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Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial(THERESA-3)

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World Journal of Gastroenterology 2014年第6期20卷 1594-1601页

作者： Francisco Hernández-Bernal georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto Pedro A López-Saura Center for Genetic Engineering and Biotechnology "Juan B. Zayas" Hospital National Center for the Coordination of Clinical Trials

AIM: To compare the efficacy and safety of recombinant streptokinase (rSK) and phenylephrine-based suppositories in acute hemorrhoidal disease.

关键词： Streptokinase Suppository Phenylephrine Thrombolysis Hemorrhoids Randomized clinical trial

Butterfly Species Diversity and Abundance in University of Ibadan Botanical Garden, Nigeria

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Open Journal of Ecology 2015年第8期5卷 352-360页

作者： Abideen Abiodun Alarape James Kehinde Omifolaji georgina Samuel Mwansat Department of Wildlife and Ecotourism Management University of Ibadan Ibadan Nigeria Department of Forestry and Wildlife Federal University Dutse Dutse Nigeria Department of Zoology University of Jos Jos Nigeria

Understanding the significance of butterflies in an ecosystem as an environmental healthy indicator and pollination of flowering plants is crucial to achieving sustainability and conservation of floral diversity. The aim of the study was to investigate the butterfly species diversity and abundance and compare the relationship between physical factor and butterfly species. Line transect were used to survey three habitats around botanical garden with scooped-net between June and July, 2010. Diversity varied from habitat to habitat. A checklist was made comprising a total of 57 butterfly species that were surveyed belonging to 9 families. There was a relationship between temperature and butterfly species diversity and abundance. There was no correlation between physical factors (relative humidity and temperature) and the total number of species and families. Moreover, butterfly numbers were not related to relative humidity in any species and family. However, temperature was significantly correlated with species. Therefore, understanding of the factors that affect butterfly species diversity and abundance in University of Ibadan Botanical Garden is important for conservation.

关键词： Butterfly Species Botanical Garden Diversity

Hepatitis E Virus Infection in HIV Positive ART Naive and Experienced Individuals in Nigeria

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World Journal of AIDS 2013年第3期3卷 216-220页

作者： georgina N. Odaibo David O. Olaleye Department of Virology College of Medicine University of Ibadan Ibadan Nigeria

Background: Studies have shown Hepatitis E Virus to be a causative agent of acute and chronic hepatitis in severely immunocompromised patients such as organ transplant recipients and person with HIV infection. This study was designed to determine the burden of HEV infection among HIV positive individuals in Nigeria and the effect of HIV treatment on the burden of HEV infection among this group of patients. Methods: Aliquot of plasma samples collected for laboratory investigations such as CD4 enumeration, blood chemistry (AST, ALT, Creatine, Urea) were used to determine the presence of HEV IgG and IgM antibodies using commercially available ELISA. Samples analysed in the study were collected from 180 HIV positive individuals (90 ART naive and 90 ART experienced) attending the ART clinic at the University College Hospital, Ibadan, Nigeria. Results: Twenty two of the 180 (12.2%) samples were positive for either HEV IgG (20/180) or IgM (2/180). The rate of HEV IgG was higher among ART naive individuals and the two IgM positive persons were ART naive. There was no significant difference in the mean CD4 count and mean ALT between HEV seronegative and seropositive individuals (P = 0.8 and 0.2 respectively). Conclusions: The results of this study suggest the need to test for HEV infection in HIV positive individuals for the early diagnosis and proper management since HEV is known to be fulminant in the presence of underlying liver disease that is common among HIV infected persons. In addition, the use of ART may reduce the incidence of HEV infection in HIV positive persons.

关键词： HEV Infection HIV Positive ART Nigeria

Circulation of the low pathogenic avian influenza subtype H5N2 virus in ducks at a live bird market in Ibadan, Nigeria

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Infectious Diseases of Poverty 2014年第1期3卷 347-352页

作者： Temitope Coker Clement Meseko georgina Odaibo David Olaleye Virology Department College of MedicineUniversity of IbadanIbadanNigeria

Background:To monitor carrier hosts of avian influenza in Nigeria,we randomly collected cloaca swab specimens from 155 ducks at a live bird market(LBM)in Ibadan,southwest Nigeria,between July 2011 and July ***:The samples were analyzed by real-time reverse transcription-polymerase chain reaction(RT-PCR)and virus isolation was carried out in embryonated chicken *** sequencing of the antigenic cleavage site of the haemagglutinin(HA)gene was performed,multiple sequence alignment was carried out using ClustalW,and a phylogenetic tree was constructed using the neighbor joining ***:Twenty(13%)of the 155 samples were positive for avian influenza subtype H5N2 by real-time RT-PCR and three isolates were obtained from embryonated chicken *** sequencing of the amino acid cleavage site of the HA genes of two isolates corresponded to a PQRETGL*F sequence that is common in low pathogenic avian influenza(LPAI).Phylogenetically,the HA genes of the two influenza viruses are monophyletic and clustered with H5N2 viruses detected in wild ducks from ***:The occurrence of LPAI in domestic ducks in Nigeria underscores the importance of continuous surveillance and monitoring of the virus(in a country that is considered to be free of avian influenza)in order to prevent the emergence of virulent strains that may spread to commercial poultry and humans.

