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Heart rate is an independent predictor of all-cause mortality in individuals with type 2 diabetes: The diabetes heart study

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World Journal of Diabetes 2018年第1期9卷 33-39页

作者： Sameer Prasada Cameron Oswalt Phyllis Yeboah georgia Saylor Donald Bowden Joseph Yeboah Department of Medical School (Medical students) Wake Forest University Department of Internal Medicine Wake Forest Baptist Health Department of Heart and Vascular Center of Excellence Wake Forest Baptist Health Department of Biochemistry Genomics and Personalized Medicine Research Wake Forest University

AIM To assess the association of resting heart rate with allcause and cardiovascular disease(CVD) mortality in the Diabetes Heart Study(DHS).METHODS Out of a total of 1443 participants recruited into the DHS, 1315 participants with type 2 diabetes who were free of atrial fibrillation and supraventricular tachycardia during the baseline exam were included in this analysis. Heart rate was collected from baseline resting electrocardiogram and mortality(all-cause and CVD) was obtained from state and national death registry. Kaplan-Meier(K-M) and Cox proportional hazard analyses were used to assess the *** The mean age, body mass index(BMI) and systolic blood pressure(SBP) of the cohort were 61.4 ± 9.2 years, 32.0 ± 6.6 kg/m2, and 139.4 ± 19.4 mmHg respectively. Fiftysix percent were females, 85% were whites, 15% were blacks, 18% were smokers. The mean ± SD heart rate was 69.8(11.9) beats per minute(bpm). After a median follow-up time of 8.5 years(maximum follow-up time is 14.0 years), 258 participants were deceased. In K-M analysis, participants with heart rate above the median had a significantly higher event rate compared with those below the median(log-rank P = 0.0223). A one standard deviation increase in heart rate was associated with allcause mortality in unadjusted(hazard ratio 1.16, 95%CI: 1.03-1.31) and adjusted(hazard ratio 1.20, 95%CI: 1.05-1.37) models. Similar results were obtained with CVD mortality as the outcome of *** Heart rate is an independent predictor of all-cause mortality in this population with type 2 diabetes. In this study, a 1-SD increase in heart rate was associated with a 20% increase in risk suggesting that additional prognostic information may be gleaned from this ubiquitously collected vital sign.

关键词： Diabetes mellitus Mortality Resting heart rate Prevention

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Transforming catalysis to produce e‐fuels:Prospects and gaps

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Chinese Journal of Catalysis 2022年第5期43卷 1194-1203页

作者： georgia Papanikolaou Gabriele Centi Siglinda Perathoner Paola Lanzafame Department ChiBioFarAm‐Section of Industrial Chemistry University of MessinaERIC aisbl and CASPE‐INSTMV.le F.Stagno d’Alcontres 3198166 MessinaItaly

After short introducing the crucial role of e‐fuels to meet net‐zero emissions targets,this perspective paper discusses the differences between reactive catalysis(electro‐,photo‐and plasma‐catalysis,with focus on the first for conciseness)and thermal catalysis used at *** main point is to evidence that to progress in producing e‐fuels,the gap is not in terms of scaling‐up and pilot testing,but rather in the fundamental needs to turn the current approach and methodologies to develop reactive catalysis,including from a mechanistic perspective,to go beyond the current methods largely derived from thermal *** thus new fundamental bases to understand reactive catalysis is the challenge to accelerate the progress in this area to enable the potential role towards a sustainable net‐zero emissions *** novel aspects are highlighted,but the general aim is rather to stimulate discussion in rethinking catalysis from an alternative perspective.

关键词： Electrocatalysis e‐Fuels Solar fuels Mechanistic understanding Catalysis CO_(2) NH3

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Rare Earths Outlook 2019:EV Production to Drive Demand

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China Rare Earth Information 2019年第2期25卷 2-6页

作者： georgia Williams 不详

Of the 17 rare earth elements (REEs), some have proven rarer than others. Neodymium and praseodymium (NdPr), two metals instrumental to the rapidly expanding green energy and electric vehicle (EV) sectors, saw the greatest demand and price movement in 2018. Demand for the metals, which are used to make high-strength magnets for wind turbines and EV engines, is expected to grow as more EVs are manufactured and as clean-energy strategies are adopted.

关键词： REEs NdPr EV

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Lynas Stock Dives Following NewRegulations in Malaysia

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China Rare Earth Information 2018年第12期24卷 7-8页

作者： georgia Williams 不详

Shares of rare earth producer Lynas dropped by as much as 33 percent on December 5, after the Malaysian government set new license renewal conditions ahead of the New Year.

