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A Dimens.onal Reduction Approach Bas.d on Es.ential Cons.raints.in Linear Programming

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American Journal of Operations.Res.arch 2024年第1期14卷 1-31页

作者： Eirini I. Nikolopoulou george s. androulaki. Department of Mathematics University of Patras Patras Greece Department of Bus.nes. Adminis.ration University of Patras Patras Greece

This.paper pres.nts.a new dimens.on reduction s.rategy for medium and large-s.ale linear programming problems. The propos.d method us.s.a s.bs.t of the original cons.raints.and combines.two algorithms. the weighted average and the cos.ne s.mplex algorithm. The firs. approach identifies.binding cons.raints.by us.ng the weighted average of each cons.raint, whereas.the s.cond algorithm is.bas.d on the cos.ne s.milarity between the vector of the objective function and the cons.raints. Thes. two approaches.are complementary, and when us.d together, they locate the es.ential s.bs.t of initial cons.raints.required for s.lving medium and large-s.ale linear programming problems. After reducing the dimens.on of the linear programming problem us.ng the s.bs.t of the es.ential cons.raints. the s.lution method can be chos.n from any s.itable method for linear programming. The propos.d approach was.applied to a s.t of well-known benchmarks.as.well as.more than 2000 random medium and large-s.ale linear programming problems. The res.lts.are promis.ng, indicating that the new approach contributes.to the reduction of both the s.ze of the problems.and the total number of iterations.required. A tree-bas.d clas.ification model als. confirmed the need for combining the two approaches. A detailed numerical example, the general numerical res.lts. and the s.atis.ical analys.s.for the decis.on tree procedure are pres.nted.

关键词： Linear Programming Binding Cons.raints Dimens.on Reduction Cos.ne s.milarity Decis.on Analys.s Decis.on Trees

Rocahepevirus.ratti: An underrecognis.d caus. of acute hepatitis

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World Journal of Hepatology 2024年第8期16卷 1084-1090页

作者： george s.Gherlan Department of Infectious.Dis.as.s “Carol Davila”University of Medicine and PharmacyBucharest 050474Romania

Zoonos.s.are res.ons.ble for many of all emerging infectious.dis.as.s.as.well as.for thos. already *** ratti is.a rat-originated virus.related to the hepatitis.E virus.Pas.ahepevirus.balayani)but highly divergent genetically from this.with a high cros.-s.ecies.infection potential and zoonotic *** can infect humans.leading to acute hepatitis.and is.primarily trans.itted through the cons.mption of contaminated *** ratti was.firs. dis.overed in Germany in *** firs. human cas. was.des.ribed in 2017 in Hong Kong in an immune-compromis.d *** firs. cas. of chronic infection with Rocahep-evirus.ratti was.des.ribed in 2023.A meta-analys.s.bas.d on 38 s.udies.publis.ed between 2000 and 2023 identified 21 cas.s.in humans.des.ribed up to this.date and 489 infections.in different *** awarenes. regarding this.virus.is.es.ential,as.there are probably many cas.s.that remain undiagnos.d,and the virus.even has.the ability to produce chronic infections.in s.lected patients.

关键词： Hepatitis Rocahepevirus.ratti Rats Zoonos.s Hepeviridae Liver

Robotic-as.is.ed retroperitoneal lymph node dis.ection for s.age II tes.icular cancer

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As.an Journal of Urology 2024年第1期11卷 121-127页

作者： george McClintock Ahmed s.Goolam Don Perera Ryan Downey s.ott Les.ie Peter Grimis.n Henry Woo Peter Fergus.n Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaes.hes.a Chris O'Brien LifehouseSydneyNSWAustralia The Univers.ty of s.dney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as.well as.early oncological outcomes.of patients.undergoing robotic retroperitoneal lymph node dis.ection for treatment of tes.icular ***:We conducted a pros.ective cons.cutive cas. s.ries.of patients.undergoing robotic as.is.ed retroperitoneal lymph node dis.ection for metas.atic tes.icular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteris.ics.intraoperative and pos.operative parameters.and functional and oncological *** s.atis.ics.are ***:Nineteen patients.were identified;18(94.7%)completed the procedure robotically and one was.converted to open s.rgery;78.9%of patients.had s.age≥IIB and 12(63.2%)patients.had undergone prior *** median operative time was.300(interquartile range[IQR]240-315)*** blood los. was.100(IQR 50-175)*** length of s.ay was.2(range 1-11)*** robotically completed patients.commenced diet and pas.ed flatus.on Day 1 and were dis.harged by Day *** median lymph node yield was.40.5(IQR 38-51)*** patients.undergoing nerve-s.aring procedures.recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous.as.ites.requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months.one patient developed retroperitoneal recurrence,which was.s.cces.fully treated with s.cond-line chemotherapy;no other patients.have had ***:Robotic retroperitoneal lymph node dis.ection is.a s.fe and feas.ble alternative to open s.rgery in appropriately s.lected patients.offering low *** oncological outcomes.are *** cohorts.and longer follow-ups.are required to validate our ins.itution's.findings.

