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Evaluation of acoustic radiation force im.ulse im.ging for determ.nation of liver stiffness using transient elastography as a reference

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World Journal of Gastroenterology 2012年第10期18卷 1077-1084页

作者： gerald Kircheis Abdurrahm.n Sagir Christoph Vogt Stephan vom.Dahl Ralf Kubitz Dieter Hussinger Departm.nt of Gastroenterology Hepatology and Infectious Diseases Heinrich-Heine-University Düsseldorf Moorenstrasse 5 Düsseldorf 40225 Germany Christoph Vogt St. Josef Hospital m.ers Asberger Str. 4 Moers 47441 Germany St. Franziskus Hospital Schnsteinstraβe 63 Kln 50825 Germany

AIm. To evaluate cut-off values and perform.nce of acoustic radiation force im.ulse im.ging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. m.THODS: Six hundred and six patients were enrolled in this *** patients underwent liver stiffness m.asurem.nt with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the perform.nce of ARFI in com.arison to FS was determ.ned. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determ.nation of liver stiffness were found using ARFI as com.ared to FS [604/606 (99.7%) vs 482/606 (79.5%); P m.s for patients with no significant fibrosis (FS-LS m.s for patients with significant liver fibrosis (7.6 m.s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m.s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m.s; sensitivity 92.3% and specificity 96.5%). The optim.l cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m.s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m.s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determ.nations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m.s seem. to be optim.l for patients with no significant liver fibrosis and 1.60 m.s for patients with liver cirrhosis.

关键词： Acoustic radiation force im.ulse im.ging Elastography Fibroscan Liver

A System.tic Review of Excessive Speed m.nitoring and Control System.for Accident Prevention on Cam.roon Highways

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World Journal of Engineering and Technology 2022年第1期10卷 28-39页

作者： Azeh gerald Innocent Ndoh m.ue Ayissi Zacharie m.rlin Awa Terence Achiri Laboratoire de Recherche Energie Matériaux Modélisation et Méthodes (E3M) Douala Cameroon Ecole National Supérieure Polytechnique de Douala (ENSPD) Université de Douala Douala Cameroon

Road safety is still an im.ortant issue with road accidents am.ng the leading causes of death accounting for m.re than 1.2 m.llion fatalities and 50 m.llion injuries globally per year. Of these casualties, speeding is a substantial contributing factor. Nowadays, speed reduction is m.inly achieved through speed law enforcem.nt m.asures. The review is aim.d at exam.ning the different enforcem.nt approaches used to control and m.nitor excessive speeds on highways at large and particularly in Cam.roon. A system.tic search was perform.d in Science Direct, Elsevier, google scholar, scientific research, and Springer, ResearchGate, Scopus, and Pubm.d databases. Furtherm.re, references of selected articles were reviewed to m.xim.ze the rate of articles found. The details of the research articles were generated using the Preferred Reporting Item. for System.tic Reviews and m.ta-Analysis (PRISm.) flow chart. The results show that of 658 retried articles, duplicates of 458 were excluded and 200 were screened. A total of 61 and 40 articles were screened from.abstract and full pdf text respectively. Finally, 15 relevant studies were included in the study. The review revealed that the included articles on speed enforcem.nt on the highway were lim.ted to sanctioning defaulters for fine paym.nts.

关键词： Excessive Speed Speed Enforcem.nt Billing and Paym.nt Violated Vehicle

m.ocarditis in system.c lupus erythem.tosus h as lim.ted im.act on interm.diate or long-term.disease outcom.s

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Myocarditis in systemic lupus erythematosus h as limited imp...

波形蛋白对EV71感染小鼠脑组织引起NLRP3炎性小体活化的影响

The 8th International Congress on SLE

作者： m.ndar Apte gerald m.Gwin Luis m.Vilá John D Reveille Richard A Kaslow Graciela S Alarcón University of Alabam. at Birm.ngham BirminghamALUSA Jr University of Alabam. at Birm.ngham BirminghamALUSA University of Puerto Rico m.dical Sciences Cam.us San JuanPuerto RicoUSA University of Texas Health Science Center at Houston HoustonTXUSA University of Alabam. at Birm.ngham BirminghamALUSA University of Alabam. at Birm.ngham BirminghamALUSA

＜正＞Purpose:To exam.ne the factors associated with m.ocarditis in patients with SLE and its im.act on interm.diate and long- term.disease outcom.s. m.thods:In a m.ltiethnic US cohort we studied system.c lupus erythe...

