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Intraoperative cholangiography 2020:Quo vadis? A systematic review of the literature

Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 145-153页

作者： Konstantinos georgiou Gabriel Sandblom Nicholas Alexakis Lars Enochsson First Department of Propaedeutic Surgery Hippokration General Hospital of AthensAthens Medical SchoolNational and Kapodistrian University of AthensAthens 10679Greece Department of Clinical Science and Education Department of SurgeryKarolinska InstitutetSödersjukhusetStockholm 17177SESweden Department of Surgical and Perioperative Sciences SurgeryUmeåUniversityUmeå90187SESweden

Background: There are few randomized controlled trials with sufficient statistical power to assess the effectiveness of intraoperative cholangiography(IOC) in the detection and treatment of common bile duct injury(BDI) or retained stones during cholecystectomy. The best evidence so far regarding IOC and reduced morbidity related to BDI and retained common bile duct stones was derived from large populationbased cohort studies. Population-based studies also have the advantage of reflecting the outcome of the procedure as it is practiced in the community at large. However, the outcomes of these population-based studies are conflicting. Data sources: A systematic literature search was conducted in 2020 to search for articles that contained the terms “bile duct injury”, “critical view of safety”, “bile duct imaging” or “retained stones” in combination with IOC. All identifed references were screened to select population-based studies and observational studies from large centers where socioeconomic or geographical selections were assumed not to cause selection bias. Results: The search revealed 273 references. A total of 30 articles fulflled the criteria for a large observational study with minimal risk for selection bias. The majority suggested that IOC reduces morbidity associated with BDI and retained common bile duct stones. In the short term, IOC increases the cost of surgery. However, this is offset by reduced costs in the long run since BDI or retained stones detected during surgery are managed immediately. Conclusions: IOC reduces morbidity associated with BDI and retained common bile duct stones. The reports reviewed are derived from large, unselected populations, thereby providing a high external validity. However, more studies on routine and selective IOC with well-defned outcome measures and sufficient statistical power are needed.

关键词： Cholangiography Cholecystectomy Bile duct stones Bile duct injury Cost

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Novel time slicing approach for customer defection models in e-commerce:a case study

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Data Science and Management 2022年第3期5卷 149-162页

作者： Kyriakos georgiou Alexandros Chasapis Data Science Department Finloup S.A.2 Evristheos11854AthensGreece Department of Statistics and Stochastic Modeling and Applications Laboratory Athens University of Economics and Business6 Patission Str10434AthensGreece

In this study,we examine the problem of predicting customer defection in a noncontractual *** by recent work on machine learning using multiple time slices,we develop a novel training and testing framework,the sliding multi-time slicing(SMTS)*** apply this method to data from the largest marketplace in Greece,namely,Skroutz,considering the standard features that account for the important characteristics of customer activity and custom performance metrics aimed at capturing business-related goals established by the *** dataset comprises customers over a relatively short period,since April 2018,the number of which has also exhibited a significant increase in recent *** these difficulties and the inherent seasonality of customer defection,our results demonstrate that,with SMTS,developing models that outperform previous approaches and optimize decision-making is *** validate the approach to a benchmark dataset from the commerce sector and discuss the practical considerations and requirements of the proposed method.

关键词： E-commerce Defection Seasonality Machine learning

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Retinal imaging in inherited retinal diseases

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Annals of Eye Science 2020年第3期5卷 30-49页

作者： Michalis georgiou Kaoru Fujinami Michel Michaelides UCL Institute of Ophthalmology University College LondonLondonUK Moorfields Eye Hospital NHS Foundation Trust LondonUK Laboratory of Visual Physiology Division of Vision ResearchNational Institute of Sensory OrgansNational Hospital Organization Tokyo Medical CenterTokyoJapan

Inherited retinal diseases(IRD)are a leading cause of blindness in the working age *** advances in ocular genetics,retinal imaging and molecular biology,have conspired to create the ideal environment for establishing treatments for IRD,with the first approved gene therapy and the commencement of multiple therapy *** scope of this review is to familiarize clinicians and scientists with the current landscape of retinal imaging in *** we present in a comprehensive and concise manner the imaging findings of:(I)macular dystrophies(MD)[Stargardt disease(ABCA4),X-linked retinoschisis(RS1),Best disease(BEST1),pattern dystrophy(PRPH2),Sorsby fundus dystrophy(TIMP3),and autosomal dominant drusen(EFEMP1)],(II)cone and cone-rod dystrophies(GUCA1A,PRPH2,ABCA4 and RPGR),(III)cone dysfunction syndromes[achromatopsia(CNGA3,CNGB3,PDE6C,PDE6H,GNAT2,ATF6],blue-cone monochromatism(OPN1LW/OPN1MW array),oligocone trichromacy,bradyopsia(RGS9/R9AP)and Bornholm eye disease(OPN1LW/OPN1MW),(IV)Leber congenital amaurosis(GUCY2D,CEP290,CRB1,RDH12,RPE65,TULP1,AIPL1 and NMNAT1),(V)rod-cone dystrophies[retinitis pigmentosa,enhanced S-Cone syndrome(NR2E3),Bietti crystalline corneoretinal dystrophy(CYP4V2)],(VI)rod dysfunction syndromes(congenital stationary night blindness,fundus albipunctatus(RDH5),Oguchi disease(SAG,GRK1),and(VII)chorioretinal dystrophies[choroideremia(CHM),gyrate atrophy(OAT)].

