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Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis

World Journal of Gastroenterology 2019年第5期25卷 539-551页

作者： Tilemachos Koutouratsas Theodora Kalli georgios Karamanolis Maria Gazouli Department of Basic Medical Science Laboratory of Biology School of Medicine University of Athens Gastroenterology Department Larnaca General Hospital Gastroenterology Unit 2nd Department of Surgery "Aretaieio"University Hospital School of Medicine University of Athens

Functional gastrointestinal disorders(FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis,exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue. Ghrelin's gene shows genetic polymorphism, while its protein product undergoes complex regulation and metabolism in the human body. Numerous studies have studied ghrelin's relation to the emergence of FGIDs, its potential value as an index of disease severity and as a predictive marker for symptom relief during attempted treatment. Despite the mixed results currently available in scientific literature, the plethora of statistically significant findings shows that disruptions in ghrelin genetics and expression are plausibly related to FGID pathogenesis. The aim of this paper is to review current literature studying these associations, in an effort to uncover certain patterns of alterations in both genetics and expression, which could delineate its true contribution to FGID emergence, either as a causative agent or as a pathogenetic intermediate.

关键词： Functional gastrointestinal disorders Functional colonic diseases Irritable bowel syndrome Cyclic vomiting syndrome Infantile colic Gastrointestinal disease Ghrelin Genetics Epigenetic processes

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On the connection between the solutions to the Dirac and Weyl equations and the corresponding electromagnetic four-potentials

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Communications in Theoretical Physics 2020年第4期72卷 52-63页

作者： Aristides I Kechriniotis Christos A Tsonos Konstantinos K Delibasis georgios N Tsigaridas Department of Physics University of ThessalyGR 35100 LamiaGreece Department of Computer Science and Biomedical Informatics University of ThessalyGR-35100 LamiaGreece Department of Physics School of Applied Mathematical and Physical SciencesNational Technical University of AthensGR-15780 Zografou AthensGreece

In this work we study in detail the connection between the solutions to the Dirac and Weyl equations and the associated electromagnetic ***,it is proven that all solutions to the Weyl equation are degenerate,in the sense that they correspond to an infinite number of electromagnetic *** far as the solutions to the Dirac equation are concerned,it is shown that they can be classified into two *** elements of the first class correspond to one and only one four-potential,and are called non-degenerate Dirac *** the other hand,the elements of the second class correspond to an infinite number of four-potentials,and are called degenerate Dirac ***,it is proven that at least two of these fourpotentials are gauge-inequivalent,corresponding to different electromagnetic *** order to illustrate this particularly important result we have studied the degenerate solutions to the forcefree Dirac equation and shown that they correspond to massless *** have also provided explicit examples regarding solutions to the force-free Weyl equation and the Weyl equation for a constant magnetic *** all cases we have calculated the infinite number of different electromagnetic fields corresponding to these ***,we have discussed potential applications of our results in cosmology,materials science and nanoelectronics.

关键词： Dirac equation Weyl equation degenerate solutions electromagnetic four-potentials electromagnetic fields massless particles

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Think twice before implanting leads in a swimmer:challenges in lead implantation of an implantable cardioverter-defibrillator

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Journal of Geriatric Cardiology 2021年第7期18卷 595-596页

作者： Dimitrios Varvarousis Vasileios Doulamis Nikolaos Parzakonis georgios Kourgiannidis Cardiology Department Asklepeion General HospitalAthensGreece Cardiology Department 251 Air Force General HospitalAthensGreece

An 84-year-old male patient with an implantable cardioverter defibrillator(ICD)was admitted due to an alarming sound of his *** had a left-sided,dual chamber,dual-coil ICD implanted 7 years ago due to ischemic cardiom... 详细信息

关键词： admitted cardiomyopathy implantation

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Acute coronary syndrome after infliximab therapy in a patient with Crohn’s disease

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World Journal of Gastroenterology 2006年第38期12卷 6235-6238页

作者： Vasilios Panteris Anna Perdiou Vasilios Tsirimpis Demetrios georgios Karamanolis Department of Gastroenterology "Tzaneio" General Hospital Piraeus Greece Hematology and Laboratory Medicine "Tzaneio" General Hospital Piraeus Greece Department of Cardiology "Tzaneio" General Hospital Piraeus Greece

Infliximab is a potent anti-TNF antibody, which is used with great success in Crohn’s disease patients. Since its release in clinical practice, several adverse reactions have been observed. The interest in possible consequences of its administration is still high because of the recent introduction of the drug for the long-term maintenance therapy of refractory luminal and fistulizing Crohn’s disease. We present a case of acute coronary syndrome (non-STEMI) in a patient with corticoid resistant Crohn’s disease after his first dose of infliximab. By reviewing the scant articles that exist in the literature on this topic we made an effort to delineate the possible mechanisms of this phenomenon.

