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Pseudoexfoliation syndrome and cardiovascular diseases

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World Journal of Cardiology 2014年第8期6卷 847-854页

作者： georgios k andrikopoulos Dimitrios k Alexopoulos Sotirios P Gartaganis Department of Ophthalmology University of Patras Medical School26504 PatrasGreece Department of Internal Medicine Division of CardiologyUniversity of Patras Medical School26504 PatrasGreece

Pseudoexfoliation(PEX) syndrome is a well-recognized late-onset disease caused by a generalized fibrillopathy. It is linked to a broad spectrum of ocular complications including glaucoma and perioperative problems during cataract surgery. Apart from the long-known intraocular manifestations, PEX deposits have been found in a variety of extraocular locations and they appear to represent a systemic process associated with increased cardiovascular and cerebrovascular morbidity. However, as published results are inconsistent, the clinical significance of the extraocular PEX deposits remains controversial. Identification of PEX deposits in the heart and the vessel wall, epidemiologic studies, as well as, similarities in pathogenetic mechanisms have led to the hypothesis of a possible relation between fibrillar material and cardiovascular disease. Recent studies suggest that PEX syndrome is frequently linked to impaired heart and blood vessels function. Systemic and ocular blood flow changes, altered parasympathetic vascular control and baroreflex sensitivity, increased vascular resistance and decreased blood flow velocity, arterial endothelial dysfunction, high levels of plasma homocysteine and arterial hypertension have all been demonstrated in PEX subjects. Common features in the pathogenesis of both atherosclerosis and PEX, like oxidative stress and inflammation and a possible higher frequency of abdominal aorta aneurysm in PEX patients, could imply that these grey-white deposits and cardiovascular disorders are related or reflect different manifestations of the same process.

关键词： Pseudoexfoliation Cardiovascular disease Cerebrovascular disease Coronary artery disease Homocysteine

Real-time cardiovascular magnetic resonance-guided radiofrequency ablation:A comprehensive review

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世界心脏病学杂志:英文版(电子版) 2023年第9期15卷 415-426页

作者： konstantinos Tampakis Sokratis Pastromas Alexandros Sykiotis Stamatina kampanarou georgios kourgiannidis Chrysa Pyrpiri Maria Bousoula Dimitrios Rozakis George andrikopoulos Department of Pacing&Electrophysiology Henry Dunant Hospital CenterAthens 11526Greece Department of Radiology Henry Dunant Hospital CenterAthens 11526Greece Department of Anesthesiology Henry Dunant Hospital CenterAthens 11526Greece

Cardiac magnetic resonance(CMR)imaging could enable major advantages when guiding in real-time cardiac electrophysiology procedures offering high-resolu-tion anatomy,arrhythmia substrate,and ablation lesion visualization in the absence of ionizing *** the last decade,technologies and platforms for performing electrophysiology procedures in a CMR environment have been ***,performing procedures outside the conventional fluoro-scopic laboratory posed technical,practical and safety *** development of magnetic resonance imaging compatible ablation systems,the recording of high-quality electrograms despite significant electromagnetic interference and reliable methods for catheter visualization and lesion assessment are the main limiting *** first human reports,in order to establish a procedural workflow,have rationally focused on the relatively simple typical atrial flutter ablation and have shown that CMR-guided cavotricuspid isthmus ablation represents a valid alternative to conventional *** expansion to other more complex arrhythmias,especially ventricular tachycardia and atrial fibrillation,would be of essential impact,taking into consideration the widespread use of substrate-based ***,all limitations need to be solved before application of CMR-guided ablation in a broad clinical setting.

关键词： Interventional cardiac magnetic resonance Image-guided ablation Substrate ablation Cavotricuspid isthmus Catheter ablation Tracking

On the connection between the solutions to the Dirac and Weyl equations and the corresponding electromagnetic four-potentials

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Communications in Theoretical Physics 2020年第4期72卷 52-63页

作者： Aristides I kechriniotis Christos A Tsonos konstantinos k Delibasis georgios N Tsigaridas Department of Physics University of ThessalyGR 35100 LamiaGreece Department of Computer Science and Biomedical Informatics University of ThessalyGR-35100 LamiaGreece Department of Physics School of Applied Mathematical and Physical SciencesNational Technical University of AthensGR-15780 Zografou AthensGreece

