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A new hemostatic agent composed of Zn^(2+)-enriched Ca^(2+)alginate activates vascular endothelial cells in vitro and promotes tissue repair in vivo

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Bioactive Materials 2022年第12期7卷 368-382页

作者： Anne-Charlotte Ponsen Richard Proust Sabrina Soave Françoise Mercier-Nom´e Isabelle Garcin Laurent Combettes Jean-Jacques Lataillade georges uzan INSERM UMRS-MD 1197 Universit´e Paris-SaclayInstitut Andr´e LwoffHˆopital Paul BrousseVillejuifFrance Plateforme d’Histologie Immunopathologie de Clamart(PHIC) Universit´e Paris-SaclayINSERMCNRSInstitut Paris Saclay d’Innovation Th´erapeutiqueChˆatenay-MalabryFrance Universit´e Paris-Saclay INSERMInflammationMicrobiome and ImmunosurveillanceClamartFrance INSERM UMRS 1174 Universit´e Paris-SaclayOrsayFrance Centre de Transfusion Sanguine des Arm´ees ClamartFrance

To control capillary bleeding, surgeons may use absorbable hemostatic agents, such as Surgicel® and TachoSil®. Due to their slow resorption, their persistence in situ can have a negative impact on tissue repair in the resected organ. To avoid complications and obtain a hemostatic agent that promotes tissue repair, a zinc-supplemented calcium alginate compress was developed: HEMO-IONIC®. This compress is non-absorbable and is therefore removed once hemostasis has been achieved. After demonstrating the hemostatic efficacy and stability of the blood clot obtained with HEMO-IONIC, the impact of Surgicel, TachoSil, and HEMO-IONIC on cell activation and tissue repair were compared (i) in vitro on endothelial cells, which are essential to tissue repair, and (ii) in vivo in a mouse skin excision model. In vitro, only HEMO-IONIC maintained the phenotypic and functional properties of endothelial cells and induced their migration. In comparison, Surgicel was found to be highly cytotoxic, and TachoSil inhibited endothelial cell migration. In vivo, only HEMO-IONIC increased angiogenesis, the recruitment of cells essential to tissue repair (macrophages, fibroblasts, and epithelial cells), and accelerated maturation of the extracellular matrix. These results demonstrate that a zinc-supplemented calcium alginate, HEMO-IONIC, applied for 10 min at the end of surgery and then removed has a long-term positive effect on all phases of tissue repair.

关键词： Hemostatic agent Alginate Surgery Hemostasis Endothelial cells Tissue repair

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Differences and similarities between mesenchymal stem cell and endothelial progenitor cell immunoregulatory properties against T cells

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World Journal of Stem Cells 2021年第8期13卷 971-984页

作者： Mehdi Razazian Maryam Khosravi Sheyda Bahiraii georges uzan Sara Shamdani Sina Naserian Institut national de la santéet de la recherche médicale(Inserm)UnitéMixte de Recherche-Inserm-Ministère de la Défense 1197 Hôpital Paul BrousseVillejuif 94800France Microenvironment&Immunity Unit Institut PasteurParis 75724France Institut national de la santéet de la recherche médicale(Inserm)Unit 1224 Paris 75724France Department of Pharmacognosy University of ViennaVienna 1090Austria Paris-Saclay University Villejuif 94800France CellMedEx Saint Maur Des Fossés 94100France

Bone-marrow-derived mesenchymal stem cells and endothelial progenitor cells have some interesting biological properties that make them unique for cell therapy of degenerative and cardiovascular *** both cell populations have been already studied and used for their regenerative potentials,recently their special immunoregulatory features have brought much more *** stem cells and endothelial progenitor cells have both proangiogenic functions and have been shown to suppress the immune response,particularly T cell proliferation,activation,and cytokine *** makes them suitable choices for allogeneic stem cell ***,these two cells do not have equal immunoregulatory *** elements including their extraction sources,age/passage,expression of different markers,secretion of bioactive mediators,and some others could change the efficiency of their immunosuppressive ***,to our knowledge,no publication has yet compared mesenchymal stem cells and endothelial progenitor cells for their immunological interaction with T *** review aims to specifically compare the immunoregulatory effect of these two populations including their T cell suppression,deactivation,cytokine production,and regulatory T cells induction ***,it evaluates the implications of the tumor necrosis factor alpha-tumor necrosis factor receptor 2 axis as an emerging immune checkpoint signaling pathway controlling most of their immunological properties.

