检索结果-南通市图书馆

Complement-dependent neuroinf.ammation in spinal cord injury:f.om pathology to therapeutic implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tf.ily f.ras Kobeissy Juanmarco Gutierrez Gonzalez Daniel Ref.i gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew f.Gary Ali M.Alawieh Department of.Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of.Neurology Yale UniversityNew HavenCTUSA Center f.r Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of.disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of.injury and optimize recovery in this *** the thorough investigation of.the complement system in triggering and propagating cerebral neuroinf.ammation,a similar role f.r complement in spinal neuroinf.ammation is a f.cus of.ongoing *** this work,we survey the current literature investigating the role of.complement in spinal cord injury including the sources of.complement proteins,triggers of.complement activation,and role of.ef.ector f.nctions in the *** study relevant data demonstrating the dif.erent triggers of.complement activation af.er spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** ef.ector f.nctions of.complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of.complement anaphylatoxins in spinal cord injury while emphasizing the lack of.pathophysiological understanding of.the role of.opsonins in spinal cord *** this pathophysiological review,we systematically review the dif.erent translational approaches used in preclinical models of.spinal cord injury and discuss the challenges f.r f.ture translation into human *** review emphasizes the need f.r f.ture studies to dissect the roles of.dif.erent complement pathways in the pathology of.spinal cord injury,to evaluate the phases of.involvement of.opsonins and anaphylatoxins,and to study the role of.complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinf.ammation neuroplasticity regeneration spinal cord injury targeted therapy

Artif.cial intelligence as a means to improve recognition of.gastrointestinal angiodysplasia in video capsule endoscopy

在线全文

学校读者我要写书评

暂无评论

Artif.cial Intelligence in Gastrointestinal Endoscopy 2021年第4期2卷 179-184页

作者： gerald A cox II Christian S Jackson Kenneth J Vega Department of.Medicine Loma Linda University Medical CenterLoma LindaCA 92354United States Gastroenterology Section VA Loma Linda Healthcare SystemLoma LindaCA 92357United States Division of.Gastroenterology and Hepatology Augusta University-Medical College of GeorgiaAugustaGA 30912United States

Gastrointestinal angiodysplasia(GIAD)is def.ned as the pathological process where blood vessels,typically venules and capillaries,become engorged,tortuous and thin walled–which then f.rm arteriovenous connections within the mucosal and submucosal layers of.the gastrointestinal *** are a signif.cant cause of.gastrointestinal bleeding and are the main cause f.r suspected small bowel *** make the diagnosis,gastroenterologists rely on the use of.video capsule endoscopy(VCE)to“target”***,the use of.VCE can be cumbersome secondary to reader f.tigue,suboptimal preparation,and dif.iculty in distinguishing *** human eye is *** same capsule study read by two dif.erent readers are noted to have miss rates like other f.rms of.*** intelligence(AI)has been a means to bridge the gap between human imperf.ction and recognition of.*** use of.AI in VCE have shown that detection has improved,however the other burdens and limitations still need to be *** use of.AI f.r the diagnosis of.GIAD shows promise and the changes needed to enhance the current practice of.VCE are near.

关键词： Artif.cial intelligence Video capsule endoscopy Gastrointestinal angiodysplasia Detection Bleeding Small bowel

Exploring the modulatory role of.bovine lactof.rrin on the microbiome and the immune response in healthy and Shiga toxin‑producing *** challenged weaned piglets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of.Animal Science and Biotechnology 2024年第3期15卷 1278-1291页

作者： Matthias Dierick Ruben Ongena Daisy Vanrompay Bert Devriendt Eric cox Laboratory of.Immunology Department of Translational PhysiologyInfectiology and Public HealthFaculty of Veterinary MedicineGhent UniversitySalisburylaan 1339820 MerelbekeBelgium Laboratory f.r Immunology and Animal Biotechnology Faculty of Bioscience EngineeringGhent UniversityCoupure links 6539000 GhentBelgium

Background Post-weaned piglets suf.er f.om f.8+Escherichia coli(***)inf.ctions resulting in post-weaning diar-rhoea or oedema *** used management strategies,including colistin and zinc oxide,have contrib-uted to the emergence and spread of.antimicrobial *** antimicrobials capable of.directly interacting with pathogens and modulating the host immune responses are being *** has shown promising results against porcine enterotoxigenic *** strains,both in vitro and in *** We investigated the inf.uence of.bovine lactof.rrin(bLf.on the microbiome of.healthy and inf.cted weaned ***,we assessed whether bLf.inf.uenced the immune responses upon Shiga toxin-producing ***(STEC)***,2 in vivo trials were conducted:a microbiome trial and a challenge inf.ction trial,using an f.8+STEC *** did not af.ect theα-andβ-***,bLf.groups showed a higher relative abundance(RA)f.r the Actinobacteria phylum and the Bif.dobacterium genus in the ileal *** analysing the immune response upon inf.ction,the STEC group exhibited a signif.cant increase in f.8-specif.c IgG serum levels,whereas this response was absent in the bLf.*** Taken together,the oral administration of.bLf.did not have a notable impact on theα-andβ-diversity of.the gut microbiome in weaned ***,it did increase the RA of.the Actinobacteria phylum and Bif.-dobacterium genus,which have previously been shown to play an important role in maintaining gut ***,bLf.administration during STEC inf.ction resulted in the absence of.f.8-specif.c serum IgG responses.