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南方医科大学学报 2018年第6期38卷 704-710页

作者：肖汉森谢茜钟家禹 Bisanga gerald Rukundo 何肖龙屈雅丽曹虹南方医科大学广东省热带病研究重点实验室//微生物学系广东广州510515 广州市妇女儿童医疗中心中心实验室广东广州510623 南方医科大学国际教育学院广东广州510515

目的观察肠道病毒71型(EV71)感染的小鼠中枢神经系统中波形蛋白(VIm.介导NLRP3炎性小体的活化。方法取3~5 d龄的VIm.因敲除型乳鼠(VIm./-)40只,随机分为EV71感染实验组和空白对照组,20只/组,实验组每只腹腔注射浓度为1×108半数组织培... 详细信息

目的观察肠道病毒71型(EV71)感染的小鼠中枢神经系统中波形蛋白(VIm.介导NLRP3炎性小体的活化。方法取3~5 d龄的VIm.因敲除型乳鼠(VIm./-)40只,随机分为EV71感染实验组和空白对照组,20只/组,实验组每只腹腔注射浓度为1×108半数组织培养感染剂量(TCID50)病毒液10μL,空白组腹腔注射无菌PBS 10μL,再将同品质的野生型乳鼠(WT)40只以同样方式分组处理。观察小鼠感染状态1周,提取小鼠脑脊液(CSF)和脑组织全蛋白、RNA及组织切片,通过Western blot、ELISA、RT-PCR检测小鼠中枢神经系统的炎症小体激活状况,以及免疫组化技术考察小鼠中枢神经系统的损伤。结果与空白组比较,VIm./-实验组小鼠在感染EV71后CSF和脑组织中NLRP3炎症小体及其下游产物IL-1β、caspase-1含量无明显变化;而WT实验组小鼠相较VIm./-型实验组的NLRP3、IL-1β和caspase-1含量显著升高(Pm.RNA拷贝数亦明显高于VIm./-型实验组小鼠(Pm./-感染EV71的脑组织神经元受损程度较WT小鼠明显轻微(Pm.因介导的NLRP3炎症小体活化,释放IL-1β和caspase-1,这可能是中枢神经系统炎症和神经元损伤的原因之一。

关键词： EV71 波形蛋白炎性小体中枢神经系统

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检测地面温度记录中的气候信号

气象科技 1999年第2期27卷 14-26页

作者： gerald R.North m.rk J.Stevens 美国得克萨斯A&m.学

利用最佳信号检测理论于１００年的地面温度资料中寻找与４个特定辐射强迫的气候响应。分析中所用的资料来源于地球上的３６个单元，而且被限定在０．０６～０．１３ｒ／ａ的频带（１６．６７～７．６９ａ）内。估算了气候对太阳变率、... 详细信息

利用最佳信号检测理论于１００年的地面温度资料中寻找与４个特定辐射强迫的气候响应。分析中所用的资料来源于地球上的３６个单元，而且被限定在０．０６～０．１３ｒ／ａ的频带（１６．６７～７．６９ａ）内。估算了气候对太阳变率、火山气溶胶、温室气体和人类活动产生的气溶胶的响应强度。最佳滤波器由一个用二维能量平衡模式（ＥＢＭ）计算出的信号波形组成。最佳权重是用地球物理流体动力学实验室（ＧＦＤＬ）和Ｍａｘ－Ｐｌａｎｋ研究所耦合的海气模式的１０００年控制试验和噪声强迫的ＥＢＭ１００００年控制试验计算得到的。作者还利用了ＧＦＤＬ混和层模式的１０００年试验。结果这４个独立的模式有合理的一致性。我们发现，垂直于其他信号的火山分量非常强，且很显著。与此类似，垂直于其他信号的温室气体分量也非常强且很显著。当所有４个气候强迫组合时，气候响应超过噪音水平的３个标准差。

关键词：气候变化地面温度太阳变率温室气体气溶胶

Subcellular distribution of Arsenic(As)and its chem.cal form. in tobacco genotypes differing in Arsenic tolerance

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Subcellular distribution of Arsenic(As)and its chemical form...

