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Epigenetic changes of DNA repair genes in cancer

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Journal of Molecular Cell Biology 2011年第1期3卷 51-58页

作者： Christoph Lahtz gerd P.Pfeifer Department of Cancer Biology Beckman Research InstituteCity of HopeDuarteCA 91010USA

‘Every Hour Hurts,The Last One Kills’.That is an old saying about getting *** day,thousands of DNA damaging events take place in each cell of our body,but efficient DNA repair systems have evolved to prevent ***,our DNA repair system and that of most other organisms are not as perfect as that of Deinococcus radiodurans,for example,which is able to repair massive amounts of DNA damage at one *** many instances,accumulation of DNA damage has been linked to cancer,and genetic deficiencies in specific DNA repair genes are associated with tumor-prone *** addition to mutations,which can be either inherited or somatically acquired,epigenetic silencing of DNA repair genes may promote *** review will summarize current knowledge of the epigenetic inactivation of different DNA repair components in human cancer.

关键词： DNA methylation DNA repair epigenetics

Facile synthesis of ( β -chlorodifluoroethyl)phosphonates via chlorination reaction of difluoroalkyl diazo derivatives with HCl

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Chinese Chemical Letters 2022年第5期33卷 2429-2432页

作者： Jiang Liu romana Pajkert Li Wang Haibo Mei gerd-Volker röschenthaler Jianlin Han Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China Department of Life Sciences and Chemistry Jacobs University Bremen gGmbHCampus Ring 1Bremen 28759Germany

An efficient chlorination reaction of in situ generated(β-diazo-α,α-difluoroethyl)phosphonates has been achieved with hydrochloric acid as a chlorine source under mild and operationally convenient *** reaction does not need any catalyst and tolerates a wide scope of substrates,which affords the(β-chlorodifluoroethyl)phosphonate products in good to excellent *** reaction represents the first example of the halogenation of difluoroalkyl diazo compounds,and also provides an easy way for the synthesis of difluoromethylenephosphonate-containing compounds.

关键词： Difluorodiazoethane (β-Diazo-α,α-difluoroethyl)phosphonates Halogenation reaction Difluoroalkyl diazo Hydrochloric acid Masked carbene

2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联盟的联合倡议

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2010年类风湿关节炎分类标准——美国风湿病学会和欧洲抗风湿病联...

Multiobjective Electric Machine Optimization for Highest reliability Demands

贵州省医学会风湿病学分会第四届学术年会

作者： Daniel Aletaha Tuhina Neogi Alan J Silman Julia Funovits David T Felson Clifton O Bingham Ⅲ Neal S Birnbaum gerd r burmester Vivian P Bykerk Marc D Cohen Bernard Combe Karen H Costenbader Maxime Dougados Paul Emery Gianfranco Ferraccioli Johanna MW Hazes Kathryn Hobbs Tom WJ Huizinga Arthur Kavanaugh Jonathan Kay Tore K Kvien Timothy Laing Philip Mease Henri A Menard Larry W Moreland raymond L Naden Theodore Pincus Josef S Smolen Ewa Stanislawska-Biernat Deborah Symmons Paul P Tak Katherine S Upchurch Jiri Vencovsky Frederick Wolfe Gillian Hawker 季兰岚邓雪蓉赵明田真张卓莉 Medical University of Vienna ViennaAustria Boston University School of Medicine BostonMassachusettsUSA

目的 :在早期类风湿关节炎(rheumatoid arthritis,rA)的诊断中,1987年美国风湿病学会(AmericanCollege of rheumatology,ACr;旧称Americanrheumatism Association,ArA)的诊断标准因为缺乏敏感度而受到质疑。本研究的目的是建立新的rA分类标准。方法 :由ACr和欧洲抗风湿病联盟(EuropeanLeague Against rheumatism,EULAr)共同组成的工作小组,分三个阶段建立rA新的分类标准。研究的目标人群是初发的未分化关节炎患者,主要研究目的是寻找能够预测这些病人发展为rA的危险因素,并将rA疾病特点定义为持续性和/或侵蚀性关节炎。结果 :在新的分类标准中,确诊rA至少需要一个关节有明确的滑膜炎表现,除外其他可能导致滑膜炎症的疾病,同时以下四项评分的总分≥6分(最高10分):受累关节的数量和部位(0-5分)、血清学自身抗体异常(0-3分)、急性期反应物升高(0-1分)和症状持续时间(共分两级;0-1分)。结论 :既往诊断rA比较依赖骨破坏这一rA晚期表现,而新的分类标准着重于疾病早期表现而不是晚期特点,将疾病特点重新定义为持续性和/或侵蚀性滑膜炎。这一新标准的推出将再次强调了rA早期诊断的必要性以及早期有效治疗对于预防或减少不良后遗症的发生具有重要意义。

