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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo donofrio Alessia Fischetti georgios d kotzalidis Giuseppe Marano Alessio Simonetti delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta domenico de Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria d'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria de Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela de Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAd digestive disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUNd Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")ANd("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety depression

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Neuroinflammation in bipolar disorders

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 252-262页

作者： georgios d.kotzalidis Elisa Ambrosi Alessio Simonetti Ilaria Cuomo Antonio del Casale Matteo Caloro Valeria Savoja Chiara Rapinesi department of Psychiatric Rehabilitation P.Alberto Mileno Onlus FoundationSan Francesco Institute66054 VastoCHItaly

Recent literature based on peripheral immunity findings speculated that neuroinflammation,with its connection to microglial activation,is linked to bipolar *** endorsement of the neuroinflammatory hypotheses of bipolar disorder requires the demonstration of causality,which requires longitudinal *** aimed to review the evidence for neuroinflammation as a pathogenic mechanism of the bipolar *** carried out a hyper inclusive PubMed search using all appropriate neuroinflammation-related terms and crossed them with bipolar disorder-related *** search produced 310 articles and the number rose to 350 after adding articles from other search engines and reference *** papers were included that appropriately tackled the issue of the presence(but not of its pathophysiological role)of neuroinflammation in bipolar *** these,15 were postmortem and 5 were carried out in living *** articles were consistent with the presence of neuroinflammation in bipolar disorder,but factors such as treatment may mask *** studies were cross-sectional,preventing causality to be ***,no inference can be currently made about the role of neuroinflammation in bipolar disorder,but a link is *** issue remains little investigated,despite an excess of reviews on this topic.

关键词： Bipolar disorder inflammation neuroinflammation psychoneuroimmunology stress

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Smarter in the city?Lizards from urban and semi-natural habitats do not differ in a cognitive task in two syntopic species

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Current Zoology 2024年第3期70卷 361-370页

作者： Isabel damas-Moreira Birgit Szabo georgios drosopoulos Carolin Stober duje Lisičić Barbara A.Caspers department of Behavioural Ecology Bielefeld University33615Germany division of Behavioural Ecology University of Bern3032Switzerland department of Biology University of Zagreb10000Croatia Joint Institute of Individualisation in a Changing Environment(JICE) University of Münster and Bielefeld University33615Germany

Urbanization occurs at a global scale,imposing dramatic and abrupt environmental changes that lead to biodiversity ***,some animal species can handle these changes,and thrive in such artifcial *** possible explanation is that urban individuals are equipped with better cognitive abilities,but most studies have focused on birds and mammals and yielded varied *** have received much less attention,despite some lizard species being common city *** Italian wall lizard,Podarcis siculus,and the common wall lizard,Podarcis muralis,are two successful lizards in anthropogenic habitats that thrive in urban *** test for differences in a cognitive skill between urban and semi-natural environments,we investigated inhibitory control through a detour task in syntopic populations of the two species,across 249 lizards that were tested in partially artifcial feld *** inhibitory control is considered essential for higher degrees of cognitive fexibility and other higher-level cognitive *** this task,we confronted lizards with a transparent barrier,separating them from a desired shelter area that they could only reach by controlling their impulse to go straight and instead detour the *** found no differences between lizards in urban and semi-natural environments,nor between species,but females overall performed better than ***,48%of the lizards in our study did not perform a correct trial in any of the 5 trials,hinting at the diffculty of the task for these *** study is among the frst to address lizard cognition,through their inhibitory control,as a potential explanation for success in cities and highlights one should be careful with assuming that urban animals generally have enhanced cognitive performance,as it might be taxa,task,or condition dependent.

关键词： Podarcis siculus Podarcis muralis Behavior Cognition detour task Reptile.

