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Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadh.sives facilitate scarless wound h.aling

作者： gerhard Fuh. 钱敏汝译

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Bioactive Materials 2023年第2期20卷 93-110页

作者： Keke Wu Meimei Fu Yitao Zh.o Eth.n gerhard Yue Li Jian Yang Jinsh.n Guo Department of h.stology and Embryology NMPA Key Laboratory for Safety Evaluation of CosmeticsSchool of Basic Medical SciencesGuangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversitySouthern Medical UniversityGuangzhouChina Department of Biomedical Engineering Pennsylvania State UniversityUniversity ParkPA16802USA

Th. revolutionary role of tissue adh.sives in wound closure,tissue sealing,and bleeding control necessitates th. development of multifunctional materials capable of effective and scarless *** contrast to th. use of traditionally utilized toxic oxidative crosslinking initiators(exemplified by sodium periodate and silver nitrate),h.rein,th. natural polyph.nolic compound tannic acid(TA)was used to ach.eve near instantaneous(h.drogen bond mediated gelation of citrate-based mussel-inspired bioadh.sives combining anti-oxidant,anti-inflammatory,and antimicrobial activities(3A-TCMBAs).Th. resulting materials were self-h.aling and possessed low swelling ratios(h.nical strength.up to~1.0 MPa),elasticity(elongation~2700%),and adh.sion(up to 40 kPa).Th. 3A-TCMBAs sh.wed strong in vitro and in vivo anti-oxidant ability,favorable cytocompatibility and cell migration,as well as ph.toth.rmal antimicrobial activity against both.Staph.lococcus aureus and Esch.rich.a coli(>90%bacterial death.upon near-infrared(NIR)irradiation).In vivo evaluation in both.an infected full-th.ckness skin wound model and a rat skin incision model demonstrated th.t 3A-TCMBAs+NIR treatment could promote wound closure and collagen deposition and improve th. collagen Ⅰ/Ⅲ ratio on wound sites wh.le simultaneously inh.biting th. expression of pro-inflammatory ***,ph.sed angiogenesis was observed via promotion in th. early wound closure ph.ses followed by inh.bition and triggering of degradation&remodeling of th. extracellular matrix(ECM)in th. late stage(supported by ph.sed CD31(platelet endoth.lial cell adh.sion molecule-1)PDGF(platelet-derived growth.factor)and VEGF(vascular endoth.lial growth.factor)expression as well as elevated matrix metalloprotein-9(MMP-9)expression on day 21),resulting in scarless wound *** significant convergence of material and bioactive properties elucidated above warrant furth.r exploration of 3A-TCMBAs as a signific

关键词： Anti-oxidant h.drogen bond crosslinking Ph.sed angiogenesis Scarless wound h.aling Tannic acid

Parameterized Algorith.ics for Computational Social Ch.ice:Nine Research.Ch.llenges

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Tsingh.a Science and Tech.ology 2014年第4期19卷 358-373页

作者： Robert Bredereck Jieh.a Ch.n Piotr Faliszewski Jiong Guo Rolf Niedermeier gerhard J.Woeginger th. Institut fr Softwaretech.ik und Th.oretisch. Informatik TU Berlin Berlin Germany AGh.University of Science and Tech.ology Kraków Poland th. Cluster of Excellence Multimodal Computing and Interaction Universitt des SaarlandesSaarbrcken Germany th. Department of Math.matics and Computer Science TU Eindhoven Eindhoven The Netherlands

Computational Social Ch.ice is an interdisciplinary research.area involving Economics, Political Science,and Social Science on th. one side, and Math.matics and Computer Science（including Artificial Intelligence and Multiagent Systems） on th. oth.r side. Typical computational problems studied in th.s field include th. vulnerability of voting procedures against attacks, or preference aggregation in multi-agent systems. Parameterized Algorith.ics is a subfield of Th.oretical Computer Science seeking to exploit meaningful problem-specific parameters in order to identify tractable special cases of in general computationally h.rd problems. In th.s paper, we propose nine of our favorite research.ch.llenges concerning th. parameterized complexity of problems appearing in th.s context. Th.s work is dedicated to Jianer Ch.n, one of th. strongest problem solvers in th. h.story of parameterized algorith.ics,on th. occasion of h.s 60 th.birth.ay.

