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High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D

Bioactive Materials 2022年第7期7卷 37-52页

作者： Diana Krüger Silvia Galli Berit Zeller-Plumhoff D.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese Philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht21502Germany University of Malmo Faculty of OdontologyDepartment of ProsthodonticsCarl Gustafs vag 34Klerken20506MalmoSweden Lund University Department of Clinical Sciences LundMedical Radiation PhysicsBarngatan 422242LundSweden Deutsches Elektronen-Synchrotron(DESY) Notkestrasse 8522607HamburgGermany Institute of Materials Physics Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht21502Germany University of Gothenburg Institute of OdontologyDepartment of ProsthodonticsMedicinaregatan 12 f41390GoteborgSweden

Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal ***,they are not yet routinely applied because their degradation behavior is not fully *** this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high ***-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 ***,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and ***(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate *** results showed that Mg-5Gd degraded faster and less homogeneously than *** alloys gradually form a stable degradation layer at the interface and were surrounded by new bone *** results were correlated to in vitro data obtained from the same material and *** average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for *** results suggest that both Mg-xGd alloys are suitable as materials for bone implants.

关键词： Magnesium alloys Biodegradable implant Micro-computed tomography degradation rate Degradation homogeneity Ex vivo imaging Ex vivo histology Histology vs.tomography

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On a Game of Gas Pipeline Projects Competition

On a Game of Gas Pipeline Projects Competition

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International Congress of Mathematicians 2002 Satellite Conference on Game Theory and Applications(ICM 2002 GTA)

作者： ger Klaassen Arkadii Kryazhimskii Oleg Nikonov Yaroslav Minullin International Institute for Applied Systems Analysis A-2361 Laxenburg Austria Moscow State University Urals State Technical University 620002 Mira 19EkaterinburgRussia

＜正＞Many models of energy market development and decision-making processes take into account the competition between energy suppliers,and the theory of games is an appropriate tool to study these *** known models deal with investment plans of large natural gas exporters to a specified gas market.A lot of papers are devoted to the market of Western Europe,some papers concern the Turkish and Asian gas *** paper is devoted to numerical analysis and modification of the game-theoretical gas market model developed in[10].We describe a software G-TIME elaborated for this purpose,results of simulation and sensitivity analysis on the data of Turkish gas *** last section deals with a notion of generalized Nash equilibrium which seems to be useful to take risk and uncertainty into account.1

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Palliative chemotherapy for gastroesophageal cancer in old and very old patients: A retrospective cohort study at the National Center for Tumor Diseases, Heidelberg

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World Journal of Gastroenterology 2015年第16期21卷 4911-4918页

作者： Anne Katrin Berger Stefanie Zschaebitz Christine Komander Dirk Jger Georg Martin Haag National Center for Tumor Diseases Heidelberg University Hospital NCT Clinical Cancer Registry German Cancer Research Center

AIM:To investigate the outcome of palliative chemotherapy in old patients with gastroesophageal cancer at the National Center for Tumor Diseases,***:Using a prospectively generated database,we retrospectively analyzed 55 patients≥70years under palliative chemotherapy for advanced gastroesophageal cancer at the outpatient clinic of the National Center for Tumor Diseases Heidelberg,germany between January 2006 and *** requirements for inclusion were(1)histologically proven diagnosis of gastroesophageal cancer;(2)advanced(metastatic or inoperable)disease;and(3)no history of radiation or *** clinical information included Eastern Cooperative Oncology Group performance status(ECOG PS),presence and site of metastases at diagnosis,date of previous surgery and perioperative chemotherapy,start and stop date of first-line treatment,toxicities and consecutive dosage reductions of first-line treatment,response to first-line therapy,date of progression,usage of second-line therapies and date and cause of *** times[progression-free survival(PFS),overall survival(OS)and residual survival(RS)]were *** and safety were *** factors including ECOG PS,age and previousperioperative treatment were ***:Median age of our cohort was 76 years.86%of patients received a combination of two cytotoxic drugs.76 percent of patients had an oxaliplatin-based first-line therapy with the oxaliplatin and 5-fluorouracil regimen being the predominantely chosen regimen(69%).Drug modifications due to toxicity were necessary in 56%of patients,and 11%of patients stopped treatment due to *** times of our cohort are in good accordance with the major phaseⅢtrials that included mostly younger patients:PFS and OS were 5.8 and 9.5 mo,*** differed significantly between patient groups with low(≤1)and high(≥2)ECOG PS(12.7 mo vs 3.8 mo,P<0.001).Very old patients(≥75 years)did not sho

关键词： Gastroesophageal cancer Old patients Palliative chemotherapy Toxicity Eastern CooperativeOncology Group performance status