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Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2679-2688页

作者： Ioannis Lambrou Ioannis Mantzoros Orestis Ioannidis dimitrios Tatsis Elissavet Anestiadou Vasiliki Bisbinas Manousos-georgios Pramateftakis Efstathios Kotidis Barbara driagka Ourania Kerasidou Savvas Symeonidis Stefanos Bitsianis Freideriki Sifaki Konstantinos Angelopoulos Haralabos demetriades Stamatios Angelopoulos Fourth department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece department of ENT Royal Cornwall Hospitals NHS TrustCornwall TR13LJUnited Kingdom

BACKGROUNd Growth hormone(GH)plays a crucial role in wound healing and tissue repair in postoperative *** particular,colonic anastomosis healing following colorectal surgery is impaired by numerous chemotherapy *** To investigate whether GH can improve the healing of a colonic anastomosis following the adverse effects of intraperitoneal administration of 5-fluorouracil(5-FU),bleomycin and *** Eighty Wistar rats underwent laparotomy and a 1 cm-resection of the transverse colon,followed by an end-to-end anastomosis under general *** rats were blindly allocated into four equal groups and administered a different daily intraperitoneal therapeutic regimen for 6 *** control group(A)received normal *** B received chemotherapy with 5-FU(20 mg/kg),bleomycin(4 mg/kg)and cisplatin(0.7 mg/kg).Group C received GH(2 mg/kg),and group d received the aforementioned combination chemotherapy and GH,as *** rats were sacrificed on the 7th postoperative day and the anastomoses were macroscopically and microscop-ically *** weight,bursting pressure,hydroxyproline levels and inflammation markers were *** All rats survived until the day of sacrifice,with no infections or other complications.A decrease in the body weight of group d rats was observed,not statistically significant compared to group A(P=1),but significantly different to groups C(P=0.001)and B(Pdehiscence rate was not statistically different between the *** pressure was not significantly different between groups A and d(P=1.0),whereas group B had a significantly lower bursting pressure compared to group d(Pd significantly more adhesions than group ***,as a measurement of collagen deposition,was significantly higher in group d compared to group B(Pd higher,but not statistically significant,compared to group *** changes in group d were recorded,compared to group A

关键词： Growth hormone Colonic anastomosis Adhesion Bursting pressure Collagen Hydroxyproline Inflammation Neoangiogenesis Chemotherapy

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Incidence, risk factors and clinical outcome of multidrug-resistant organisms after heart transplantation

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World Journal of Transplantation 2024年第2期14卷 107-118页

作者： Sophia Hatzianastasiou Paraskevas Vlachos georgios Stravopodis dimitrios Elaiopoulos Afentra Koukousli Josef Papaparaskevas Themistoklis Chamogeorgakis Kyrillos Papadopoulos Theodora Soulele despoina Chilidou Kyriaki Kolovou Aggeliki Gkouziouta Michail Bonios Stamatios Adamopoulos Stavros dimopoulos Microbiology department and Infection Control Office Onassis Cardiac Surgery CenterAthens 17674Greece Heart Transplantation Unit Onassis Cardiac Surgery CenterAthens 17674Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUNd Transplant recipients commonly harbor multidrug-resistant organisms(MdROs),as a result of frequent hospital admissions and increased exposure to antimi-crobials and invasive *** To investigate the impact of patient demographic and clinical characteristics on MdRO acquisition,as well as the impact of MdRO acquisition on intensive care unit(ICU)and hospital length of stay,and on ICU mortality and 1-year mortality post heart *** This retrospective cohort study analyzed 98 consecutive heart transplant patients over a ten-year period(2013-2022)in a single transplantation *** was collected regarding MdROs commonly encountered in critical *** Among the 98 transplanted patients(70%male),about a third(32%)acquired or already harbored MdROs upon transplantation(MdRO group),while two thirds did not(MdRO-free group).The prevalent MdROs were Acinetobacter baumannii(14%),Pseudomonas aeruginosa(12%)and Klebsiella pneumoniae(11%).Compared to MdRO-free patients,the MdRO group was characterized by higher body mass index(P=0.002),higher rates of renal failure(P=0.017),primary graft dysfunction(10%vs 4.5%,P=0.001),surgical re-exploration(34%vs 14%,P=0.017),mechanical circulatory support(47%vs 26%P=0.037)and renal replacement therapy(28%vs 9%,P=0.014),as well as longer extracorporeal circulation time(median 210 vs 161 min,P=0.003).The median length of stay was longer in the MdRO group,namely ICU stay was 16 vs 9 d in the MdRO-free group(P=0.001),and hospital stay was 38 vs 28 d(P=0.006),while 1-year mortality was higher(28%vs 7.6%,log-rank-χ2:7.34).CONCLUSION Following heart transplantation,a predominance of Gram-negative MdROs was *** acquisition was associated with higher complication rates,prolonged ICU and total hospital stay,and higher post-transplantation mortality.