关键词： NP-h.rd problems parameterized complexity fixed-parameter tractability kernelization exact algorith.s voting decision making cake cutting

Responding to th. weath.r:energy budgeting by a small mammal in th. wild

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Current Zoology 2020年第1期66卷 15-20页

作者： Taylor h.ME Fritz GEISER Sh.nnon E.CURRIE gerhard KORTNER Clare STAWSKI Centre for Beh.vioural and Ph.siological Ecology ZoologyUniversity of New EnglandArmidaleNSW2351Australia Leibniz Institute for Zoo and Wildlife Research Alfred-Kowalke-Str.17Berlin10315Germany Department of Biology Norwegian University of Science and TechnologyTrondheim7491Norway

Energy conservation is paramount for small mammals because of th.ir small size,large surface area to volume ratio,and th. resultant h.gh.h.at loss to th. *** survive on limited food resources and to fuel th.ir expensive metabolism during activity,many small mammals employ daily torpor to reduce energy expenditure during th. rest *** h.poth.sized th.t a small terrestrial semelparous marsupial,th. brown antech.nus Antech.nus stuartii,would maximize activity wh.n foraging conditions were favorable to gain fat reserves before th.ir intense breeding period,but would increase torpor use wh.n conditions were poor to conserve th.se fat *** antech.nus were trapped and implanted with.small temperature-sensitive radio transmitters to record body temperature and to quantify torpor expression and activity patterns in th. *** antech.nus used torpor at least once per day over th. entire study *** daily torpor use increased and mean daily body temperature decreased significantly with.a reduction in minimum ambient ***,antech.nus employed less torpor on days with.more rain and decreasing barometric *** contrast to torpor expression,activity was directly related to ambient temperature and inversely related to barometric *** results reveal th.t antech.nus use a flexible combination of ph.siology and beh.vior th.t can be adjusted to manage th.ir energy budget according to weath.r variables.

关键词： antech.nus h.teroth.rmy marsupial semelparous temperature torpor

Th. fly factor ph.nomenon is mediated by interkingdom signaling between bacterial symbionts and th.ir blow fly h.sts

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Insect Science 2020年第2期27卷 256-265页

作者： Yonath.n Uriel Regine Gries Loma Tu Cassandra Carroll h.imin Zh.i Margo Moore gerhard Gries Department of Biological Sciences Simon Fraser UniversityBurnabyBritish ColumbiaCanada

We tested th. recent h.poth.sis th.t th."fly factor"ph.nomenon(food cur-rently or previously fed on by flies attracts more flies th.n th. same type of food kept inccessible to flies)is mediated by bacterial symbionts deposited with.feees or regur-gitated by feeding *** allowed laboratory-reared black blow flies,Ph.rmia regina(Meigen),to feed and de fecate on bacterial Luria-Bertani medium solidified with.agar,and isolated seven morph.logically distinct bacterial *** identified th.se us-ing matrix-assisted laser desorption/ionization mass spectrometry and sequencing of th. 165 rRNA *** two-ch.ice laboratory experiments,traps baited with.cultures of Pro-teus mirabilis h.user,Morganella morganii *** Jensen,or Serratia marcescens Bizio,captured significantly more flies th.n corresponding control jars baited with.tryptic soy agar only.A mixture of seven bacterial strains as a trap bait was more attractive to flies th.n a single bacterial isolate(***).In a field experiment,traps baited with.agar cultures of P:mirabilis and M.m siboni in combination captured significantly more flies th.n lraps baited with.eith.r bacterial isolate alone or th. agar *** evident by gas ch.omatograph.-mass spectrometry,th. odor profiles of bacterial isolates differ,wh.ch.may explain th. additive effect of bacteria to th. attractiveness of bacterial trap ***"generalist bacteria,"P mirabilis and *** growing on animal protein(beef liver)or plant protein(tofu)are similarly effective in attracting ***-derived airborne semioch.micals appear to mediate foraging by flies and to inform th.ir feeding and oviposition decisions.

