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Earthquake Engineering and Engineering Vibration 2004年第1期3卷 107-115页

作者： george m.lloyd ming L.Wang Department of Civil and material Engineering University of Illinois at Chicago

In this paper we present a comparative analysis of global frequency and local deformation data for a large concrete bridge. The asymptotic probability distributions of the central statistics are presented, and compared with empirical bootstrap estimates. Bootstrapped distributions are calculated from reference data obtained during 1999–2000 and used to develop change-point alarm criteria for the structure, using reasonable sensitivity measures developed from FEm simulations and structural analysis. The implications of the frequency data are discussed in conjunction with the strain and displacement measurements in order to discern if the load carrying capacity of the bridge has been affected. The critical need for more advanced temperature compensation models for large structures continually in thermal disequilibrium is discussed.

关键词： thermomechanical effects bootstrap methods local & global monitoring long term measurement concrete bridge

First Search for Pulsed CH maser Emission Stimulated by a Pulsar

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Research in Astronomy and Astrophysics 2025年第2期25卷 62-71页

作者： mengting Liu Di Li J.R.Dawson Joel m.Weisberg george Hobbs Ningyu Tang Gan Luo Duo Xu Donghui Quan Research Center for Astronomical Computing Zhejiang Laboratory Department of Astronomy Tsinghua University National Astronomical Observatories Chinese Academy of Sciences CSIRO Astronomy & Space Science Australia Telescope National Facility School of mathematical and Physical Sciences and Astrophysics and Space Technologies Research Centre Macquarie University Department of Physics and Astronomy Carleton College Department of Physics Anhui Normal University Institut de Radioastronomie millimetrique 300 Rue de la Piscine Canadian Institute for Theoretical Astrophysics University of Toronto 60 St.George Street

We present the first search for pulsed CH maser emission potentially stimulated by PSR J1644-4559,conducted using the ultra-wide-bandwidth low-frequency receiver on murriyang,CSIRO's Parkes Radio *** targeted three CHΛ-doublet transitions at 3264,3335,and 3349 mHz,with a variability timescale of78 *** detected ten CH emission features at 3335 and 3349 mHz,and seven features at 3264 mHz,during both pulsar-ON and pulsar-OFF *** observed velocities align with the OH emission and absorption reported by a previous study,suggesting a close spatial association between CH and OH *** derived column densities for CH clouds within the Parkes beam range from 0.05 to 9.8×1013cm-2,indicating that these clouds are likely in diffuse and translucent *** limits for CH column densities within the pulsar beam ranged from 0.3 to 9.8×*** of these column densities suggests that CH clouds may exhibit clumpiness and *** significant stimulated emission feature was detected in the optical depth ***,as part of our search for pulsed stimulated emission,we investigated the potential CH absorption of the pulsar signal and found none,in agreement with astrophysical *** upper limits for the potential maser amplification factors towards PSR J1644-4559 at 3264,3335,and 3349 mHz are 1.014,1.009,and 1.009,*** study demonstrates the feasibility of detecting pulsed CH maser emission in the interstellar medium stimulated by pulsar photons.

关键词： (stars:) pulsars: general ISm: molecules masers

Assessing the Potential of Innovative Clay Designs for Enhancing Oyster Reef Restoration

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Open Journal of marine Science 2025年第1期15卷 35-58页

作者： Natacha m. S. Juste-Poinapen Quentin Gentili Natanael Hazel george C. Birch Camille Saurel Oyster Heaven Rotterdam The Netherlands Nucleus Rotterdam The Netherlands National Institute of Aquatic Resources Danish Shellfish Centre Technical University of Denmark Nykobing Mors Denmark