关键词： Endothelial Progenitor Cells Mesenchymal Stem Cells T cells Immunosuppression Immunoregulation TNFα-TNFR2 signaling pathway

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Celastrol targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation

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Journal of Integrative Medicine 2016年第3期14卷 203-208页

作者： Yu-fan Shen Xue Zhang Ying Wang Fan-fan Cao georges uzan Bin Peng Deng-hai Zhang Department of Clinical Laboratory Diagnostics Postgraduate Education College Ningxia Medical University Sino-French Cooperative Central Laboratory Shanghai Gongli Hospital Second Military Medical University U972 Inserm Lavoisier Building Paul Brousse Hospital

OBJECTIVE： Celastrol has been established as a nuclear factor-κB（NF-κB） activation inhibitor; however, the exact mechanism behind this action is still unknown. Using text-mining technology, the authors predicted that int erleukin-1 receptor-associated kinases（IRA Ks） are potential celastrol targets, and hypothesized that targeting IRAKs might be one way that celastrol inhibits NF-κB. This is because IRAKs are key molecules for some crucial pathways to activate NF-κB（e.g., the inter leukin-1 receptor（IL-1R）/Toll- like receptor（TLR） superfamily）.METHODS： The human hepatocellular cell line（Hep G2） treated with palmitic acid（PA） was used as a model for stimulating TLR4/NF-κB activation, in order to observe the potential effects of celastrol in IRAK regulation and NF-κB inhibition. The transfection of small interfering RNA was used for down-regulating TLR4, IRAK1 and IRAK4, and the Western blot method was used to detect changes in the protein ***： The results showed that celastrol could effectively inhibit PA-caused TLR4-dependent NF-κB activation in the Hep G 2 cells; PA also activated IRAKs, which were inhibited by celastrol. Knocking down IRAKs abolished PA-caused NF-κB ***： The results for the first time show that targeting IRAKs is one way in which celastrol inhibits NF-κB activation.

关键词： celastrol interleukin-1 receptor-associated kinases nuclear factor-kappa B Toll-like receptor 4 hepatocytes

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Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

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Neural Regeneration Research 2024年第3期19卷 536-541页

作者： georges Jourdi Samuel Fleury Imane Boukhatem Marie Lordkipanidzé Research Center Montreal Heart InstituteMontrealQCCanada Faculty of Pharmacy Universitéde MontréalMontrealQCCanada UniversitéParis Cité INSERMInnovative Therapies in HaemostasisParisFrance Service d’Hématologie Biologique AP-HPHôpital LariboisièreParisFrance

Neurodegenerative diseases are often misdiagnosed,especially when the diagnosis is based solely on clinical *** p75 neurotrophic receptor(p75^(NTR))has been studied as an index of sensory and motor nerve development and *** cleavable extracellular domain(ECD)is readily detectable in various biological fluids including plasma,serum and *** is evidence for increased p75NTR ECD levels in neurodegenerative diseases such as Alzheimer’s disease,amyotrophic lateral sclerosis,age-related dementia,schizophrenia,and diabetic *** p75^(NTR) ECD could be used as a biomarker for diagnosis and/or prognosis in these disorders,and whether it could potentially lead to the development of targeted therapies,remains an open *** this review,we present and discuss published studies that have evaluated the relevance of this emerging biomarker in the context of various neurodegenerative *** also highlight areas that require further investigation to better understand the role of p75^(NTR) ECD in the clinical diagnosis and management of neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis biomarker dementia diabetic neuropathy nerve growth factor receptor(NGFR) neurodegeneration p75^(NTR) schizophrenia