关键词： E.coli Immune modulation Lactof.rrin Microbiome

Quantum-mechanical ef.ects in photoluminescence f.om thin crystalline gold f.lms

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第4期13卷 783-794页

作者： Alan R.Bowman Alvaro Rodríguez Echarri f.temeh Kiani f.dil Iyikanat Ted V.Tsoulos Joel D.cox Ravishankar Sundararaman f.Javier García de Abajo Giulia Tagliabue Laboratory of.Nanoscience f.r Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICf.–Institut de Ciencies f.toniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Born-Institut BerlinGermany. POLIMA–Center f.r Polariton-driven Light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute f.r Advanced Study University of Southern DenmarkOdense MDenmark. Department of.Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. Department of.Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana de Recerca i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique source of.insight into hot carrier processes in metals,including those in plasmonic nanostructures used f.r sensing and energy ***,being weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly debated,and its potential f.r unraveling nanoscale carrier dynamics largely ***,we reveal quantum-mechanical ef.ects in the luminescence emanating f.om thin monocrystalline gold ***,we present experimental evidence,supported by f.rst-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission f.om electron/hole recombination)when exciting in the interband *** model allows us to identif. changes to the measured gold luminescence due to quantum-mechanical ef.ects as the gold f.lm thickness is ***,such ef.ects are observable in the luminescence signal f.om f.akes up to 40 nm in thickness,associated with the out-of.plane discreteness of.the electronic band structure near the f.rmi *** qualitatively reproduce the observations with f.rst-principles modeling,thus establishing a unif.ed description of.luminescence in gold monocrystalline f.akes and enabling its widespread application as a probe of.carrier dynamics and light-matter interactions in this *** study paves the way f.r f.ture explorations of.hot carriers and charge-transf.r dynamics in a multitude of.material systems.

关键词： luminescence quantum crystalline

Two upper bounds f.r the Erdos-Hooley Delta-f.nction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2023年第12期66卷 2683-2692页

作者： Regis de la Breteche gerald Tenenbaum Institut de Mathematiques Universite Paris CiteSorbonne UniversiteCNRSParis F-75013France Institut Elie Cartan Universite de LorraineVandoeuvre-les-NancyBP 70239France

f.r integer n≥1 and real u,let Δ(n,u):=|{d:d] n,e^(u)f.nction is then def.ned by Δ(n):=Max_(u∈R)Δ(n,u).We improve the current upper bounds f.r the average and normal orders of.... 详细信息

f.r integer n≥1 and real u,let Δ(n,u):=|{d:d] n,e^(u)f.nction is then def.ned by Δ(n):=Max_(u∈R)Δ(n,u).We improve the current upper bounds f.r the average and normal orders of.this arithmetic f.nction.

关键词： concentration of.divisors average order normal order Waring’s problem

Triphase Catalysis Based on Gemini Surf.ctant-Clay Intercalates

在线全文

学校读者我要写书评

暂无评论

Modern Research in Catalysis 2014年第2期3卷 26-34页

作者： Nahid Shabestary Derek T. Rensing Danielle N. Reed Alex f. Austif. Mark D. cox Department of.Chemistry Southern Illinois University Edwardsville Edwardsville USA

A series of.novel catalysts was developed using cationic Gemini surf.ctants intercalated in natural montmorillonite (MMT) clay. These Gemini surf.ctant-MMT intercalates were used to study the kinetics of.a nucleophilic displacement reactions converting n-butyl bromide to n-butyl chloride in a triphase catalytic (TC) system. Most reaction rates compared f.vorably to those of.biphase catalytic reactions where Gemini surf.ctants were used in the absence of.MMT. Catalytic activity varied with Gemini surf.ctant structure, specif.cally with carbon spacer group and side chain length. In addition to the ease of.catalyst separation that a triphase system af.ords, Gemini-MMT catalysts are stable and can be recycled and re-used several times.

