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An AuNPs/Mesoporous NiO/Nickel Foam Nanocomposite as a Miniaturized Electrode for Heavy Metal Detection in Groundwater

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Engineering 2023年第8期27卷 199-208页

作者： Boyuan Xue Qian yang Kaidong Xia Zhihong Li george y.chen Dayi Zhang Xiaohong Zhou State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China National Key Laboratory of Science and Technology on Micro/Nano Fabrication Institute of MicroelectronicsPeking UniversityBeijing 100871China Shenzhen Key Laboratory of Photonic Devices and Sensing Systems for Internet of Things Guangdong and Hong Kong Joint Research Centre for Optical Fiber SensorsShenzhen UniversityShenzhen 518060China College of New Energy and Environment Jilin UniversityChangchun 130021China The Research Institute of Environmental Innovation(Suzhou) Tsinghua UniversitySuzhou 215000China

Heavy metals,notably Pb2+and Cu^(2+),are some of the most persistent contaminants found in *** monitoring of these metals,which relies on efficient,sensitive,cost-effective,and reliable methods,is a *** present a nanocomposite-based miniaturized electrode for the concurrent measurement of Pb2+and Cu^(2+)by exploiting the electroanalytical technique of square wave *** also propose a facile in situ hydrothermal calcination method to directly grow binder-free mesoporous Ni O on a three-dimensional nickel foam,which is then electrochemically seeded with gold nanoparticles(Au NPs).The meticulous design of a low-barrier Ohmic contact between mesoporous Ni O and Au NPs facilitates target-mediated nanochannel-confined electron transfer within mesoporous Ni *** a result,the heavy metals Pb2+(0.020 mg.L^(-1)detection limit;2.0–16.0 mg.L^(-1)detection range)and Cu^(2+)(0.013 mg.L^(-1)detection limit;0.4–12.8 mg.L^(-1)detection range)can be detected simultaneously with high ***,other heavy metal ions and common interfering ions found in groundwater showed negligible impacts on the electrode’s performance,and the recovery rate of groundwater samples varied between 96.3%±2.1%and 109.4%±0.6%.The compactness,flexible shape,low power consumption,and ability to remotely operate our electrode pave the way for onsite detection of heavy metals in groundwater,thereby demonstrating the potential to revolutionize the field of environmental monitoring.

关键词： AuNPs Mesoporous NiO Miniaturized electrode Heavy metal ions Groundwater Square wave voltammetry

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu ying Wang yan Sun Lingxiao Deng Melissa Walker chen chen Heqiao Dai Qi Han ying Ding yongzhi Xia george Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Deciphering deformation mechanisms of hierarchical dual-phase CrCoNi coatings

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Journal of Materials Science & Technology 2020年第4期39卷 7-13页

作者： S.J.Tsianikas y.chen Z.Xie School of Mechanical Engineering The University of AdelaideAdelaideSA5005Australia Centre for Advanced Thin Film Materials and Device Faculty of Materials and EnergySouthwest UniversityChongqing400715China School of Engineering Edith Cowan UniversityWA6027Australia

Hierarchical Cr Co Ni medium entropy alloy(MEA)thin films with a dual-phase face-centred cubic(FCC)and hexagonal closed-packed(HCP)nanostructure were prepared on M2 steel substrates by closed field unbalanced magnetron *** tests show an ultra-high hardness of 9.5 GPa,attributable to large amounts of innate planar defects(i.e.,growth twins and stacking faults)impeding dislocation motion in the coatings.A deep analysis of undeformed and post-mortem samples reveals grain refinement as the dominant deformation mechanism in FCC dominated regions,while phase transformation and shear banding played major roles in regions occupied by HCP *** grain refinement was facilitated by twin/matrix lamellae,with dislocations piling up and arranging into interconnecting grain *** shear banding was accelerated by innate planar defects in the HCP phase due to a lack of slip *** particular interest is the observation of HCP→FCC phase transformation,which was catalysed by deformation-induced grain reorientation with innate stacking faults acting as embryos to grow the FCC *** results of this work suggest that multiple deformation pathways could be activated in Cr Co Ni coatings with assistance of growth defects,thereby imparting these technically important coatings appreciable ductility.