关键词： LPAI H5N2 Domestic ducks Live bird market Circulation Nigeria

Evaluation of Ocimum basilicum *** Different Concentrations of K^(+)as an Inhibitor of Pathogenic Bacterial Strains

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 533-541页

作者： Mercedes georgina Ramírez-Aragón Victoria Jared Borroel-García Ramón Valenzuela-Soto Ricardo David Valdez-Cepeda Francisco Javier Wong-Corral JoséLuis García-Hernández Universidad Politécnica de Gómez Palacio Gómez Palacio35120México Universidad Autónoma Chapingo Centro Regional Universitario Centro-NorteZacatecasZac.Universidad Autónoma de ZacatecasFacultad de MatemáticasZacatecas98053México Departamento de Investigación y Posgrado en Alimentos Universidad de SonoraHermosillo83000México Facultad de Agricultura y Zootecnia Universidad Juárez del Estado de DurangoGómez Palacio34000México

The extraction of bioactive compounds has become one of the most interesting areas of modern *** therapeutic reasons,it´s important to obtain antimicrobial agents from natural *** objective of the present study was to determine the inhibitory effect of ethanolic extract of basil(Ocimum basilicum *** Rubin)subjected to different concentrations of potassium(K^(+))on the activity of three bacterial strains that are pathogens in *** was evaluated by inhibition surface and these results were compared to two antibiotics:Gentamicin(GE)and Ciprofloxacin(CPF)for their efficacy against each bacterial *** variables presented significant difference(p≤0.05).According to the results,basil extract evaluated showed positive antibacterial activity against the three strains of Pseudomonas aeruginosa,Listeria monocytogenes and Staphylococcus aureus on Mueller Hinton *** was observed highest inhibition areas of different diameters(15.3 mm,21.3 mm and 21.6 mm respectively)when the extract used was obtained from the plants with the highest concentration of potassium(13 mmol L-1).These values were even superior to the highest values showed on the treatments with the antibiotic gentamicin.

关键词： Basil inhibition potassium secondary metabolites antibiotics

游仆虫信息素Er-1和Er-2对四膜虫的种间作用(英文)

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动物学报 2006年第6期52卷 1125-1132页

作者： László K?HIDAI georgina GL Rosalba BANCHETTI Department of Genetics Cell-and Immunobiology Semmelweis University Budapest Hungary Department of Biology University of Pisa via A. Volta Pisa Italy

信息素是生物体向外释放的化学物质,在细胞及生物体中具有种内信息传递的生理学功能。信息素这一类分子广泛分布于系统发生史中,它们的特异活性在单细胞生物、昆虫以及脊椎动物中均有报道。脊椎动物中信息素的信号传输已被证实是一嗅觉... 详细信息

信息素是生物体向外释放的化学物质,在细胞及生物体中具有种内信息传递的生理学功能。信息素这一类分子广泛分布于系统发生史中,它们的特异活性在单细胞生物、昆虫以及脊椎动物中均有报道。脊椎动物中信息素的信号传输已被证实是一嗅觉依赖过程,7TM-受体被认为是信号传输过程中的信号转换器。在低等单细胞生物(例如:来可夫游仆虫)的细胞膜上存在有信息素异构体,作为信息素分子的有效结合位点而行使其功能。本研究主要探讨单细胞的信息素(Er-1和Er-2)的基础细胞生理学作用是仅限于产生该信息素的物种,还是对其它的原生动物(例如:四膜虫)或对系统发育中分类地位较高的细胞(例如:MRC5成纤维细胞或J774巨噬细胞)均具有调节活性。研究结果表明,游仆虫的两种信息素对梨形四膜虫GL的生长调节有显著不同的作用:当信息素浓度为10-11M时,Er-1具有正调控作用,而Er-2具有抑制剂的作用。这两种配体的趋化作用也有很不同:Er-1具有一种广范的化学排斥特性,而Er-2具有一个双峰的化学吸引剂的性质。计算机检测发现,与Er-2的作用不同,Er-1可略微降低被测细胞的游动速率。趋化现象的选择特性表明Er-2信息素的受体有一种“短期”的特性;而Er-1是不能选择任何亚种群的,这也支持了我们先前的研究数据,即这两种信息素在四膜虫GL内产生两种不同的信号。四膜虫对信息素特异性的反应表明四膜虫能辨别非常近似但带有微小差异的配体(如Er-1和Er-2的电荷差异)。