关键词： Retinal imaging inherited retinal disease retinitis pigmentosa macular dystrophy leber congenital amaurosis

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Acute chylous peritonitis due to acute pancreatitis

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World Journal of Gastroenterology 2012年第16期18卷 1987-1990页

作者： Georgios K georgiou Haralampos Harissis Michalis Mitsis Haralampos Batsis Michalis Fatouros Department of Surgery University Hospital of Ioannina45500 IoanninaGreece

We report a case of acute chylous ascites formation presenting as peritonitis(acute chylous peritonitis) in a patient suffering from acute pancreatitis due to hypertriglyceridemia and alcohol *** development of chylous ascites is usually a chronic process mostly involving malignancy,trauma or surgery,and symptoms arise as a result of progressive abdominal ***,when accumulation of "chyle" occurs rapidly,the patient may present with signs of *** diagnosis is difficult since the clinical picture usually suggests hollow organ perforation,appendicitis or visceral *** than 100 cases of acute chylous peritonitis have been *** is a rare cause of chyloperitoneum and in almost all of the cases chylous ascites is discovered some days(or even weeks) after the onset of symptoms of *** is the second case in the literature where the patient presented with acute chylous peritonitis due to acute pancreatitis,and the presence of chyle within the abdominal cavity was discovered simultaneously with the establishment of the diagnosis of *** patient underwent an exploratory laparotomy for suspected perforated duodenal ulcer,since,due to hypertriglyceridemia,serum amylase values appeared within the normal ***,abdominal computed tomography imaging was not diagnostic for *** abdominal lavage and drainage,the patient was successfully treated with total parenteral nutrition and octreotide.

关键词： Chylous ascites Chyloperitoneum Chyle Peritonitis Pancreatitis

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Tunable D peak in gated graphene

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Nano Research 2014年第3期7卷 338-344页

作者： Anna Ott Ivan A. Verzhbitskiy Joseph Clough Axel Eckmann Thanasis georgiou Cinzia Casiraghi Physics Departmen t Freie Universitat Berlin Berlin 14195 Germany School of Physics andAstronomy University of Manchester ManchesterM 13 9PL UK School of Chemistry University of Manchester Manchester M 13 9PL UK

We report the gate-modulated Raman spectrum of defective graphene. We show that the intensity of the D peak can be reversibly tuned by applying a gate voltage. This effect is attributed to chemical functionalization of the graphene crystal lattice, generated by an electrochemical reaction involving the water layer trapped at the interface between silicon and graphene.

关键词： graphene gating defects doping electrochemistry

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Role of probiotics,prebiotics and synbiotics in chemoprevention for colorectal cancer

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World Journal of Gastroenterology 2008年第42期14卷 6453-6457页

作者： Constantine Iosif Fotiadis Christos Nikolaou Stoidis Basileios georgiou Spyropoulos Eleftherios Dimitriou Zografos 3rd Surgical Clinic of the university hospital 'ATTIKON' Athens Greece

Colorectal cancer is the third most common form of *** treatments are all associated with a high risk of complications and a low success ***,synbiotics have been proposed as a new preventive and therapeutic *** is no direct experimental evidence for cancer suppression in humans as a result of the consumption of pro-,pre-or ***,there is a wealth of evidence emerging from laboratory *** mechanisms by which pro-,pre-and synbiotics may inhibit colon cancer are now beginning to be understood and will be addressed in the present review.

关键词： Probiotics Prebiotics Synbiotics Colorectalcancer Treatment Prevention

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Association of dissected ascending aorta diameter with preoperative adverse events in patients with acute type A aortic dissection

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World Journal of Cardiology 2022年第4期14卷 231-238页

作者： George Samanidis Meletios Kanakis Charalampos georgiou Konstantinos Perreas Department of Adult Cardiac Surgery Onassis Cardiac Surgery CenterAthens 17674Greece Department of Pediatric and Congenital Heart Surgery Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUND Acute type A aortic dissection(ATAAD)is a life-threatening disease associated with high morbidity and *** To evaluate the diameter of dissected ascending aorta in patients diagnosed with ATAAD and whether the aortic diameter is associated with preoperative adverse *** A total of 108 patients diagnosed with ATAAD who underwent emergency operation under hypothermic circulatory arrest were enrolled in this *** characteristics and perioperative data were *** all patients,preoperative chest and abdomen computed tomography(CT)scans were *** Median age of the patients was 61.5(52.5-70.5)years and median body mass index(BMI)was 28.2(25.1-32.6)cm^(2).The number of female patients was 37(25%).Median diameter of the ascending aorta was 5.0(4.5-6)cm and 53.8%of the patients had an aortic diameter5.5 cm,most of the patients with ATAAD had an aortic diameter of less than 5.5 *** diameter of the ascending aorta in patients diagnose with ATAAD is not associated with preoperative adverse events.

