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Mechanical behavior of colonic anastomosis in experimental settings as a measure of wound repair and tissue integrity

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World Journal of Gastroenterology 2006年第35期12卷 5668-5673页

作者： Konstantinos A Ekmektzoglou georgios c zografos Stavros K Kourkoulis Ismene A Dontas Panagiotis K Giannopoulos Κaterina A Marinou Maria V Poulakou Despina N Perrea Laboratory of Experimental Sur- gery and Surgical Research "NS christeas" University of Athens Medical School Athens Greece 1st Univer- sity Department of General Surgery Athens School of Medicine Hippocration Hospital Athens Greece Laboratory of Testing and Materials De- partment of Mechanics National Technical University of Athens Greece BVMS MVM Laboratory of Experimen- tal Surgery and Surgical Research "NS Christeas" University of Athens Medical School Athens Greece and Greek Ministry of Rural Development and Food General Directorate of Veterinary Services

AIM: To determine the mechanical properties of anasto- motic colonic tissue in experimental settings and there- fore give a measure of wound healing. METHODS: Thirty-six male Wistar rats were used as ex- perimental models of anastomotic tissue integrity. On the 5th post-operative day, the tensile strength was measured by application of an axial force, providing a quantitative measure of anastomotic dehiscence and leakage. RESULTS: Diagrams of the load as a function of the time [P = P (t)] and of the displacement also as a func- tion of time [Δs = Δs (t)] were recorded for each test, permitting the design of the load versus the displace- ment diagram and thus providing significant data about the critical values of anastomotic failure. Quantitative data were obtained concerning the anastomotic strength of both control specimens (healthy rats), as well as spec- imens from non-healthy rats for comparison. cONcLUSION: This experimental model provides an excellent method of measuring anastomotic strength. Despite the relative small number of specimens used, this method provides an accurate way of measuring wound repair. More experimental measurements need to be performed to correlate emerging tensile strength val-ues to anastomotic failure.

关键词： Mechanical behavior Failure load colon Anastomosis Wound healing

Burril-Bernard crohn(1884-1983)and the disease which bears his name

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History & Philosophy of Medicine 2024年第4期6卷 16-23页

作者： georgios Androutsos Konstantinos Laios Pavlos Lytsikas-Sarlis Evangelia Mourellou constantinos georgios zografos Gregory Tsoucalas Marianna Karamanou School of Medicine National and Kapodistrian University of AthensAthens 11527Greece Department of History of Medicine and Medical Ethics School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece Graduate School of Medicine National and Kapodistrian University of AthensAthens 11527Greece Department of the History of Medicine and Medical Deontology School of MedicineUniversity of CreteHeraklion 71003Greece Surgery Department School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece

Background:crohn’s disease,described by *** crohn and his colleagues in 1932,continues to be of great research and clinical *** was initially perceived as a distinct condition and it has evolved since into a complex disease,with debates still going regarding its classification and *** though more that 80 years of research have passed,numerous significant questions regarding the disease’s causes and best possible treatment strategies still ***:This article reviews both historical and contemporary perspectives on crohn’s disease,including its initial description,the research developments that happened in the years to follow,as well as the way it is regarded *** refers to notable contributions from medical figures,such as *** and his colleagues,examines related advances made in medical research and mentions the challenges and the treatment strategies that are still being ***:This article highlights the evolution of crohn’s disease from a distinct condition to a more heterogeneous ***,it refers to advancements made in medical research,such as the identification of cARD15(NOD2)gene mutations and the role of dysbiosis,and it examines current therapeutic ***:Even though significant progress has been made since the initial description of chron’s disease,there is no definitive cure,even though it has been determined that genetic and environmental factors are of great *** ongoing research could possibly lead to future discoveries and therefore aid in the discovery of efficient management and treatment of crohn’s disease.

关键词： regional ileitis granulomatous inflammation endoscopic evaluation historical figures

Role of non-coding RNAs in pathogenesis of gastrointestinal stromal tumors

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World Journal of Meta-Analysis 2020年第3期8卷 233-244页

作者： Ioannis K Stefanou Maria Gazouli georgios c zografos Konstantinos G Toutouzas Department of Surgery Hippocration Hospital AthensAthens 11527Greece Department of Basic Medical Sciences Laboratory of BiologyNational and Kapodistrian University of AthensAthens 11527Greece 1^st Propaedeutic Department of Surgery National and Kapodistrian University of AthensAthens 11527Greece

Gastrointestinal stromal tumors(GISTs)are considered the model solid malignancies of targeted therapy after the discovery of imatinib effectiveness against their tyrosine kinase ***-coding RNAs are molecules with no protein coding capacity that play crucial role to several biological steps of normal cell proliferation and *** the expression of these molecules found to be altered it seems that they affect the process of carcinogenesis in multiple ways,such as proliferation,apoptosis,differentiation,metastasis,and drug *** review aims to provide an overview of the latest research papers and summarize the current evidence about the role of non-coding RNAs in pathogenesis of GISTs,including their potential clinical applications.

