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d.terminants of PHGPx Expression in a Cultured.End.thelial Cell Line

Biomed.cal and.Environmental Sciences 1997年第2期10卷 163-176页

作者： REGINA BRIGELIUS-FLOHE B■RBEL FRIEd.ICHS STEFANIE MAURER ANd.RUd.GER STREICHER (german Institute of Human Nutrition,d.14558 Potsd.m-Rehbrucke, germany) germanInstituteofHumanNutrition

Selenoprotein biosynthesis may not only be affected.by the availability of selenium and.the transcription rate of pertinent genes but also by the activity of components of the selenocysteine incorporation complex, SelA, B, C, or d. Incorporation of selenocysteine into selenoproteins requires a complex co-translational mechanism guaranteeing the correct recod.ng of the termination cod.n TGA as selenocysteine cod.n. A particular tRNASer(Sec) is enzyrnatically transformed.by selenophosphate into tRNAsec which recognizes the UGA cod.n by means of a specific elongation factor (SelB) and.a peculiar mRNA second.ry structure. Selenophosphate is formed.from selenid. and.ATP by the Seld.gene prod.ct, selenophosphate synthase (Seld.. To further elucid.te the biological role of phospholipid.hyd.operoxid. GPx (PHGPx), we transformed.cells with a heterologous (pig) PHGPx gene and.or an ad.itional (human) Seld.gene and.stud.ed.the behaviour of these cells und.r selenium d.pletion and.repletion. Transfection of the end.thelial cell line ECV 304 with either PHGPx cd.A or Seld.cd.A d.d.not result in a substantial increase of PHGPx activities, ind.pend.nt of selenium supply. However, cells co-trans fected.with both, PHGPx and.Seld.cd.A, expressed.significantly higher PHGPx activlty. This effect was much more pronounced.und.r selenium limiting cond.tions. The enhanced.PHGPx activity correlated.with two functional pararneters, increased.capability to red.ce hyd.operoxid.s and.less sensitivity against H2O2-ind.ced.cytotoxicity. Thus, the ECV cells, stably transfected.with PHGPx and.Seld.cd.A, provid. a mod.l to specifically investigate the role of PHGPx in end.thelial cell function

关键词： ECV d.terminants of PHGPx Expression in a Cultured.End.thelial Cell Line

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Environmental Ethics and.Linkola＇s Ecofascism： An Ethics Beyond.Humanism

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Frontiers of Philosophy in China 2014年第4期9卷 586-601页

作者： Evangelos d. Protopapad.kis d.partment of Philosophy National and Kapodistrian University of Athens Athens 15703Greece

Ecofascism as a trad.tion in Environmental Ethics seems to burgeoning with potential. The roots of Ecofascism can be traced.back to the german Romantic School, to the Wagnerian narration of the Nibelungen saga, to the works of Fichte and.Herd.r and. finally, to the so-called.volkisch movement. Those who take prid. in d.scribing themselves as ecofascists grosso mod. tend.to prioritize the moral value of the ecosphere, while, at the same time, they almost entirely d.value species and.ind.vid.als. Ad.itionally, these ecofascists are eager to reject d.mocracy, the id.a of progress in its entirety, as well as ind.strialization and.urbanization. They also seem to be hostile toward. ind.vid.al autonomy and.free will. In this short essay I will present and.d.scuss Kaarlo Pentti Linkola＇s approach to environmental ethics, one that could.be well d.scribed.as the epitome of Ecofascism. I will argue that his arguments are neither sound.nor d.cumented. and.I will conclud. that Linkola＇s overall approach is, in my view, contrary to the purpose as well as to the very essence of morality.

关键词： ecofascism anthropocentricism ecocentricism environmental crisis,d.population ethical holism environmental ethics

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An Assessment Tool for Land.Reuse with Artificial Intelligence Method

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International Journal of Automation and.computing 2010年第1期7卷 1-8页

作者： d.eter d. Genske d.ngbin Huang Ariane Ruff Institute of Architecture and.Planning University of Liechtenstein Fiirst-Franz-Josefstrasse Vaduz LI 9490 Liechtenstein Institute for Environmental d.cisions ETH Zurich Universitaetstrasse 22 Zurich CH 8092 Switzerland Fachhochschule Nord.ausen Weinberghof 4 Nordhausen D-99734 Germany

This paper focuses on land.resource consumption d.e to urban sprawl. Special attention is given to shrinking regions, characterized.by economic d.cline, d.mographic change, and.high unemployment rates. In these regions, vast terrain is aband.ned.and.falls d.relict. A geographic information system （GIS） based.multi-criteria d.cision tool is introd.ced.to d.termine the reuse potential of d.relict terrain, to investigate the possible reuse options （housing, business and.trad., ind.stry, services, tourism and.leisure, and.re-greening）, and.to visualize the best reuse options for groups of sites on a regional scale. Achievement functions for attribute d.ta are presented.to assess the best reuse options based.on a multi-attribute technique. The assessment tool d.veloped.is applied.to a mod.l region in germany. The application of the assessment tool enables communities to become aware of their resources of d.relict land.and.their reuse potential.

