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Bone changes in alcoholic liver disease

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World Journal of Hepatology 2015年第9期7卷 1258-1264页

作者： Emilio González-Reimers geraldine Quintero-Platt Eva Rodríguez-Rodríguez Antonio Martínez-Riera Julio Alvisa-Negrín Francisco Santolaria-Fernández Servicio de Medicina Interna Hospital Universitario de Canarias Universidad de La Laguna

Alcoholism has been associated with growth impairment, osteomalacia, delayed fracture healing, and aseptic necrosis(primarily necrosis of the femoral head), but the main alterations observed in the bones of alcoholic patients are osteoporosis and an increased risk of fractures. Decreased bone mass is a hallmark of osteoporosis, and it may be due either to decreased bone synthesis and/or to increased bone breakdown. Ethanol may affect both mechanisms. It is generally accepted that ethanol decreases bone synthesis, and most authors have reported decreased osteocalcin levels(a "marker" of bone synthesis), but some controversy exists regarding the effect of alcohol on bone breakdown, and, indeed, disparate results have been reported for telopeptide and other biochemical markers of bone resorption. In addition to the direct effect of ethanol, systemic alterations such as malnutrition, malabsorption, liver disease, increased levels of proinflammatory cytokines, alcoholic myopathy and neuropathy, low testosterone levels, and an increased risk of trauma, play contributory roles. The treatment of alcoholic bone disease should be aimed towards increasing bone formation and decreasing bone degradation. In this sense, vitamin D and calcium supplementation, together with biphosphonates are essential, but alcohol abstinence and nutritional improvement are equally important. In this review we study the pathogenesis of bone changes in alcoholic liver disease and discuss potential therapies.

关键词： Alcoholism Liver disease Osteoporosis Vitamin D Bone fractures

Liver steatosis in hepatitis C patients

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World Journal of Hepatology 2015年第10期7卷 1337-1346页

作者： Emilio González-Reimers geraldine Quintero-Platt Melchor Rodríguez-Gaspar Remedios Alemán-Valls Onán Pérez-Hernández Francisco Santolaria-Fernández Servicio de Medicina Interna Hospital Universitario de CanariasUniversidad de La LagunaTenerife

There is controversy regarding some aspects of hepatitis C virus(HCV) infection-associated liver steatosis,and their relationship with body fat stores. It has classically been found that HCV,especially genotype 3,exerts direct metabolic effects which lead to liver steatosis. This supports the existence of a so called viral steatosis and a metabolic steatosis,whichwould affect HCV patients who are also obese or diabetics. In fact,several genotypes exert metabolic effects which overlap with some of those observed in the metabolic syndrome. In this review we will analyse the pathogenic pathways involved in the development of steatosis in HCV patients. Several cytokines and adipokines also become activated and are involved in "pure" steatosic effects,in addition to inflammation. They are probably responsible for the evolution of simple steatosis to steatohepatitis,making it difficult to explain why such alterations only affect a proportion of steatosic patients.

关键词： Hepatitis C virus steatosis adiponectin Leptin Insulin resistance Proinflammatory cytokines Triglyceride synthesis Fatty acid oxidation

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具备瞬时抗皱性能的植物紧肤剂

日用化学品科学 2018年第1期41卷 54-57页

作者： DAVID BOUDIER ANNE-ISABEL GUZMAN STRUILLOU ESTELLE LE DUDAL MICHEL DANA geraldine BON MAUD LE GUILLOU BRIGITTE CLOSS SILAB

通过3D分子结构的糖交联剂创新技术,INSTENSYL~?PX(INCI木薯淀粉)能迅速附着在皮肤表面并延展形成一层粘弹性膜,同时改善一系列皮肤参数。通过其对皮肤表面功效、感知效果以及处理时间和皮肤区域的测试,表明INSTENSYL~?PX具有快速紧肤功... 详细信息