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晚期内皮祖细胞大量扩增方法

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中华医学杂志 2012年第36期92卷 2574-2577页

作者：吴立华宋增璇刘旭辉李尚珠韩忠朝 georges uzan 中国医学科学院北京协和医学院血液病医院血液学研究所内科天津300020 National Institute of Health and Medical Research Unit602

目的通过实验验证一个体外大量扩增晚期内皮祖细胞（EPC）的方法。方法先预铺经辐射后的滋养层细胞（晚期EPC或脐带脐静脉内皮细胞），而后植入分离的人外周血单个核细胞，计数并对比培养21d后获得的晚期EPC克隆数目，并检测目的细胞免... 详细信息

目的通过实验验证一个体外大量扩增晚期内皮祖细胞（EPC）的方法。方法先预铺经辐射后的滋养层细胞（晚期EPC或脐带脐静脉内皮细胞），而后植入分离的人外周血单个核细胞，计数并对比培养21d后获得的晚期EPC克隆数目，并检测目的细胞免疫表型，应用基质胶（matrigel）鉴定其体外管状结构形成能力。结果21d时在预铺的两种滋养层细胞培养条件下获得的晚期EPC克隆数目均比无滋养层细胞的培养方法高20倍（40．0±3．9、39．3±3．1比2．0±1．3，均P〈0．05）；且细胞克隆出现的早。目的细胞表达CD31、CD34、内皮型一氧化氮合酶（eNOS）、血管内皮细胞生长因子受体Fit-1、CDl46的2个表型（P1H12、Sendo）、血管内皮钙黏蛋白（VEcadherin）、CDll7，且具有能在体外与matrigel形成管状结构的功能。结论通过提供滋养层细胞的方法可以大量扩增晚期EPC，提示微环境在晚期EPC扩增中起重要作用。

关键词：干细胞细胞增殖晚期内皮祖细胞滋养层细胞

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微环境在体外大量扩增晚期内皮祖细胞中的作用

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中国医学科学院学报 2012年第3期34卷 202-206页

作者：吴立华宋增璇刘旭辉李尚珠韩忠朝 georges uzan 中国医学科学院北京协和医学院血液学研究所&血液病医院内科天津300020 法国国家健康与医学研究院法国巴黎94807

目的探讨做为微环境的滋养层细胞在体外大量扩增晚期内皮祖细胞(EPC)中的作用。方法预铺辐射后的滋养层细胞,而后植入分离的外周血单个核细胞,计数培养21 d后获得的晚期EPC克隆数目,并检测目的细胞免疫表型,用Matrigel鉴定其体外血管形... 详细信息

目的探讨做为微环境的滋养层细胞在体外大量扩增晚期内皮祖细胞(EPC)中的作用。方法预铺辐射后的滋养层细胞,而后植入分离的外周血单个核细胞,计数培养21 d后获得的晚期EPC克隆数目,并检测目的细胞免疫表型,用Matrigel鉴定其体外血管形成能力。采用动态显微镜追踪单个干细胞在滋养层细胞上的分化过程。结果培养21 d时,在预铺晚期EPC和人脐静脉内皮细胞(HUVEC)为滋养层的培养环境下,每100ml外周血单个核细胞分别获得(40.0±3.9)和(39.3±3.1)个晚期EPC克隆,均明显高于无滋养层条件下的(2.0±1.3)个(P均<0.05)。目的细胞可表达CD31、CD34、eNOS、FLt-1、P1H12、Sendo、VEcadherin和CD117,并在体外与Matrigel形成管状结构。动态追踪示单个干细胞的扩增是在有滋养层细胞参与下完成不对称分裂的。结论通过提供滋养层细胞方法可以大量扩增晚期EPC,滋养层细胞可能参与了早阶段内皮干细胞的不对称分裂扩增。

