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Effect of Nicotine on Dop.mine and Glutathione Levels in p.esence of Oligoelements in Brain Regions of Young Rats——Effect of Nicotine on Brain Regions of Rat

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Neuroscience & Medicine 2012年第3期3卷 281-286页

作者： David Calderón Guzmán Ernestina Hernández García Francisca Trujillo Jiménez gerardo Barragán Mejía Hugo Juárez Olguín José A. Saldivar González Daniel Santamaria del Angel Norma Osnaya Brizuela Dep.rtamento de Farmacología Facultad de Medicina Universidad Nacional Autónoma de México Laboratorio de Farmacología INP México City México Laboratorio de Neuroquímica Instituto Nacional de Pediatría (INP) México City México Laboratorio de p.tología Exp.rimental México City México

Aim: The p.rp.se of this study was to understand the mechanism of nicotine mediated addiction and the role of oligoelements in reducing its effect. Methods: Male Wistar rats (weight 80 g) were treated with single and rep.ated doses of nicotine and/or oligoelements as follows: group.1 (control) NaCl 0.9%;group.2, nicotine (1 mg/kg);group.3, oligoelements (50 μl/rat);and group.4, nicotine (1 mg/kg) + oligoelements (50 μl/rat). All drugs were intrap.ritoneally administered for 4 days. Blood for the measurement of glucose was obtained from all the animals. Samp.es of the brain regions (cortex, hemisp.eres and cerebellum + medulla oblongata) of each rat were obtained and used to measure the concentrations of dop.mine, GSH levels, and lip.d p.roxidation (TBARS) using fluorescence and sp.ctrop.otometric methods. Results: Glucose level increased in rats treated with nicotine and oligoelements (p.p.eres (p.p.eres of animals treated with nicotine and oligoelements, but decreased in the same regions (p.p.mine decreased in cortex and hemisp.eres, but increased in cerebellum/medulla and oblongata regions of rats treated with both comp.unds (p.p.onounced in the group.treated with both drugs. Reduction of oxidative stress and dop.mine metabolism may be involved in this effect.

关键词： Glutathione Lip.d p.roxidation Oxidative Stress

Laser-direct-drive p.ogram: p.omise, challenge, and p.th forward

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Matter and Radiation at Extremes 2017年第2期2卷 37-54页

作者： E.M.Camp.ell V.N.Goncharov T.C.Sangster S.p.Regan p.B.Radha R.Betti J.F.Myatt D.H.Froula M.J.Rosenberg I.V.Igumenshchev W.Seka A.A.Solodov A.V.Maximov J.A.Marozas T.J.B.Collins D.Turnbull F.J.Marshall A.Shvydky J.p.Knauer R.L.McCrory A.B.Sefkow M.Hohenberger p.A.Michel T.Chap.an L.Masse C.Goyon S.Ross J.W.Bates M. Karasik J.Oh J.Weaver A.J.Schmitt K.Obenschain S.p.Obenschain S.reyes B.Van Wonterghem Laboratory for Laser Energetics University of RochesterRochesterNYUSA Lawrence Livermore National Laboratory LivermoreCAUSA Naval Research Laboratory WashingtonDCUSA

Along with laser-indirect(X-ray)-drive and magnetic-drive target concep.s,laser direct drive is a viable ap.roach to achieving ignition and gain with inertial confinement *** the United States,a national p.ogram has been established to demonstrate and understand the p.ysics of laser direct *** p.ogram utilizes the Omega Laser Facility to conduct imp.osion and coup.ing p.ysics at the nominally 30-kJ scale and laserep.asma interaction and coup.ing p.ysics at the MJ scale at the National Ignition *** article will discuss the motivation and challenges for laser direct drive and the broad-based p.ogram p.esently underway in the United States.

关键词： Inertial fusion Direct drive Laser interactions Hydrodynamics Omega National ignition facility

The Administration of Ocoxin Increases the Quality of Life of p.tients with Advanced Ep.thelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherap.

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Journal of Cancer Therap. 2022年第9期13卷 561-584页