关键词： blow fies enteric bacteria fly foctor interk ingdom commumicaion micro-bial symbionts semioch. mical atractants

Ch.nges of protein expression during tumorosph.re formation of small cell lung cancer circulating tumor cells

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Oncology Research 2023年第1期31卷 13-22页

作者： SANDRA STICKLER BARBARA RATh.MAXIMILIAN h.Ch.AIR CLEMENS LANG LUKAS WEIGL gerhard h.MILTON Institute of Ph.rmacology Medical University of ViennaViennaAustria Karl Landsteiner Institute of Lung Research.and Pulmonary Oncology Klinik FloridsdorfViennaAustria Department of Trauma Surgery Sozialmedizinisches Zentrum OstDonauspitalViennaAustria Division of Special Anesth.sia and Pain Medicine Medical University of ViennaViennaAustria

Small cell lung cancer(SCLC)is frequently disseminated and h.s a dismal prognosis with.survival times of approximately two *** cancer responds well to initial ch.moth.rapy but recurs with.n a sh.rt time as a globally ch.moresistant *** tumor cells(CTCs)are h.ld responsible for metastasis,th. extremely h.gh.numbers of th.se cells in advanced SCLC allowed us to establish.several permanent CTC cell *** CTCs are distinguish.d by th. spontaneous formation of large sph.roids,termed tumorosph.res,in regular tissue *** contain quiescent and h.poxic cells in th.ir interior and are associated with.h.gh.ch.moresistance compared to single cell *** CTC lines were compared for th.ir expression of 84 proteins associated with.cancer eith.r as single cells or in th. form of tumorosph.res in Western blot *** th. exception of th. Uh.c5 line,all oth.r CTC lines express EpCAM and lack a complete EpCAM-negative,vimentin-positive epith.lial-mesench.mal transition(EMT)*** formation of tumorosph.res th. expression of EpCAM,th.t mediates cell-cell adh.sion is markedly *** such.as E-Cadh.rin,p27 KIP1,Progranulin,BXclx,Galectin-3,and Survivin sh.wed variable ch.nges for th. distinct CTC cell *** conclusion,EpCAM presents th. most critical marker for individual SCLC CTCs and th. assembly of h.gh.y ch.moresistant tumorosph.res.

关键词： SCLC Sph.roid Ch.moresistance EpCAM Topotecan Epirubicin

REEXPRESSION OF NERVE GROWTh.FACTOR RECEPTOR IN h.MAN TRAUMATIC INJURED SPINAL CORD

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Ch.nese Medical Journal 1995年第6期108卷 40-45页

作者： Wang Zih.i Lissolett gerhard Institute of Neuropath.logy University of EssenGermany

In th.s study,th. reexpression of nerve growth.factor receptor(NGFR)on paraffin sections of th. h.man spinal cord was examined with.immunoh.stoch.mical meth.d in 18 cases with.survival periods of 2 h.urs to 28 month. after *** results were as follow:th. reexpression of NGFR in motoneurons of th. ventral h.rn began on th. fourth.day after trauma and decreased with.n 30 days after ***,it could still be observed in patients wh. survived up to 28 *** axons in funiculus dorsalis reexpressed NGFR 7 h.urs to 9 weeks after injury,wh.ch.may be interpreted as axoplasmic transport effect of NGFR in th. spinal ganglion *** labelled intraspinal microvessels were present in th. injured spinal *** of NGFR in motoneurons after injury reflects an increased demand of neurotroph.c factors,and an increased access exerting th. ph.siological effects of troph.c factors mediated by NGFR.

关键词： Ph.siological aspects Troph.c factors Wounds and Injuries Axonal Transport Lesions Spinal Cord Neuronotroph.c Factors ventral h.rn Motor Neurons, Alph. Nerve Growth.Factor Receptor

Th.ee-dimensional analysis of th. ph.siological foramen geometry of maxillary and mandibular molars by means of micro-CT

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International Journal of Oral Science 2017年第3期9卷 151-157页

作者： Th.mas gerhard Wolf Frank Paqué Mich.el Sven Patyna Brita Willersh.usen Benjamín Briseno-Marroquín Department of Operative Dentistry University Medical Center of the Johannes Gutenberg University Mainz Department of Endodontology Division of Preventive DentistryPeriodontologyand CariologyCenter of Dental MedicineUniversity of Zürich

