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Hepatoprotective properties of oleanolic and ursolic acids in anti-tubercular drug-induced liver damage

Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 625-632页

作者： Gabriel A.Gutiérrez-Rebolledo georgina a.siordia-reyes Mariana Meckes-Fischer Adelina Jiménez-Arellanes Unidad de Investigación Médica en Farmacología (UIMF) UMAE Hospital de EspecialidadesCentro Médico Nacional-Siglo XXI (CMN-SXXI)Instituto Mexicano del Seguro Social (IMSS) Servicio de Patología UMAE Hospital de PediatríaCMN-SXXIIMSS Centro de Diagnóstico en Metabolismo Energético y Medicina Mitocondrial A.C.

Objective:To estimate to what extent the mixture of ursolic acid and oleanolic acid,in addition to the antitubercular standard regime,affects the hepatotoxicity ***:Liver injury was induced in male BALB/c mice by administering,per os and daily for 11 weeks,a combination of anti-Tubercular(anti-TB) agents Rifampicin(10 mg/kg),Isoniazid(10 mg/kg),and Pyrazinamide(30 mg/kg).The ursolic acid and oleanolic acid mixture at doses of 100 or 200 μg/mouse/day was subcutaneously injected throughout the entire study period(11 weeks).Biochemical and hematological analysis was supplemented by liver histological ***:Animals treated with the mixture of triterpenic acids exhibited significantly decreased aspartate transaminase and alanine aminotransferase levels and amelioration of the histopathological alterations produced by the anti-TB ***:The triterpene mixture is able to prevent the steatosis induced by the anti-TB drugs.

关键词： Ursolic acid Oleanolic acid Hepatoprotector effect Antitubercular drugs Triterpenes

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Mathematical Modelling of Einstein’s Rate Equations for Zinc Phosphate Glass with Er<sup>3+</sup>-Yb<sup>3+</sup>

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Open Journal of Applied Sciences 2021年第9期11卷 1038-1045页

作者： Frida Lissete Flores Rivera Grethell georgina Pérez-Sánchez Miguel Angel Barron-Meza Joan reyes Miranda Dulce Yolotzin Medina Velázquez Division of Basic Science and Engineering Universidad Autónoma Metropolitana México City México

There is a constant growth in the demand of data information transmission capacity, that is, more and more people send data, voice, video signals, among others, through communications networks. Due to the above there is great interest in improving network devices, such as optical amplifiers, which must cover a large bandwidth and generate greater gain than those currently available. For this reason in this work a computational simulation for a Quasi-system was carried out three energy levels of Erbium and Ytterbium varying their concentrations and proving that they are optimal candidates in a zinc phosphate matrix as this type of glass contains properties such as, high transparency, low melting point, high thermal stability, high gain density due to high solubility, low refractive index and low dispersion, which makes them optimal as signal amplifiers. The results confirm that by increasing the doping of the Erbium ion the gain of the amplifier decreases, contrary to the Ytterbium ion that by increasing the doping the gain of the amplifier increases.

关键词： Optical Telecommunications Rare Earths Doping Optical Amplifier Gain

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Clinical and microbiological features of vulvovaginitis in Mexican girls

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Open Journal of Obstetrics and Gynecology 2013年第2期3卷 243-248页

作者： Mario I.Ortiz Edna J.Arreola-Bautista Beatriz A.Sánchez-reyes georgina Romo-Hernández Marco A.Escamilla-Acosta Area Académica de Medicina del Instituto de Ciencias de la Salud de la Universidad Autónoma del Estado de Hidalgo PachucaHidalgoMexico Universidad del Futbol y Ciencias del Deporte San Agustín TlaxiacaHidalgoMexico Hospital del Nino DIF Hidalgo PachucaHidalgoMexico

