmée J Grobbee Manon van Engeland Manon C W Spaander gerrit a meijer Evelien Dekker Department of Gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 *** analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis Colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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World Journal of Gastroenterology 2012年第38期18卷 5397-5403页

作者： Sietze T van Turenhout Leo GM van Rossum Frank A Oort Robert JF Laheij Anne F van Rijn Jochim S Terhaar sive Droste Paul Fockens René WM van der Hulst Anneke A Bouman Jan BMJ Jansen gerrit a meijer Evelien Dekker Chris JJ Mulder Department of Gastroenterology and Hepatology VU University Medical Center1081 HV Amsterdam The Netherlands Department of Epidemiology Biostatistics and HTA Radboud University Nijmegen Medical Center6500 HB Nijmegen The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center6500 HB Nijmegen The Netherlands Department of Gastroenterology and Hepatology Academic Medical Center1105 AZ Amsterdam The Netherlands Department of Gastroenterology and Hepatology Kennemer Gasthuis 2035 RC Haarlem The Netherlands Clinical Chemistry VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center 6500 HB Nijmegen The Netherlands Department of Pathology VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Gastroenterology and Hepatology Academic Medical Center 1105 AZ Amsterdam The Netherlands Department of Gastroenterology and Hepatology VU University Medical Center 1081 HV Amsterdam The Netherlands

AIM: To improve the interpretation of fecal immunochemical test (FIT) results in colorectal cancer (CRC) cases from screening and referral cohorts. METHODS: In this comparative observational study, two prospective cohorts of CRC cases were compared. The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with FIT, of which, only subjects with a positive FIT were referred for colonoscopy. The second cohort was obtained from 3637 subjects scheduled for elective colonoscopy with a positive FIT result. The same FIT and positivity threshold (OC sensor; ≥ 50 ng/mL) was used in both cohorts. Colonoscopy was performed in all referral subjects and in FIT positive screening subjects. All CRC cases were selected from both cohorts. Outcome measurements were mean FIT results and FIT scores per tissue tumor stage (T stage). RESULTS: One hundred and eighteen patients with CRC were included in the present study: 28 cases obtained from the screening cohort (64% male; mean age 65 years, SD 6.5) and 90 cases obtained from the referral cohort (58% male; mean age 69 years, SD 9.8). The mean FIT results found were higher in the referral cohort (829 ± 302 ng/mLvs 613 ± 368 ng/mL,P = 0.02). Tissue tumor stage (T stage) distribution was dif-ferent between both populations [screening population: 13 (46%) T1, eight (29%) T2, six (21%) T3, one (4%) T4 carcinoma; referral population: 12 (13%) T1, 22 (24%) T2, 52 (58%) T3, four (4%) T4 carcinoma], and higher T stage was significantly associated with higher FIT results (P < 0.001). Per tumor stage, no significant difference in mean FIT results was observed (screening vs referral: T1 498 ± 382 ng/mL vs 725 ± 374 ng/mL, P = 0.22; T2 787 ± 303 ng/mL vs 794 ± 341 ng/mL, P = 0.79; T3 563 ± 368 ng/mLvs 870 ± 258 ng/mL,P = 0.13; T4 not available). After correction for T stage in logistic regression analysis, no significant differences in mean FIT results were observed between both types of cohorts (P = 0.10). CONCLUSION

关键词： Screening population Referral cohort Fecal immunochemical test Tumor stage distribution Colorectal cancer

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Colonoscopic yield of colorectal neoplasia in daily clinical practice

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World Journal of Gastroenterology 2009年第9期15卷 1085-1092页

作者： Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk gerrit a meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder Department of Gastroenterology and Hepatology VU University Medical CentrePO Box 70571007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Kennemer Gasthuis2000 AKHaarlemThe Netherlands Gastroenterology and Hepatology Academic Medical Centre1100 DDAmsterdamThe Netherlands Epidemiology and Biostatistics VU University Medical Centre1007 MBAmsterdamThe Netherlands Pathology VU University Medical Centre1007 MBAmsterdamThe Netherlands Gastroenterology and Hepatology Slotervaart Hospital1006 BKAmsterdamThe Netherlands Gastroenterology and Hepatology Medical Centre Alkmaar1800 AMAlkmaarThe Netherlands Gastroenterology and Hepatology Sint Lucas Andreas Hospital1061 AEAmsterdamThe Netherlands

AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per ***:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or ***:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients.

