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Light-Triggered Reactions Do Not Bias Boron Deficiency-Induced Root Inhibition of Arabidopsis Seedlings Grown in Petri Dishes

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Molecular Plant 2021年第8期14卷 1211-1214页

作者： Zhaojun Liu Ricardo Fabiano Hettwer Giehl Manuela Desiree bienert Nicolaus von Wiren gerd patrick bienert Department of Physiology and Cell Biology Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)06466 GaterslebenGermany Crop Physiology TUM School of Life SciencesTechnical University of Munich85354 FreisingGermany Soil Sciences TUM School of Life SciencesTechnical University of Munich85354 FreisingGermany

Dear Editor,For more than two decades,Arabidopsis thaliana plants have been routinely grown in vitro within transparent Petri dishes containing agar-based solid *** convenient to study root developmental,nutritional and morphological responses to abiotic cues and to elucidate gene functions following reverse and forward genetic approaches,this system exposes roots to light during illumination of the ***,Zheng et al.(2019)raised serious concerns whether root growth behavior and molecular root reactions in this experimental set-up are solely due to the designedly and chemically defined growth substrate composition,in their case phosphate(Pi)deficiency,or due to light-triggered reactions that are artificially-induced by exposing roots to light.

关键词： Arabidopsis roots Root

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气候对伊比利亚半岛尼安德特人向现代人人种转变的影响

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Science Bulletin 2023年第11期68卷 1176-1186,M0004页

作者： Konstantin Klein gerd-Christian Weniger patrick Ludwig Christian Stepanek 张旭 Christian Wegener 邵亚平 Institute for Geophysics and Meteorology University of CologneCologne 50923Germany Institute of Prehistory University of CologneCologne 50923Germany Institute of Meteorology and Climate Research Karlsruhe Institute of TechnologyKarlsruhe 76131Germany Paleoclimate Dynamics Alfred Wegener InstituteHelmholtz Centre for Polar and Marine ResearchBremerhaven 27570Germany Alpine Paleoecology and Human Adaption Group State Key Laboratory of Tibetan Plateau Earth SystemChinese Academy of SciencesBeijing 100101China

伊比利亚半岛对从尼安德特人到现代人的人种转变有着特殊的意义.从东欧向西迁徙的现代人较晚才抵达伊比利亚,因此两个种群之间在这里发生任何可能接触的时间要晚于其他地方.伊比利亚半岛的人种转变发生在海洋同位素第3阶段的早期(约6万... 详细信息

伊比利亚半岛对从尼安德特人到现代人的人种转变有着特殊的意义.从东欧向西迁徙的现代人较晚才抵达伊比利亚,因此两个种群之间在这里发生任何可能接触的时间要晚于其他地方.伊比利亚半岛的人种转变发生在海洋同位素第3阶段的早期(约6万到2.7万年前),其间反复强烈的气候变化影响了种群稳定性.本文研究了气候变化和人类相互作用如何影响种群的过渡.结合气候数据与考古遗址数据重建了GI11-10(格陵兰间冰期)和GS10-9/HE4(格陵兰冰期)时期尼安德特人和现代人的生存潜力或生存概率.结果发现,由于气候变化,在GS10-9/HE4期间,伊比利亚半岛的大部分地区已不适合尼安德特人的生存.尼安德特人的定居区收缩为较为孤立的沿海热点.这可能使得尼安德特人的种群结构变得更不稳定,从而引发人口的最终崩溃.现代人大约在GI10期间抵达了伊比利亚,但仅限于半岛最北部地带的局部地区.GS10-9/HE4的寒冷气候阻止了他们的进一步扩张,甚至导致了他们定居区域的缩小.气候变化与人口迁徙使得尼安德特人和现代人两个种群的人口分散在半岛的不同区域.因此,尼安德特人和现代人在广泛的地区共存的可能性不大,而现代人对尼安德特人的最后消亡的影响也有限.

关键词：尼安德特人伊比利亚半岛数据重建气候变化影响考古遗址人口迁徙生存概率人口分散

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Human immune cells＇ behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model

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Cellular & Molecular Immunology 2013年第2期10卷 151-158页

作者： Paula Hoff patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit Department of Rheumatelogy and Clinical Immunology Charite University Hospital Berlin Germany German Arthritis Research Center (DRFZ) Berlin Germany Berlin-Brandenburg Center for Regenerative Therapies (BCRT) Berlin Germany Julius Wolff Institute Berlin Germany Department of Orthopedics Charite University Hospital Berlin Germany These authors contributed equally to this work

The initial inflammatory phase of bone fracture healing represents a critical step for the outcome of the healing process. However, both the mechanisms initiating this inflammatory phase and the function of immune cells present at the fracture site are poorly understood. In order to study the early events within a fracture hematoma, we established an in vitro fracture hematoma model： we cultured hematomas forming during an osteotomy （artificial bone fracture） of the femur during total hip arthroplasty （THA） in vitro under bioenergetically controlled conditions. This model allowed us to monitor immune cell populations, cell survival and cytokine expression during the early phase following a fracture. Moreover, this model enabled us to change the bioenergetical conditions in order to mimic the in vivo situation, which is assumed to be characterized by hypoxia and restricted amounts of nutrients. Using this model, we found that immune cells adapt to hypoxia via the expression of angiogenic factors, chemoattractants and pro-inflammatory molecules. In addition, combined restriction of oxygen and nutrient supply enhanced the selective survival of lymphocytes in comparison with that of myeloid derived cells （i.e., neutrophils）. Of note, non-restricted bioenergetical conditions did not show any similar effects regarding cytokine expression and/or different survival rates of immune cell subsets. In conclusion, we found that the bioenergetical conditions are among the crucial factors inducing the initial inflammatory phase of fracture healing and are thus a critical step for influencing survival and function of immune cells in the early fracture hematoma.

关键词： apoptosis fracture hematoma model hypoxia immune cells inflammation

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The effect of melatonin in functional heartburn: A randomized, placebo-controlled clinical trial

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Open Journal of Gastroenterology 2014年第2期4卷 56-61页

作者： patrick P. Basu Hemanth Hempole Nitya Krishnaswamy Niraj J. Shah Mark M. Aloysius Columbia University College of Physicians and Surgeons New York USA James J. Peters VA Medical Center Mount Sinai School of Medicine New York USA King’s County Hospital New York USA North Shore University Hospital at Forest Hills Forest Hills USA

Background: Melatonin is a safe and effective treatment for patients with functional pain and gastrointestinal disorders. Objective: To evaluate the efficacy and safety of melatonin for 3 months in patients with functional heartburn. Methods: In the randomized, placebo-controlled pilot study, patients with functional heartburn were treated with omeprazole 20 mg before breakfast and randomized to receive either melatonin 6 mg (n = 20), nortripty line 25 mg (n = 20), or placebo (n = 20) at bedtime for 3 months. Gastroesophageal Reflux Disease-Health-Related Quality of Life (gerd-HRQOL) scores were assessed at baseline and at the end of the study. Results: Melatonin improved gerd-HRQOL scores compared with nortriptyline (P = 0.0015) and placebo (P < 0.0001). Fewer adverse events were reported by patients receiving melatonin compared with those receiving nortriptyline or placebo. Conclusions: Melatonin was a safe and effective treatment for functional heartburn.

关键词： Melatonin Functional Heartburn Nortriptyline HRQOL

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