The restoration of European flat oyster (Ostrea edulis) population is critical for biodiversity and ecosystem services recovery. This study evaluates the potential of innovative clay substrates, developed and patented by Oyster Heaven, as cost-effective and degradable alternatives for large-scale oyster reef restoration. Field trials conducted in an oyster aquaculture site and hatchery experiments under controlled conditions assessed the larvae settlement efficiency, microbial biofilm composition, and environmental influences. Results showed significantly lower larvae recruitment on clay prototypes and spat collectors used as control, in wild conditions, with environmental factors such as temperature and hypoxia playing a key role. In the hatchery, larvae preferred oyster shells (17,174 ± 659 spats/m2) over clay prototypes (2917 ± 111 spats/m2) and spat collectors (1451 ± 160 spats/m2). microbial analysis revealed a shift towards Cyanobacteria and Woeseia species, with Pseudoalteromonadaceae, a genus previously linked to both stimulating and inhibiting larvae settlement, detected only on clay surfaces. Despite challenges, the clay prototypes demonstrated potential as sustainable substrates for restoration, particularly in managed “spats-on-reefs” strategies. This research highlights the importance of environmental monitoring, microbial interactions, and substrate optimization in enhancing restoration success for O. edulis populations. Further investigations are recommended to refine clay designs and assess their broader applicability under variable environmental conditions.

关键词： Oyster Restoration Larvae Settlement Artificial Substrate microbial Biofilm Ostrea edulis

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan george Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest miller School of medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Non-functional neuroendocrine tumors of the pancreas: Advances in diagnosis and management

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World Journal of Gastroenterology 2015年第32期21卷 9512-9525页

作者： Jordan m Cloyd george A Poultsides Department of Surgery Stanford University Stanford

Nonfunctional neuroendocrine tumors of the pancreas(NF-PNETs) are a heterogeneous group of neoplasms. Although rare, the incidence of NF-PNETs is increasing significantly. The classification of PNETs has evolved over the past decades and is now based on a proliferation grading system. While most NF-PNETs are slow growing, tumors with more aggressive biology may becomeincurable once they progress to unresectable metastatic disease. Tumors of higher grade can be suspected preoperatively based on the presence of calcifications, hypoenhancement on arterial phase computed tomography, positron emission technology avidity and lack of octreotide scan uptake. Surgery is the only curative treatment and is recommended for most patients for whom complete resection is possible. Liver-directed therapies(thermal ablation, transarterial embolization) can be useful in controlling unresectable hepatic metastatic disease. In the presence of unresectable progressive disease, somatostatin analogues, everolimus and sunitinib can prolong progression-free survival. This article provides a comprehensive review of NF-PNETs with special emphasis on recent advances in diagnosis and management.

关键词： Pancreas Neuroendocrine tumor Neuroendocrine carci

Comparative Analysis of Equal and Unequal Grounding Grid Configurations by Compression Ratio and Least Square Curve Fitting Techniques

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Energy Engineering 2023年第3期120卷 597-616页

作者： m.Soni Abraham george Dayananda Sagar College of Engineering Bangalore560078India

The primary aim of the power system grounding is to safeguard the person and satisfying the performance of the power systemtomaintain reliable *** equal conductor spacing grounding grid design,the distribution of the current in the grid is not ***,unequal grid conductor span in which grid conductors are concentrated more at the periphery is safer to practice than equal *** paper presents the comparative analysis of two novel techniques that create unequal spacing among the grid conductors:the least-square curve fitting technique and the compression ratio techniquewith equal grid configuration for both square and rectangular *** Swarm Optimization(PSO)is adopted for finding out one optimal feasible solution among many feasible solutions of equal grid configuration for both square and rectangular *** analysis is also carried out between square and rectangular grids using the least square curve fitting technique as it results in only one unequal grid *** results are obtained by themATLAB software *** of improvement in ground potential rise,step voltage,touch voltage,and grid resistancewith variation in compression ratios are plotted.