关键词： Shares New Year

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Post-partum reactivation of chronic hepatitis B virus infection among hepatitis B e-antigen-negative women

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World Journal of Gastroenterology 2015年第4期21卷 1261-1267页

作者： Ioannis Elefsiniotis Elena Vezali Dimitrios Vrachatis Sofia Hatzianastasiou Stefanos Pappas George Farmakidis georgia Vrioni Athanasios Tsakris University Department of Internal Medicine-Hepatology Unit Maternal and Perinatal Hospital "Elena Venizelou"11521 AthensGreece Department of Obstetricsand Gynecology Maternal and Perinatal Hospital "Elena Venizelou"11521 AthensGreece Department of Microbiology Medical SchoolUniversity of Athens15771 AthensGreece

AIM: To investigate the frequency and timing of post-partum chronic hepatitis B virus(HBV) reactivation and identify its pre-partum predictors. METHODS: Forty-one hepatitis B e antigen(HBe Ag)-negative chronic HBV infected pregnant women were prospectively evaluated between the 28 th and the 32 nd week of gestation. Subjects were re-evaluated at 3-mo intervals during the first post-partum year and every 6 mo during the following years. HBV DNA was determined using real-time reverse transcription polymerase chain reaction(Cobas Taq Man HBV Test) with a lower detection limit of 8 IU/m L. Post-partum reactivation(PPR) was defined as abnormal alanine aminotransaminase(ALT) levels and HBV DNA above 2000 IU/m L. RESULTS: Fourteen out of 41 women(34.1%) had prepartum HBV DNA levels > 2000 IU/m L, 18(43.9%) had levels 10000 IU/m L exhibited PPR compared with 3 of the 21(14.3%) women with HBV DNA 2000 and the third with HBV DNA of 1850IU/m L), P = 0.004. An HBV DNA level ≥ 10000 IU/m L independently predicted post-partum HBV infection reactivation(OR = 57.02, P = 0.033). Mean pre-partum ALT levels presented a non-significant increase in PPR cases(47.3 IU/L vs 22.2 IU/L, respectively, P = 0.094).CONCLUSION: In the present study, PPR occurred in approximately 30% of HBe Ag-negative pregnant women; all events were observed during the first semester after delivery. Pre-partum HBV DNA level > 10000 IU/m L predicted PPR.

关键词： Hepatitis B Pregnancy Reactivation Post-Partum Hep

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Stimulating erythropoiesis in inflammatory bowel disease associated anemia

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World Journal of Gastroenterology 2007年第36期13卷 4798-4806页

作者： georgia Tsiolakidou Ioannis E Koutroubakis Department of Gastroenterology University Hospital Heraklion Crete Greece

Anemia is a frequent complication in patients with inflammatory bowel disease (IBD), and is associated with decreased quality of life and increased rate of hospitalization. The primary therapeutic targets of IBD- associated anemia are iron deficiency and anemia of chronic disease. An important prognostic parameter of the success or failure of therapy is the outcome of the underlying disease. Iron deficiency should be appropriately managed with iron supplementation. However, the use of oral iron therapy is limited by several problems, the most important being gastrointestinal side effects leading occasionally to disease relapse and poor iron absorption. Intravenous iron preparations are more reliable, with iron sucrose demonstrating the best efficacy and tolerability. Treatment with erythropoietin or darbepoetin has been proven to be effective in patients with anemia, who fail to respond to intravenous iron. Patients with ongoing inflammation have anemia of chronic disease and may require combination therapy comprising of intravenous iron sucrose and erythropoietin. After initiating treatment, careful monitoring of hemoglobin levels and iron parameters is needed in order to avoid recurrence of anemia. In conclusion, anemia in the setting of IBD should be aggressively diagnosed, investigated, and treated. Future studies should define the optimal dose and schedule of intravenous iron supplementation and appropriate erythropoietin therapy in these patients.

关键词： Anemia Crohn’s disease Erythropoiesis Erythropoietin Iron Ulcerative colitis

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STOCK LOAN VALUATION UNDER A REGIME-SWITCHING MODEL WITH MEAN-REVERTING AND FINITE MATURITY

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Journal of Systems Science & Complexity 2010年第3期23卷 572-583页

作者： David PRAGER Department of Mathematics University of Georgia

Stock loans are business contracts between borrowers and lenders in which the borroweruses shares of stock as collateral for the *** the value of the collateral is subject to wide andfrequent price swings,valuing such a transaction behaves more like an option pricing problem thana debt valuation *** paper will list,prove,and analyze formulas for stock loan valuationwith finite horizon under various stock models,including classical geometric Brownian motion,meanreverting,and two-state regime-switching with both mean-reverting and geometric Brownian *** examples are reported to illustrate the results.

关键词： Mean reversion regime switching stock loan.