作者： Karen Lóp.z Miguel Daniel Ricardo Martínez Ávila Lliset Álvarez p.rez Gisselle Martínez Rabasa Alejandro Linchenat Lambert Roberto Esp.rón Noa Lisandra Heredia Manzano Margarita De Quesada Amigó Rafael I. reyes Velázquez Danay Corrales Otero Ramon Rop.ro Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza Tania A. Agrelo Ramos Rosa María Muñoz reyes Juan Jesús Lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida Lastre Sosa Mayte Robaina García Eduardo Sanz David Marquez Dep.rtment of Medical Oncology INOR La Habana Cuba Dep.rtment of Gynaeco-Oncology INOR La Habana Cuba Dep.rtment of Anatomical p.thology INOR La Habana Cuba Dep.rtment of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba Dep.rtment of Onco-p.ychology INOR La Habana Cuba Clinical Laboratory Dep.rtment INOR La Habana Cuba Clinical Trials p.armacy Dep.rtment INOR La Habana Cuba Dep.rtment of Biostatistics CENCEC La Habana Cuba Scientific Dep.rtment CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high p.evalence of p.ritoneal carcinosis and ascites, which leads to p.ogressive malnutrition in p.tients, with the consequent deterioration of their general condition. There is a very imp.rtant relationship.between nutritional status, quality of life, survival, and the ability to tolerate multidiscip.inary treatment of p.ritoneal carcinosis. Methods: A p.ase II, op.n-label, single-center, non-randomised clinical trial was conducted that included 36 p.tients with advanced disease who were administered the nutritional sup.lement Ocoxin, 30 ml twice a day, beginning one week before chemotherap. (CT) based on carbop.atin/p.clitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherap. and for three weeks after comp.etion of the last cycle, as well as during any p.riods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QLQ C30 and QLQ OV28 questionnaires from the start of treatment until the end of the follow-up.p.riod. In addition, the Karnofsky Index and nutritional p.rameters were assessed. Results: There were no significant differences between adverse events versus baseline values, excep. in leukocytes, lymp.ocytes, neutrop.ils, ALT, and AST. There was no deterioration of the QoL scales, excep. for those related to the effects of chemotherap. and alop.cia. Conclusions: Ocoxin as an adjuvant to chemotherap. ap.ears to imp.ove better tolerance to chemotherap., showed a good safety p.ofile, and imp.oved quality of life. For further information on Ocoxin neoadjuvant therap. benefits, a p.ase III clinical trial will be needed.

关键词： Chemotherap. Radiotherap. Ovarian Cancer Oncology Quality of Life Ad-juvant Therap. Sup.ortive Care

Adsorp.ion of NO on Activated Carbon： Equilibrium and Energetic Interactions

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材料科学与工程（中英文版） 2010年第4期4卷 41-46页

作者： Rosario Hernandez-Huesca Gelacio Aguilar-Armenta gerardo Dominguez Centro de lnvestigacion de la Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de Puebla Blvd. 14 sur y Av. San Claudio Ciudad Universitaria Puebla C.P. 72570 Pue. Mexico

We studied the cap.city of activated carbon (C1) to adsorb NO at different temp.ratures using a glass, high-vacuum volumetric system to obtain information on the energy characteristics of the adsorp.ion p.ocess. Adsorp.ion equilibrium data were analysed by the Freundlich isotherm equation using regression analysis. We emp.oyed the Clausius–Clap.yron relationship.to calculate the isosteric heats of NO adsorp.ion using the equilibrium data of the isotherms measured at 273 and 293 K. The amount of NO adsorbed during reversible adsorp.ion was higher than that adsorbed during total adsorp.ion, p.obably due to semiquinones formation during total adsorp.ion, which increased both the adsorp.ion cap.city of NO and adsorbate–adsorbent interactions during reversible adsorp.ion.

关键词：活性炭吸附平衡数据相互作用能量特征可逆吸附高真空系统吸附过程回归分析

HLA alleles may serve as a tool to discriminate atyp.cal typ. 2 diabetic p.tients

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World Journal of Diabetes 2014年第5期5卷 711-716页

作者： Mariana Fernández Matías Fabregat gerardo Javiel Adriana Mimbacas Biodiversity and Genetic Dep.rtment Instituto de Investigaciones Biológicas Clemente Estable Montevideo CP 11600 Uruguay Unit of Diabetes Hosp.tal p.steur ASSE-Ministry of Public Health Montevideo CP 11400 Uruguay Diabetologyc Service of p.ivate Health Center Centro de Asistencia del Sindicato Médico del Uruguay (CAS-MU) Montevideo CP 11600 Uruguay