关键词： Medium entropy alloys Sputter deposition Grain refinement Shear banding Phase transformation

Polar Gini Curve:A Technique to Discover Gene Expression Spatial Patterns from Single-cell RNA-seq Data

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Genomics, Proteomics & Bioinformatics 2021年第3期19卷 493-503页

作者： Thanh Minh Nguyen Jacob John Jeevan Nuo Xu Jake y.chen Informatics Institute the University of Alabama at BirminghamBirminghamAL 35294USA Collat School of Business the University of Alabama at BirminghamBirminghamAL 35294USA

In this work,we describe the development of Polar Gini Curve,a method for characterizing cluster markers by analyzing single-cell RNA sequencing(scRNA-seq)*** Gini Curve combines the gene expression and the 2D coordinates(“spatial”)information to detect patterns of uniformity in any clustered cells from scRNA-seq *** demonstrate that Polar Gini Curve can help users characterize the shape and density distribution of cells in a particular cluster,which can be generated during routine scRNA-seq data *** quantify the extent to which a gene is uniformly distributed in a cell cluster space,we combine two polar Gini curves(PGCs)—one drawn upon the cell-points expressing the gene(the“foreground curve”)and the other drawn upon all cell-points in the cluster(the“background curve”).We show that genes with highly dissimilar foreground and background curves tend not to uniformly distributed in the cell cluster—thus having spatially divergent gene expression patterns within the *** with similar foreground and background curves tend to uniformly distributed in the cell cluster—thus having uniform gene expression patterns within the *** quantitative attributes of PGCs can be applied to sensitively discover biomarkers across clusters from scRNA-seq *** demonstrate the performance of the Polar Gini Curve framework in several simulation case *** this framework to analyze a real-world neonatal mouse heart cell dataset,the detected biomarkers may characterize novel subtypes of cardiac muscle *** source code and data for Polar Gini Curve could be found at http://***/PGC/or https://***/projects/Polar_Gini_Curve/76749.

关键词： Single-cell gene expression Polar Gini curve Spatial pattern Biomarker discovery

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology research 2025年第1期33卷 103-121页

作者： yan Lu Kang Wang yuanhong Peng Meng chen Lin Zhong Luji Huang F U cheng Xindan Sheng Xin yang Manzhao Ouyang george A Calin Zhiwei He China-America Cancer Research Institute Guangdong Medical University Dongguan 523808 China. GCP Center Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. Department of Gastrointestinal Surgery Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China. The Second School of Clinical Medicine Southern Medical University Guangzhou 510080 China. Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA. Department of Oncology Shunde Hospital Southern Medical University (The First People's Hospital of Shunde Foshan) Shunde 528300 China.

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors, but the currently used immune checkpoint inhibitors targeting programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and cytotoxic T-lymphocyte antigen-4 (CTLA-4) show limited clinical efficacy in many breast cancers. B7H3 has been widely reported as an immunosuppressive molecule, but its immunological function in breast cancer patients remains unclear.Methods:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program (TCGA) and the Gene Expression Omnibus (GEO) databases. MicroRNAs were selected using the TarBase, miRTarBase, and miRBase databases. The regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays, which identified the specific action sites of interaction. The expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR (qPCR). experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and apoptosis. Additionally, the regulatory impact of hsa-miR-214-3p on B7H3 was examined. Enzyme-linked immunosorbent assays (ELISA) and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells (PBMCs) on immune cells and associated cytokines.Results:In breast cancer tissues, the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p, as well as with the regulatory effects on breast cancercell behavior. Hsa-miR-214-3p was found to inhibit breast cancer cell growth by downregulating B7H3. Importantly, our research identified, for the first time, two binding sites for hsa-miR-214-3p on the 3' UTR of B7H3, both of which exert similar effects independently. Co-culture experime

关键词： B7H3 Breast cancer Hsa-miR-214-3p Immunotherapy

Alloy solidification: Assessment and improvement of an easy-to-apply model

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Journal of Materials Science & Technology 2022年第35期130卷 1-11页

作者： H.Liu y.Liu S.L.Lu y.Zhang H.chen y.chen M.Qian School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu 610031China Centre for Additive Manufacturing School of EngineeringRMIT UniversityMelbourneVIC 3000Australia School of Materials Science and Engineering Sichuan UniversityChengdu 610065China

It has been a central task of solidification research to predict solute microsegregation. Apart from the Lever rule and the Scheil-Gulliver equation, which concern two extreme cases, a long list of microsegregation models has been proposed. However, the use of these models often requires essential experimental input information, e.g., the secondary dendrite arm spacing(λ), cooling rate( ˙T) or actual solidification range(△T). This requirement disables these models for alloy solidification with no measured values for λ,˙T and △T. Furthermore, not all of these required experimental data are easily obtainable. It is therefore highly desirable to have an easy-to-apply predictive model that is independent of experimental input,akin to the Lever rule or Scheil-Gulliver model. Gong, chen, and co-workers have recently proposed such a model, referred to as the Gong-chen model, by averaging the solid fractions(f_(s)) of the Lever rule and Scheil-Gulliver model as the actual solid fraction. We provide a systematic assessment of this model versus established solidification microsegregation models and address a latent deficiency of the model, i.e.,it allows the Lever rule solid fraction fsto be greater than one(f_(s)> 1). It is shown that the Gong-chen model can serve as a generic model for alloy solidification until fsreaches about 0.9, beyond which(f_(s)> 0.9) its applicability is dictated by both the equilibrium solute partition coefcient(k) and the solute diffusion coefcient in the solid(Ds), which has been tabulated in detail.

