检索结果-南通市图书馆

Microbial markers in colorectal cancer detection and/or prognosis

World Journal of Gastroenterology 2018年第22期24卷 2327-2347页

作者： Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet Université Clermont Auvergne Research Biologics Sanofi R&D Chirurgie digestive Centre Hospitalier Universitaire Université Clermont Auvergne Institut Universitaire de Technologie de Clermont-Ferrand

Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations.

关键词： Colorectal cancer microbiota F.nucleatum Colibactin-producing E.coli prognostic markers diagnostic markers dysbiosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Potential availability of non-woody biomass feedstock for pellet production within the Republic of Ireland

引用

International Journal of Agricultural and Biological Engineering 2010年第1期3卷 63-73页

作者： Anthony Nolan Kevin Mc Donnell ger J.Devlin John P.Carroll John Finnan Biosystems Engineering UCD School of AgricultureFood Science and Veterinary MedicineUniversity College DublinBelfieldDublin 4Ireland Teagasc Crops Research Centre Oak ParkCarlowIreland

The threat of increasing fuel prices and climate change necessitates the need for clean,renewable and independent energy sources.A GIS(Geographical Information Systems)model was developed using ArcGIS 9.2 to analyze the availability of non-woody biomass(wheat,oat,barley and rape straw,willow and miscanthus)for pellet production in *** within the heating and electricity sector would displace currently used fossil fuels with cleaner,carbon neutral non-woody *** aim of the analysis was to determine the total hectares of biomass within Ireland and compute the potential non-woody biomass *** greatest potential source of biomass for pelleting is cereal *** the Republic of Ireland the South-East,South-West and Mid-East of Ireland have the greatest biomass yield for pellet production and likely to be most economically ***-woody biomass has a realistic potential to displace fossil fuels within the heating and electricity sector resulting in CO2 mitigation.

关键词： biomass pellet production non-woody biomass GIS analysis renewable energy source CO2 mitigation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

德国GPS在线位移监控和预警系统工作原理与工程应用

引用

地质科技情报 2005年第B7期24卷 126-128页

作者：项伟 R.Jger 中国地质大学工程学院武汉430074 德国卡尔斯鲁厄应用科技大学卡尔斯鲁厄76133

德国GPS在线位移监控和预警系统,除了可以进行GPS测量和数据处理外,还可给出观测点的实时三维位移数据、位移速度和位移加速度,绘出分析曲线,其划量精度达毫米级,并可根据预先设定的破坏概率自动报警。该系统可预测和预警自然灾害如滑... 详细信息

德国GPS在线位移监控和预警系统,除了可以进行GPS测量和数据处理外,还可给出观测点的实时三维位移数据、位移速度和位移加速度,绘出分析曲线,其划量精度达毫米级,并可根据预先设定的破坏概率自动报警。该系统可预测和预警自然灾害如滑坡、泥石流、地震等;在矿山开采作业中,可对矿坑、尾矿坝及采空区的地表塌陷进行监控;可用于岩土工程和土木工程建设中的高边坡、建筑物、基坑、挡土墙以及塔楼和桥梁高频率运动的监测;可广泛应用于水利工程建设,如大坝、大堤位移和沉陷的监控等。在道路建设中,可应用于隧道开挖、路堤沉陷和桥梁位移的观测。

关键词：德国GPS 在线监测位移预警系统大坝

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The human sebaceous function

The human sebaceous function

引用

中华医学会第14次全国皮肤性病学术年会

作者： Dr.Saint-Léger L’Oreal Recherche

Modern therapeutic approaches allow to control sebaceous secretion but knowledge about the sebaceous gland and its precise function within the pilosebaceous unit is still insufficient. Steroid hormones are the principal al- beit not exclusive regulators of the sebaceous glands. Three phases may be distinguished in sebaceous physiol- ogy: secretion -production, stocking in the follicular reservoir, and excretion. Human"native"intracellular sebum, before secretion, is composed of squalene, waxes, and triglycerides. Once secreted, the sebum is col- onised by various xenobiots whose development is controlled by several defensive humoral mechanisms and by

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Towards Safer and More Sustainable Ways for Exploiting Nuclear Power

引用

World Journal of Nuclear Science and Technology 2020年第3期10卷 91-115页

作者： Wolfgang Krö ger Didier Sornette Ali Ayoub Department of Management Technology and Economics (D-MTEC) ETH Zurich Zurich Switzerland

Future electricity systems are challenged by deep decarbonization and concurrently increasing demand and there are growing concerns that renewables cannot shoulder this alone. Starting from the proven principle of diversity, we argue for keeping the nuclear option open or even for expanding its use. However, the perspectives are dim for the current technology as safety concerns and social aversion remain as fundamental problems. While looking for future revolutionary safe and more sustainable nuclear concepts we first review the main characteristics of civil nuclear energy, as well as its safety records and technical progress. We then list the key requirements for innovative nuclear systems designs which are less dependent on active safety systems and human performance as well as social stability. This allows us to provide a concept by concept comparison and assessment of existing and novel technologies and designs including different coolants and neutron spectra. The results indicate a high potential for far-reaching improvements compared to most advanced LWRs, although none of the candidate concepts meets all requirements convincingly, yet, helium cooled, small modular reactors (HTR-PM) come closest. We end by stressing the need for future research and development, and keeping human capital and know-how in nuclear energy;we call for an urgent increase in government and international RD&D funding by the order of a few hundreds of billions of USD per year, which will likely lead to breakthroughs that will restart productivity growth in severely affected stagnating modern economies.