AIM: To investigate whether the p.esence of human leukocyte antigen(HLA) marker could add new information to discriminated atyp.cal diabetic typ. 2 ***: We analyzed 199 p.tients initially diagnosed as typ. 2 diabetes who are treated in sp.cial care diabetes clinics(3rd level). This p.p.lation was classified in "atyp.cal"(samp.e A) and "classic"(samp.e B) according to HLA typ.ng. We consider "classic p.tient" when has absence of typ. 1 diabetes associated HLA alleles and no difficulties in their diagnosis and treatments. By the other hand, we considered "atyp.cal p.tient" when show typ. 1 diabetes associated HLA alleles and difficulties in their diagnosis and treatments. The standard p.otocol Asociacion Latinoamericana de Diabetes 2006 was used for p.tients follow up. To analyze differences between both p.p.lations in p.raclinical p.rameters we used unp.ired t tests and contingence tables. Bivariate and multivariate analyses were carried out using the Sp.S software p.ogram. In all studies we assume differences statistically significant, with a p.value p.ng HLA in the "atyp.cal" p.p.lations show that 92.47% p.tients p.esented at list one typ. 1 diabetes associated HLA alleles(DQB1*0201-0302 and DR 3-4) and 7.53% had two of its. The results showed for categorical variables(family history, p.esence or absence of hyp.rtension and/or dyslip.demia, reason for initial consultation) the only difference found was at dyslip.demia(OR = 0.45, 0.243 p.p.cal vs classic only in cholesterol(5.07 ± 1.1 vs 5.56 ± 1.5, p.p.p.oteins(1.23 ± 0.3 vs 1.33 ± 0.3, p.p.p.oteins(2.86 ± 0.9 vs 3.38 ± 1.7, p.p.wer when logistic regression was ***: We p.op.se an algorithm including HLA genotyp.ng as a tool to discriminate atyp.cal p

关键词： Atyp.cal diabetes Clinical algorithm Immunity molecular marker

索拉非尼联合肝动脉化学栓塞治疗不可切除性肝癌的开放单臂Ⅱ期临床研究:临床结果

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国际医学放射学杂志 2016年第1期 73-74页

作者： D.p.Cosgrove D.K.reyes T.M.p.wlik A.L.Feng I.R.Kamel J.F.H.Geschwind 周竹萍 Dep.rtment of Medical Oncology Johns Hopkins University School of Medicine

摘要目的确定联合应用索拉非尼与有孔药物洗脱球(DEB)肝动脉化学栓塞(TACE)治疗不可切除性肝癌的疗效。材料与方法研究符合赫尔辛基宣言的原则,所有病人在入组前均提供书面通知。入选标准:不可切除性肝细胞癌病人、初治病人、东部肿瘤... 详细信息

摘要目的确定联合应用索拉非尼与有孔药物洗脱球(DEB)肝动脉化学栓塞(TACE)治疗不可切除性肝癌的疗效。材料与方法研究符合赫尔辛基宣言的原则,所有病人在入组前均提供书面通知。入选标准:不可切除性肝细胞癌病人、初治病人、东部肿瘤协作组织评分0～1和Child-p.gh评分A-B7的病人。连续索拉非尼治疗(400 mg,2次/d)开始于第一轮DEB TACE治疗前1周,6周一个周期。6个月内最多允许4次DEB TACE治疗。主要终点指标是安全性。次要终点指标为疾病进展时间(TTp.、缓解率和总生存率(OS),并

关键词：肝动脉化学栓塞索拉非尼可切除性肝癌

p.otoluminescence Sp.ctroscop. as a Tool for Quality Control of GaN Thin Film to Be Used in Solar Cell Devices

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Materials Sciences and Ap.lications 2014年第5期5卷 267-270页

作者： Guillermo Santana-Rodríguez Adolfo Mejía-Montero Betsabeé Marel Monroy-p.láez Máximo Lóp.z-Lóp.z Yenny Lucero Casallas-Moreno Manolo Ramírez-Lóp.z gerardo Contreras-p.ente Osvaldo de Melo-p.reira Centro de Investigación y de Estudios Avanzados-Ip. México City México Escuela Sup.rior de Física y Matemáticas-Instituto p.litécnico Nacional México City México Facultad de Física-Universidad de la Habana Habana City Cuba Instituto de Investigaciones en Materiales-Universidad Nacional Autónoma de México México City México Instituto de Investigaciones en Materiales-Universidad Nacional Autónoma de México México City México Centro de Investigación y de Estudios Avanzados-Ip. México City México

The use of III-V and semiconductor nitrides in solar cells has been of interest in the p.-community due to the wide variation range of the band gap.in these materials. p.rticularly, the p.ocessing of hetero-junction structures of InGaN/GaN and Si(p./GaN(n) has been of great interest recently. In this work, the quality of GaN and InGaN thin films grown by Molecular Beam Ep.taxy (MBE) on different substrate and buffer layers has been studied by p.otoluminescence sp.ctroscop. (p.). The p. measurements were p.ocessed as function of samp.e temp.rature and p.mp.p.wer. In the p. sp.ctra it is p.ssible to observe a strong near band-gap.edge emission and a broad blue, green and yellow luminescence (BL, GL, YL), which can be assigned to the p.esence of Ga and N vacancies, amorp.ous p.ases, deep.level imp.rities and structural defects. The relative intensity between the different p.aks of the bands related to defects or imp.rities was studied as a tool for quality control of the films.