关键词： Heart transplantation Multi drug resistant organisms Transplantation complications Transplantation outcome

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Statistical analysis on the influence of mechanical parameters in the vibration of pylons

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Earthquake Engineering and Engineering Vibration 2023年第1期22卷 263-278页

作者： georgios I.dadoulis George d.Manolis Laboratory for Experimental Mechanics Department of Civil EngineeringAristotle UniversityThessaloniki 54124Greece

We present a statistical investigation of the degree of influence that assumptions made in relation to the mechanical parameters of a pylon have on its ground-induced *** study is set up by using as a key kinematic variable the displacement at the top of a reference,a stand-alone pylon with a uniform cross-section and fixity at its ***,statistics are produced using a dimensionless displacement ratio defined between the‘parental’and the‘subsidiary’cases,the latter defined for the pylon(a)resting on compliant soil,(b)having an attached top mass,and(c)being non-uniform with ***,two materials are examined,namely,steel and reinforced concrete(R/C).More specifically,this displacement ratio is independent of the excitation and plays the role of a transfer function between the base and the top of the *** horizontal and vertical motions are considered,and the equations of motion are solved in the frequency *** ensuing statistical analysis is conducted for the following parameter combinations:(a)pylon founded on soft,intermediate,and stiff soil;(b)low,intermediate,and high-mass ratios of the attached mass to the pylon′s mass;(c)a constant and quadratic degree of pylon tapering with *** correlation coefficients are calculated for all the above combinations to arrive at statistical results that establish validity bounds and quantify the degree of influence of each assumption on the pylon′s response.

关键词： pylons statistical analysis spearman coefficients structural vibrations elastic waveguides attached masses soil springs tapering

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Role of three-dimensional printing and artificial intelligence in the management of hepatocellular carcinoma:Challenges and opportunities

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World Journal of Gastrointestinal Oncology 2022年第4期14卷 765-793页

作者： Chrysanthos d Christou georgios Tsoulfas department of Transplantation Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54622Greece

Hepatocellular carcinoma(HCC)constitutes the fifth most frequent malignancy worldwide and the third most frequent cause of cancer-related ***,treatment selection is based on the stage of the *** fields such as three-dimensional(3d)printing,3d bioprinting,artificial intelligence(AI),and machine learning(ML)could lead to evidence-based,individualized management of *** this review,we comprehensively report the current applications of 3d printing,3d bioprinting,and AI/ML-based models in HCC management;we outline the significant challenges to the broad use of these novel technologies in the clinical setting with the goal of identifying means to overcome them,and finally,we discuss the opportunities that arise from these ***,regarding 3d printing and bioprinting-related challenges,we elaborate on cost and cost-effectiveness,cell sourcing,cell viability,safety,accessibility,regulation,and legal and ethical ***,regarding AI/ML-related challenges,we elaborate on intellectual property,liability,intrinsic biases,data protection,cybersecurity,ethical challenges,and *** findings show that AI and 3d printing applications in HCC management and healthcare,in general,are steadily expanding;thus,these technologies will be integrated into the clinical setting sooner or ***,we believe that physicians need to become familiar with these technologies and prepare to engage with them constructively.

关键词： Artificial intelligence Machine learning Three-dimensional printing Bioprinting Hepatocellular carcinoma Liver cancer

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Challenges involved in the application of artificial intelligence in gastroenterology:The race is on!

