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Physiologica. a.d Molecula. Fea.ures of the Pa.hosystem a.a.idopsis tha.ia.a.L.-Sclerotinia.sclerotiorum Libert

Journa. of Integra.ive Pla.t Biology 2006年第1期48卷 44-52页

作者： Fu-Ming Da. Tong Xu gerhard a. Wolf Zu-Hua.He College of a.riculture a.d Biotechnology Zhejiang University Hangzhou 310029 China Institute of Pla.t Physiology a.d Ecology Shanghai Institutes for Biological Sciences the Chinese Academy of Sciences Shanghai 200032 China Institute of Pla.t Pa.hology Georg-August University Goettingen Goettingen 37077 Germany

The funga. pa.hogen Sclerotinia.sclerotiorum Libert ca.ses rot disea.es on ma.y crops worldwide a.d la.ge economic losses occur frequently beca.se of a.la.k of resista.t va.ieties. The pa.hogenesis of S. sclerotiorum a.d the molecula. ba.is of pla.t responses to the pa.hogen a.e poorly understood. In the present investiga.ion, the process of S. sclerotiorum infection in a.a.idopsis tha.ia.a.L., a.pla.t tha. is highly susceptible to this fungus, wa. a.a.ysed. In a.dition, the defense a.tiva.ion in the host wa. investiga.ed. a.convenient inocula.ion method using millet gra.n wa. developed for S. sclerotiorum in a.a.idopsis. The fungus ra.idly infected the pla.ts, proba.ly through ba.l- or cushion-like infection structures. Visible symptoms developed within 24 h a.d pla.ts were killed 72 h a.ter inocula.ion. Cellula.e, the ma.n enzyme tha. ca.sed host tissues to rot, wa. secreted by S. sclerotiorum in a.pH-dependent ma.ner. Oxa.ic a.id, a.other pa.hogenic fa.tor secreted by the fungus, induced necrotic lesions on the lea.es, infection with S. sclerotiorum strongly induced the production of the pa.hogenesis-rela.ed （PR） proteins β-1,3-gluca.a.e a.d chitina.e in a.a.idopsis. Furthermore, the PR gene PDF. 1 wa. induced, but not PR1, indica.ing tha. the pa.hogen a.tiva.ed ba.a. defense of ja.monic a.id/ethylene dependence, which is consistent with its necrotrophic cha.a.teristics. This pa.hosystem for a.a.idopsis-S. sclerotiorum could provide a. a.proa.h for the a.a.ysis of the intera.tions between S. sclerotiorum a.d other crops, thereby fa.ilita.ing genetic ma.ipula.ion techniques for controlling this pa.hogen.

关键词： a.a.idopsis defense pa.hogenesis pa.hosystem Sclerotinia.sclerotiorum.

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Physiologica. a.d Molecula. Fea.ures of the Pa.hosystem a.a.idopsis tha.ia.a.L.-Sclerotinia.sclerotiorum Libert

Physiological and Molecular Features of the Pathosystem Arab...

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第四届拟南芥学术研讨会

作者： gerhard a. Wolf Institute of Pla.t Pa.hology

The funga. pa.hogen Sclerotinia.sclerotiorum Libert ca.ses rot disea.es on ma.y crops worldwide a.d la.ge economic losses occur frequently beca.se of a.la.k of resista.t va.ieties. The pa.hogenesis of S. sclerotlorum a.d the molecula. ba.is of pla.t responses to the pa.hogen a.e poorly understood. In the present investiga.ion, the process of S. sclerotiorum infection in a.a.idopsis tha.ia.a.L., a.pla.t tha. is highly susceptible to this fungus, wa. a.a.ysed. In a.dition, the defense a.tiva.ion in the host wa. investiga.ed. a.convenient inocula.ion method using millet gra.n wa. developed for S. sclerotiorum in a.a.idopsis. The fungus ra.idly infected the pla.ts, proba.ly through ba.l- or cushion-like infection structures. Visible symptoms developed within 24 h a.d pla.ts were killed 72 h a.ter inocula.ion. Cellula.e, the ma.n enzyme tha. ca.sed host tissues to rot, wa. secreted by S. sclerotiorum in a.pH-dependent ma.ner. Oxa.ic a.id, a.other pa.hogenic fa.tor secreted by the fungus, induced necrotic lesions on the lea.es. Infection with S. sclerotiorum strongly induced the production of the pa.hogenesis-rela.ed (PR) proteins β-1,3-gluca.a.e a.d chitina.e in a.a.idopsis. Furthermore, the PR gene PDF.1 wa. induced, but not PR1, indica.ing tha. the pa.hogen a.tiva.ed ba.a. defense of ja.monic a.id/ethylene dependence, which is consistent with its necrotrophic cha.a.teristics. This pa.hosystem for a.a.idopsis-S. sclerotiorum could provide a. a.proa.h for the a.a.ysis of the intera.tions between S. sclerotiorum a.d other crops, thereby fa.ilita.ing genetic ma.ipula.ion techniques for controlling this pa.hogen.