关键词： Retroperitoneal lymph node dis.ection Robotic s.rgery Tes.icular cancer Retroperitoneal node dis.ection

Probiotics. s.aping the gut immunological res.ons.s

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World Journal of Gas.roenterology 2024年第15期30卷 2096-2108页

作者： Eirini Filidou Leonidas.Kandilogiannakis.Anne s.rews.ury george Kolios.Katerina Kotzampas.i Faculty of Medicine Laboratory of PharmacologyDemocritus University of ThraceAlexandroupolis 68100Greece Department of s.rgery Aristotle University of ThessalonikiThessaloniki 54636Greece

Probiotics.are live microorganis.s.exerting beneficial effects.on the hos.’s.health when adminis.ered in adequate *** the mos. popular and adequately s.udied probiotics.are bacteria from the families.Lactobacillaceae,Bifidobacteriaceae and *** of them have been s.own,both in vitro and in vivo s.udies.of intes.inal inflammation models.to provide favorable res.lts.by means.of improving the gut microbiota compos.tion,promoting the wound healing proces. and s.aping the immunological *** intes.inal conditions.s.ch as.inflammatory bowel dis.as.s.IBD),are characterized by an imbalance in microbiota compos.tion,with decreas.d divers.ty,and by relaps.ng and pers.s.ing inflammation,which may lead to mucos.l *** the res.lts.of the clinical s.udies.inves.igating the effect of probiotics.on patients.with IBD are s.ill controvers.al,it is.without doubt that thes. microorganis.s.and their metabolites.now named pos.biotics.have a pos.tive influence on both the hos.’s.microbiota and the immune s.s.em,and ultimately alter the topical tis.ue *** influence is.achieved through three axes.(1)By dis.placement of potential pathogens.via competitive exclus.on;(2)by offering protection to the hos. through the s.cretion of various.defens.ve mediators.and(3)by s.pplying the hos. with es.ential *** will analyze and dis.us. almos. all the in vitro and in vivo s.udies.of the pas. 2 years.dealing with the pos.ible favorable effects.of certain probiotic genus.on gut immunological res.ons.s.highlighting which s.ecies.are the mos. beneficial agains. intes.inal inflammation.

关键词： Probiotics Lactobacillaceae Bifidobacteriaceae s.ccharomyces Intes.inal inflammation Immune res.ons.s

Characteris.tion of the Bacteria and Archaea Community As.ociated with Wild Oys.ers. At Three Pos.ible Res.oration s.tes.in the North s.a

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Open Journal of Marine s.ience 2024年第2期14卷 19-40页

作者： Natacha M. s. Jus.e-Poinapen Yang Lu Blanca Bolaños.De Hoyos.george C. Birch Camille s.urel Oys.er Heaven Rotterdam Netherlands Nucleus Rotterdam Netherlands Microbial Ecology and Was.ewater Microbiology Queensland University of Technology Brisbane Australia National Ins.itute of Aquatic Res.urces Technical University of Denmark Lyngby Denmark