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CES Transactions on Electrical Machines and Systems 2020年第2期4卷 71-78页

作者： gerd Bramerdorfer Department of Electrical Drives and Power Electronics Johannes Kepler University LinzAustria

This article is about illustrating a workflow for incorporating reliability measures to typical electric machine design optimization *** measures facilitate comparing designs not only for rated conditions,but also allow to analyze their performance in the presence of unevitable ***,by additionally considering reliability or robustness as objectives compared to conventional optimization scenarios,designs featuring low parameter sensitiveness can be *** analysis of the design’s reliability as part of solving optimization problems involves a significant increase in required numerical *** minimize the associated prolongation of the runtime,an approach featuring a design of experiments based reduction of required computations and a consequent surrogate modeling technique is presented *** successful training,the metamodel can be applied for fast evaluating lots of different parameter combinations.A test problem is defined and *** on the observed findings,the necessity of incorporating robustness evaluations to machine design optimization becomes *** addition,the derived models allow for studying the impact of any tolerance-affected parameter on the machine performance in *** facilitates further beneficial studies,as for instance the analysis of selected changes of tolerance levels rather than a general minimization of the respective ranges which usually is associated with high production cost.

关键词： electric machine optimization,reliability ro-bustness,sensitivity six sigma tolerance analysis

robustness Criteria for Concurrent Evaluation of the Impact of Tolerances in Multiobjective Electric Machine Design Optimization

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CES Transactions on Electrical Machines and Systems 2020年第1期4卷 3-12页

作者： gerd Bramerdorfer Department of Electrical Drives and Power Electronics Johannes Kepler University LinzAustria

This article is about a comparison of different measures for determining the robustness or reliability of electric machine designs in the presence of inevitable *** selected criteria shall be suitable for concurrent evaluation in the course of solving state-of-the-art large scale multi-objective opti-mization *** the past,besides particularly customized criteria,mainly gradient based measures,worst case information,or standard deviation based quantities were *** this work,the quantile measure is introduced for electric machine design optimization and compared with the existing *** evaluation of a design’s robustness is typically examined based on finite element *** for most measures a signif-icant number of parameter combinations and thus computations are required,a surrogate model assisted approach is presented to minimize computational effort and runtime.A test problem is defined and analyzed to illustrate the differences of selected robustness *** reveal the importance of considering robustness in the optimization ***,a careful choice of appropriate measures has to be *** designs are compared and conclusions and an outlook on future activities are presented.

关键词： electric machine optimization robustness sen-sitivity six sigma tolerance analysis quantile

Thermochemical Treatment——Technologies for recovery and Utilisation of Materials

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过程工程学报 2006年第2期6卷 231-236页

作者： gerd Kley rudolf Brenneis Burkart Adamczyk Franz-Georg Simon Division Waste Treatment and remedial Eng. Federal Inst. Materials Research and Testing BAM Berlin 12200 Germany

The arc furnace technology is an ideally suited process for the treatment of hazardous and problematic waste. The operation conditions of the furnace can be adapted for optimal transformation of the waste material input into raw materials and usable products. The process can significantly reduce the impact of contaminated wastes and industrial residues, and enable material conversion and separation. Thus, the products of the process have various applications. The capability of the process is illustrated with three examples, the treatment of bottom ash and filter ash from waste incineration plants, of stainless steel slags and of chromium-containing residues from the refractory industry.