关键词： Acute Aortic dissection Type A Ascending aorta Diameter

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Three dimensional hydrodynamic modeling over bed forms in open channels

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International Journal of Sediment Research 2010年第4期25卷 431-440页

作者： K.EL KHEIASHY J.MCCORQUODALE I.georgiou E.MESELHE Kellogg Brown and Root Inc. (KBR) 4100 Clinton Drive 03-1130 Houston TX 77020 USA Civil and Environmental Engineering Department University of New Orleans New Orleans LA 70148 USA Earth and Environmental Sciences Department University of New Orleans New Orleans LA 70148 USA Civil Engineering Department University of Louisiana at Lafayette Lafayette LA 70504USA

Three dimensional numerical modeling ofidealized sand dunes was used to assess the capability of various modeling formulations to capture the flow structure and resistance introduced by bed forms which are similar to those in the Lower Mississippi River. The selected models were: ECOMSED (HydroQual), MIKE 3 [Danish Hydraulic Institute (DHI)] and H3D (Hayco). The study revealed that the hydrostatic versions of models did not capture the flow separation at the crest of the dunes; however, they did respond to the presence of bed forms and gave a total resistance similar to the nonhydrostatic models.

关键词： Bed forms Alluvial rivers Three dimensional models Mississippi river

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Early-onset gastrointestinal cancer:An epidemiological reality with great significance and implications

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 583-597页

作者： John K Triantafillidis Konstantinos georgiou Manousos M Konstadoulakis Apostolos E Papalois Department of IBD and GI Endoscopy Metropolitan General HospitalHolargos 15562AthensGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece 2nd Department of Surgery University of Athens School of MedicineAretaieion HospitalAthens 11528Greece

During the last few years,epidemiological data from many countries suggest that the incidence and prevalence of many cancers of the digestive system are shifting from the older to the younger ages,the so-called“early-onset cancer”.This is particularly evident in colorectal cancer and secondarily in other malignant digestive neoplasms,mainly stomach and in a lesser degree pancreas,and biliary *** should be emphasized that data concerning digestive neoplasms,except for those referring to the colon and stomach,could be characterized as rather *** exact magnitude of the shift in younger ages is expected to become clearer shortly,as long as relevant epidemiological data from many parts of the world would be *** most important question concerns the etiology of this phenomenon,since its magnitude cannot be explained solely by the better diagnostic methodology and the preventive programs applied in many *** existing data support the assumption that a number of environ-mental factors may play a primary role in influencing carcinogenesis,sometimes from *** that have appeared in the last decades related mainly to eating habits,consistency of gut microbiome and an increase of obese people interacting with genetic factors,ultimately favor the process of *** these factors however,are not entirely sufficient to explain the age-related changes in the frequency of digestive *** of the individual effect of each of the already known factors or factors likely to be involved in the etiology of this phenomenon and studies using state-of-the-art technologies to accurately determine the degree of the population exposure to these factors are *** this article,we attempt to describe the epidemiological data supporting the age-shifting of digestive malignancies and their possible ***,we propose some measures regarding the attitude of the scientific community to this alarming phenomenon.

关键词： Gastrointestinal cancer Endoscopy Epidemiology Early-onset Environment

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A Global Solution of the Einstein-Maxwell Field Equations for Rotating Charged Matter

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Journal of Modern Physics 2012年第9期3卷 1301-1310页

作者： Andreas georgiou School of Physics Astronomy and Mathematics University of Hertfordshire Hatfield UK

A stationary axially symmetric exterior electrovacuum solution of the Einstein-Maxwell field equations was obtained. An interior solution for rotating charged dust with vanishing Lorentz force was also obtained. The two spacetimes are separated by a boundary which is a surface layer with surface stress-energy tensor and surface electric 4-current. The layer is the spherical surface bounding the charged matter. It was further shown, that all the exterior physical quantities vanished at the asymptotic spatial infinity where spacetime was shown to be flat. There are two different sets of junction conditions: the electromagnetic junction conditions, which were expressed in the traditional 3-dimensional form of classical electromagnetic theory;and the considerably more complicated gravitational junction conditions. It was shown that both—the electromagnetic and gravitational junction conditions—were satisfied. The mass, charge and angular momentum were determined from the metric. Exact analytical formulae for the dipole moment and gyromagnetic ratio were also derived. The conditions, under which the latter formulae gave Blackett’s empirical result for rotating stars, were investigated.

关键词： Gravitation Exact Solutions Einstein-Maxwell Equations Rotation Charged Dust

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