通过3D分子结构的糖交联剂创新技术,INSTENSYL~?PX(INCI木薯淀粉)能迅速附着在皮肤表面并延展形成一层粘弹性膜,同时改善一系列皮肤参数。通过其对皮肤表面功效、感知效果以及处理时间和皮肤区域的测试,表明INSTENSYL~?PX具有快速紧肤功效,仅使用5min后即可体验,并能持续4h以上。同时,INSTENSYL~?PX还具有即时平滑和抗皱功效,无论对年轻还是成熟肌肤均适用。

关键词：植物紧肤剂瞬时效果平滑抗皱

Initial Study of Electrospinning PCL/PLLA Blends

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Advances in Materials Physics and Chemistry 2011年第3期1卷 94-98页

作者： Guinea B. C. Cardoso geraldine N. R. Perea Marcos A. D’Avila Carmen G. B. T. Dias Cecília A. C. Zavaglia Antonio C. F. Arruda 不详

The process of electrospinning is considered one of the most promising methods for the fabrication of poly- mer nanofibers. This essentially consists of applying a high electric field, which causes stretching of the polymer which exits through a capillary. Among the numerous applications of this process, electrospinning allows the fabrication of semiconductor and conductive nanofibers from mixtures or solutions, which have great potential for applications in sensors and the fabrication of scaffolds for cell growth. The aim of this work was to analyze the properties of the blend, produces by the electrospinning of the PCL and PLLA solu- tion, with the focus to generate a promissory scaffold. PCL is a semi-crystalline aliphatic polymer that has a slower degradation rate 12 - 24 months. It has a low glass transition temperature at –60?C, a melting tem-perature at about 60?C, and a high thermal stability. Properties of PLA depend on the component isomers, processing temperature, annealing time and molecular weight. Thus were used PCL, from Aldrich, with Mw of 80,000 g/mol, and PLLA, sintered in laboratory, with Mw of 240,000 g/mol, were dissolved in chloroform (CHCl3, Merck) and acetone (Synth) by stirring for 6 hours. The solution was electrospinning for 1 hour us- ing the equipment made in the laboratory, the voltage used was 13 kv, the rate of 0.5 ml/h and an approxi- mate distance from the tip of the needle to the collector of 12 cm. The morphology of the samples was ob- served by images made with scanning electron microscopy (SEM) and also was analyzed by FT-IR and DSC.

关键词： Polymers Poly (ε-Caprolactone) Poly (L-Lactic Acid) Electrospinning

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HPV疫苗接种相关交流面临着挑战

中国全科医学 2010年第31期13卷 3487-3487页

作者： Elizabeth CF Brown Paul Little geraldine MLeydon 周淑新(译) 不详中国石油中心医院

背景自2008年秋天,英国启动了12～13岁女孩做人乳头状瘤病毒(HPV)免疫接种的国家项目。之前研究就公众对宫颈癌病因理解状况进行了调查,调查中发现,对HPV作用了解甚微。目的探究全科医生和开业护士对HPV免疫接种的看法,及早地实施国家... 详细信息

背景自2008年秋天,英国启动了12～13岁女孩做人乳头状瘤病毒(HPV)免疫接种的国家项目。之前研究就公众对宫颈癌病因理解状况进行了调查,调查中发现,对HPV作用了解甚微。目的探究全科医生和开业护士对HPV免疫接种的看法,及早地实施国家免疫接种项目,关注他们的角色和预期困难。方法 2008年3月,对英国汉普郡和威尔特郡17位全科医生和开业护士进行了半结构式面谈。结果识别交流新挑战流行话题,这些挑战与解释、认同及父母和孩子之间因疫苗接种发生分歧的管理关联。对学校的学生及其父母,要强调抉择的重要性,所表达出的担心关系到提供的信息是否充足。父母和孩子是否同意,对不同意见怎样管理还存在着不确定性。会晤的参与者认为若有提供疫苗无需父母同意的标准或许较为妥当,如资格评估。结论国家免疫项目的成功依赖于应对解释服务挑战能力,以保证个体能够了解做HPV免疫接种的潜在益处。初级保健起着重要作用,本研究也提示有些基本问题还需做进一步澄清。