With 85% of the global oys.er reefs.des.royed, there is.an urgent need for large s.ale res.oration to benefit from the ecos.s.em s.rvices.provided by biogenic oys.er reefs.and their as.ociated biodivers.ty, including microorganis.s.that drive marine biogeochemical cycles. This.experiment es.ablis.ed a bas.line for the monitoring of the bacterial and archaeal community as.ociated with wild oys.ers. us.ng s.mples.from their immediate environment of the Voordelta, with cohabiting Cras.os.rea gigas.and Os.rea edulis. Duikplaats.with only C. gigas.attached to rocks. and the Dans. s.aldyrcentre, with no ons.te oys.ers. The microbial profiling was.carried out through DNA analys.s.of s.mples.collected from the s.rfaces.of oys.er s.ells.and their s.bs.rate, the s.diment and s.awater. Following 16s.rRNA amplicon s.quencing and bioinformatics. alpha indices.implied high s.ecies.abundance and divers.ty in s.diment but low abundance in s.awater. As.expected, Proteobacteria, Bacteroidetes. Firmicutes.and Thaumarchaeota dominated the top 20 OTUs. In the Voordelta, OTUs.related to Colwellia, s.ewanella and Ps.chrobium differentiated the oys.ers.collected from a reef with thos. attached to rocks. Duikplaats.were dis.inct for s.lfur-oxidizers.s.lfurimonas.and s.lfate-reducers.from the s.a 0081 s.diment group. Archaea were found mainly in s.diments.and the oys.er as.ociated microbiome, with greater abundance at the reef s.te, cons.s.ing mos.ly of Thaumarchaeota from the family Nitros.pumilaceae. The oys.er free s.te dis.layed archaea in s.diments.only, and algal bloom indicator microorganis.s.from the Rhodobacteraceae, Flavobacteriaceae family and genus.[Polaribacter] huanghezhanens.s. in addition to the as.idian s.mbiotic partner, s.nechococcus. This.s.udy s.gges.s.s.te s.ecific microbiome s.ifts. influenced by the pres.nce of oys.ers.and the type of s.bs.rate.

关键词： Oys.er Reefs Microbiome Marine Bacteria Marine Archaea Res.oration

Accuracy and precis.on of dried urine s.ot method for the detection of s.his.os.ma mans.ni circulating cathodic antigens.in res.urce-limited s.ttings

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Infectious.Dis.as.s.of Poverty 2024年第1期13卷 103-104页

作者： Abdallah Zacharia Clemence Kinabo Twilumba Makene Huda Omary george Ogweno Faraja Lyamuya Billy Ngas.la Muhimbili Univers.ty of Health and Allied s.iences Dar es Salaam Tanzania National Ins.itute for Medical Res.arch Mwanza Tanzania Neglected Tropical Dis.as.s.Control Program Ministry of Health Dodoma Tanzania

Background The World Health Organization recommends.the us. of s.his.o point-of-care circulating cathodic anti-gens.s.his.o POC-CCA)for s.reening of s.his.os.ma mans.ni as.it offers.better s.ns.tivity than ***,there are limitation facing the us. of this.method including timely availability of the tes. *** aim of this.s.udy was.to determine the reliability of dried urine s.ot(DUs.method for collection of urine and detection of *** us.ng s.his.o POC-CCA cas.ettes.in a res.urce-limited *** A cros.-s.ctional s.udy was.conducted between October and November 2022 among 250 primary s.hool children in s.ngerema Dis.rict,northwes.ern *** CCA was.detected in filter paper-bas.d DUs.,liquid urine us.ng DUs.s.his.o POC-CCA(index),and direct urine s.his.o POC-CCA(comparator)methods.*** eggs.in s.ool were detected us.ng duplicate Kato-Katz(KK)*** meas.res.of accuracy were com-puted and compared between the index and comparator *** s.rength of agreement between inter-raters.precis.ons.was.tes.ed us.ng Cohen's.kappa(k).Res.lts.This.s.udy revealed *** prevalence rates.of 28.8%,54.0%and 50.8%by duplicate KK,direct urine s.his.o POC-CCA and DUs.s.his.o POC-CCA methods.*** mean intens.ty of infection among infected participants.Was.86.3 eggs.per gram of s.ool(EPG)ranging from 12.0 EPG to 824.0 *** s.ns.tivity of DUs.s.his.o POC-CCA and direct urine s.his.o POC-CCA Was.94.44%(95%CI:89.15-99.74%)and 97.22%(95%CI:93.43-100.00%)*** DUs.s.his.o POC-CCA method had s.ightly higher s.ecificity(66.85%)than direct urine s.his.o POC-CCA method(63.48%).The accuracy of the DUs.s.his.o POC-CCA Was.found to be s.ightly high(74.80%,95%CI:68.94-79.06%)compared to that of direct urine s.his.o POC-CCA(73.20%,95%CI:67.25-78.59%).There was.good agreement between two laboratory technologis.s.who performed the DUs.s.his.o POC-CCA method on s.milar s.mples.k=0.80,95%CI:0.59-0.95).Con

关键词： Accuracy Point-of-care circulating cathodic antigen Dried urine s.ot s.his.os.ma mans.ni s.ns.ti s.ecificity

s.cure s.art contract-bas.d digital twins.for the Internet of Things

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BLOCKCHAIN-REs.ARCH AND APPLICATIONs 2024年第1期5卷 39-49页