In this work we study in detail the connection between the solutions to the Dirac and Weyl equations and the associated electromagnetic ***,it is proven that all solutions to the Weyl equation are degenerate,in the sense that they correspond to an infinite number of electromagnetic *** far as the solutions to the Dirac equation are concerned,it is shown that they can be classified into two *** elements of the first class correspond to one and only one four-potential,and are called non-degenerate Dirac *** the other hand,the elements of the second class correspond to an infinite number of four-potentials,and are called degenerate Dirac ***,it is proven that at least two of these fourpotentials are gauge-inequivalent,corresponding to different electromagnetic *** order to illustrate this particularly important result we have studied the degenerate solutions to the forcefree Dirac equation and shown that they correspond to massless *** have also provided explicit examples regarding solutions to the force-free Weyl equation and the Weyl equation for a constant magnetic *** all cases we have calculated the infinite number of different electromagnetic fields corresponding to these ***,we have discussed potential applications of our results in cosmology,materials science and nanoelectronics.

关键词： Dirac equation Weyl equation degenerate solutions electromagnetic four-potentials electromagnetic fields massless particles

Radiological simultaneous portohepatic vein embolization(RASPE)and major hepatectomy with hepatocellular carcinoma(HCC)

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 267-269页

作者： georgios k.Glantzounis Anastasia karampa Dimitra Peristeri HPB Unit Department of SurgeryUniversity Hospital of Ioannina and School of MedicineUniversity of IoanninaIoanninaGreece

Radiological simultaneous portohepatic vein embolization(RASPE)is a relatively new technique,which aims to rapidly increase the future liver remnant(FLR)in patients with very small FLR in order to undergo major hepate... 详细信息

关键词： hepatic hepatectomy simultaneous

Anion effect on Li/Na/k hybrid electrolytes for Graphite//NCA(LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2))Li-ion batteries

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Journal of Energy Chemistry 2022年第1期31卷 451-462,I0012页

作者： Aiman Jrondi georgios Nikiforidis Meriem Anouti Laboratoire PCM2E Universite de ToursFaculte des sciences et technologiePare de Grandmont37200 ToursFrance LE STUDIUM Institute for Advanced Studies 45000 OrleansFrance

The electrolyte is an essential component of a battery system since it is responsible for the conduction of ions between the *** the quest for cheaper alternatives to common organic electrolytes for lithium-ion batteries(LIB),we formulated hybrid electrolytes comprising a mixture of Na,k,and Li alkaline salts with ethylene carbonate(EC),ethyl methyl carbonate(EMC),and lithium hexafluorophosphate(LiPF_(6)),giving a total salt concentration of 1.5 M;we determined their physicochemical properties and investigated their electrochemical behavior on a nickel cobalt aluminum oxide(NCA)cathode and graphite(Gr)*** electrolytes demonstrated a melting transition peak(T_(m)).eutectic behavior,and ionic conductivities(-13 mS cm^(-1))close to those of a commercial LIB electrolyte(SE,EC/EMC+1 M LiPF_(6))and activation energies of ca.3 kJ mol^(-1).The half-cell coin cells revealed high coulombic efficiency(99%),specific capacity(175 mAh g^(-1) at C/10),and capacity retention(92% for NaCF_(3)SO_(3))for the NCA cathode and a moderate performance(coulombic efficiency of 98%for 20 cycles)on the graphite anode after the formation of the SEI *** hybrid electrolytes were cycled at 25℃ in a Gr//NCA cell yielding specific capacities of ca.225 mAh g^(-1) at a C/5 rate,corroborating that the anion plays a key role and highlighting their potential for energy storage applications.

关键词： Hybrid electrolyte Alkali salts NCA//Li cell Li-ion battery

On the refracted patterns produced by liquid vortices

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Acta Mechanica Sinica 2007年第1期23卷 11-15页

作者： Yasser Aboelkassem georgios H.Vatistas McGill University MontrealQCH3A-2K6Canada Concordia University MontrealQCH3G 1M8Canada

A theoretical analysis of the refracted shadows produced by steady and time-decaying liquid vortices under uniform illumination from above is given in this article. An expression for the induced shadow intensity is derived and found to be a function of the vortex＇s free surface profile, i.e., function of the static pressure distribution. The patterns for different focusing depth are given and compared with previous visualization results from the literature. The phenomenon is examined and illustrated as a bench mark case by using both steady and time-decaying algebraic vortex models. However, this study can be extended to check the feasibility of recovering the main flow properties by analyzing the luminous image intensity of the refracted patterns. The present analysis is valid only when the swirl velocity is order of magnitude higher than the meridional flow components and the vorticity is concentrated within the core region and of intense conditions.