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Hepatocellular carcinoma in non-alcoholic fatty liver disease with and without cirrhosis

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Hepatoma Research 2019年第3期5卷 1-7页

作者： georgia Onzi Fernanda Moretti Silvana Sartori Balbinot Raul Angelo Balbinot Jonathan Soldera Internal Medicine Hospital GeralUniversidade de Caxias do SulCaxias do Sul 95084-180Brazil Clinical Gastroenterology Universidade de Caxias do SulCaxias do Sul 95084-180Brazil

Non-alcoholic fatty liver disease has become the leading chronic liver disease in the developed world,with a prevalence of 6%-35%.Its pathological spectrum ranges from simple steatosis(non-alcoholic fatty liver)to different degrees of inflammation and liver cell damage[non-alcoholic steatohepatitis(NASH)].NASH has gained attention in recent years because of its association with hepatocellular carcinoma(HCC).Although the occurrence of HCC is more frequent in the presence of cirrhosis,studies have shown that hepatic carcinogenesis may also develop in the context of NASH without association with advanced fibrosis,as well as from simple *** of the onset of HCC in the absence of cirrhosis is of concern,since recent surveillance and screening guidelines for liver cancer do not include this population ***,it is imperative that new effective screening and monitoring measures for HCC,or even the reformulation of these recommendations,be taken to handle these patients considered to be at high *** present paper aims to review the literature on the occurrence of HCC in patients with NASH with or without *** addition,we report a case showing the development of HCC in a patients with NASH without cirrhosis.

关键词： Non-alcoholic fatty liver disease non-alcoholic steatohepatitis cirrhosis hepatocellular carcinoma

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Impact of periampullary diverticula on the outcome and fluoroscopy time in endoscopic retrograde cholangiopancreatography

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Hepatobiliary & Pancreatic Diseases International 2013年第4期12卷 408-414页

作者： Panagiotis Katsinelos Grigoris Chatzimavroudis Kostas Tziomalos Christos Zavos Athanasios Beltsis georgia Lazaraki Sotiris Terzoudis Jannis Kountouras Department of Endoscopy and Motility Unit G. Gennimatas General Hospital School of Medicine Aristotle University of Thessaloniki Ippokration HospitalThessaloniki Greece Department of Internal Medicine School of Medicine Aristotle University of Thessaloniki Ippokration HospitalThessaloniki Greece

BACKGROUND: It is unclear whether the presence of periampullary diverticula (PAD) affects technical success and complication rates during endoscopic retrograde cholangio- pancreatography (ERCP). Moreover, the impact of PAD on fluoroscopy duration is still unknown. The present study aimed to investigate the success rate and difficulty of common bile duct (CBD) cannulation, post-procedure complications and fluoroscopy duration in patients with and without PAD. METHODS: Patients from January 2008 to December 2010 with PAD (group A) and without PAD (group B) and similar indications for therapeutic ERCP were prospectively compared. The comparison included patient characteristics, findings of ERCP, and details of procedure and fluoroscopy time. The influence of papilla’s location with respect to the diverticulum on procedure was also investigated. RESULTS: A total of 428 consecutive patients who had undergone therapeutic ERCP for similar indications were divided in two groups according to the presence (group A, 107 patients) or absence (group B, 321 patients) of PAD. The mean age and ASA score of the patients with PAD were significantly higher than those patients without PAD. The main indication was choledocholithiasis. Successful final CBD cannulation was achieved in 97.20% of the patients in group A vs 99.69% in group B (P=0.05). CBD diameter, number of stones and the largest stone size were significantly higher in group A thangroup B (P<0.001). Complete clearance of the CBD after the first attempt was achieved in 85.86% and 94.75% of the patients in groups A and B, respectively (P=0.03). In both groups, the time needed to complete the procedure and fluoroscopy time was significantly longer in patients with PAD (22.87 vs 18.99 minutes, P<0.001; 76.51 vs 47.42 seconds, P<0.001). There was no significant difference between the two groups in the complication rate. The type of papilla’s location with respect to the diverticulum did not influence the total cannulati

关键词： endoscopic retrograde cholangiopancreatography anatomy ampulla of Vater

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Fully Polarimetric Land Cover Classification Based on Markov Chains

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Advances in Remote Sensing 2021年第3期10卷 47-65页

作者： georgia Koukiou Vassilis Anastassopoulos Electronics Laboratory (ELLAB) Physics Department University of Patras Patras Greece

A novel land cover classification procedure is presented utilizing the information content of fully polarimetric SAR images. The Cameron coherent target decomposition (CTD) is employed to characterize land cover pixel by pixel. Cameron’s CTD is employed since it provides a complete set of elementary scattering mechanisms to describe the physical properties of the scatterer. The novelty of the proposed land classification approach lies on the fact that the features used for classification are not the types of the elementary scatterers themselves, but the way these types of scatterers alternate from pixel to pixel on the SAR image. Thus, transition matrices that represent local Markov models are used as classification features for land cover classification. The classification rule employs only the most important transitions for decision making. The Frobenius inner product is employed as similarity measure. Ten different types of land cover are used for testing the proposed method. In this aspect, the classification performance is significantly high.

关键词： Fully Polarimetric SAR Coherent Decomposition Elementary Scatterers Markov Chains Land Cover Classification

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