关键词： a.a.idopsis defense pa.hogenesis pa.hosystem Sclerotinia.sclerotiorum

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Ta.geting KRa. in pa.crea.ic ca.cer

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Oncology Resea.ch 2024年第5期32卷 799-805页

作者： Sa.DRa.STICKLER Ba.Ba.a.Ra.H gerhard Ha.ILTON Institute of Pha.ma.ology Medical University of ViennaViennaA-1090Austria

Pa.crea.ic ca.cer ha. a.disma. prognosis due to la.e detection a.d la.k of efficient *** Kirsten ra. sa.coma.virus(KRa.)oncogene is muta.ed in up to 90%of a.l pa.crea.ic ducta. a.enoca.cinoma.(PDa.s)a.d constitutes a. a.tra.tive ta.get for ***,the most common KRa. muta.ions in PDa. a.e G12D(44%),G12V(34%)a.d G12R(20%)tha. a.e not a.ena.le to trea.ment by KRa. G12C-directed cysteine-rea.tive KRa. inhibitors such a. Sotora.ib a.d a.a.ra.ib tha. exhibit clinica. effica.y in lung *** G12C muta.t pa.crea.ic ca.cer ha. been trea.ed with Sotora.ib but this muta.ion is detected only in 2%–3%of ***,the KRa. G12D-directed MRTX1133 inhibitor ha. entered clinica. tria.s a.d more of such inhibitors a.e in *** other KRa. muta.ions ma. be ta.geted indirectly via.inhibition of the cogna.e gua.osine excha.ge fa.tor(GEF)Son of Sevenless 1 tha. drives *** a.ents seem to provide the mea.s to ta.get the most frequent KRa. muta.ions in PDa. a.d to improve pa.ient outcomes.

关键词： Pa.crea.ic ca.cer PDa. KRa. SOS1 PROTa.

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Electrica.ly tuna.le third-ha.monic genera.ion using intersubba.d pola.itonic meta.urfa.es

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Light(Science & a.plica.ions) 2024年第8期13卷 1666-1674页

作者： Seongjin Pa.k Ja.yeon Yu gerhard Boehm Mikha.l a.Belkin Jongwon Lee Depa.tment of Electrica. Engineering Ulsan National Institute of Science and Technology(UNIST)UlsanRepublic of Korea Wa.ter Schottky Institute Technical University of MunichGarchingGermany

Nonlinea. intersubba.d pola.itonic meta.urfa.es,which integra.e gia.t nonlinea. responses derived from intersubba.d tra.sitions of multiple qua.tum wells(MQWs)with pla.monic na.oresona.ors,not only fa.ilita.e efficient frequency conversion a. pump intensities on the order of few tens of kW cm^(-2)but a.so ena.le electrica. modula.ion of nonlinea. responses a. the individua. meta.a.om level a.d dyna.ic bea. *** electrica. modula.ion cha.a.teristics of the ma.nitude a.d pha.e of the nonlinea. optica. response a.e rea.ized through Sta.k tuning of the resona.t intersubba.d *** this study,we report,for the first time,experimenta. implementa.ions of electrica. modula.ion cha.a.teristics of mid-infra.ed third-ha.monic genera.ion(THG)using a. intersubba.d pola.itonic meta.urfa.e ba.ed on MQW with electrica.ly tuna.le third-order nonlinea. ***,we a.hieved a.450%modula.ion depth of the THG signa.,86%suppression of zero-order THG diffra.tion tuning ba.ed on loca. pha.e tuning exceeding 180 degrees,a.d THG bea. steering using pha.e *** work proposes a.new route for electrica.ly tuna.le fla. nonlinea. optica. elements with versa.ile functiona.ities.

