检索结果-南通市图书馆

Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Biological Chemistry 2017年第1期8卷 57-80页

作者： Vitor Sueth-Santiago Debora Decote-Ricardo Alexandre Morrot celio geraldo Freire-de-Lima Marco Edilson Freire Lima Instituto Federal de Educacao Ciência e Tecnologia do Rio de JaneiroCampus Sao Goncalo Universidade Federal Rural do Rio de Janeiro Instituto de Ciências ExatasDepartamento de Química Universidade Federal Rural do Rio de Janeiro Instituto de VeterináriaDepartamento de Microbiologia e Imunologia Veterinária Universidade Federal do Rio de Janeiro

Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.

关键词： Trypanosoma cruzi Trans-sialidase Trypanothione reductase CYP51 Cruzipain Tubulin

Analysis of Fatigue Fracture with Scanning Electron Microscopy of Valve Spring Steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mechanics Engineering and Automation 2014年第5期4卷 422-426页

作者： Marcelo Sampaio Martins Daniel Julien Barros da Silva Sampaio Jose geraldo Trani brandao Jose Elias Tomazini Department of Mechanical Faculty of Engineering Guaratinguet6 UNESP (Univ. Estadual Paulista Julio de Mesquita Filho)Guaratingueta/SP 12516-410 Brazil

Valve spring steel for engines, belonging to the class of super clean steel, must be supported due to their application, high numbers of cycles in fatigue and cannot suffer any type of failure, which would be catastrophic for the vehicle. From these considerations, it was tested in axial fatigue, a test that can detect possible internal defects in their structure, caused by inclusions, a class of valve spring steel, where it aimed to discover the values of their fatigue life, followed by an analysis ofmicrostructural fracture surface by SEM （scanning electron microscopy）. It was proved, after testing, the specimens tested broke up a number of cycles always compatible with the life work of a valve spring and that fractures always occurred by surface defects in the specimens.

关键词： Valve spring steel axial fatigue SEM.

Photoluminescence emissions of Ca_(1-x)WO_(4):xEu^(3+):Bridging between experiment and DFT calculations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2022年第10期40卷 1527-1534页

作者： Amanda Fernandes Gouveia Marcelo Assis Lara Kelly Ribeiro Aline Estefany brandao Lima Eduardo de Oliveira Gomes Daniele Souza Yara Gobato Galvao Ieda Lucia Viana Rosa geraldo Eduardo da Luz Jr Eva Guillamón Elson Longo Juan Andrés Miguel Angel San-Miguel Department of Physical and Analytical Chemistry University Jaume I(UJI)12071CastelloSpain Institute of Chemistry State University of Campinas(Unicamp)13083-970CampinasSPBrazil CDMF Federal University of S?o Carlos(UFSCar)P0.Box 67613565-905Sao CarlosSao PauloBrazil Departamento de Química Federal University of Piauí(UFPI)64049-550TeresinaPiautBrazil Physics Department Federal University of S?o Carlos(UFSCar)P.0.Box 67613565-905Sao CarlosSao PauloBrazil

In this work,the impact of the doping process on the photoluminescence emission of CaWO_(4) as a function of the concentration of Eu^(3+) cation(0.01 mol%,0.02 mol%,0.04 mol%,0.06 mol%,0.08 mol%,and 0.10 mol%) is discussed in ***_(1-x)WO~4:xEu^(3+) samples were successfully synthesized by a simple coprecipitation method followed by microwave *** blue shift in the absorption edge confirms the quantum confinement effect and the band gap energy covers the range from 3.91 to 4.18 eV,as the amount of Eu^(3+) cations *** experimental results are sustained by first-principles calculations,at the density functional theory level,to decipher the geometry and electronic properties,thereby enabling a more accurate and direct comparison between theory and experiment for the Ca_(1-x)WO_(4):xEu^(3+) structure.

关键词： Ca_(1-x)WO_(4):xEu^(3+) DFT calculations Photoluminescence emissions Rare earths

B-1 cells modulate the murine macrophage response to Leishmania major infection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Biological Chemistry 2017年第2期8卷 151-162页

作者： Angelica F Arcanjo Marise P Nunes Elias B Silva-Junior Monique Leandro Juliana Dutra Barbosa da Rocha Alexandre Morrot Debora Decote-Ricardo celio geraldo Freire-de-Lima Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de Janeiro Instituto Oswaldo Cruz FIOCRUZ Instituto de Microbiologia Paulo de Góes Universidade Federal do Rio de Janeiro Instituto de Veterinária Universidade Federal Rural do Rio de Janeiro

AIM To investigate the modulatory effect of B-1 cells on murine peritoneal macrophages infected with Leishmania major(L. major) in *** Peritoneal macrophages obtained from BALB/c andBALB/c XID mice were infected with L. major and cultured in the presence or absence of B-1 cells obtained from wild-type BALB/c mice. Intracellular amastigotes were counted, and interleukin-10(IL-10) production was quantified in the cellular supernatants using an enzymelinked immunosorbent assay. The levels of the lipid mediator prostaglandin E2(PGE2) were determined using a PGE2 enzyme immunoassay kit(Cayman Chemical, Ann Arbor, MI), and the number of lipid bodies was quantified in the cytoplasm of infected macrophages in the presence and absence of B-1 cells. Culturing the cells with selective PGE2-neutralizing drugs inhibited PGE2 production and confirmed the role of this lipid mediator in IL-10 production. In contrast, we demonstrated that B-1 cells derived from IL-10 KO mice did not favor the intracellular growth of L. *** We report that B-1 cells promote the growth of L. major amastigotes inside peritoneal murine macrophages. We demonstrated that the modulatory effect was independent of physical contact between the cells, suggesting that soluble factor(s) were released into the cultures. We demonstrated in our co-culture system that B-1 cells trigger IL-10 production by L. major-infected macrophages. Furthermore, the increased secretion of IL-10 was attributed to the presence of the lipid mediator PGE2 in supernatants of L. major-infected macrophages. The presence of B-1 cells also favors the production of lipid bodies by infected macrophages. In contrast, we failed to obtain the same effect on parasite replication inside L. major-infected macrophages when the B-1 cells were isolated from IL-10 knockout mice. CONCLUSION Our results show that elevated levels of PGE2 and IL-10 produced by B-1 cells increase L. major growth, as indicated by the number of parasites

关键词： Leishmania major Macrophages B-1 cells Interleukin-10 Prostaglandin E2 Infection