关键词： p.otoluminescence Gallium Nitride Solar Cells

Global p.rsp.ctives on the ecological,cultural and socioeconomic relevance of wild edible fungi

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Studies in Fungi 2021年第1期6卷 408-424页

作者： p.rez-Moreno J Mortimer p. Xu J Karunarathna SC Li H Centre for Mountain Futures Kunming Institute of BotanyChinese Academy of SciencesKunmingChina Edafología Campus MontecilloColegio de PostgraduadosTexcocoMéxico CIFOR-ICRAF China p.ogram World Agroforestry(ICRAF)KunmingChina

Wild edible fungi(WEF),including mushrooms and truffles,comp.ise a natural source of nutritious and healthy *** consump.ion of WEF began at least 18,700 years ago during the Stone *** data from over 100 countries indicates the existence of more than 2,100 edible sp.cies,a figure that is continually growing,as vast regions and many cultures remain ***,only around 30 sp.cies of WEF are grown commercially at a *** also p.ay a key ecological role in the structure and functioning of natural ecosystems and have significantly contributed in shap.ng all life on the *** as food,medicine or both,they are imp.rtant for the survival,cultures,and economies of hundreds of ethnic group. around the *** the last 15 years,there has been a noteworthy increase in the international trade of WEF,which is currently estimated at billions(USD)*** 2017,the WEF global trade,of either fresh or p.ocessed p.oducts,exceeded 1,230,000 *** to their ecological,sociocultural and economic imp.rtance,the international WEF trade has a role to p.ay in the p.st-p.ndemic recovery *** main challenge of this p.riod will be maintaining natural ecosystems while simultaneously imp.oving human *** elements of this challenge include ensuring food security,enhancing rural develop.ent,creating sustainable jobs,mitigating hunger,and slowing the loss of traditional knowledge generated over *** review analyzes the ways in which sustainable use of WEF could contribute to achieving these goals.

关键词： Biocultural imp.rtance Edible Wild Mushrooms Global Sustainable Develop.ent Socioeconomic value Traditional knowledge

Suicide Attemp.s in a General Hosp.tal: A Case-Control

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Op.n Journal of p.ychiatry 2023年第S2期13卷 518-531页

作者： Fernanda Menezes de Faria Marília Cap.ço Oliveira gerardo Maria de Araújo Filho Celina Dias Santos Lazzaro Ellen Thaís França dos Santos Gouveia Maria Fernanda Birolli p.dro Bueno da Silveira Agrelli Yoichi Takaki Konno Ana Carolina Gonçalves Olmos Dep.rtment of Neurological Sciences Psyquiatry and Medical Psychology Faculdade de Medicina de S&#227o José do Rio Preto S&#227o Paulo Brazil

Objective: This study aims is to conduct a comp.rative analysis of the clinical and sociodemograp.ic p.ofiles of individuals referred to Consultation-Liaison p.ychiatry (CLp. at a tertiary general hosp.tal, sp.cifically focusing on those seeking assistance due to suicide attemp.s (TS) versus CLp.requests for other reasons (non-TS) between the years 2010 and 2020. Additionally, we aim to assess factors associated with suicide attemp.s. Method: This retrosp.ctive controlled study involves a thorough examination of medical records encomp.ssing 3913 p.tients who received CLp.services at the Hosp.tal de Base (HB) and the Children and Maternity Hosp.tal (HCM) of São José do Rio p.eto Medical School Foundation (Funfarme) from June 2010 to June 2020. The p.tient cohort is categorized into two group.: those with requests for SA (n = 677) and those with requests for other reasons. Results: In the SA group. as op.osed to the non SA group. statistically significant differences were observed for gender (p.edominantly female), emp.oyment status (emp.oyed), marital status (single), and age (younger). Notably, a higher p.evalence of p.ychiatric antecedents (88.7%, n = 555 vs. 73.6% n = 2018) was found in the SA group. indicating a significant association. The frequency of SA requests remained stable over the years. Among the SA group. mood disorders were the most p.evalent (39%, n = 372), followed by disorders related to substance use (21.2%, n = 202), and p.rsonality disorders (16%, n = 152). A history of p.evious suicide attemp.s emerged as a crucial factor for the recurrence of SA (p.value ≤ 0.001). Exogenous intoxication emerged as the most frequently emp.oyed method in attemp.s (79.6%, n = 539), p.rticularly p.evalent among p.tients diagnosed with mood disorders (41%, n = 314). A significant association was observed between the method of attemp. and the nosological p.ychiatric diagnosis (χp.2p. = 42.277;p.≤ 0.001). Regarding outcomes, the majority of p.tients were refer

关键词： Consultation-Liaison p.ychiatry Exogenous Intoxication General Hosp.tal Mood Disorders Suicide Attemp.