关键词： Gastrointestinal stromal tumors Non-coding RNA MicroRNA Transcriptomics Biomarker Long non-coding RNAs

Inverse Electromagnetic Scattering by a Penetrable chiral Object

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Journal of Applied Mathematics and Physics 2024年第9期12卷 3081-3098页

作者： Sotiria Dimitroula Paraskevi Roupa Spyridon c. Athanasiadis georgios Halikias Department of Mathematics National and Kapodistrian University of Athens Athens Greece Department of Informatics and Telecommunications National and Kapodistrian University of Athens Athens Greece School of Electrical and computer Engineering National and Technical University of Athens Athens Greece

We consider the inverse electromagnetic scattering problem of determining the shape of a perfectly conducting core inside a penetrable chiral body. We prove the well-posedness of the corresponding direct scattering problem by the variational method. We focus on a uniqueness result for the inverse scattering problem that is under what conditions an obstacle can be identified by the knowledge of the electric far-field pattern corresponding to all time-harmonic incident planes waves with a fixed wave number. To this end, we establish a chiral mixed reciprocity relation that connects the electric far-field pattern of a spherical wave with the scattered field of a plane wave.

关键词： chiral Media Inverse Scattering Problem chiral Mixed Reciprocity Relation

Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2679-2688页

作者： Ioannis Lambrou Ioannis Mantzoros Orestis Ioannidis Dimitrios Tatsis Elissavet Anestiadou Vasiliki Bisbinas Manousos-georgios Pramateftakis Efstathios Kotidis Barbara Driagka Ourania Kerasidou Savvas Symeonidis Stefanos Bitsianis Freideriki Sifaki Konstantinos Angelopoulos Haralabos Demetriades Stamatios Angelopoulos Fourth Department of Surgery Medical SchoolAristotle University of ThessalonikiThessaloniki 57010Greece Department of ENT Royal Cornwall Hospitals NHS TrustCornwall TR13LJUnited Kingdom

BAcKGROUND Growth hormone(GH)plays a crucial role in wound healing and tissue repair in postoperative *** particular,colonic anastomosis healing following colorectal surgery is impaired by numerous chemotherapy *** To investigate whether GH can improve the healing of a colonic anastomosis following the adverse effects of intraperitoneal administration of 5-fluorouracil(5-FU),bleomycin and *** Eighty Wistar rats underwent laparotomy and a 1 cm-resection of the transverse colon,followed by an end-to-end anastomosis under general *** rats were blindly allocated into four equal groups and administered a different daily intraperitoneal therapeutic regimen for 6 *** control group(A)received normal *** B received chemotherapy with 5-FU(20 mg/kg),bleomycin(4 mg/kg)and cisplatin(0.7 mg/kg).Group c received GH(2 mg/kg),and group D received the aforementioned combination chemotherapy and GH,as *** rats were sacrificed on the 7th postoperative day and the anastomoses were macroscopically and microscop-ically *** weight,bursting pressure,hydroxyproline levels and inflammation markers were *** All rats survived until the day of sacrifice,with no infections or other complications.A decrease in the body weight of group D rats was observed,not statistically significant compared to group A(P=1),but significantly different to groups c(P=0.001)and B(Pc dehiscence rate was not statistically different between the *** pressure was not significantly different between groups A and D(P=1.0),whereas group B had a significantly lower bursting pressure compared to group D(Pcantly more adhesions than group ***,as a measurement of collagen deposition,was significantly higher in group D compared to group B(Pcally significant,compared to group *** changes in group D were recorded,compared to group A

关键词： Growth hormone colonic anastomosis Adhesion Bursting pressure collagen Hydroxyproline Inflammation Neoangiogenesis chemotherapy

Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with crohn's disease

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World Journal of Gastroenterology 2014年第13期20卷 3609-3614页

作者： Diamantis Thomas Maria Gazouli Theodoros Karantanos Stella Rigoglou georgios Karamanolis Konstantinos Bramis George zografos George E Theodoropoulos colorectal Unit 1st Department of Propaedeutic Surgery"Hippokrateio" HospitalSchool of MedicineUniversity of Athens11527 AthensGreece Department of Basic Medical Science Laboratory of BiologySchool of MedicineUniversity of Athens11527 AthensGreece Gastroenterology Unit 2nd Department of Surgery"Aretaieio" HospitalUniversity of AthensAthens 11527Greece

AIM: To investigate the correlation between rs1568885, rs1813443 and rs4411591 polymorphisms and response to infliximab in a cohort of Greek patients with crohn’s disease (cD).