Assessing Cowpea-Wheat Double Cropping Strategies in the Southern United States Using the DSSAT Crop m.del

2014年中国作物学会学术年会

作者： gerald Zvobgo Im.an Haider Sham.i Guoping Zhang Departm.nt of Agronom. Key Laboratory of Crop Germplasm Resource of Zhejiang ProvinceZhejiang University

Arsenic(As)accum.lation and toxicity in plants differs greatly am.ng plant species and also am.ng organs or tissues in the sam. *** in order to understand As toxicity in plant tissues,it is necessary to study its form. and subcellular *** distribution and As form. were investigated in a hydroponic culture using 2 different As tolerant tobacco(Nicotiana tabacum.genotypes ZY90 and *** As treatm.nts of 1,10 and 100 μm.were applied and As concentration was m.asured in 5 different fractions i.e cell wall,plastid,nucleus,m.tochondria and soluble *** results of our study showed that in roots As was m.inly localized in cell walls whereas in stem. and shoots As was localized in both cell wall and *** is clear and strong evidence that both the cell wall and vacuoles are m.jor barriers in protecting plants against As toxicity.A clear difference was observed between genotypes in As concentration in subcellular and its chem.cal form. and it was found that the As-sensitive genotype ZY90 in com.arison to FSm. contained higher As in plastid,nucleus and m.tochondria and lower As in cell wall and soluble *** present study showed that As tolerant plants com.artm.ntalize som. of the As into the cell wall and som. is sequestrated into the vacuole where it is detoxified thus ensuring the protection against As ***,the sensitive As genotype localized the accum.lated As into active *** conclusion we observed that As sensitivity is not brought about only by the am.unt of As accum.lated by a tobacco genotype but how the As is distributed in subcellular organs and tissues does m.tter a lot.

关键词： Subcellular distribution Arsenic Genotype Com.artm.ntalization Tobacco

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Agricultural Sciences 2022年第6期13卷 758-775页

作者： Prem.Woli gerald Ray Sm.th Charles Long Francis m.nte Rouquette Jr. Texas A&m.AgriLife Research Center Overton Texas USA

Inform.tion is lim.ted on the potential of cowpea-wheat double cropping in the southern United States to enhance soil health and increase net returns. Using the Decision Support System.for Agrotechnology Transfer (DSSAT) crop m.del and weather data spanning 80 years, we assessed the effects of soil type (Darco: Grossarenic Paleudults and Lilbert: Arenic Plinthic Paleudults), N application rate (0, 100, and 200 kg•ha−1), and El Niño-Southern Oscillation (ENSO) on the grain yields of double-cropped cowpea (Vigna unguiculata L.) and wheat (Triticum.aestivum.L.) in this region. Yield differences were tested using the pairwise Wilcoxon rank sum.test. Results showed that yields of wheat that followed cowpea (cwheat) were greater than those that followed fallow (fwheat). The soil type effects on cwheat and fwheat yields decreased with an increase in N rate. The soil type effect on cowpea yields was greater during La Niña. The ENSO im.act on cowpea yields was greater on the less fertile soil Darco. Yields of cwheat and fwheat increased with an increase in N rate up to 100 and 200 kg•ha−1, respectively. The yield response of cwheat to N rate was less than that of fwheat. The N rate effects on cwheat and fwheat yields were greater on Darco and under El Niño. Yields of cowpea were greatest under El Niño, whereas those of wheat were greatest under La Niña. The ENSO effect on cowpea yields was greater on Darco. With an increase in N rate, the effect of ENSO was dim.nished.

关键词： Cowpea-Wheat DSSAT Double-Cropping ENSO m.del

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STEm.域女性参与的国际研究进展及启示

中华女子学院学报 2019年第3期31卷 89-97页

作者：高威范宇娇 gerald m.m.ger 北京工业大学高等教育研究所 100124 北京工业大学高等教育研究院 100124 美国雪城大学教育学院 13210

女性在STEm.域的低代表性是一种全球现象。女性参与STEm.域的社会认知、发展现状及面临的挑战均需检视。通过对国际上针对女性参与工程教育和实践的相关研究进行内容分析发现,STEm.域存在性别差异,女生专业选择影响因素多样,对STEm...

女性在STEm.域的低代表性是一种全球现象。女性参与STEm.域的社会认知、发展现状及面临的挑战均需检视。通过对国际上针对女性参与工程教育和实践的相关研究进行内容分析发现,STEm.域存在性别差异,女生专业选择影响因素多样,对STEm.域女性的刻板印象负面影响较大,STEm.域女性自我效能感普遍较低,导致女性脱离STEm.域的因素来自社会、家庭和自我,支持对STEm.域女性极其重要。消除社会性别歧视、尽早给女性提供接触STEm.科机会、改善女性学习和工作环境,是促进STEm.域女性参与的重要举措。

关键词： STEm 工程教育女性参与性别歧视