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Numerical investigation of the dynamics of a rigidspherical particle in a vortical cross-slot flow atmoderate inertia

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Microsystems & Nanoengineering 2023年第4期9卷 181-195页

作者： Konstantinos Kechagidis Benjamin Owen Lionel Guillou Henry Tse Dino Di Carlo Timm Krüger School of Engineering Institute for Multiscale ThermofluidsUniversity of EdinburghW Mains RdEdinburgh EH93JW ScotlandUK Cytovale Inc.Executive Park Blvd.San Fransisco CA 90095 CAUSA Department of Bioengineering University of CaliforniaWestwood PlazaLos Angeles 610101 CAUSA

The study of flow and particle dynamics in microfluidic cross-slot channels is of high relevance for lab-on-a-chipapplications. In this work, we investigate the dynamics of a rigid spherical particle in a cross-slot junction for a channelheight-to-width ratio of 0.6 and at a Reynolds number of 120 for which a steady vortex exists in the junction *** an in-house immersed-boundary-lattice-Boltzmann code, we analyse the effect of the entry position of theparticle in the junction and the particle size on the dynamics and trajectory shape of the particle. We find that thedynamics of the particle depend strongly on its lateral entry position in the junction and weakly on its vertical entryposition;particles that enter close to the centre show trajectory oscillations. Larger particles have longer residencetimes in the junction and tend to oscillate less due to their confinement. Our work contributes to the understanding ofparticle dynamics in intersecting flows and enables the design of optimised geometries for cytometry and particlemanipulation.

关键词： particle dynamics spherical

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Fungal Decay, Coating, Burning Properties and Change of Color of Particleboards Manufactured with Woody Biomass, Agricultural Wastes and Tetra Pak Residues

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Journal of Biomaterials and Nanobiotechnology 2013年第4期4卷 334-342页

作者： Róger Moya Diego Camacho Julio Mata Roy Soto Fallas Escuela de Ingeniería Forestal Instituto Tecnológico de Costa Rica Cartago Costa Rica Escuela de Química Facultad de Ciencias Exactas y Naturales Universidad Nacional Heredia Costa Rica. Escuela de Química Facultad de Ciencias Universidad de Costa Rica San José Costa Rica

Lignocellulosic residues resulting from agricultural activities and urban centers cause pollution. A possible solution to this problem is to combine these residues with woody plants to produce particleboards. The purpose of this study was to evaluate decay resistance, coating and burning properties and the change of color caused by accelerated weathering of particleboards manufactured with a combination of 3 woody species used for commercial reforestation in tropical areas (Cupressus lusitanica, Gmelina arborea and Tectona grandis), pineapple (Ananas comosus) leaves from the crown and the plant (PL), empty fruit bunch of Elaeis guineensis (EBF) and tetra pak packages (TP). According to the results, the mixtures of T. grandis and EFB were classified as moderately resistant and other mixtures (woody species and PL or TP) were classified as slightly resistant. The finish performance test determined that the mixtures with TP presented the best performance, followed by the mixtures with oil palm components and the mixtures composed of pineapple leaves. Regarding lacquer consumption, no differences were found between the mixtures. The combustion test determined that particleboards with TP and EFB showed the highest resistance to combustion, while pineapple presented the lowest resistances to combustion. In the accelerated weathering exposure test, the mixtures of the three species with TP showed the best performance in accelerated weathering. Contrariwise, the mixtures with pineapple leaves showed the lowest resistance to accelerated weathering. Oil palm particleboards presented lower resistance to weathering than TP, though higher than pineapple leaves’ resistance.

关键词： Tropical Species Particleboards Lignocellulosic Residues Agricultural Crop

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电线套管固定部位的密封

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润滑与密封 2009年第7期34卷 91-93,83页

作者： Claus gerald Pflüger Werner Haas 沈洁斯图加特大学机械元件研究所斯图加特70569

反应室的电线通入口的密封是比较困难的。不良的密封条件,如蒸气、真空、高温以及医疗上除菌的用途使得电线密封需要特别的解决办法。提出了四种密封方案,并进行了密封性能实验。结果表明,采用将电线处密封和箱体处密封两个密封任务分... 详细信息

反应室的电线通入口的密封是比较困难的。不良的密封条件,如蒸气、真空、高温以及医疗上除菌的用途使得电线密封需要特别的解决办法。提出了四种密封方案,并进行了密封性能实验。结果表明,采用将电线处密封和箱体处密封两个密封任务分开进行的方法,即在反应室通入口处安装一个钢管,电线通过钢管伸入腔体,钢管和反应室间的密封采用O形圈,电线用热缩塑性套管加固的密封方案,实现了电线套管固定部位的密封。