关键词： Fluid dynamics - Vortices - Dark shadows Intensity - Time decay

Flecainide: Current status and perspectives in arrhythmia management

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World Journal of Cardiology 2015年第2期7卷 76-85页

作者： George k andrikopoulos Sokratis Pastromas Stylianos Tzeis Department of Cardiology Henry Dunant Hospital

Flecainide acetate is a class IC antiarrhythmic agent and its clinical efficacy has been confirmed by the results of several clinical trials. Nowadays, flecainide is recommended as one of the first line therapies for pharmacological conversion as well as maintenance of sinus rhythm in patients with atrial fibrillation and/or supraventricular tachycardias. Based on the Cardiac Arrhythmia Suppression Trial study results, flecainide is not recommended in patients with structural heart disease due to high proarrhythmic risk. Recent data support the role of flecainide in preventing ventricular tachyarrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia associated both with ryanodine receptor and calsequestrin mutations. We herein review the current clinical data related to flecainide use in clinical practice and some concerns about its role in the management of patients with coronary artery disease.

关键词： Flecainide Class IC antiarrhythmic drugs Atrial fibrillation Ventricular tachycardia Proarrhythmia

Chios mastic treatment of patients with active Crohn's disease

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World Journal of Gastroenterology 2007年第5期13卷 748-753页

作者： Andriana C kaliora Maria G Stathopoulou John k Triantafillidis George VZ Dedoussis Nikolaos k andrikopoulos Department of Science of Dietetics-Nutrition Harokopio University Athens Greece Department of Gastroenterology Saint Panteleimon General State Hospital Nicea Athens Greece

AIM: To evaluate the effectiveness of mastic administra-tion on the clinical course and plasma inflammatory me-diators of patients with active Crohn’s disease (CD).METHODS: This pilot study was conducted in patients with established mild to moderately active CD, attend-ing the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Ac-tivity Index (CDAI), Nutritional Risk Index (NRI), C-re-active protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Results were expressed as mean values ± SE and P kind of side effects. CONCLUSION: The results suggest that mastic signifi-cantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately ac-tive CD. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with CD.

关键词： Chios mastic Crohn's disease C-reactive protein Cytokines Antioxidant potential Conservativetreatment

Fragility assessment of wood sheathing panels and roof-to-wall connections subjected to wind loading

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Frontiers of Structural and Civil Engineering 2021年第4期15卷 867-876页

作者： Amira Gill Aikaterini S.GENIkOMSOU georgios P.BALOMENOS Department of Civil Engineering Queen’s UniversityKingstonK7L 3N9Canada Department of Civil Engineering McMaster UniversityHamiltonL8S 4L7Canada

The performance of the wood-frame buildings after tornadoes has shown that the majority of the wind damage resulted from building envelope failure most typically due to the loss of the *** assess the performance and the reliability of low-rise wood-frame residential buildings with a focus on the roofs,fragility analysis can be used to estimate the probability of failure of a roof when constructed with specified nails and sheathing ***,this paper examines the fragility of specific types of nails,roof-to-wall(RW)connection details,and sheathing sizes based on the damaged roofs that were previously assessed in the Dunrobin area in Ottawa(Ontario)that was hit with an Enhanced Fujita(EF3)tornado on September 21,*** presented fragility analysis considers four scenarios,including different sheathing and nail *** loads,wind loads,and resistance on the sheathing panels were compiled and analyzed to determine the failure of the examined *** eight fragility models suggest that the safest roof sheathing(RS)is the 1.22 m×1.22 m sheathing panel with 8 d nails,and the safest RW connections is achieved by using H2.5 hurricane clips.

关键词： tornadoes wind loads low-rise buildings fragility analysis risk assessment structural failures