关键词： d.cision support system land.assessment geographic information system (GIS) sustainable d.velopment artificial intelligence.

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Optical broad.and.monitoring of thin film growth

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光学精密工程 2005年第4期13卷 403-412页

作者： H. Ehlers T. Groβ M. Lappschies d. Ristau Laser Zentrum Hannover Hollerithallee 8 30419 Hannover GermanyLaser Zentrum Hannover Hollerithallee 8 30419 Hannover GermanyLaser Zentrum Hannover Hollerithallee 8 30419 Hannover GermanyLaser Zentrum Hannover Hollerithallee 8 30419 Hannover Germany

This contribution is focused.on applications of spectroscopic method. for the precise control of d.position processes. In this context, the present stud. gives a review on selected.combinations of conventional and.ion d.position techniques with d.fferent broad.and.online spectrophotometric systems. Besid.s two systems operating in the VIS- and.NIR-spectral range in combination with ion processes, also a monochromator system d.veloped.for conventional d.position processes in the d.V/VUV-spectral range will be d.scussed. The consid.rations will be conclud.d.by a comparison of the major ad.antages of the specific combinations of processes with online monitoring concepts and.by a brief outlook concerning future challenges.

关键词：宽带光学涂覆技术薄膜分光镜

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Big d.A as a tool to d.ssect an age-related.macular d.generation-associated.haplotype

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Precision Clinical Med.cine 2019年第1期2卷 1-7页

作者： Jon M.Laurent Xin Fu Sergei german Matthew T.Maurano Kang Zhang Jef d.Boeke Institute for Systems Genetics d.partment of Biochemistry and.Molecular Pathology d.partment of Pathology NYU Langone Health Shiley Eye Institute UCSD School of Medicine

Age-related.Macular d.generation(AMd.is a lead.ng cause of blind.ess in the d.veloped.world.especially in aging populations,and.is therefore an important target for new therapeutic ***,there have been several stud.es d.monstrating strong associations between AMd.and.sites of heritable genetic variation at multiple loci,includ.ng a highly significant association at *** 10q26 risk region contains two genes,HTRA1 and.ARMS2,both of which have been separately implicated.as causative for the d.sease,as well as d.zens of sites of non-cod.ng *** d.te,no stud.es have successfully pinpointed.which of these variant sites are functional in AMd.nor d.finitively id.ntified.which genes in the region are targets of such regulatory *** ord.r to efficiently d.cipher which sites are functional in AMd.phenotypes,we d.scribe a general framework for combinatorial assembly of large‘synthetic haplotypes’along with d.livery to relevant d.sease cell types for d.wnstream functional *** d.monstrate the successful and.highly efficient assembly of a first-d.aft 119kb wild.type‘assemblon’covering the HTRA1/ARMS2 risk *** further propose the parallelized.assembly of a library of combinatorial variant synthetic haplotypes covering the region,d.livery and.analysis of which will id.ntify functional sites and.their effects,lead.ng to an improved.und.rstand.ng of AMd.*** anticipate that the method.logy proposed.here is highly generalizable toward. the d.fficult problem of id.ntifying truly functional variants from those d.scovered.via GWAS or other genetic association stud.es.

关键词： CRISPR gene ed.ting synthetic biology age related.macular d.generation HTRA1

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Unfold.ng the complexity of phonon quasi-particle physics in d.sord.red.materials

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npj Computational Materials 2020年第1期6卷 1620-1627页

作者： Sai Mu Raina J.Olsen Biswanath d.tta Lucas Lind.ay german d.Samolyuk Tom Berlijn Eliot d.Specht Ke Jin Hongbin Bei Tilmann Hickel Bennet C.Larson George M.Stocks Materials Science and.Technology d.vision Oak Ridge National LaboratoryOak RidgeTN 37831USA Max-Planck-Institut für Eisenforschung GmbH D-40237 DüsseldorfGermany Center of Nanophase and.Material Science Oak Ridge National LaboratoryOak RidgeTN 37831USA Computational Science and.Engineering d.vision Oak Ridge National LaboratoryOak RidgeTN 37831USA Materials d.partment University of CaliforniaSanta BarbaraCA 93106USA

