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Neurotrophic factor therapy for Parkinson's disease: past, present and future

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Neural Regeneration Research 2016年第2期11卷 205-207页

作者： Aideen M.Sullivan gerard W.O'Keeffe Department of Anatomy and Neuroscience University College Cork

One of the greatest unmet needs in the treatment of Parkinson’s disease（PD）is a disease-modifying therapy,which can halt the ongoing degeneration of dopaminergic neurons that is characteristic of this *** therapies focus on managing symptoms,rather than on addressing their *** candidates for disease-modifying therapies are the dopaminergic neurotrophic factors（NTFs）.

关键词： GDNF present and future Neurotrophic factor therapy for Parkinson’s disease past

Otilonium bromide in irritable bowel syndrome:A dose-ranging randomized double-blind placebo-controlled trial

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World Journal of Gastroenterology 2014年第34期20卷 12283-12291页

作者： Danuta Chmielewska-Wilkoń Giorgio Reggiardo Colin gerard Egan Department of Gastrointestinal Endoscopy Gabinet Endoskopii Przewodu PokarmowegoSzewska31-009 KrakowPoland Medi Service World Trade Center16149 GenoaItaly Primula Multimedia SRL 56121 PisaItaly

AIM: To examine the efficacy and safety of otilonium bromide (OB) in treatment-sensitive functional irritable bowel syndrome (IBS) clinical parameters.

关键词： Otilonium bromide Irritable bowel syndrome Spasmolytic Acute treatment

Microstructure Variation and Hardness Diminution During Low Cycle Fatigue of 55NiCrMoV7 Steel

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Journal of Iron and Steel Research International 2007年第6期14卷 68-73页

作者： ZHANG zhan ping QI Yu-hong DELAGNES Denis BERNHART gerard Electro Mechanics and Materials College Dalian Maritime University Dalian 116026 Liaoning China Research Center on Tools Materials and Processes Ecole des Minesd＇Albi Carmaux 81013 Albi CT cedex 09 France

The influence of temperature and hardness level on the cyclic behavior of 55NiCrMoV7 steel, and the mierostrueture variation and hardness diminution during low cycle fatigue behavior were investigated. By means of SEM and XRD, the modality of carbides and the full width half-maximum （FWHM） of martensite （211） [M（211）] of Xray diffraction spectrum in fatigue specimen were studied. The results showed that the cyclic stress response behav ior generally showed an initial exponential softening for the first few cycles, followed by a gradual softening without cyclic softening saturation. The fatigue behavior of the steel is closely related to the hardness level. The hardness diminution and the variation of half-width M（211） are remarkably influenced by the interaction between the cyclic plastic deformation and the thermal loading when the fatigue temperature exceeds the tempering temperature of the steel.

关键词： low cycle fatigue 55NiCrMoV7 steel microstructure hardness half width

Model Predictive Control Strategy for Residential Battery Energy Storage System in Volatile Electricity Market with Uncertain Daily Cycling Load

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Journal of Modern Power Systems and Clean Energy 2023年第2期11卷 534-543页

作者： Dejan P.Jovanović gerard F.Ledwich Geoffrey R.Walker Institute of Electrical and Electronic Engineers QueenslandAustralia School of Electrical Engineering&Robotics Queensland University of TechnologyBrisbaneAustralia

This paper presents a control strategy for residential battery energy storage systems,which is aware of volatile electricity markets and uncertain daily cycling *** economic benefits of energy trading for prosumers are achieved through a novel modification of a conventional model predictive control(MPC).The proposed control strategy guarantees an optimal global solution for the applied control action.A new cost function is introduced to model the effects of volatility on customer benefits more ***,the newly presented cost function models a probabilistic relation between the power exchanged with the grid,the net load,and the electricity *** probabilistic calculation of the cost function shows the dependence on the mathematical expectation of market price and net *** techniques for calculating this value are *** proposed strategy differs from the stochastic and robust MPC in that the cost is calculated across the market price and net load variations rather than across model constraints and parameter variations.

关键词： Optimal control model predictive control(MPC) energy market nonlinear constrained optimization revenue for battery energy storage system Gaussian mixture model autoregressive integrated moving average model

Pharmacological interventions targeting nuclear factor-kappa B signaling in multiple sclerosis

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Neural Regeneration Research 2021年第10期16卷 2023-2025页

作者： Kim M.A.De Kleijn gerard J.M.Martens Department of Molecular Animal Physiology Donders Institute for BrainCognition and BehaviourCentre for NeuroscienceFaculty of ScienceRadboud University6525AJ NijmegenThe Netherlands NeuroDrug Research Ltd 6525ED NijmegenThe Netherlands(De Kleijn KMAMartens GJM)Department of Molecular Animal PhysiologyDonders Institute for BrainCognition and BehaviourCentre for NeuroscienceFaculty of ScienceRadboud University6525AJ NijmegenThe Netherlands

Multiple sclerosis(MS)is an inflammatory neurodegenerative disease of the central nervous system(CNS).Pathological characteristics of the disease include activation of CNS-intrinsic immune cells,such as microglia and astrocytes,and loss of neuronal connections,myelin and blood-brain barrier(BBB)integrity as well as peripheral immune cell infiltration into the *** has long been considered a predominantly immunological disease,which has led to the development of essentially only immune-directed *** this traditional“outside-in”MS hypothesis,a dysregulation of the peripheral immune system causes immune cell infiltration into the CNS,leading to autoreactivity against myelin sheath components and secondary BBB ***,recent findings indicate that overactivation of microglia and astrocytes represents an important first step in MS pathology,as appears to be the case for other neurodegenerative diseases such as Alzheimer’s disease(AD)and Parkinson’s disease(PD).