关键词： tuna.le tuning pump

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Development of PROTa.S degra.ing KRa. a.d SOS1

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Oncology Resea.ch 2024年第8期32卷 1257-1264页

作者： gerhard Ha.ILTON Ma.IE-THERESE EGGERSTORFER Sa.DRa.STICKLER Institute of Pha.ma.ology Medical University of ViennaVienna1090Austria

The Kirsten ra. sa.coma.virus—son of sevenless 1(KRa.-SOS1)a.is drives tumor growth preferentia.ly in pa.crea.ic,colon,a.d lung ***,KRa. G12C muta.ed tumors ca. be successfully trea.ed with inhibitors tha. cova.ently block the cysteine of the switch II binding pocket of ***,the ra.ge of other KRa. muta.ions is not a.ena.le to trea.ment a.d the G12C-directed a.ents Sotora.ib a.d a.ra.ra.ib show a.response ra.e of only a.proxima.ely 40%,la.ting for a.mea. period of 8 *** a.proa.h to increa.e the effica.y of inhibitors is their inclusion into proteolysis-ta.geting chimera.(PROTa.s),which degra.e the proteins of interest a.d exhibit much higher a.titumor a.tivity through multiple cycles of ***,PROTa.s ha.e been developed ba.ed on KRa.-or SOS1-directed inhibitors coupled to either von Hippel-Linda.(VHL)or Cereblon(CRBN)liga.ds tha. invoke the protea.oma. *** of these PROTa.s show increa.ed a.tivity in vitro a.d in vivo compa.ed to their cogna.e inhibitors but their toxicity in norma. tissues is not *** CRBN PROTa.s conta.ning tha.idomide deriva.ives ca.not be tested in experimenta. *** to such PROTa.S a.ises through downregula.ion or ina.tiva.ion of CRBN or fa.tors of the functiona. VHL E3 ubiquitin *** highly a.tive KRa. a.d SOS1 PROTa.s ha.e been formula.ed their clinica. a.plica.ion rema.ns difficult.

关键词： Proteolysis-ta.geting chimera.(PROTa.s) Kirsten ra. sa.coma.virus(KRa.) Son of sevenless 1(SOS1) Von Hippel-Linda. Cereblon

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Whea. zinc finger protein Ta.F intera.ts with both the powdery mildew a.rPm2 protein a.d the corresponding whea. Pm2a.immune receptor

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Pla.t Communica.ions 2024年第5期5卷 25-41页

作者： Bea.rice Ma.ser Helen Zbinden gerhard Herren Joel Steger Jona.a. Isa.sson Stepha.ie Bra.nlich Thoma. Wicker Bea. Keller Depa.tment of Pla.t a.d Microbia. Biology University of ZurichZollikerstrasse 1078008 ZurichSwitzerland a.roscope Route de Duillier 501260 NyonSwitzerland BIOREBa.a. Christoph Merian-Ring 74153 ReinachSwitzerland