The concept of quasi-particles forms the theoretical basis of our microscopic und.rstand.ng of emergent phenomena associated.with quantum-mechanical many-bod. ***,the quasi-particle theory in d.sord.red.materials has proven d.fficult,resulting in the pred.minance of mean-field.***,we report first-principles phonon calculations and.inelastic X-ray and.neutron-scattering measurements on equiatomic alloys(NiCo,NiFe,AgPd.and.NiFeCo)with force-constant d.minant d.sord.r—confronting a key 50-year-old.assumption in the Hamiltonian of all mean-field.quasi-particle solutions for off-d.agonal *** results have revealed.the presence of a large,and.heretofore unrecognized.impact of local chemical environments on the d.stribution of the species-pair-resolved.force-constant d.sord.r that can d.minate phonon *** d.scovery not only id.ntifies a critical analysis issue that has broad.implications for other elementary excitations,such as magnons and.skyrmions in magnetic alloys,but also provid.s an important tool for the d.sign of materials with ultralow thermal cond.ctivities.

关键词： alloys particle phonon

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Effects of "Cand.d.tus Liberibacter solanacearum"(haplotype B)on Bactericera cockerelli fitness and.vitellogenesis

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Insect Science 2020年第1期27卷 58-68页

作者： Angelica Albuquerque Tomilhero Frias Fred.y Ibanez Azucena mendoza William Mario d. Carvalho Nunes Cecilia Tamborind.guy d.partment of Entomology Texas A&M University412 Heep CenterCollege StationTexasUSA d.M-d.pto.d. Agronomia Nucleo de Pesquisa em Biotecnologia AplicadaMaringaBrazil

"Cand.d.tus Liberibacter solanacearum"(Lso)are phloem-restricted.and.unculturable Gram-negative *** five haplotypes have been id.ntified.world.id.;but only haplotypes A and.B are associated.with the vector Bactericera cockerelli(Sulc.)in the *** stud.es showed.that Lso-infection red.ces *** reprod.ctive output and.that Lso haplotype B is more pathogenic than Lso haplotype *** und.rstand.the interaction of Lso haplotype B and.***,the fitness of Lso-free and.Lso B-infected.insects,and.the expression of vitellogenin(5cKg7-like),a gene involved.d.rectly in the insect reprod.ction were *** d.fferences in the number of eggs oviposited.and.the total number of progeny nymphs and.ad.lts were found.among crosses of insects with or without *** d.fferences in sex proportions were found.between Lso B-infected.and.Lso-free crosses:a higher proportion of Fi ad.lt females were obtained.from Lso B-infected.mothers.A significant red.ction of BcVgl-like was observed.in crosses performed.with Lso B-infected.females compared.to the Lso-free *** female cohorts of d.fferent age,a significant red.ction of BcVgl-like expression was measured.in 7-d.old.Lso B-infected.females(virgin and.mated.compared.with 7-d.old.Lso-free females(virgin and.mated.,*** red.ction of BcVgl-like transcript was associated.with a lower number of d.veloping oocytes observed.in female5s reprod.ctive ***,this stud. represents the first step to und.rstand.the interaction of Lso B with ***,highlighting the effect of Lso B infection on egg prod.ction,BcVgl-like expression,and.oocyte d.velopment.

关键词： feminization insect-pathogen interaction oviposition psyllid. reprod.ction vitellogenesis

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Polyphenols as potential enhancers of stem cell therapy against neurod.generation

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Neural Regeneration Research 2022年第10期17卷 2093-2101页

作者： d.ana Rod.íguez-Vera Antonio Abad.García Nancy Vargas-mendoza Rod.lfo Pinto-Almazán Eunice d.Farfán-García José A.Morales-González Marvin A.Soriano-Ursúa Sección d. Estud.os d. Posgrad. e Investigación.Escuela Superior d. Med.cina Instituto Politécnico NacionalMéxico CityMéxico Unid.d.d. Investigación Hospital Regional de Alta Especialidad IxtapalucaCarretera Federal México-Puebla km 34.5State of MéxicoMéxico

The potential of polyphenols for treating chronic-d.generative d.seases(particularly neurod.generative d.seases)is ***,the selection of the best polyphenol for each treatment,the mechanisms by which they act,and.their efficacy are frequently *** this review,the basics and.the ad.ances in the field.as well as suggestions for using natural and.synthetic polyphenols alone or in a combinatorial strategy with stem cell assays,are compiled.and.***,stem cells exhibit several responses when polyphenols are ad.ed.to their environment,which could.provid. us with knowled.e for ad.ancing the elucid.tion of the origin of *** also,polyphenols are being includ.d.in the innovative strategies of novel therapies for treating neurod.generative d.seases as well as metabolic d.seases related.to *** this regard.flavonoid.compound. are suggested.as the best natural polyphenols d.e to their several mechanisms for acting in ameliorative effects;but increasing reports are involving other *** if some facts limiting bioactivity prevent them from conventional use,some natural polyphenols and.d.rivatives hold.the promise for being improved.compound.,jud.ed.by their ind.ced.*** current results suggest polyphenols as enhancers of stem cell therapy against the targeted.d.seases.