关键词： O形圈密封电缆真空帆

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多变鱼腥藻半稳定状态连续培养的若干特征

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水生生物学报 1992年第3期16卷 224-229页

作者：刘永定黎尚豪 Ernst A Bger P 中国科学院水生生物研究所武汉430072 德意志联邦共和国Konstanz大学

分别使用恒化装置和全玻璃发酵罐连续培养多变鱼腥藻。在稳定条件下加以周期性的光照(L∶D=12∶12),经5—6d得到半稳定状态连续培养物。在光照阶段,培养物的生物量增长速度约等于稀释速度D的两倍,叶绿素的增长速度略小于D的两倍,糖原的... 详细信息

分别使用恒化装置和全玻璃发酵罐连续培养多变鱼腥藻。在稳定条件下加以周期性的光照(L∶D=12∶12),经5—6d得到半稳定状态连续培养物。在光照阶段,培养物的生物量增长速度约等于稀释速度D的两倍,叶绿素的增长速度略小于D的两倍,糖原的累积速度几乎高出D^5的一个数量级。细胞内糖原和蛋白质含量变化的时间过程反映出培养物在光-暗条件下的碳氮物质合成与消耗相互联系的代谢特点。半稳定状态连续培养受培养物内在的生理活性支配,生长参数的变化符合方程X=X_(oe)^((μ-D)~t),但不同于恒浊培养和恒化培养。外界因素的强弱变化只改变生长参量变化的强度。本法适用于研究微藻的生态生理。

关键词：连续培养多变鱼腥藻生态生理

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A NOVEL APPROACH FOR SIMULTANEOUS REDUCTION OF Fe^Ⅱ （EDTA） NO AND Fe^Ⅲ （EDTA） USING MICROORGANISMS

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化工学报 2003年第9期54卷 1340-1342页

作者：李伟施耀荆国华马碧瑶 CHANG Shih-ger Institute of Environmental Engineering Zhejiang University Environmental Energy Technology Division Lawrence Berkeley National Laboratory University of California

The emission of nitrogen oxides (NO_x) is one of the major causes of acid rain. The use of metal chelate additives in wet flue gas desulfurization (FGD) systems for combined removal of NO_x and SO_2 has attracted a great deal of attention. Fe~(II) (EDTA), (EDTA, thylenediaminetetraacetate) is one of the most promising additives to promote the solubility of NO by formation of Fe~(II) (EDTA) NO.

关键词：微生物法大气污染酸雨氮氧化物铁离子还原

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Tuning of surface plasmon resonances by preparation of silver/gold core- shell and alloy nanoparticles.

Tuning of surface plasmon resonances by preparation of silve...

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Ⅻ International Symposium on Small Particles and Inorganic Clusters

作者： Frank Hubenthal Torsten Ziegler Christian Hendrich Frank Trger Institut für Physik and Center for Interdisciplinary Nanostructure Science Technology-CINSaT Universitt KasselHeinrich-Plett-Str.4034132 KasselGermany

The optical properties of metal nanoparticles have been investigated quite extensively in the past. In particular, the field enhancement, which is associated with surface plasmon excitation has found special interest, because it is exploited in processes like surface-enhanced Raman scattering or enhanced fluorescence. For optimum interaction with a given wavelength, tailor-made nanoparticles of a certain size or shape are needed. This alone, however, does not nec-

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A SDUDY OF NEUROPHYSIOLOGICALLY COMPUTATIONAL MODEL FOR SPEECH PRODUCTION

A SDUDY OF NEUROPHYSIOLOGICALLY COMPUTATIONAL MODEL FOR SPEE...

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第十三届全国人机语音通讯学术会议(NCMMSC2015)

作者： Bogu Li Zhilei Liu Jianwu Dang Bernd Kr?ger Tianjin Key Lab.of Cognitive Computing and Application Department of Phoniatrics Pedaudiology and Communication Disorders Medical School RWTH Aachen University

In this paper, we propose a neurophysiologically computational model with a physio-logical articulatory model to simulate the entire neurophysiological process of speech production. Firstly, a set of speech data for vowels and consonant-vowel(CV) syllables was generated using the physiological articulatory model driven by muscle activations;and then, the generated dataset was used as training data to learn four self-organizing maps(SOMs):speech planning, motor control, auditory feedback, and somatosensory feedback. Experimental results demonstrate that the implementation of the physiological articulatory model in the neurophysiologically computational model faithfully reflects the neurophysiological process of human speech production. The multi-connection of neurons is well verified through the "One-to-many" projection between the SOMs. The distribution of tongue and jaw in the well learned motor control map is comparable with which observed in the electrocortigraphic(ECo G) studies.

关键词： neurophysiologically computational model speech production physiological articulatory model self-organizing map

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