关键词： Colorectal cancer Screening Advanced neoplasia Colonoscopy Adenoma

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Chirality enables thermal magnon transistors

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 161-166页

作者： Tao Yu Chengyuan Cai gerrit E.W.Bauer School of Physics Huazhong University of Science and TechnologyWuhan 430074China .WPI-AIMR and Institute for Materials Research and SCIS Tohoku UniversitySendai 980-8577Japan Kavli Institute for Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China

We report a theory of thermal spin pumping into proximity magnets under a transverse-bias-driven heat flow of magnons in magnetic films when the dipolar coupling to the magnetic gate is tuned to be “chiral”. While there is no rectification of the magnon current in the film, we predict that chirality diverts a large percentage(50% for perfect chirality) of it into the gate. This transverse thermal spin pumping effect can be controlled by rotating the film magnetization and may help manage the heat flow in future magnonic circuits.

关键词： magnon chirality quantum transport transistor

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Flood events and their effects in a Himalayan mountain river: Geomorphological examples from the Buri Gandaki Valley, Nepal

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Journal of Mountain Science 2017年第7期14卷 1303-1316页

作者： gerrit TOMBRINK Institute of Geography University of Gottingen

This research examines flood events and related human interactions in the northwestern Himalayan Buri Gandaki Valley(Nepal). Past flood events that left traces at elevations between 3745 m to 780 m above sea level were investigated and reconstructed using morphometric and descriptive fluvial geomorphological analyses of historical flood markers and their related forms in the Buri Gandaki River system. Furthermore, the discharge of the Buri Gandaki River was measured, and infrastructure and permanent and temporary settlements potentially influenced by floods in the region due to their proximity to natural hazard areas were mapped. All reconstructed flood indicators have been documented with photographs that illustrate the evolution of the landscape over a short period in the Holocene. Moreover, satellite images have confirmed the morphological findings at the mesoscale and macroscale. An analysis of the flood levels showed that the high-water marks between 2160 m and 1710 m above sea level represented the highest reconstructed paleoflood stages. An intense flood hazard was observed in the upper stream of the Buri Gandaki near the Birendra Kund glacial lake and Samagaun settlement(3520 m above sea level). Further conclusions may be drawn from the anthropogenic reactions to flooding, such as those of the ethnic groups in this valley, who have used their local knowledge of floods and high discharge events along the Buri Gandaki River to takesafety precautions. Thus, local knowledge has reduced the social vulnerability in the settled areas of the valley. As a result of these local adaption strategies within the valley, we must rethink our implementation of protection and urbanisation strategies.

关键词： Floods Vulnerability Fluvialgeomorphology Himalaya Buri Gandaki River

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Factors influencing the removal of fine non-cohesive sediment by vortex settling basin at small river abstraction works

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International Journal of Sediment Research 2021年第4期36卷 501-511页

作者： Kuria Kiringu gerrit Basson Department of Civil Engineering University of Stellenbosch

Diverted sediment causes a wide range of problems at small diversion works. The difference in water levels between low flows and floods, low investment capital and presence of cohesive sediment and fine non-cohesive sediment coupled with a requirement for a high level of supply assurance makes the design of such hydraulic structures complex. Vortex settling basins(VSBs) offer a promising alternative to conventional settling structures or hydro-cyclones. In the current study, parameters affecting the trapping of particles >75 mm were numerically investigated using ANSYS Fluent and were validated by physical modeling. It was established that the inlet velocity needs to be maintained at 0.26 m/s, the underflow to inflow ratio should be between 0.05 and 0.10, the cylinder height to cylinder diameter ratio should be greater than 0.5, and the positioning of the inlet pipe to cylinder height ratio should be greater than 0.7, with a cone of slope ratio of 2:1(V:H) and the cylinder diameter to inlet diameter ratio should be 8.2. These parameters form the basic design guidelines for VSB use at small diversion works(<100 L/s duty capacity).