关键词： Solidification Microsegregation Solute Back diffusion Eutectic formation

EFFECT OF CHEMICAL COMPOSITION AND PROCESSES ON THE TEXTURE OF HOT-ROLLED DEEP DRAWING STEEL SHEET

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Acta Metallurgica Sinica(English Letters) 2002年第3期15卷 324-330页

作者： y.chen X.chen C.y.Li X.y.Li y.L.Kang Technical Center of Wuhan Iron and Steel Group Co. Wuhan 430080China Wuhan University of Science and Technology Wuhan 430080China Central General Iron and Steel Research Institute Beijing 100081China University of Science and Technology Beijing Beijing 100083China

A hot-rolled deep drawing(HDD)steel with high r-value and uniformdistribution of{111}texture in thickness was developed by hot rolling in ferrite region withlubricating between the roller and the *** experimental results show that the carbon contentand finish rolling temperature have significant effects on beneficial texture{111},and lubricatingduring hot rolling at low temperature in alpha-region makes the distribution of the *** basic requirements needed to meet for HDD steel were concluded by comparing differentcarbon contents and hot rolling processes.

关键词： ultra low carbon hot rolling in alpha-region lubricating r-value {111}texture

Decoding defect statistics from diffractograms via machine learning

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npj Computational Materials 2021年第1期7卷 601-609页

作者： Cody Kunka Apaar Shanker Elton y.chen Surya R.Kalidindi Rémi Dingreville Center for Integrated Nanotechnologies Sandia National LaboratoriesAlbuquerqueNMUSA.2Georgia Institute of TechnologyAtlantaGAUSA

Diffraction techniques can powerfully and nondestructively probe materials while maintaining high resolution in both space and ***,these characterizations have been limited and sometimes even erroneous due to the difficulty of decoding the desired material information from features of the ***,these features are identified non-comprehensively via human intuition,so the resulting models can only predict a subset of the available structural *** the present work we show(i)how to compute machine-identified features that fully summarize a diffractogram and(ii)how to employ machine learning to reliably connect these features to an expanded set of structural *** exemplify this framework,we assessed virtual electron diffractograms generated from atomistic simulations of irradiated *** based on machine-identified features rather than human-identified features,our machine-learning model not only predicted one-point statistics(***)but also a two-point statistic(*** distribution)of the defect ***,this work demonstrates that machine-learning models that input machine-identified features significantly advance the state of the art for accurately and robustly decoding diffractograms.

关键词： diff learning defect

WIPER: Weighted in-Path Edge Ranking for biomolecular association networks

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Quantitative Biology 2019年第4期7卷 313-326页

作者： Zongliang yue Thanh Nguyen Eric Zhang Jianyi Zhang Jake y.chen Informatics Institute School of MedicineUniversity of AlabamaBirminghamAL 35233USA Department of Biomedical Engineering University of AlabamaBirminghamAL 35233USA Department of Computer Science University of AlabamaBirminghamAL 35233USA

Background:In network biology researchers generate biomolecular networks with candidate genes or proteins experimentally-derived from high-throughput data and known biomolecular *** bioinformatics research focuses on characterizing candidate genes/proteins,or nodes,with network characteristics,e.g.,betweenness ***,there have been few research reports to characterize and prioritize biomolecular associations("edges"),which can represent gene regulatory events essential to biological ***:We developed Weighted In-Path Edge Ranking(WIPER),a new computational algorithm which can help evaluate all biomolecular interactions/associations("edges")in a network model and generate a rank order of every edge based on their in-path traversal scores and statistical significance test *** validate whether WIPER worked as we designed,we tested the algorithm on synthetic network ***:Our results showed WIPER can reliably discover both critical"well traversed in-path edges",which are statistically more traversed than normal edges,and"peripheral in-path edges",which are less traversed than normal *** with other simple measures such as betweenness centrality,WIPER provides better biological *** the case study of analyzing postanal pig hearts gene expression,WIPER highlighted new signaling pathways suggestive of cardiomyocyte regeneration and *** the case study of Alzheimer's disease genetic disorder association,WIPER reports SRC:APP,AR:APP,APP:FyN,and APP:NES edges(gene-gene associations)both statistically and biologically important from PubMed ***:We believe that WIPER will become an essential software tool to help biologists discover and validate essential signaling/regulatory events from high-throughput biology data in the context of biological ***:The free WIPER API is described at the website(***/wiper/).

关键词： networks network molecular