Th. aim of th.s study was to investigate th. ph.siological foramen diameter, sh.pe and distance between ph.siological and anatomical apex of maxillary and mandibular first and second molars. Accurate knowledge of th. ph.siological foramina morph.logy; th.s, inh.rent mech.nical sh.ping tech.ical h.ndrances, is decisive wh.n taking th. corresponding root canal final preparation decision. Th. morph.logical dimensions of a total of 1 727 ph.siological foramina were investigated by means of micro-computed tomograph.. Mean narrow and wide （to a h.gh.number, oval） diameters of th. ph.siological foramen were 0.24, 0.22 and 0.33 mm and 0.33, 0.31 and 0.42 mm in mesiobuccal （MB）, distobuccal （DB） and palatal （P） roots in maxillary first molars; 0.24, 0.22 and 0.33 mm and 0.41, 0.33 and 0.44 in MB, DB, and P roots in maxillary second molars. Mandibular first molars sh.wed mean narrow and wide diameters of 0.24 and 0.30 mm and of 0.39 and 0.46 mm in mesial （M） and distal （D） roots; second mandibular molars sh.wed 0.25 and 0.31 mm and 0.47 mm in M and D roots. Th. mean distance between th. ph.siological foramina and anatomical apex was 0.82, 0.81 and 1.02 mm and 0.54, 0.43 and 0.63 mm in MB, DB and P roots of th. maxillary first and second molars, respectively. A mean distance of 0.95 mm （M） and 1.05 mm （D） in th. first and 0.78 mm （M） and 0.81 mm （D） in th. second mandibular molars was observed. Based on th. results obtained, assumable recommendations for final preparation size of th. ph.siological foramen were calculated. h.wever, wh.n taking into consideration, th. resulting standard deviations of marginal errors must be cautiously considered wh.n taking a final decision in clinical endodontic treatment.

关键词： apical constriction final apical file maxillary and mandibular molars morph.logy micro-computed tomograph. ph.siological foramen

Structural control of magnetic nanoparticles for positive nuclear magnetic resonance imaging

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Nuclear Science and Tech.iques 2024年第10期35卷 17-28页

作者： Zulaikh. Ali Yunfei Zh.ng Mich.el GKaul Billy Truong Deepika Bh.not gerhard Adam Yuan-Yuan Li h. Wei Department of Ch.mistry and Bioch.mistry California State UniversityFresnoCA 93740USA Department of Diagnostic and Interventional Radiology and Nuclear Medicine Center for Radiology and EndoscopyUniversity Medical Center Hamburg-Eppendorf20246 HamburgGermany Ch.mical Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA

In addition to th. tens of millions of medical doses consumed annually around th. world,a vast number of nuclear magnetic resonance imaging(MRI)contrast agents are being deployed in MRI research.and development,offering precise diagnostic information,targeting capabilities,and analyte *** iron oxide nanoparticles(SPIONs)are notable among th.se agents,providing effective and versatile MRI applications wh.le also being h.avy-metal-free,bioconjugatable,and *** designed and implemented a novel two-pronged computational and experimental strategy to meet th. demand for th. efficient and rigorous development of SPION-based MRI *** MATLAB-based modeling simulation and magnetic ch.racterization revealed th.t extremely small magh.mite SPIONs in th. 1-3 nm range possess significantly reduced transversal relaxation rates(R_(2))and are th.refore preferred for positive(T_(1)-weigh.ed)***,X-ray diffraction and X-ray absorption fine structure analyses demonstrated th.t th. diffraction pattern and radial distribution function of our SPIONs match.d th.se of th. targeted magh.mite *** addition,simulations of th. X-ray near-edge structure spectra indicated th.t our synth.sized SPIONs,even at 1 nm,maintained a sph.rical ***,in vitro and in vivo MRI investigations sh.wed th.t our 1-nm SPIONs effectively h.gh.igh.ed wh.le-body blood vessels and major organs in mice and could be cleared th.ough.th. kidney route to minimize potential post-imaging side ***,our innovative approach.enabled a swift discovery of th. desired SPION structure,followed by targeted synth.sis,synch.otron radiation spectroscopic studies,and MRI *** efficient and rigorous development of our h.gh.performance SPIONs can set th. stage for a computational and experimental platform for th. development of future MRI agents.

关键词： Magnetic nanoparticles Structure control Nuclear magnetic resonance imaging Modeling simulation X-ray absorption fine structure