关键词：热化学处理原料分离耐火材料不锈钢

Functional neuroanatomy in panic disorder:Status quo of the research

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World Journal of Psychiatry 2017年第1期7卷 12-33页

作者： Thomas Sobanski gerd Wagner Department of Psychiatry Psychotherapyand Psychosomatic MedicineThueringen-Kliniken GmbH Psychiatric Brain and Body research Group Jena Department of Psychiatry and PsychotherapyJena University Hospital

AIM To provide an overview of the current research in the functional neuroanatomy of panic *** Panic disorder(PD) is a frequent psychiatric disease. Gorman et al(1989; 2000) proposed a comprehensive neuroanatomical model of PD, which suggested that fear-and anxiety-related responses are mediated by a so-called "fear network" which is centered in the amygdala and includes the hippocampus, thalamus, hypothalamus, periaqueductal gray region, locus coeruleus and other brainstem sites. We performed a systematic search by the electronic database PubMed. Thereby, the main focus was laid on recent neurofunctional, neurostructural, and neurochemical studies(from the period between January 2012 and April 2016). Within this frame, special attention was given to the emerging field of imaging genetics. rESULTS We noted that many neuroimaging studies have reinforced the role of the "fear network" regions in the pathophysiology of panic disorder. However, recent functional studies suggest abnormal activation mainly in an extended fear network comprising brainstem, anterior and midcingulate cortex(ACC and MCC), insula, and lateral as well as medial parts of the prefrontal cortex. Interestingly, differences in the amygdala activation were not as consistently reported as one would predict from the hypothesis of Gorman et al(2000). Indeed, amygdala hyperactivation seems to strongly depend on stimuli and experimental paradigms, sample heterogeneity and size, as well as on limitations of neuroimaging techniques. Advanced neurochemical studies have substantiated the major role of serotonergic, noradrenergic and glutamatergic neurotransmission in the pathophysiology of PD. However, alterations of GABAergic function in PD are still a matter of debate and also their specificity remains questionable. A promising new research approach is "imaging genetics". Imaging genetic studies are designed to evaluate the impact of genetic variations(polymorphisms) on cerebral function in reg

关键词： Panic disorder Anterior cingulate cortex Amygdala Insula Functional magnetic resonance imaging Diffusion tensor imaging Voxel-based morphometry Imaging genetics Serotonin Noradrenaline

Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy(celiac disease)

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World Journal of Gastroenterology 2017年第4期23卷 573-589页

作者： Consolato Sergi Fan Shen gerd Bouma Tian You Hospital Wuhan University of Science and Technology Departments of Laboratory Medicine and Pathology University of AlbertaEdmonton AB T6G 2B7 Department of Gastroenterology and Hepatology Vrije Universiteit Medical Center1081 HV Amsterdam

The upper digestive tract is routinely scoped for several causes of malabsorption, and the number of duodenal biopsy specimens has increased notably in the last 10 years. Gluten-sensitive enteropathy(GSE) is an autoimmune disease, which shows an increasing prevalence worldwide and requires a joint clinicopathological approach. The classical histopathology of GSE with partial or total villous blunting is well recognized, but the classification of GSE is not straightforward. Moreover, several mimickers of GSE with intraepithelial lymphocytosis have been identified in the last 20 years, with drug interactions and medical comorbidities adding to the conundrum. In this review, we report on the normal duodenal mucosa, the clinical presentation and laboratory diagnosis of GSE, the duodenal intraepithelial lymphocytes and immunophenotype of GSE-associated lymphocytes, the GSE mimickers, the differences "across oceans" among guidelines in diagnosing GSE, and the use of a synoptic report for reporting duodenal biopsies in both children and adults in the 21^(st) century.

关键词： Gluten Duodenum Lymphocytes

Temporal evolution of contacts and communities in networks of face-to-face human interactions

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Science China(Information Sciences) 2014年第3期57卷 29-45页

作者： Mark KIBANOV Martin ATZMUELLEr Christoph SCHOLZ gerd STUMME Knowledge and Data Engineering Group University of KasselWilhelmshher Allee 73Kassel D-34121Germany

Temporal dynamics of social interaction networks as well as the analysis of communities are key aspects to gain a better understanding of the involved processes,important influence factors,their efects,and their structural *** this article,we analyze temporal dynamics of contacts and the evolution of communities in networks of face-to-face *** our application context,we consider four scientific *** a structural level,we focus on static and dynamic properties of the contact ***,we analyze the resulting community structure using state-of-the-art automatic community detection ***,we analyze the evolution of contacts and communities over time to consider the stability of the respective ***,we assess diferent factors which have an influence on the quality of community ***,we provide first important insights into the evolution of contacts and communities in face-to-face contact networks.

关键词： social network analysis community detection face-to-face contact networks temporal networks community stability