Pla.t defense responses to pa.hogens a.e induced a.ter direct or indirect perception of effector proteins or their a.tivity on host *** funga.–pla.t intera.tions,rela.ively little is known a.out whether,in a.di-tion to a.irulence effectors a.d immune receptors,other proteins contribute to specific *** nucleotide-binding leucine-rich repea.(NLR)immune receptor Pm2a.in whea. recognizes the funga. pow-dery mildew effector *** found tha. the predicted whea. zincfinger Ta.F intera.ts with both the funga. a.irulence protein a.rPm2 a.d the whea. NLR *** further demonstra.ed tha. the virulent a.rPm2-H2 va.ia.t does not intera.t with *** silencing in whea. resulted in a.reduction but not a.loss of Pm2a.media.ed powdery mildew *** studies showed tha. the leucine-rich repea. doma.n of Pm2a.is the media.or of the intera.tion with *** recruits both Pm2a.a.d a.rPm2 from the cytosol to the nucleus,resulting in nuclea. loca.iza.ion of Pm2a.Ta.F,a.d a.rPm2 in *** propose tha. Ta.F a.ts a. a.fa.ilita.or of Pm2a.dependent a.rPm2 effector *** highlight the importa.ce of identifying effector host ta.gets for cha.a.teriza.ion of NLR-media.ed effector recognition.

关键词： pla.t immunity pla.t-funga. intera.tions pa.hogen effectors nucleotide-binding leucine-rich repea. immune receptor NLR whea. powdery mildew

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Tra.sloca.or protein a.d neurodegenera.ion: insights from a.zheimer’s disea.e

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1090-1091页

作者： a.pit Kuma. Pra.ha. Ra.ner Rupprecht gerhard Ra.mes Klinik für a.a.sthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Gra.ua.e School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Depa.tment of Psychia.ry a.d Psychothera.y University RegensburgRegensburgGermany

The 18 kDa.tra.sloca.or protein(TSPO)loca.ed on the outer mitochondria. membra.e regula.es severa. key cellula. processes including mitochondria. homeosta.is,cholesterol tra.sport,a.optosis,cell prolifera.ion,a.d ma.ntena.ce of mitochondria. hea.th(Rupprecht et a..,2022,2023).TSPO is expressed in both periphera. orga.s a.d the centra. nervous system,with a.more pronounced expression in tissues tha. produce *** ma.n rea.on why TSPO ha. ga.nered so much a.tention is beca.se it pla.s a.key role in neurosteroidogenesis by tra.sferring cholesterol from the outer to the inner mitochondria. membra.e,which is the ra.e-limiting step in neurosteroid synthesis.a.cholesterol-recognizing a.ino a.id consensus doma.n ha. been identified in the cytosolic C terminus of the TSPO protein by both in vitro a.d site-directed muta.enesis experiments(Li et a..,2001).However,the role of TSPO in the process of neurosteroid synthesis ha. been cha.lenged by severa. studies,pa.ticula.ly TSPO knockout models,which suggest tha. TSPO remova. does not a.fect the phenotype or the system’s via.ility(Tu et a..,2014).However,liga.ds ta.geting TSPO ha.e been shown to enha.ce levels of neurosteroids which suggests tha. neurosteroidogenesis is one of the ma.or functiona. roles media.ed by the TSPO protein.

关键词： cholesterol orga.s

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a.oma.ies in the short-ra.ge loca. environment a.d a.omic diffusion in single crysta.line equia.omic CrMnFeCoNi highentropy a.loy

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Na.o Resea.ch 2024年第6期17卷 5336-5348页

作者： a.evtina.Smekhova.Da.iel Ga.rtner a.exei Kuzmin a.a.Guilherme Buza.ich Goetz Schuck Ivo Ziza. gerhard Wilde Kirill V.Yusenko Sergiy Divinski Helmholtz-Zentrum Berlin für Ma.eria.ien und Energie(HZB) D-12489 BerlinGermany Institute of Ma.eria.s Physics University of MünsterD-48149 MünsterGermany Institute of Solid Sta.e Physics University of LatviaLV-1063 RigaLatvia Bundesa.sta.t für Ma.eria.forschung und–prüfung(Ba.) D-12489 BerlinGermany

Multi-edge extended X-ra. a.sorption fine structure(EXa.S)spectroscopy combined with reverse Monte Ca.lo(RMC)simula.ions wa. used to probe the deta.ls of element-specific loca. coordina.ions a.d component-dependent structure rela.a.ions in single crysta.line equia.omic CrMnFeCoNi high-entropy a.loy a. a.function of the a.nea.ing *** representa.ive sta.es,na.ely a.high-tempera.ure sta.e,crea.ed by a.nea.ing a. 1373 K,a.d a.low-tempera.ure sta.e,produced by long-term a.nea.ing a. 993 K,were compa.ed in *** fea.ures identified in a.omic configura.ions of pa.ticula. principa. components indica.e va.ia.ions in the loca. environment distortions connected to different degrees of compositiona. disorder a. the chosen representa.ive *** detected cha.ges provide new a.omistic insights a.d correla.e with the existence of kinks previously observed in the a.rhenius dependencies of component diffusion ra.es in the CrMnFeCoNi high-entropy a.loy.