关键词：游仆虫四膜虫信息素游动趋化性增殖

Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary

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World Journal of Gastroenterology 2019年第42期25卷 6365-6372页

作者： Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy Division of Gastroenterology First Department of MedicineUniversity of SzegedSzeged 6720Hungary Department of Physiology University of SzegedSzeged 6720Hungary of Clinical Microbiology University of SzegedSzeged 6725Hungary Hungarian National Blood Transfusion Service Szeged 6722Hungary

BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(***)infection in Western *** To obtain data regarding the prevalence of *** in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive *** One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this *** were tested for *** IgG antibody positivity via enzyme-linked immunosorbent *** analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also *** The overall seropositivity of *** was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of *** infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural *** accepted risk factors for *** positivity appeared to be valid for the studied population.

关键词： Helicobacter pylori Epidemiology Prevalence Central Europe Healthy volunteers Enzyme-linked immunosorbent assay Differences in urban and rural population

Attitude of Health Care Providers towards Adolescent Sexual and Reproductive Health Services in Developing Countries: A Systematic Review

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Health 2014年第14期6卷 1706-1713页

作者： Idesi Chilinda georgina Hourahane Mercy Pindani Caroline Chitsulo Alfred Maluwa Kamuzu College of Nursing University of Malawi Lilongwe Campus Lilongwe Malawi Wales Centre for Evidence-Based Care School of Nursing and Midwifery Studies Cardiff University Cardiff UK

The aim of the review was to synthesise the best available evidence regarding attitude of health care providers towards adolescent sexual and reproductive health services in developing countries. The review was conducted following qualitative research method. An online search of Cumulative Index to Nursing and Allied Health Literature (CINAHL), British Nursing Index (BNI), EMBASE and MEDLINE databases was conducted to identify relevant studies for the review. There were nine studies that met the inclusion criteria and these were critically assessed by two independent reviewers using the standardised Joanna Briggs Institute (JBI) critical appraisal forms. Data were extracted using the standardised JBI data extraction forms. A narrative synthesis was done on the findings. Key findings from the review indicate that unprofessional attitude of health care professionals and lack of youth friendly reproductive health services, inhibit adolescents from gaining access to sexual and reproductive health services in developing countries. It is recommended that youth friendly reproductive health services be provided to increase uptake of re-productive health services by adolescents.

关键词： Adolescents Reproductive Health Systematic Review Access to Health Services Qualitative Studies Barriers Attitudes Developing Countries

Orientation in upper gastrointestinal endoscopy—the only way is up

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World Journal of Gastrointestinal Endoscopy 2023年第3期15卷 146-152页

作者： Arun Sivananthan georgina Kerry Ara Darzi Kinesh Patel Nisha Patel Department of Surgery and Cancer Imperial College LondonLondon W21NYUnited Kingdom Liver Intensive Care Unit King’s College Hospital NHS Foundation TrustLondon SE59RSUnited Kingdom Gastroenterology Chelsea and Westminster NHS Foundation TrustLondon SW109NHUnited Kingdom

BACKGROUND Oesophagogastroduodenoscopy is the gold standard investigation for the upper gastrointestinal(UGI)*** during endoscopy is challenging and United Kingdom training focusses on technical competence and procedural *** reported location of UGI pathologies is crucial to post-endoscopic *** To evaluate endoscopists’ability to spatially orientate themselves within the UGI *** A cross sectional descriptive study elicited,using an anonymised survey,the ability of endoscopists to orientate themselves within the UGI *** primary outcome was percentage of correct answers from all surveyed;secondary outcomes were percentage of correct answers from experienced vs novice ***’sχ2 test was applied to compare *** Of 188 respondents,86 were experienced endoscopists having completed over 1000 endoscopies.44.4%of respondents correctly identified the anterior stomach and 47.3%correctly identified the posterior of the second part of the duodenum(D2).Experienced endoscopists were significantly more likely than novice to identify the anterior stomach correctly[61.6%vs 31.3%,X2(1,n=188)=11.10,P=0.001].There was no significant difference between the two groups in identifying the posterior of *** The majority of endoscopists surveyed were unable to identify key landmarks within the UGI *** orientation appears to improve with experience yet there are some areas still not well *** has potential considerable impact on post-endoscopic management of patients with posterior duodenal ulcers being more likely to perforate and associated with a higher rebleeding *** suggest the development of a consensus statement on endoscopic description.

关键词： Endoscopy Orientation Upper gastrointestinal Gastric cancer Duodenal ulcer