关键词： HPV WONCA 疫苗接种论文摘要人乳头状瘤病毒汇编免疫接种开业护士

18F-FES PET显像:临床应用现状及潜力

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中华核医学与分子影像杂志 2019年第9期39卷 570-576页

作者：张敬勉张召奇(译) 赵新明(审校) geraldine J.Liao Amy S.Clark Erin K. Schubert David A. Mankoff 河北医科大学第四医院核医学科&PET/CT中心石家庄050011 Department of Radiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania Department of Radiology Hospital of the University of Pennsylvania Philadelphia Pennsylvania Division of Hematology Oncology Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania Division of Nuclear Medicine Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania

乳腺癌雌激素受体(ER)阳性表达提示预后良好,是内分泌治疗有效的必要指标。ER表达一般是通过体外肿瘤活组织检测评估。然而,最近的研究能够应用18F-氟雌二醇(18F-FES)PET显像进行体内ER表达的评估。临床研究已经证实应用18F-FES PET显... 详细信息

乳腺癌雌激素受体(ER)阳性表达提示预后良好,是内分泌治疗有效的必要指标。ER表达一般是通过体外肿瘤活组织检测评估。然而,最近的研究能够应用18F-氟雌二醇(18F-FES)PET显像进行体内ER表达的评估。临床研究已经证实应用18F-FES PET显像可在体内定量评估ER阳性表达,并且已开展将其作为活体内评估内分泌治疗效果方法的探索。该文概述了18F-FES的生物学和药代动力学特性,以及18F-FES PET显像在乳腺癌和其他疾病研究中的现有经验,并探讨了18F-FES PET显像潜在及未来的临床应用价值。

关键词：雌激素受体正电子发射计算机断层显像乳腺癌 18 F-FES

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如何保住你的工作

海外英语 2009年第7期 31-31页

作者： geraldine Sealey 常韦娜

除非你是希尔顿失散多年的妹妹，否则你一定要为经济状况（以及如何保位你的职业）担心。莱昂纳多·兰黛作为雅诗·兰黛公司的主席管理数千人，他的建议可以帮助你远离被解雇的风险。

关键词：经济状况希尔顿管理公司解雇

Agreement and conversion formula between mini-mental state examination and montreal cognitive assessment in an outpatient sample

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World Journal of Psychiatry 2016年第3期6卷 358-364页

作者： Luqman Helmi David Meagher Edmond O'Mahony Donagh O'Neill Owen Mulligan Sutha Murthy geraldine McCarthy Dimitrios Adamis Sligo Medical Academy NUI Galway and Sligo/Leitrim Mental Health Services Cognitive Impairment Research Group Graduate Entry Medical SchoolUniversity of Limerick Department of Psychiatry University Hospital Limerick Sligo/Leitrim Mental Health Services

AIM To explore the agreement between the mini-mental state examination(MMSE) and montreal cognitive assessment(Mo CA) within community dwelling older patients attending an old age psychiatry service and to derive and test a conversion formula between the two *** Prospective study of consecutive patients attending outpatient *** tests were administered by the same researcher on the same day in random *** The total sample(n = 135) was randomly divided into two *** to derive a conversion rule(n = 70),and a second(n = 65) in which this rule was *** agreement(Pearson's r) of MMSE and Mo CA was 0.86(P < 0.001),and Lin's concordance correlation coefficient(CCC) was 0.57(95%CI:0.45-0.66).In the second sample Mo CA scores were converted to MMSE scores according to a conversion rule from the first sample which achieved agreement with the original MMSE scoresof 0.89(Pearson's r,P < 0.001) and CCC of 0.88(95%CI:0.82-0.92).CONCLUSION Although the two scales overlap considerably,the agreement is *** conversion rule derived herein demonstrated promising accuracy and warrants further testing in other populations.

关键词： Mini mental state examination Montreal cognitive assessment Cognition Equation Assessment Old age psychiatry

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孤独症儿童早期干预丹佛模式