关键词： crohn’ s disease, Treatment response, Infliximab, Polymorphisms

colonic duplication in adults: Report of two cases presenting with rectal bleeding

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World Journal of Gastroenterology 2005年第32期11卷 5072-5074页

作者： c Fotiadis M Genetzakis I Papandreou EP Misiakos E Agapitos Gc zografos 3rd Department of SurgeryUniversity of Athens School of MedicineAthensGreece 1st Department of Propedeutic SurgeryUniversity of Athens School of MedicineHippokration HospitalAthensGreece Department of PathologyUniversity of Athens School of MedicineAthensGreece

Gastrointestinal duplication is an uncommon congenital abnormality in two-thirds of cases manifesting before the age of 2 years. Ileal duplication is common while colonic duplication, either cystic or tubular, is a rather unusual clinical entity that remains asymptomatic and undiagnosed in most cases. Mostly occurring in pediatric patients,colonic duplication is encountered in adults only in a few cases. This study reports two cases of colonic duplication in adults. Both cases presented with rectal bleeding on admission. The study was focused on clinical, imaging,histological, and therapeutical aspects of the presenting cases. Gastrografin enema established the diagnosis in both cases. The cystic structure and the adjacent part of the colon were excised en-block. The study implies that colonic duplication, though uncommon, should be included in the differential diagnosis of rectal bleeding.

关键词： colonic duplication Gastrointestinal bleeding

Extraskeletal myxoid chondrosarcoma metastatic to the pancreas: A case report

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World Journal of Gastroenterology 2005年第14期11卷 2203-2205页

作者： c Fotiadis A charalambopoulos S chatzikokolis Gc zografos M Genetzakis R Tringidou Third University Department of General Surgery Athens School of Medicine AthensGreece First University Department of General Surgery Athens School of Medicine Ippokration HospitalAthensGreece Department of Pathology Sotiria Hospital AthensGreece

Extraskeletal myxoid chondrosarcoma (EMc) is a lowgrade sarcoma characterized by developing metastases and local recurrence in high rate. It is mainly deep seated in the proximal extremities. The most common metastatic sites are the lungs, soft tissues, lymph nodes, bones and the brain. To our knowledge, no case of clearly defined EMc has been reported to date developing a metastasis in the pancreas. We describe a case of a man suffering from EMc who developed a single pancreatic metastasis 20 years after the initial diagnosis. A 49-year-old man was submitted to surgical excision of an EMc, in left thigh, 20 years ago. Fourteen years after the initial diagnosis a local recurrence in left thigh occurred. Multiple lesions of metastatic origin, in both lungs, were excised via thoracotomies until the time being. In 2003, as a part of a periodically performed imaging control, an abdominal cT scan was performed revealing a solid lesion in the pancreas. Distal pancreatectomy was performed. The histopathology of the excised specimen proved to be the one of metastatic lesion of EMc. The above-mentioned case of EMc is, as far as we know, the first one described developing a certain pancreatic metastasis.

关键词： Extraskeletal myxoid chondrosarcoma Metastasis Pancreas

Energy storage and harvesting in BaTiO_(3)/epoxy nanodielectrics

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High Voltage 2016年第4期1卷 151-157页

作者： Georgia c.Manika georgios c.Psarras Department of Materials Science University of Patras26504PatrasGreece

composite nanodielectrics consisted of an epoxy resin and barium titanate nanoparticles were developed and *** measurements were performed via broadband dielectric *** results reveal the presence of three relaxation processes,which are attributed to(a)glass to rubber transition of the polymer matrix(α-mode),(b)re-arrangement of polar side groups(β-mode)and(c)interfacial polarisation between system’s *** ability of the examined nanodielectrics to store and harvest energy was also examined in dc *** dc voltage varied in the range of 10–240 *** data indicate that increasing the applied dc field results to higher values of the stored and harvested *** energy efficiency was also investigated in all *** filler content enhances the coefficient of energy efficiency(neff)up to 58.2%for the 7 phr BaTiO_(3)nanocomposite at 200 V and 10 s charging/discharging time.

关键词： spectroscopy. rubber arrangement