关键词： Low-Carbon Energy Systems Sustainability Nuclear Safety Safety Requirements Advanced Reactor Concepts SMR RD&D Needs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用蒙特卡罗哈密顿量方法研究非S态

引用

高能物理与核物理 2005年第7期29卷 717-720页

作者：黄纯青黎永耀罗向前 H.Krger 中山大学物理系佛山科学技术学院光电子与物理学系佛山528000 华南农业大学应用物理系广州510642 Département de Physique Université Laval Québec PQ G1K 7P4 Canada

以氢原子为例,验证了MonteCarloHamiltonian(MCH)方法推广应用到量子力学系统中在原点发散的势的非S态的有效性,给出估计误差的新思路,得到和解析解相符的能谱和约化径向波函数.

关键词：哈密顿量蒙特卡罗量子力学系统径向波函数推广应用估计误差氢原子新思路发散原点约化能谱

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Direct extrusion of thin Mg wires for biomedical applications

引用

Transactions of Nonferrous Metals Society of China 2020年第2期30卷 373-381页

作者： K.TESAŘ K.BALÍK Z.SUCHARDA A.JÄger department of materials faculty of nuclear sciences and physical engineeringczech technical university in praguetrojanova 13prague12000czech republic department of dielectrics institute of physicsczech academy of sciencesna slovance 2prague18221czech republic department of composites and carbon materials institute of rock structure and mechanicsczech academy of sciencesv holešovičkách 41prague18209czech republic department of mechanics faculty of civil engineeringczech technical university in praguethákurova 7prague16629czech republic

Biodegradable wires,able to provide load-bearing support for various biomedical applications,are the novel trends in current biomaterial research.A thin 99.92%Mg wire with a diameter of 250μm was prepared via direct extrusion with an extreme reduction ratio of 1:*** total imposed strain in a single processing step was *** was carried out at elevated temperatures in the range from 230 to 310℃and with various ram speeds ranging from^0.2 to^0.5 mm/*** resulting wires show very good mechanical properties which vary with extrusion *** true tensile stress at room temperature reaches^228 MPa and ductility reaches^13%.The proposed single-step direct extrusion can be an effective method for the production of Mg wires in sufficient quantities for *** fractographic analysis revealed that failure of the wires may be closely connected with inclusions(e.g.,Mg O particles).The results are essential for determining the optimal processing conditions of hot extrusion for thin Mg *** smaller grain size,as the outcome of the lower extrusion temperature,is identified as the main parameter affecting the tensile properties of the wires.

关键词： biomedical materials mechanical properties fracture nonferrous metals magnesium

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A TDG/CBP/RARα Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes

引用

Genomics, Proteomics & Bioinformatics 2014年第1期12卷 8-18页

作者： Hélène Léger Caroline Smet-Nocca Amel Attmane-Elakeb Sara Morley-Fletcher Arndt G.Benecke Sebastian Eilebrecht Vaccine Research Institute INSERM U955Institut Mondor de Recherche Biomédicale Institut des Hautes tudes Scientifiques Unité de Glycobiologie Structurale et Fonctionnelle–CNRS UMR 8576 Group of NMR and Structural BiologyUniversité Lille 1 Unité de Glycobiologie Structurale et Fonctionnelle–CNRS UMR 8576 Neuroplasticity TeamUniversité Lille 1 CNRS UMR 7224 Université Pierre et Marie Curie

The thymine DNA glycosylase （TDG） is a multifunctional enzyme,which is essential for embryonic *** mediates the base excision repair （BER） of G：T and G：U DNA mismatches arising from the deamination of 5-methyl cytosine （5-MeC） and cytosine,*** studies have pointed at a role of TDG during the active demethylation of 5-MeC within CpG *** interacts with the histone acetylase CREB-binding protein （CBP） to activate CBP-dependent *** addition,TDG also interacts with the retinoic acid receptor α （RARα）,resulting in the activation of RARα target *** we provide evidence for the existence of a functional ternary complex containing TDG,CBP and activated RARα.Using global transcriptome profiling,we uncover a coupling of de novo methylation-sensitive and RA-dependent transcription,which coincides with a significant subset of CBP target *** introduction of a point mutation in TDG,which neither affects overall protein structure nor BER activity,leads to a significant loss in ternary complex stability,resulting in the deregulation of RA targets involved in cellular networks associated with DNA replication,recombination and *** thus demonstrate for the first time a direct coupling of TDG＇s epigenomic and transcription regulatory function through ternary complexes with CBP and RARα.