作者： Pittaras. Iakovos.Fotiou, Nikos.Karapapas. Chris.os.s.ris. Vas.lios.A. Polyzos. george C. Athens.Univ Econ & Bus.nes. Sch Informat Sci & Technol Dept Informat Mobile Multimedia Lab Athens 10434 Greece Chines. Univ Hong Kong Sch Data Sci Shenzhen 518172 Peoples R China

The proliferation of Internet of Things.(IoT) devices.that operate unattended providing a multitude of important and often s.ns.tive s.rvices.highlights.the need for s.amles. interoperability and increas.d s.curity. We argue that digital twins.of IoT devices. with the right des.gn, can enhance the s.curity, reliability, auditability, and interoperability of IoT s.s.ems. The s.lient features.of digital twins.have made them key elements.for the IoT and Indus.ry 4.0. In this.paper, we leverage advances.in W3C's.Web of Things.(WoT) s.andards.and dis.ributed ledger technologies.(DLTs. to pres.nt a novel des.gn of the s.art contract-bas.d digital twins.with enhanced s.curity, trans.arency, interoperability, and reliability. We provide two different variations.of that general des.gn us.ng two different blockchains.(one public and one private, permis.ioned blockchain), and we pres.nt des.gn tradeoffs. Furthermore, we introduce an architecture for acces.ing and controlling IoT devices.s.curely and reliably, providing full auditability, while at the s.me time us.ng the propos.d digital twins.as.an indirection mechanis. (proxy). The propos.d architecture leverages.the blockchain to offer notable properties. namely,decentralization, immutability, auditability, non-repudiation, availability, and reliability. Moreover, it introduces.mas. actuation, eas.er management of IoT devices. and enhanced s.curity to the IoT gateways. enables.new bus.nes. models. and makes.cons.mer devices.(vendor-)agnos.ic.

关键词： Digital twins Internet of Things Web of Things Dis.ributed ledger technologies Hyperledger Fabric Ethereum

Dynamics.of a Quantum Dis.ipative s.s.em Coupled with an Os.illator

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Journal of Applied Mathematics.and Phys.cs 2024年第4期12卷 1472-1491页

作者： Emmanouil george Thraps.niotis Athens Greece

We s.udy the dynamics.of a quantum dis.ipative s.s.em. Bes.des.its.linear coupling with a harmonic bath modelling the dis.ipation, we s.ppos. that it is.coupled with an os.illator with an interaction of the form s.2 x 2 . In our s.udy, we integrate over the bath and the os.illator, extract the corres.onding influence functionals.and then s.lve the s.s.em’s.s.gn problem. We apply the theory to the cas. of a double well and s.udy the time evolution of the expectation value of the pos.tion.

关键词： Double Well Harmonic Bath Os.illator Influence Functional s.gn s.lved Propagator Pos.tion

Hydrodynamic s.mulation of the Pagas.tikos.Gulf, Greece

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Computational Water, Energy, and Environmental Engineering 2024年第1期13卷 58-85页

作者： george Bous.ouras.Panagiotis.Angelidis Divis.on of Hydraulics Department of Civil Engineering School of Engineering Democritus University of Thrace Kimmeria Campus Xanthi Greece

s.mi-enclos.d s.a bas.ns.have difficulty in recharging their waters.due to limited communication with larger water bodies. with unders.andable cons.quences.for their environmental s.atus. This.paper aims.at the computational s.mulation of the hydrodynamic characteris.ics.of the waters.of the Pagas.tikos.Gulf (Greece), which has.limited communication and water exchange with the Aegean s.a and is.s.bject to intens. environmental pres.ures.The Es.uary, Lake & Coas.al Ocean 3d hydrodynamic Model (ELCOM 2.2) combined with its.later vers.on Aquatic Ecos.s.em Model-3d (AEM3D) were us.d for the s.mulation. The s.mulation included the topography of the area, the bay’s.bottom geometry, atmos.heric loadings. tides. the influence of the Coriolis.force and boundary conditions. The hydrodynamic behaviour of the bay, water circulation, velocities.at the s.rface and in depth, water recharge and res.dence time throughout the bay, dens.ty variation and other factors.were examined to determine the impact of all thes. on the aquatic ecos.s.em.

关键词： Hydrodynamic s.mulation s.mi-Enclos.d s.a Bas.ns Pagas.tikos.Gulf Greece