Study Objective: To determine the prevalence of vulvovaginitis, predisposing factors, microbial etiology and therapy in patients treated at the Hospital del Nino DIF, Pachuca, Hidalgo, Mexico. Design. This was an observational and descriptive study from 2006 to 2009. Setting: Hospital del Nino DIF, Pachuca, Hidalgo, Mexico. Participants. Patients from 0 to 16 years, with vulvovaginitis and/or vaginal discharge were included. Interventions: None. Main Outcome Measures: Demographic data, etiology, clinical features, risk factors and therapy were analyzed. Results: Four hundred twenty seven patients with diagnosis of vulvovaginitis were included. The average prevalence to 4 years in the study period was 0.19%. The age group most affected was schoolchildren (225 cases: 52.69%). The main signs and symptoms presented were leucorrhea (99.3%), vaginal hyperemia (32.6%), vulvar itching (32.1%) and erythema (28.8%). Identified risk factors were poor hygiene (15.7%), urinary tract infection (14.7%), intestinal parasites (5.6%) and obesity or overweight (3.3%). The main microorganisms found in vaginal cultures were enterobacteriaceae (Escherichia coli, Klebsiella and Enterococcus faecalis), Staphylococcus spp, and Gardnerella vaginalis. Several inconsistent were found in the drug prescription of the patients. Conclusion: Vulvovaginitis prevalence in Mexican girls is low and this was caused mainly by opportunist microorganisms. The initial treatment of vulvovaginitis must include hygienic measure and an antimicrobial according to the clinical features and microorganism found.

关键词： Vulvovaginitis Prevalence Etiologic Microorganisms Mexican Children and Adolescents

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Organic Manures Improved the Phenolic Content, Antioxidant Capacity and Soluble Solids in Pepper

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Food and Nutrition Sciences 2016年第14期7卷 1401-1413页

作者： Alejandro Moreno-Reséndez Ricardo Parcero-Solano José Luis reyes-Carrillo Lilia Salas-Pérez María del Rosario Moncayo-Luján Mercedes georgina Ramírez-Aragón Norma Rodríguez-Dimas Universidad Autónoma Agraria Antonio Narro Unidad Laguna México Integrantes del Cuerpo Académico de Sistemas Sustentables para la Producción Agropecuaria (CASISUPA) de la UAAAN Key: UAAAN-CA-14 Torreón México Integrantes de la Red Académica de Innovación en Alimentos y Agricultura Sustentable (RAIAAS) Consejo Estatal de Ciencia y Tecnología del Estado de Coahuila de Zaragoza Comunidad de Instituciones de Educación Superior de la Laguna (COECYT-CIESLAG) Torreón México Universidad Politécnica de Gómez Palacio Gómez Palacio México Integrantes del Cuerpo Académico Ingeniería en Biotecnología y Administración de Negocios Internacionales Key: UPGOP-CA-1 Gómez Palacio México

The aim of this research was to determine the effect of three organic manures (vermicompost, simple compost, compost with gypsum) with four different levels, as sources of fertilization, and mixed with river sand, this was used as an inert material, on the phenolic content, antioxidant capacity and total soluble solids of bell peppers (Capsicum annuum L.). The 12 mixtures formulated, with eight replications, were distributed in a completely randomized design. Data were statistically analyzed by analysis of variance and means were compared by test Tukey5%. All variables were significantly affected (p ≤ 0.001). Fruits with highest phenolic content were developed in the mixtures M2, M5 and M6 with 538.76, 541.54 and 565.04 mg GAE·100 kg-1 DW, respectively. Antioxidant capacity of fruits was increased with mixtures M2, M5, M6 and M7 with values of 934.48, 942.04, 921.69 and 924.17 μM TEAC·g-1 DW, respectively. The soluble solids content was higher in mixtures M1 and M2 with values of 4.93 and 4.97 °Brix, respectively. It was concluded that the variables studied were favored when applying, as sources of fertilization, mixtures of these organic manures with river sand, which could represent a suitable alternative for food production with quality nutraceutical.

关键词： Organic Agriculture Capsicum annuum Phenolic Compounds Antioxidant Capacity Soluble Solids

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