关键词：晚期内皮祖细胞滋养层细胞微环境不对称分裂

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Efficacy of Botanicals on Parasitoids of Mango Fruit Flies in Burkina Faso

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Advances in Entomology 2024年第1期12卷 24-37页

作者： Rabieta Simde Delphine Ouattara Elias Mano georges Kambou georges Kambou Souleymane Nacro Institute of Environment and Agricultural Research (INERA) Central Horticulture Laboratory of the Regional Center of Excellence in Fruits and Vegetables of Bobo-Dioulasso Bobo-Dioulasso Burkina Faso Institute of Research in Applied Sciences and Technologies (IRSAT) Laboratory of Natural Substances and Technologies of Natural Products and the Environment (LABTECH-PRONE) Ouagadougou Burkina Faso Kamboinsé Environmental Agricultural Research and Training Center Ouagadougou Burkina Faso

The effect of Capsicum annuum and Strophantus hispidus formulations was evaluated on Diachasmimorpha longicaudata. The formulations were obtained from the crude total extracts of C. annuum;S. hispidus and the adjuvant previously developed. The formulations were prepared according to three concentrations of extracts of each plant species (low, medium and high). These concentrations were calculated on the basis of 1.5 mg/mL of each formulation causing 18% and 15% mortality respectively in Ceratitis cosyra within 72 h. The effect of the formulations on D. longicaudata was tested using a Fisher block design with 8 treatments (C. annuum (3.75;7.5;12.5 g/L);S. hispidus (4.5;9;15 g/L);Success bait 2.4 g/L;control) and 5 replicates. For each formulation, 1.5 mL was poured into a vial containing 0.25 g of cotton. Then 20 adults of the parasitoid were added and the whole was covered with muslin and held in place with rubber bands. The parasitoids were examined after 24 and 72 hours, and those that did not react to the touch of a fine brush were considered dead. The results showed a difference between the treatments. After 24 hours of exposure, the parasitoid showed high mortality at the S. hispidus concentrations (15 g/L;4.5 g/L) followed by the Success bait. These concentrations resulted in mortality rates of 22.50% for S. hispidus and 20.50% for Success bait. After 72 h, low parasitoid mortality (35.81%) was obtained with 3.75 g/L C. annuum, but high mortality was observed with S. hispidus (59.95%;64.20%;57.15%) and Success bait (54.80%). The use of C. annuum formulations at 3.75 g/L could be recommended for conserving D. longicaudata in the nature.

关键词： Concentrations Exposure Mortality Parasitoid Formulations

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Advancing critical care recovery:The pivotal role of machine learning in early detection of intensive care unit-acquired weakness

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World Journal of Clinical Cases 2024年第21期12卷 4455-4459页

作者： georges Khattar Elie Bou Sanayeh Department of Medicine Staten Island University HospitalStaten IslandNY 10305United States

This editorial explores the significant challenge of intensive care unit-acquiredweakness(ICU-AW),a prevalent condition affecting critically ill patients,characterizedby profound muscle weakness and complicating patient *** paradox of modern medical advances,it emphasizes the urgent needfor early identification and intervention to mitigate ICU-AW's ***,the study by Wang et al is showcased for employing a multilayer perceptronneural network model,achieving high accuracy in predicting *** advancement underscores the potential of neural network models inenhancing patient care but also calls for continued research to address limitationsand improve model *** editorial advocates for the developmentand validation of sophisticated predictive tools,aiming for personalized carestrategies to reduce ICU-AW incidence and severity,ultimately improving patientoutcomes in critical care settings.