关键词： Vortex settling basin Sediment trapping efficiency River diversion works ANSYS Fluent Numerical modeling

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Impact of Crisis Communication Strategies on People's Attitudes toward Behavioral Guidelines Regarding COVID-19 and on Their Trust in Local Officials

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International Journal of Disaster Risk Science 2022年第4期13卷 495-506页

作者： gerrit Hirschfeld Meinald T.Thielsch Faculty of Business CareTech OWL–Center for HealthWelfare and TechnologyUniversity of Applied Sciences Bielefeld33619 BielefeldGermany Department of Psychology University of Münster48149 MünsterGermany

Situational Crisis Communication Theory(SCCT)guides responses of corporations in *** tested how COVID-19 related crisis communication strategies affect trust in mayors and the acceptance of behavioral measures.A total of 561 participants(53%female)with a mean age of 50 years took part in an online experiment in which we systematically manipulated the mayor's crisis communication strategy(deny crisis,diminish role in crisis,rebuild relationship after taking responsibility,bolster reputation,no response)and pre-crisis reputation(good past crisis management,bad past crisis management).Age,gender,and education served as *** also tested the predictive power of personal concern regarding the COVID-19 pandemic,as well as internal and external control *** our preregistered analysis,we found that crisis communication strategies had no significant effect on participants'ratings of behavioral measures,but they affected participants'trust in the *** deny crisis strategy resulted in the most unfavorable ratings,while the effects of the other strategies were moderated by the mayor's precrisis *** exploratory analyses showed that individual concern and trust were important predictors for the acceptance of behavioral *** though we did not find any effects of communication strategies on behavioral measures,our results support SCCT's utility in guiding communication strategy during a pandemic.

关键词： COVID-19 Crisis communication Germany Local officials Situational Crisis Communication Theory

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Anisotropic magnetoresistance:A 170-year-old puzzle solved

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Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 120-121页

作者： gerrit E.W.Bauer Advanced Institute for Materials Research Institute for Materials ResearchTohoku UniversitySendai980-8577Japan Zernike Institute for Advanced Materials University of GroningenGroningen9747 AGNetherlands

Thomson[1],the later Lord Kelvin,reported an increased electric resistance in iron and nickel when the magnetization is parallel rather than normal to the current direction,an effect now called anisotropic magnetoresistance(AMR).The AMR allows sensing magnetic fields by simply measuring the resistance change when the magnetization *** the magnetoresistance of magnetic tunnel junctions is larger,AMR sensors are attractive by their simplicity and robustness.

关键词： resistance magnetoresistance magnetization

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Enhanced Biogas Production from the Anaerobic Batch Treatment of Banana Peels

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Engineering 2019年第5期5卷 970-978页

作者： Spyridon Achinas Janneke Krooneman gerrit Jan Willem Euverink Faculty of Science and Engineering University of GroningenGroningen 9747 AGthe Netherlands

Waste disposal management and the energy crisis are important challenges facing most *** fruit-processing industry generates daily several tons of wastes,of which the major share comes from banana *** digestion(AD)technology has been applied to the treatment of wastewater,animal slurry,food waste,and agricultural residues,with the primary goals of energy production and waste *** study examines the effect of organic loading(OL)and cow manure(CM)addition on AD performance when treating banana peel waste(BPW).The maximum daily biogas production rates of banana peels(BPs)with a CM content of 10%,20%,and 30%at 18 and 22 g of volatile solids(gvs)per liter were 50.20,48.66,and 62.78 mL (gvs.d)^-1 and 40.49,29.57,and 46.54 mL (gvs.d)^-1,***,the daily biogas yield showed no clear interdependence with OL or CM *** addition,a kinetic analysis using first-order and cone models showed that the kinetic parameters can be influenced by the process parameters.

关键词： Biogas Banana peels Cow manure Anaerobic treatment Batch test Kinetic study

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