关键词： Infliximab Adverse reactions Crohn's disease Myocardial infarction Ischemic heart disease TNF-α

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The use of an artificial neural network in the evaluation of the extracorporeal shockwave lithotripsy as a treatment of choice for urinary lithiasis

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Asian Journal of Urology 2022年第2期9卷 132-138页

作者： Athanasios Tsitsiflis Yiannis Kiouvrekis georgios Chasiotis georgios Perifanos Stavros Gravas Ioannis Stefanidis Vassilios Tzortzis Anastasios Karatzas Department of Urology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissaGreece Department of Public and Integrated Health University of ThessalyKarditsaGreece Business School University of NicosiaNicosiaCyprus Department of Internal Medicine Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissaGreece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissaGreece

Objective:Artificial neural networks(ANNs)are widely applied in medicine,since they substantially increase the sensitivity and specificity of the diagnosis,classification,and the prognosis of a medical *** this study,we constructed an ANN to evaluate several parameters of extracorporeal shockwave lithotripsy(ESWL),such as the outcome and safety of the ***:Patients with urinary lithiasis suitable for ESWL treatment were *** ANN was designed using *** data were collected from all patients and 12 nodes were used as *** statistical analysis was also ***:Finally,716 patients were included in our *** analysis revealed that diabetes and hydronephrosis were positively correlated with ESWL *** efficacy,univariate analysis revealed that stone location,stone size,the number and density of shockwaves delivered,and the presence of a stent in the ureter were independent factors of the ESWL *** was further confirmed when adjusted for sex and age in a multivariate *** performance of the ANN at the end of the training state reached 98.72%.The four basic ratios(sensitivity,specificity,positive predictive value,and negative predictive value)were calculated for both training and evaluation data *** performance of the ANN at the end of the evaluation state was 81.43%.Conclusion:Our ANN achieved high score in predicting the outcome and the side effects of the ESWL treatment for urinary stones.

关键词： Artificial neural network Extracorporeal lithotripsy Urinary lithiasis Lithotripsy efficacy Lithotripsy complications

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Lingual Nerve Entrapment in Muscular and Osseous Structures

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International Journal of Oral Science 2010年第4期2卷 181-189页

作者： Maria Piagkou Theano Demesticha Giannoulis Piagkos Androutsos georgios Skandalakis Panagiotis Department of Anatomy School of MedicineFaculty of Health SciencesUniversity of Athens

Running through the infratemporal fossa is the lingual nerve （i.e. the third branch of the posterior trunk of the mandibular nerve）. Due to its location, there are various anatomic structures that might entrap and potentially compress the lingual nerve. These anatomical sites of entrapment are：（a） the partially or completely ossified pterygospinous or pterygoalar ligaments; （b） the large lamina of the lateral plate of the pterygoid process; and （c） the medial fibers of the anterior region of the lateral pterygoid muscle. Due to the connection between these nerve and anatomic structures, a contraction of the lateral pterygoid muscle, for example, might cause a compression of the lingual nerve. Any variations in the course of the lingual nerve can be of clinical significance to surgeons and neurologists because of the significant complications that might occur. To name a few of such complications, lingual nerve entrapment can lead to：（a） numbness, hypoesthesia or even anesthesia of the tongue’s mucous glands; （b） anesthesia and loss of taste in the anterior two-thirds of the tongue; （c） anesthesia of the lingual gums; and （d） pain related to speech articulation disorder. Dentists should, therefore, be alert to possible signs of neurovascular compression in regions where the lingual nerve is distributed.