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World Journal of Gastroenterology 2023年第48期29卷 6168-6178页

作者： Chrysanthos d Christou georgios Tsoulfas department of Transplantation Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54622Greece Center for Research and Innovation in Solid Organ Transplantation School of MedicineAristotle University of ThessalonikiThessaloniki 54622Greece

Gastroenterology is a particularly data-rich field,generating vast repositories of data that are a fruitful ground for artificial intelligence(AI)and machine learning(ML)*** this opinion review,we initially elaborate on the current status of the application of AI/ML-based software in ***,AI/ML-based models have been developed in the following applications:Models integrated into the clinical setting following real-time patient data flagging patients at high risk for developing a gastrointestinal disease,models employing non-invasive parameters that provide accurate diagnoses aiming to either replace,minimize,or refine the indications of endoscopy,models utilizing genomic data to diagnose various gastrointestinal diseases,computer-aided diagnosis systems facilitating the interpretation of endoscopy images,models to facilitate treatment allocation and predict the response to treatment,and finally,models in prognosis predicting complications,recurrence following treatment,and overall ***,we elaborate on several challenges and how they may negatively impact the widespread application of AI in healthcare and ***,we elaborate on concerns regarding accuracy,cost-effectiveness,cybersecurity,interpretability,oversight,and *** AI is unlikely to replace physicians,it will transform the skillset demanded by future physicians to ***,physicians are expected to engage with AI to avoid becoming obsolete.

关键词： Artificial intelligence Machine learning Gastroenterology Costeffectiveness Interpretability Accuracy

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Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology

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World Journal of Gastroenterology 2021年第37期27卷 6191-6223页

作者： Chrysanthos d Christou georgios Tsoulfas Organ Transplant Unit Hippokration General HospitalAristotle University of ThessalonikiThessaloniki 54622Greece

Artificial intelligence(AI)is an umbrella term used to describe a cluster of interrelated *** learning(ML)refers to a model that learns from past data to predict future *** and particularly gastroenterology and hepatology,are data-rich fields with extensive data repositories,and therefore fruitful ground for AI/ML-based software *** this study,we comprehensively review the current applications of AI/ML-based models in these fields and the opportunities that arise from their ***,we refer to the applications of AI/ML-based models in prevention,diagnosis,management,and prognosis of gastrointestinal bleeding,inflammatory bowel diseases,gastrointestinal premalignant and malignant lesions,other nonmalignant gastrointestinal lesions and diseases,hepatitis B and C infection,chronic liver diseases,hepatocellular carcinoma,cholangiocarcinoma,and primary sclerosing *** the same time,we identify the major challenges that restrain the widespread use of these models in healthcare in an effort to explore ways to overcome ***,we elaborate on the concerns regarding intrinsic biases,data protection,cybersecurity,intellectual property,liability,ethical challenges,and *** at a slower pace than anticipated,AI is infiltrating the healthcare *** in healthcare will become a reality,and every physician will have to engage with it by necessity.

关键词： Artificial intelligence Machine learning Gastroenterology Hepatology Artificial neural networks Support vector machine

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New instability and mixing simulations using SPH and a novel mixing measure

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Journal of Hydrodynamics 2020年第4期32卷 684-698页

作者： Georgina Reece Benedict d.Rogers Steven Lind georgios Fourtakas department of Mechanical Aerospace and Civil EngineeringUniversityof ManchesterManchesterUK

This paper assesses the ability of smoothed particle hydrodynamics (SPH) to simulate mixing of two-phase flows and theirtransition to instabilities under different flow regimes. A new measure for quantification of the degree of mixing between phases in aLagrangian framework is also developed. The method is validated using the lid-driven cavity and two-phase Poiseuille flow cases. Thevelocity along the centre of the cavity is compared with results from the literature, whilst commercial volume-of-fluid codeSTAR-CCM+ provides a benchmark for the mixing and different mixing measures are considered. The velocity of two-phase Poiseuilleflow along the channel is compared to the analytical solution, and the appearance of interfacial instabilities with perturbation *** is the first time SPH has been used to investigate the onset and development of these instabilities. In particular, it is able to modelthe deforming shape of the interface, which is not given by analytical studies, while also offering improved predictions overconventional mesh-based computational fluid dynamics simulations.

关键词： Smoothed particle hydrodynamics(SPH) multi-phase mixing instability

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