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Lanthanide molecular nanomagnets as probabilistic bits

npj Computational materials 2023年第1期9卷 322-330页

作者： gerliz m.gutiérrez-finol Silvia Giménez-Santamarina Ziqi Hu Lorena E.Rosaleny Salvador Cardona-Serra Alejandro Gaita-Ariño Instituto de Ciencia molecular(ICmol) Universitat de ValènciaPaternaSpain Department of materials Science and Engineering CAS Key Laboratory of Materials for Energy ConversionAnhui Laboratory of Advanced Photon Science and TechnologyUniversity of Science and Technology of China230026 HefeiPeople’s Republic of China

Over the decades,the spin dynamics of a large set of lanthanide complexes have been ***-based molecular nanomagnets are bistable spin systems,generally conceptualised as classical bits,but many lanthanide complexes have also been presented as candidate quantum bits(qubits).Here,we offer a third alternative and model them as probabilistic bits(p-bits),where their stochastic behaviour constitutes a computational resource instead of a *** an ad-hoc modelling tool for molecular spin p-bits and molecular nanomagnets,we simulate a minimal p-bit network under realistic ***,we go back to a recently published dataset and screen the best lanthanide complexes for p-bit behaviour,lay out the performance of the different lanthanide ions and chemical families and offer some chemical design considerations.

关键词： lanthanide magnets Lanthanide

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Isolation, Cultivation, and morphological Characteristics of Hair Follicle Adult Stem Cells in the Bulge Region in mouse and Human

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microscopy Research 2020年第2期8卷 9-30页

作者： Bélgica J. molina Héctor J. finol Center for Electron microscopy Science Faculty Central University of Venezuela Caracas Venezuela Dermatology Service University Hospital of Caracas Caracas Venezuela

Skin contains various populations of stem cells (SCs). Among these are hair follicle stem cells (HFSCs) in the bulge region. The behavior of HFSCs deserves to be widely studied due to the benefits to be derived from their identification, isolation, and amplification. Skin samples of newborn mice (n = 32) and human adults (n = 10) were used, and the bulge region was isolated and cultured. The isolation and characterization of cells were conducted through immunocytochemistry and immunofluorescence, using mainly CD34 and CD200 monoclonal antibodies. Initially, cells grew slowly from the explant around the bulge region, accruing cells with different morphology in both mouse and human, latter being mostly polygonal;the mouse cells reaching confluence faster (5 to 7 days) than the human (12 to 15 days). It was possible to isolate into subcultures cells with small size (10 - 13 μm diameter), round-shape, scant cytoplasm, central prominent nucleus and with nucleolus, which formed colonies, maintaining their phenotype in a high proportion (77% - 83% and 91% in mouse and human, respectively), without showing changes in their morphology during almost 7 months in the mouse cells, and a month and a half in the human. These results demonstrate that the selection, the isolation, and the conditioned mediums allowed population increases of bulge cells and indicate that cultured cells may retain their sternness in that they maintained their phenotypic characteristics, expressed specific markers for SCs, and showed a high proliferative capacity for long periods. Hair follicles, in mice and humans, are important repositories of multipotent stem cells, due to their tendency to differentiate into keratinocytes. Human HFSCs, obtained by depilation, preserve their potential for proliferation and prove to be easily accessible. This suggests that the bulge cells may present an alternative source of autologous stem cells for tissue engineering and regenerative medicine.

关键词： Stem Cells Hair Follicle Bulge Niche Alopecia

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<i>Trypanosoma evansi</i>: A Qualitative and Quantitative Ultrastructural Analysis of the Spleen during Experimental murine Infections

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microscopy Research 2020年第3期8卷 31-42页

作者： Lucia Proietti d’Empaire Félix Tejero Hector J. finol Pedro m. Aso Antonio Roschman-Gonzalez Centro de Biología Estructural Instituto Venezolano de Investigaciones Científicas Caracas Venezuela Instituto de Zoología y Ecología Tropical Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Centro de microscopía Electrónica Facultad de Ciencias Universidad Central de Venezuela Caracas Venezuela Departamento de Biología Celular Universidad Simón Bolívar Caracas Venezuela

A murine model is used to study qualitatively and quantitatively the splenic ultrastructural changes induced by two Trypanosoma evansi strains derived from naturally infected local equine hosts (Equusasinus and E. caballus);T. evansi causes ultrastructural modifications in the spleen of the infected mice. The modifications include tissular disorganization, fibrosis, mitochondrial swelling, apoptosis and necrosis. The initial phases of the infection are quite similar, whereas the final phases differ qualitatively depending on the strain’s source. The ultrastructural quantitative changes were studied in the reticular splenocytes covering alterations in the area of the cytoplasm and nucleus. Analysis of the results shows the induction of various splenic alterations caused by local T. evansi strains. Also, it was documented that discriminative time modulation, as well as progressive tissular, cellular and subcellular changes, are more associated with derived infections from E. caballus strain.

关键词： Trypanosoma evansi Spleen Ultrastructure mouse

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