关键词： lingual nerve compression pterygospinous ligament lateral pterygoid muscle

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Management of hepatitis B virus infection in patients with inflammatory bowel disease under immunosuppressive treatment

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World Journal of Gastroenterology 2021年第25期27卷 3762-3779页

作者： georgios Axiaris Evanthia Zampeli Spyridon Michopoulos Giorgos Bamias Gastroenterology Department "Alexandra"HospitalAthens 11528Greece GI Unit 3^(rd)Academic Department of Internal MedicineNational and Kapodistrian University of AthensSotiria HospitalAthens 11526Greece

Hepatitis B remains a significant global clinical problem,despite the implementation of safe and effective vaccination *** prevalence of hepatitis B virus(HBV)in patients with inflammatory bowel disease(IBD)largely follows the regional epidemiologic *** screening with hepatitis B surface antigen(HBsAg),and antibodies to hepatitis B surface(anti-HBs)and core(anti-HBc)proteins is a key element in the management of IBD patients and,ideally,should be performed at IBD *** of individual cases should be done according to the serologic profile and the IBD-specific treatment,with particular emphasis in patients receiving immunosuppressive *** patients who have not contracted HBV,vaccination is indicated to accomplish protective *** in immunosuppressed patients,however,is a challenging issue and several strategies for primary and revaccination have been *** risk of HBV reactivation in patients with IBD should be considered in both HBsAg-positive and HBsAg-negative/anti-HBc-positive patients,when immunosuppressive therapies are *** reactivation is preventable via the administration of prophylactic nucleot(s)ide analogues and should be the standard approach in HBsAg-positive ***-negative/anti-HBcpositive patients represent a non-homogeneous group and bear a significantly lower risk of HBV ***,serological and molecular monitoring is currently the recommended approach for anti-HBc *** HBV infection is rarely reported in IBD *** the present review,we outline the problems associated with HBV infection in patients with IBD and present updated evidence for their management.

关键词： Hepatitis B virus Inflammatory bowel disease Reactivation Immunosuppression Vaccination Prophylaxis

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Thermal Characterization of Lauric Acid and Stearic Acid Binary Eutectic Mixture in Latent Heat Thermal Storage Systems with Tube and Fins

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Journal of Wuhan University of Technology(Materials Science) 2017年第4期32卷 753-759页

作者：丁磊 WANG Lixiong georgios Kokogiannakis Lü Yajun 周卫兵 School of Architecture Tianjin University Sustainable Buildings Research Centre University of Wollongong School of Architecture North China University of Water Resources and Electric Power School of Materials Science and Engineering Wuhan University of Technology

In order to obtain the suitable phase change material（PCM） with low phase change temperature and improve its heat transfer rate, experimental investigation was conducted. Firstly, different mass ratios of lauric acid（LA） and stearic acid（SA） eutectic mixtures were prepared and characterized by differential scanning calorimetry（DSC）. Then, the performance of eutectic mixture during charging process under different fin widths in vertical condition, and performance during charging and discharging processes under different inlet temperature heat transfer fluid（HTF） in horizontal condition were investigated, respectively. The results revealed that the LA-SA eutectic mixture had the suitable phase change temperature and desired latent heat for low-temperature water floor heating system. Wide fins and high inlet temperature HTF significantly enhanced the transfer rate and decreased the melting time.

关键词： LA-SA binary eutectic mixture thermal properties heat exchanger heat transfer mechanism

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A systematic review of teleophthalmological studies in Europe

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 314-325页

作者： georgios Labiris Eirini-Kanella Panagiotopoulou Vassilios P.Kozoboli Department of Ophthalmology University Hospital of AlexandroupolisDraganaAlexandroupolis 68 100Greece Eye Institute of Thrace Alexandroupolis 68100Greece

A systematic review of the recent literature regarding a series of ocular diseases involved in European telemedicine projects was performed based on the Pub Med, Google Scholar and Springer databases in June 2017. Literature review returned 44 eligible studies; among them, emergency ophthalmology, diabetic retinopathy, glaucoma, age-related macular disease, cataract and retinopathy of prematurity. The majority of studies indicate teleophthalmology as a valid, reliable and cost-efficient method for care-provision in ophthalmology patients which delivers comparable outcomes to the traditional examination methods.

关键词： teleophthalmology telemedicine Europe glaucoma cataract diabetic retinopathy

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Infective endocarditis as a rare cause for acute limb ischemia

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World Journal of Emergency Medicine 2016年第3期7卷 231-233页

作者： George Galyfos Sotirios Giannakakis Stavros Kerasidis georgios Geropapas georgios Kastrisios Gerasimos Papacharalampous Chrisostomos Maltezos Department of Vascular Surgery KAT General Hospital Athens 14122 Greece

Infective endocarditis （IE） occurs at a rate of approximately 1-7/100 000 people per year, and has a high morbidity and mortality despite advances in antibiotic and surgical treatments.

关键词： Infective endocarditis acute limb ischemia

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