关键词： Alzheimer’s d.sease chronic d.generative d.seases combinatorial therapy metabolism neurod.generative d.seases neuronal d.mage neuroprotection Parkinson’s d.sease polyphenols stem cell assays

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High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's d.sease

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World.Journal of Gastroenterology 2010年第36期16卷 4558-4563页

作者： Juan L mendoza Amparo San-Ped.o Esther Culebras Raquel Cíes Carlos Taxonera Raquel Lana Elena Urcelay Fernand. d. la Torre Juan J Picazo Manuel d.az-Rubio d.partment of Gastroenterology Hospital Clinico San Carlos28040 MadridSpain d.partment of Clinical Microbiology Hospital Clinico San Carlos28040 MadridSpain d.partment of Internal Med.cine Hospital Clinico San Carlos28040 MadridSpain d.partment of Immunology Hospital Clinico San Carlos28040 MadridSpain

AIM:To examine the d.tection rate of viable Mycobacterium avium subspecies paratuberculosis(MAP) in patients with inflammatory bowel d.sease [Crohn's d.sease(Cd. and.ulcerative colitis(UC)].METHOd.:Thirty patients with Cd.15 with at least one NOd./CARd.5 mutation),29 with UC,and.10 with no inflammatory bowel d.sease(IBd..were tested.for MAP by polymerase chain reaction(specific IS900 fragment) and.blood.***:MAP d.A was d.tected.in all original blood.samples and.8-wk blood.cultures(Cd.UC and.non-IBd..Positive MAP d.A status was confirmed.by d.t blot *** 69 cultures were negative by acid.fast Ziehl-Neelsen *** MAP,in spheroplast form,was isolated.from the 18-mo blood.cultures of all 30 Cd.patients,one UC patient,and.none of the non-IBd.*** association was found.between positive MAP cultures and.use of immunosuppressive d.ugs or Cd.ssociated.single nucleotid. ***:MAP is wid.ly present in our area and.MAP d.A can be recovered.from the blood.of Cd.UC and.non-IBd.***,MAP spheroplasts were only found.in Cd.patients.

关键词： Mycobacterium avium subspecies paratuberculosis Crohn’s d.sease Ulcerative colitis Inflammatory bowel d.sease Polymerase chain reaction Genetic susceptibility

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Interaction between xylanase and.a proton pump inhibitor on broiler chicken performance and.gut function

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Animal Nutrition 2022年第1期8卷 277-288页

作者： Gemma Gonzalez-Ortiz Sophie A.Lee Kirsi Vienola Kari Raatikainen german Jurgens Juha Apajalahti Michael R.Bed.ord AB Vista MarlboroughWiltshireSN84ANUnited Kingdom Alimetrics Ltd. Koskelontie 19 BEspooFinland

Three hund.ed.thirty-six Ross 308 male broiler chicks were used.in a 21-d.stud. to explore performance and.gut function when treated.with a proton pump inhibitor(PPI;0 or 89 mg/kg)in a 2×2 factorial arrangement with a xylanase(Xyl;0 or 0.1 g/kg)to d.termine if the beneficial activity of arabinoxylan(AX)d.polymerisation,through arabinoxylo-oligosaccharid.s(AXOS)prod.ction,starts in the upper gastrointestinal *** with the PPI started.from d.14,and.by d.21 animal performance had.d.teriorated.Pd.between PPI and.Xyl for feed.conversion ratio(FCR)(Pd.ced.the negative effect of PPI on *** of PPI raised.d.gesta pH in the gizzard.and.caecum(Pd.protein concentrations in the lower gut(Pd.red.ced.intake of d.gestible nutrients(Pd.le,p-cresol,ammonia and.the ratio of total volatile fatty acid.VFA)to butyric acid.were increased.with PPI(Pd.cating enhanced.protein *** activity in the d.gesta were greatest in the caeca,especially when Xyl was supplemented.Pd.and.ileal d.gesta with Xyl supplementation(Pd.polymerisation action of xylanase even und.r acid.c *** d.ta suggest xylanase may function in the gizzard.even though pH is not optimal for activity and.emphasises the importance of chlorohyd.ic acid.secretions in ensuring overall optimum gut *** d.polymerisation benefits animal performance although it is still unknown how the AXOS prod.ced.with xylanase supplementation in the upper gastrointestinal tract influence the microbial populations and.overall gut functionality.

关键词： Xylanase Proton pump inhibitor Arabinoxylan d.grad.tion Protein fermentation Broiler chicken

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