关键词： sclerosis outside essentially

Patient satisfaction and penile morphology changes with postoperative penile rehabilitation 2 years after Coloplast Titan prosthesis

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Asian Journal of Andrology 2016年第5期18卷 754-758页

作者： Michael B Pryor Rafael Carrion Run Wang gerard Henry Regional Urology 255 Bert Kouns Industrial Loop Shreveport LA USA Department of Urology University of South Florida Tampa Florida USA Department ofUrology University of Texas School of Medicine at Houston and MD Anderson Cancer Center Houston TX USA.

A common complaint after inflatable penile prosthesis surgery is reduced penile length. We previously reported how using the Coloplast Titan inflatable penile prosthesis with aggressive new length measurement technique （NLMT） coupled with postoperative IPP rehabilitation of the implant for 1-year helped to improve patient satisfact on and erectile peni e measurements Th s is a 2 years follow-up of a prospective, three-center, study of 40 patients who underwent Titan prosthesis placement, With new length measurement technique for erectile dysfunction. Patient instructions were to inflate daily for 6 months and then inflate maximally for 1-2 h daily for 6-24 months. Fifteen penile measurements were taken before and immediately after surgery and at follow-up visits. Measurement changes were improved at 24 months as compared to immediately postoperative and at 12 months. 67.8% of subjects were satisfied with their length at 2 years, and 77% had perceived penile length that was longer （30.8%） or the same （46.2%） as prior to the surgery. 64.3% and 17.9% of subjects had increased and unchanged satisfaction, respectively, with penile length as compared to prior to penile implant surgery. All but one subject （96.5%） was satisfied with the overall function of his implant. This study suggests using the Coloplast Titan with aggressive cylinder sizing, and a postoperative penile rehabilitation inflation protocol can optimize patient satisfaction and erectile penile measurements at 2 years postimplant.

关键词： erectile dysfunction penile implant surgery penile prosthesis

Rebalancing China＇s Economy： Domestic and International Implications

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China & World Economy 2017年第1期25卷 1-31页

作者： Guonan Ma IvanRoberts gerard Kelly Adjunct Professor City University of Hong Kong China

This paper considers interactions between and their global implications. We present China ＂s domestic and external imbalances scenarios detailing how a rebalancing of China＇s growth pattern from investment-driven growth towards more consumption-driven growth may occur in practice. Using input-output tables for 2012, we illustrate the knife-edged nature of Chinese rebalancing, the linkages between expenditure-side and production-side rebalancing, and how an internal rebalancing could exacerbate external imbalances. A policy implication for China is that for rebalancing to be fast, consumption must be exceptionally resilient and the efficiency of investment must increase sharply. If rebalancing is too slow, the capital-to-output ratio will rise to potentially unsustainable levels and consumption will fail to attain levels of contemporary upper middle-income economies by 2030. Global input-output tables （1995-2011） suggest that the patterns of Chinese rebalancing considered in our scenarios may generate substantial headwinds for exports to China by its trading partners.

关键词： China external rebalancing internal rebalaneing

Attitudes of medical students toward the practice and teaching of integrative medicine

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Journal of Integrative Medicine 2015年第6期13卷 412-415页

作者： gerard Flaherty Jenny Fitzgibbon Peter Cantillon School of Medicine National University of Ireland

The General Medical Council encourages the integration of complementary and alternative medicine （CAM） teaching into basic medical education. We wished to explore the attitudes of medical students to CAM and its inclusion in their undergraduate curriculum. Medical students were invited to complete the validated Integrative Medicine Attitude Questionnaire （IMAQ） and to state whether they considered it appropriate for them to learn about CAM in medical school. The questionnaire was completed by 308 students （65.8% response rate）. CAM had been received by a majority of respondents and their families. Participants believed that doctors with knowledge of CAM provide better patient care and that it is desirable for physicians to exploit the placebo effect. Most students expressed the view that doctors should be able to answer patients＇ questions about herbal medicines. There was a belief that patients should be warned to avoid using supplements which have not undergone rigorous testing. Students who were current or previous users of CAM or whose family members used CAM had higher total IMAQ scores and openness subscale scores than those who did not report use of CAM. Two-hundred and nine （68%） students expressed a desire to study CAM as part of their medical curriculum. This study reveals a positive attitude towards a holistic approach to patient care which embraces CAM. Medical students believe that integrative medicine should be taught in medical school.

关键词： attitude of health personnel students, medical complementary therapies education

The Greater Bay Area(GBA)Development Strategy and Its Relevance to Higher Education

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ECNU Review of Education 2021年第1期4卷 210-221页

作者： Ailei Xie gerard A.Postiglione Qian Huang Guangzhou University The University of Hong Kong

Purpose:This article provides a policy review of the Greater Bay Area(GBA)development strategies and their relevance to higher ***/Approach/Methods:This article reviews key GBA policies adopted by the central government of China and interprets higher education cooperation policies at provincial and national levels before discussing the opportunities and challenges for higher ***:The GBA Development Strategy aims to build an integrated,innovative,and internationalized *** presents an opportunity for universities to attract new funding opportunities as well as to prepare graduates to play a key role in the *** shift toward a high-tech service-led economy would hinge upon creating an effective partnerships platform between industry and higher education *** do so would require greater institutional and professional autonomy for the academic research *** is also a need for evidence-based policies by the Central and GBA regional ***/Value:The article examines the state of the relationship between GBA strategies and higher education *** can be used to guide policies to promote higher education cooperation in the GBA in a more integrated,innovative,and internationalized way.

关键词： China Greater Bay Area higher education