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Effect of panel reactive antibodies on T cell immunity reinstatement following renal transplantation

World Journal of Transplantation 2022年第10期12卷 313-324页

作者： Lampros Vagiotas Maria Stangou Efstratios Kasimatis Aliki Xochelli Grigorios Myserlis georgios lioulios Vasiliki Nikolaidou Manolis Panteli Konstantinos Ouranos Nikolaos Antoniadis Daoudaki Maria Aikaterini Papagianni georgios Tsoulfas Asimina Fylaktou Department of Transplant Surgery School of MedicineAristotle University of ThessalonikiHippokration General HospitalThessaloniki 54642Greece Department of Nephrology School of MedicineAristotle University of ThessalonikiHippokration General HospitalThessaloniki 54642Greece Department of Immunology National Peripheral Histocompatibility CenterHippokration General HospitalThessaloniki 54642Greece Medical School Aristotle University of Thessaloniki Biochemistry LaboratorySchool of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece

BACKGROUND Chronic kidney disease is associated with immunological disorders,presented as phenotypic alterations of T *** changes are expected to be restored after a successful renal transplantation;however,additional parameters may contribute to this *** To evaluate the impact of positive panel reactive antibodies(PRAs)on the restoration of T cell phenotype,after renal *** CD4CD28null,CD8CD28null,natural killer cells(NKs),and regulatory T cells(Tregs)were estimated by flow cytometry at T0,T3,and T6 which were the time of transplantation,and 3-and 6-mo follow-up,*** were estimated regarding the presence or absence of *** Patients were classified in two groups:PRA(-)(n=43)and PRA(+)(n=28)*** and their subtypes were similar between the two groups at T0,whereas their percentage was increased at T3 in PRA(-)compared to PRA(+)[23(10.9-47.9)vs 16.4(7.5-36.8)μ/L,respectively;P=0.03].Lymphocyte changes in PRA(-)patients included a significant increase in CD4 cells(P<0.0001),CD8 cells(P<0.0001),and Tregs(P<0.0001),and a reduction of NKs(P<0.0001).PRA(+)patients showed an increase in CD4(P=0.008)and CD8(P=0.0001),and a reduction in NKs(P=0.07).CD4CD28null and CD8CD28null cells,although initially reduced in both groups,were stabilized *** Our study described important differences in the immune response between PRA(+)and PRA(-)patients with changes in lymphocytes and lymphocyte ***(+)patients seemed to have a worse immune profile after 6 mo follow-up,regardless of renal function.

关键词： Chronic kidney disease Panel reactive antibodies Lymphocyte subpopulation CD4CD28null cells CD8CD28null cells

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