关键词： Ground grid design ground potential rise grid resistance compression ratio least square curve fitting touch voltage step voltage PSO

Conductive polymer scaffolds to improve neural recovery

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Neural Regeneration Research 2017年第12期12卷 1976-1978页

作者： Shang Song Paul m.george Department of Neurology and Neurological Sciences Stanford University School of Medicine Stanford CA USA Stanford stroke Center and Stanford University School of medicine Stanford CA USA

Injuries to the nervous system manifest in various forms ranging from stroke to trauma（i.e.,motor vehicle accidents,combats）to diabetic neuropathy as well as many other neurological *** regeneration remains a complex biological process that is challenging to address *** is no effective medical treatment for central nervous system repair.

关键词： Conductive polymer scaffolds improve neural recovery

Parallelization of an Implicit Algorithm for multi-Dimensional Particle-in-Cell Simulations

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Communications in Computational Physics 2014年第8期16卷 599-611页

作者： george m.Petrov Jack Davis Naval Research Laboratory Plasma Physics Division4555 Overlook Ave.SWWashingtonDC 20375USA.

The implicit 2D3V particle-in-cell(PIC)code developed to study the interaction of ultrashort pulse lasers with matter[*** and ***,Computer ***.179,868(2008);*** 18,073102(2011)]has been parallelized using mPI(message Passing Interface).The parallelization strategy is optimized for a small number of computer cores,up to about *** on the algorithm implementation are given with emphasis on code optimization by overlapping computations with *** evaluation for 1D domain decomposition has been made on a small Linux cluster with 64 computer cores for two typical regimes of PIC operation:”particle dominated”,for which the bulk of the computation time is spent on pushing particles,and”field dominated”,for which computing the fields is *** a small number of computer cores,less than 32,the mPI implementation offers a significant numerical *** the”particle dominated”regime it is close to the maximum theoretical one,while in the”field dominated”regime it is about 75-80%of the maximum *** a number of cores exceeding 32,performance degradation takes place as a result of the adopted 1D domain *** code parallelization will allow future implementation of atomic physics and extension to three dimensions.

关键词： Particle-in-cell maxwell equations mPI lasertarget interaction.

A size-gradient hypothesis for alpine treeline ecotones

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Journal of mountain Science 2016年第7期13卷 1154-1161页

作者： george P.mALANSON Lynn m.RESLER Department of Geographical&Sustainability Sciences University of IowaIowa CityIA 52242 USA Department of Geography Virginia TechBlacksburgVA 24061 USA

Research on the stress gradient hypothesis recognizes that positive(i.e. facilitative) and negative(i.e. competitive) plant interactions change in intensity and effect relative to abiotic stress experienced on a gradient. motivated by observations of alpine treeline ecotones, we suggest that this switch in interaction could operate along a gradient of relative size of individual plants. We propose that as neighbors increase in size relative to a focal plant they improve the environment for that plant up to a critical point. After this critical point is surpassed, however, increasing relative size of neighbors will degrade the environment such that the net interaction intensity becomes negative. We developed a conceptual(not site or species specific) individual based model to simulate a single species with recruitment, growth, and mortality dependent on the environment mediated by the relative size of neighbors. Growth and size form a feedback. Simulation results show that the size gradient model produces metrics similar to that of a stress gradient model. Visualizations reveal that the size gradient model produces spatial patterns that are similar to the complex ones observed at alpine treelines. Size-mediated interaction could be a mechanism of the stress gradient hypothesis or it could operate independent of abiotic stress.

关键词： Competition Ecotone Environmental gradient Plant interaction Stress gradient Facilitation

Acetylation as a mechanism that regulates axonal regeneration

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Neural Regeneration Research 2015年第7期10卷 1034-1036页

作者： Shen Lin george m.Smith Shriners Hospitals for Pediatric Research Center Department of Neuroscience Temple University

The capacity for adult axons to regenerate after injury is diminished compared with developing *** the case of central nervous system（CNS）axons,injury causes a total failure to *** failure is due to both the intrins... 详细信息

关键词： gene HDAC Acetylation as a mechanism that regulates axonal regeneration