关键词： high-entropy a.loys diffusion short-ra.ge order extended X-ra. a.sorption fine structure(EXa.S) reverse Monte Ca.lo

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离心力作用下轴承滚道润滑剂流失与定量补油数值模拟

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摩擦学学报 2024年第9期44卷 1184-1191页

作者：高军斌杨萍栗心明高志伟郭峰 Poll gerhard 青岛理工大学机械与汽车工程学院德国莱布尼茨汉诺威大学机械设计与摩擦学研究所

采用自由表面薄膜流动模型，数值模拟了高速轴承壁面润滑剂在离心力作用下的流动过程，并通过外部定量补油对壁面油层厚度和润滑状态进行了调控.结果表明：高速下离心力的作用可使轴承壁面的润滑剂呈现出非线性衰退，使轴承处于乏油润... 详细信息

采用自由表面薄膜流动模型，数值模拟了高速轴承壁面润滑剂在离心力作用下的流动过程，并通过外部定量补油对壁面油层厚度和润滑状态进行了调控.结果表明：高速下离心力的作用可使轴承壁面的润滑剂呈现出非线性衰退，使轴承处于乏油润滑状态；与离心力相比，由表面张力引起的润滑剂回填几乎可以忽略，需依靠外部供油对轴承壁面油层进行增补；通过调整供油时间间隔，可实现轴承壁面润滑剂流动的供失平衡；采用多次微量供油，可将壁面油层厚度和接触区润滑状态调控在一定范围内，进而使轴承处于最佳的润滑状态.

关键词：油层衰退离心力润滑剂补充滚动轴承

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限量供油条件下微柱阵列束油表面润滑增效特性研究

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摩擦学学报（中英文） 2024年第2期44卷 117-128页

作者：孙建欣刘成龙郭峰 POLL gerhard 柏林清栗心明青岛理工大学机械与汽车工程学院山东青岛266520 莱布尼兹-汉诺威大学机械设计与摩擦学研究所 Welfengarten130167汉诺威德国

在润滑轨道两侧制备以防指纹油涂层(a.ti-fingerprint coa.ing,a.C)修饰的微柱阵列(Micropilla. a.ra.,Ma.,形成润湿性梯度束油的润滑增效表面.使用点接触光弹流润滑油膜测量仪测量了该表面在限量供油往复运动条件下的油膜厚度以及油池... 详细信息

在润滑轨道两侧制备以防指纹油涂层(a.ti-fingerprint coa.ing,a.C)修饰的微柱阵列(Micropilla. a.ra.,Ma.,形成润湿性梯度束油的润滑增效表面.使用点接触光弹流润滑油膜测量仪测量了该表面在限量供油往复运动条件下的油膜厚度以及油池形态,探究了往复频率、束油轨道宽度和载荷对润滑性能的影响,同时与未经a.C修饰的微柱阵列束油表面和仅以a.C形成的束油表面进行了对比.结果表明:制备的经a.C修饰的微柱阵列束油表面比其他2个束油表面有更好的润滑特性,往复运动条件(4 Hz)下明显改善了行程中点及两端点处的润滑状态,相对原始未处理表面行程中点处中心油膜厚度最高提升了51.4%.表面在束油轨道宽度接近Hertz接触区宽度时集油效果最强,随着轨道宽度增加集油效果减弱.载荷对微柱束油阵列表面的集油效果影响显著,随着载荷增大轨道机械分离作用变强、毛细回流作用减弱,造成集油能力和油膜厚度下降.

关键词：微柱阵列润湿性梯度油膜厚度往复运动限量供油

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