关键词： CREB-binding protein Thymine DNA glycosylase Retinoic acid receptor α Transcription regulation Cytosine DNA methylation Epigenomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transjugular intrahepatic portosystemic shunt vs conservative treatment for recurrent ascites:A propensity score matched comparison

引用

World Journal of Gastroenterology 2022年第41期28卷 5944-5956页

作者： Martin Philipp Theresia Blattmann Jörn Bienert Kristian Fischer Luisa Hausberg Jens-Christian Kröger Thomas Heller Marc-AndréWeber Georg Lamprecht Department of Medicine Division of Gastroenterology and EndocrinologyRostock University Medical CenterRostock 18057Germany Institute of Diagnostic and Interventional Radiology Pediatric Radiology and NeuroradiologyRostock University Medical CentreRostock 18057Germany

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS) placement is an effective intervention for recurrent tense ascites. Some studies show an increased risk of acute on chronic liver failure(ACLF) associated with TIPS placement. It is not clear whether ACLF in this context is a consequence of TIPS or of the pre-existing liver *** To better understand the risks of TIPS in this challenging setting and to compare them with those of conservative *** Two hundred and fourteen patients undergoing their first TIPS placement for recurrent tense ascites at our tertiary-care center between 2007 and 2017 were identified(TIPS group). Three hundred and ninety-eight patients of the same time interval with liver cirrhosis and recurrent tense ascites not undergoing TIPS placement(No TIPS group) were analyzed as a control group. TIPS indication,diagnosis of recurrent ascites, further diagnoses and clinical findings were obtained from a database search and patient records. The in-hospital mortality and ACLF incidence of both groups were compared using 1:1 propensity score matching and multivariate logistic *** After propensity score matching, the TIPS and No TIPS groups were comparable in terms of laboratory values and ACLF incidence at hospital admission. There was no detectable difference in mortality(TIPS: 11/214, No TIPS 13/214). During the hospital stay, ACLF occurred more frequently in the TIPS group than in the No TIPS group(TIPS: 70/214, No TIPS: 57/214, P = 0.04). This effect was confined to patients with severely impaired liver function at hospital admission as indicated by a significant interaction term of Child score and TIPS placement in multivariate logistic regression. The TIPS group had a lower ACLF incidence at Child scores < 8 points and a higher ACLF incidence at ≥ 11 points. No significant difference was found between groups in patients with Child scores of 8 to 10 *** TIPS placement for recurrent tense as

关键词： Liver cirrhosis Ascites Transjugular intrahepatic portosystemic shunt Acute on chronic liver failure Mortality Propensity score

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

敲低锌转运蛋白ZIP7抑制小鼠睾丸支持细胞增殖的研究

引用

生殖医学杂志 2024年第2期33卷 201-207页

作者：特力格尔刘璇李媛静李欢欢王树松马婧河北医科大学研究生院石家庄050017 河北师范大学化学与材料科学学院石家庄050024 河北省生殖健康医院河北省生殖医学重点实验室石家庄050071

目的探讨敲低锌转运蛋白ZIP7对小鼠睾丸支持细胞增殖的影响及其可能的作用机制。方法使用小鼠睾丸支持细胞系(TM4细胞)进行实验,TM4细胞培养后采用细胞免疫荧光染色法观察ZIP7在TM4细胞中的亚细胞定位;将TM4细胞分为对照组和ZIP7 siRNA... 详细信息

目的探讨敲低锌转运蛋白ZIP7对小鼠睾丸支持细胞增殖的影响及其可能的作用机制。方法使用小鼠睾丸支持细胞系(TM4细胞)进行实验,TM4细胞培养后采用细胞免疫荧光染色法观察ZIP7在TM4细胞中的亚细胞定位;将TM4细胞分为对照组和ZIP7 siRNA组(采用siRNA转染敲低TM4细胞中ZIP7表达),采用CCK8法检测两组细胞的增殖能力,使用DHE荧光探针检测两组细胞内活性氧(ROS)的水平,实时荧光定量PCR(qPCR)检测两组细胞内ZIP7 mRNA的相对表达量,Western blot法检测两组细胞内ZIP7、c-Jun氨基末端激酶(JNK)、磷酸化JNK(p-JNK)、细胞外信号调节激酶(ERK)及磷酸化ERK(p-ERK)蛋白表达水平。结果细胞免疫荧光染色法结果显示ZIP7定位于TM4细胞的内质网上。siRNA干扰使得ZIP7 siRNA组细胞中ZIP7的mRNA和蛋白表达显著低于对照组(P0.05),而p-JNK/JNK蛋白表达显著增加(P<0.05)。结论敲低ZIP7可以明显抑制TM4细胞增殖,该过程可能通过细胞内ROS水平的升高及JNK磷酸化的激活介导。

关键词：锌转运蛋白小鼠睾丸支持细胞活性氧 c-Jun氨基末端激酶细胞增殖

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：