关键词： Critical illness myopathy Critical illness polyneuropathy Early detection Intensive care unit-acquired weakness Neural network models Patient outcomes Personalized intervention strategies Predictive modeling

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Mapping Climate Services for Disaster Risk Management: A Systematic Review and Research Gaps from a Policy Process Perspective

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American Journal of Climate Change 2024年第2期13卷 314-360页

作者： Aboubacar Issaka Ousman Gaoh Wolfram Laube georges Abbevi Abbey Moussa Waongo West African Science Service Centre on Climate Change and Adapted Land Use (WASCAL) Accra Ghana Department of Geography-DRP-Climate Change and Disaster Risk Management University of Lom Lom Togo Department of Political and Cultural Change Centre for Development Research (ZEF) University of Bonn Bonn Germany Department of Agricultural Economics and Agribusiness Management School of Agriculture University of Lom Lom Togo Department of Training and Research Regional Centre for West Africa and the Sahel (AGRHYMET) Niamey Niger

Climate services (CS) are crucial for mitigating and managing the impacts and risks associated with climate-induced disasters. While evidence over the past decade underscores their effectiveness across various domains, particularly agriculture, to maximize their potential, it is crucial to identify emerging priority areas and existing research gaps for future research agendas. As a contribution to this effort, this paper employs the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology to review the state-of-the-art in the field of climate services for disaster risk management. A comprehensive search across five literature databases combined with a snowball search method using ResearchRabbit was conducted and yielded 242 peer-reviewed articles, book sections, and reports over 2013-2023 after the screening process. The analysis revealed flood, drought, and food insecurity as major climate-related disasters addressed in the reviewed literature. Major climate services addressed included early warning systems, (sub)seasonal forecasts and impact-based warnings. Grounded in the policy processes’ theoretical perspective, the main focus identified and discussed three prevailing policy-oriented priority areas: 1) development of climate services, 2) use-adoption-uptake, and 3) evaluation of climate services. In response to the limitations of the prevalent supply-driven and top-down approach to climate services promotion, co-production emerges as a cross-cutting critical aspect of the identified priority areas. Despite the extensive research in the field, more attention is needed, particularly pronounced in the science-policy interface perspective, which in practice bridges scientific knowledge and policy decisions for effective policy processes. This perspective offers a valuable analytical lens as an entry point for further investigation. Hence, future research agendas would generate insightful evidence by scrutinizing this critical aspect g

关键词： Climate Services Disaster Risk Management Policy Process Science-Policy Interface Institutional Analysis

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Evaluation of Procedural Pain in Neonates in Cameroon

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Open Journal of Pediatrics 2024年第3期14卷 568-578页

作者： Claude-Audrey Meguieze Rose Bidias Etouckey georges Eric Nseme Koki Ndombo Paul Olivier Pediatrics Department Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Morphologic Sciences Department Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon

Introduction: Acute pain associated with caregiving is a major cause of pain among neonates. Left untreated, it can lead to long-term neurosensory and psychoaffective consequences. In Cameroon, this subject has been scarcely explored, thus constituting an impediment to the management of care-induced pain. Objective: Assess procedural pain in neonates in Yaoundé. Material and Methods: We conducted a cross sectional study with prospective data collection over a period of eight months (October 2022 to May 2023) in three hospitals. We included neonates who were being cared for and were not crying prior to the onset of healthcare, whose parents consented to the study. Assessments were done using the DAN scale, which is specific to care-induced pain. Data was entered and analyzed using SPSS 23.0 software. Results: A total of 161 newborns were included. The hospital prevalence of care-induced pain in neonates was 85%. Neonatal sepsis was the main cause for admission (96.6%). The most common procedures were venous blood sampling (94.4%) and insertion of peripheral venous lines (93.8%). The pain intensity for these procedures was severe (83.9%). The most painful procedure was lumbar tap, followed by venous access procedures. Conclusion: Neonates in hospitals are subjected to many painful procedures. The pain experienced during these procedures is severe. The most nociceptive procedure is a lumbar puncture.

关键词： Assessment Procedural Pain Neonate Yaoundé Cameroon

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