关键词： Triphase Catalysis Gemini Surf.ctant Intercalation Reaction Nucleophilic Displacement Montmorillonite Phase Transf.r Catalysis

中国人头发纤维在UVA紫外光老化中的光谱学研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光谱学与光谱分析 2016年第6期36卷 1783-1788页

作者：唐颖 gerald J.Smith 北京工商大学北京市植物资源研究开发重点实验室北京100048 School of.Chemical and Physical Sciences Victoria University of Wellington

生活中,日光中的紫外辐射是导致头发光老化/光损伤的重要环境因素。长时间光照可使染发和天然发出现包括颜色褪变在内的退行性变化。以中老年人的自然灰发为样本来源,通过分离和人工漂染处理,获得了包括自然发色、漂白和染黑的六种头发... 详细信息

生活中,日光中的紫外辐射是导致头发光老化/光损伤的重要环境因素。长时间光照可使染发和天然发出现包括颜色褪变在内的退行性变化。以中老年人的自然灰发为样本来源,通过分离和人工漂染处理,获得了包括自然发色、漂白和染黑的六种头发类型,经过UVA（320～400nm）紫外光老化,采用漫反射光谱、三维荧光光谱和衰减全反射傅里叶变换红外光谱对头发纤维的老化特征进行无损分析,结合头发中光产生过氧化氢的定量分析,探讨了不同发色和漂染处理对头发耐光性的影响。结果表明,UVA辐照可通过Ⅱ型电子转移机制诱导头发中的光敏基团产生过氧化氢,导致纤维表面蛋白和色素分子的光氧化降解。自然发色与漂染发在光老化中的颜色变化不同：灰发和白发主要发生光黄化,人工染发和漂白发分别发生光褪色和光漂白。高湿度环境能加速头发的光降解。化学漂染处理会使头发中的光致过氧化氢水平升高,使纤维处于较高的氧化压力从而影响头发的光稳定性;而头发中的黑色素分子,包括天然黑色素和染发剂的人工黑色素,可能具有自由基产生与清除双重性。研究结果为建立中国人头发光损伤的光谱学评价方法和进一步研发针对国人发质的染护发产品提供了重要的实验基准数据。

关键词：头发纤维 UVA辐射漫反射光谱三维荧光光谱 ATR-f.IR 过氧化氢

在线全文

学校读者我要写书评

暂无评论

档案边缘

山西档案 1999年第1期 14-17页

作者： f.gerald·Ham 中国人民大学档案学院　　（100871）

为了适应社会结构的变化、文件数量剧增、信息缺失、文件易逝和技术进步，档案工作者应改变旧观念，投入智力资源，进行合作，积极主动地参与文件鉴定和档案接收，使档案工作不再是随着编史工作风气变化的“风向标”，档案不再只反映狭... 详细信息

为了适应社会结构的变化、文件数量剧增、信息缺失、文件易逝和技术进步，档案工作者应改变旧观念，投入智力资源，进行合作，积极主动地参与文件鉴定和档案接收，使档案工作不再是随着编史工作风气变化的“风向标”，档案不再只反映狭隘的研究兴趣（即原来的工作“中心”），而能真正反映人类生活的方方面面（即“边缘”）。这篇文章孕育了后保管模式的思想，六年后作者首次提出后保管概念。

关键词：档案工作者档案学专业档案馆档案工作者协会历史学家俄亥俄美国历史冯内古特口述史信息缺失

Impact of.an oligosaccharide-based polymer on the metabolic prof.les and microbial ecology of.weanling pigs experimentally inf.cted with a pathogenic ***

在线全文

学校读者我要写书评

暂无评论

Journal of.Animal Science and Biotechnology 2024年第2期15卷 749-764页

作者： Kwangwook Kim Cynthia Jinno Xunde Li David Bravo Eric cox Peng Ji Yanhong Liu Department of.Animal Science University of CaliforniaDavisCA 95616USA Department of.Animal Science Michigan State UniversityEast LansingMI 48824USA Cedars-Sinai Medical Center Los AngelesCA 90084USA School of.Veterinary Medicine University of CaliforniaDavisCA 95616USA Pancosma|ADM 1180 RolleSwitzerland Nutreco Exploration NutrecoThe Netherlands Department of.Virology Parasitology and ImmunologyGhent University9000 GhentBelgium Department of.Nutrition University of CaliforniaDavisCA 95616USA

Background Our previous study has reported that supplementation of.oligosaccharide-based polymer enhances gut health and disease resistance of.pigs inf.cted with enterotoxigenic ***(ETEC)f.8 in a manner similar to *** objective of.this study was to investigate the impacts of.oligosaccharide-based polymer or antibiotic on the host metabolic prof.les and colon microbiota of.weaned pigs experimentally inf.cted with ETEC *** Multivariate analysis highlighted the dif.erences in the metabolic prof.les of.serum and colon digesta which were predominantly f.und between pigs supplemented with oligosaccharide-based polymer and *** relative abundance of.metabolic markers of.immune responses and nutrient metabolisms,such as amino acids and carbohydrates,were signif.cantly dif.erentiated between the oligosaccharide-based polymer and antibiotic groups(qf.ld change>2.0).In addition,pigs in antibiotic had a reduced(Pf.Lachnospiraceae and Lactobacillaceae,whereas had greater(Pf.oligosaccharide-based polymer on the metabolic and microbial prof.les of.pigs is not f.lly understood,and f.rther exploration is ***,current research suggest that various mechanisms are involved in the enhanced disease resistance and perf.rmance in ETEC-challenged pigs by supplementing this polymer.

关键词： Carbadox Colon microbiota Enterotoxigenic E.coli f.8 Metabolomics Oligosaccharide-based polymer Weaned pigs