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Fatigue and Quality of life of Women Undergoing Chemotherapy or Radiotherapy for Breast Cancer

Clinical oncology and cancer researeh 2009年第3期6卷 179-185页

作者： Winnie k.W.So Gene Marsh W.M.ling F.Y.Leung Joe C.k.Lo Maggie Yeung george k.h.li Department of Nursing Studies The University of Hong Kong School of Nursing University of Colorado Health Science Center Nurse Specialist Department of Clinical OncologyPamela Youde Nethersole Eastern Hospital Infection Control Unit Princess Margaret Hospital Oncology Department Princess Margaret Hospital Clinical Oncology Department Tuen Mun Hospital Department of Surgery Queen Mary Hospital

OBJECTIVE To examine fatigue and quality of life (QOL) inbreast cancer patients undergoing chemotherapy or *** A self-report survey derived from the Chineseversion of Brief Fatigue Inventory, the Functional Assessmentof Chronic Illness Therapy for Breast Cancer, and the MedicalOutcomes Study Social Support Survey. Descriptive statisticswas used to examine the intensity of fatigue and the prevalenceof severe fatigue. Multivariate analysis of variance was used todetermine factors that affect the five domains of QOL among *** The majority of the participants (n = 261) perceiveda mild level of fatigue, but 35.6% of them suffered severe *** had a significantly negative association with all domainsof QOL except social/family wellbeing. The participants whowere receiving chemotherapy, undergoing curative treatment andhaving inadequate social support were more likely to have poorerQOL in all five domains (after adjustment for age).CONCLUSION Although the majority of the participantsexperienced a mild level of fatigue, there was a substantial groupof breast cancer patients who perceived their fatigue as severe. Thefindings of this study showed that fatigue had a detrimental effecton the various aspects of the participants' QOL. Demographic andclinical characteristics of breast cancer patients who were at riskof getting poorer QOL were identified. The results of the studydemonstrate that we should enhance healthcare professionals'awareness of the importance of symptom assessment, andprovide them with information for planning effective symptom-management strategies among this study population.

关键词： breast neoplasm fatigue quality of life drug therapy.

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Single-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao li Chun-hsien ChEN kam k.h.NG Xin YUAN Cho Yin YIU human Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a single pilot in commercial jets could be technically *** changes in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot Operations(DPO)to Single-Pilot Operations(SPO)through a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-based eye tracker,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in SPO were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial SPO measures to lessen the persistent physiological fluctuation,assisting airlines in creating SPO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations Behaviour changes Eye tracker Electroencephalogram

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Design and fabrication of Nd-Fe-B magnet with excellent thermal stability

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Journal of Rare Earths 2024年第5期42卷 980-986,I0006页

作者： Rui han Shengzhi Dong Dong li Dongmin Zhang hongsheng Chen Jiyuan Xu george Chadjipanayis Zhuolin li Ying Zhang Wei li Division of Functional Materials Research Central Iron and Steel Research InstituteBeijing100081China Department of Physics and Astronomy Sharp Lab University of DelawareNewarkDE19716USA Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China

A novel Nd-Fe-B type permanent magnet with excellent thermal stability was designed by Co replacing Fe in the main phase and the grain boundary *** remanence and coercivity temperature coefficient reach 0.058%/℃and 0.465%/℃in the te mperature range from 25 to 100℃,which are much lower than those of commercial Nd-Fe-B *** enhanced Curie temperature is obtained for the novel magnet due to the Co substitution,which significantly improves the operating *** microstructure result reveals that an amorphous phase exists in the intergranular grains which is probably responsible for the deterioration of intrinsic *** work can provide a reference for the design and optimization of components of sintered Nd-Fe-B magnets with excellent thermal stability.

关键词： Thermal stability Remanence temperature coefficient Operating temperature Atomic substitution Rare earths

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Net effect of air pollution controls on health risk in the Beijing-Tianjin-hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing lin Peter k.k.Louie Alexis k.h.Lau Jimmy C.h.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat hossain Chengcai li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China hubei key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–hebei(BTh)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTh(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide health risk Carbon neutrality Mega-events

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Convexification of hybrid AC-DC Optimal Power Flow with line-Commutated Converters

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 617-628页

作者： hongyuan liang Zhigang li J.h.Zheng Q.h.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

line-commutated converter (LCC)-based high-voltage DC (hVDC) systems have been integrated with bulk AC power grids for interregional transmission of renewable power. The nonlinear LCC model brings additional nonconvexity to optimal power flow (OPF) of hybrid AC-DC power grids. A convexification method for the LCC station model could address such nonconvexity but has rarely been discussed. We devise an equivalent reformulation for classical LCC station models that facilitates second-order cone convex relaxation for the OPF of LCC-based AC-DC power grids. We also propose sufficient conditions for exactness of convex relaxation with its proof. Equivalence of the proposed LCC station models and properties, exactness, and effectiveness of convex relaxation are verified using four numerical simulations. Simulation results demonstrate a globally optimal solution of the original OPF can be efficiently obtained from relaxed model.

关键词： AC-DC power system convex relaxation linecommutated converter optimal power flow second-order cone programming

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Editorial for the Special Issue on Emerging Technology and Advanced Application of Nondestructive Detection for Power Equipment

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Chinese Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： li J. Mei h. li S. Tianjin University China Tsinghua Shenzhen International Graduate School China Lanzhou Jiaotong University China

The rapid development of clean and renewable energy technologies represented by wind and solar energy,as well as the continuous growth of load demand,have put forward higher requirements for the safe operation of the power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,which cannot meet the reliability requirements of power systems in the new *** detection is an essential technical method in industrial development,which can detect and evaluate the defect and damage status of in-service equipment,key components,and materials without damaging the object.

关键词： service Application operation

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Multifunctional nanoparticle-mediated combining therapy for human diseases

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Signal Transduction and Targeted Therapy 2024年第2期9卷 343-375页

作者： Xiaotong li Xiuju Peng Makhloufi Zoulikha george Frimpong Boafo kosheli Thapa Magar Yanmin Ju Wei he School of Pharmacy China Pharmaceutical UniversityNanjing 2111198PR China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013PR China Shanghai Skin Disease hospital Tongji University School of MedicineShanghai 200443China

Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and *** preclinical investigations,combined effect of certain known drugs has been well established in treating extensive human *** to synergistic effects by targeting various disease pathways and advantages,such as reduced administration dose,decreased toxicity,and alleviated drug resistance,combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses,such as cancer,atherosclerosis,pulmonary hypertension,myocarditis,rheumatoid arthritis,inflammatory bowel disease,metabolic disorders and neurodegenerative *** therapy involves combining or co-delivering two or more drugs for treating a specific ***(NP)-mediated drug delivery systems,i.e.,liposomal NPs,polymeric NPs and nanocrystals,are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery,extended drug release,and higher drug stability to avoid rapid clearance at infected *** review summarizes various targets of diseases,preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical ***,we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the *** review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases.

关键词： drugs diseases prevention

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Genetic characteristics of h1N1 influenza virus outbreak in China in early 2023

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Virologica Sinica 2024年第3期39卷 520-523页

作者： Xuanxuan li Zefeng Dong Jiaming li Chuanran Dou Deyu Tian Zhenghai Ma Wenjun liu george F.Gao Yuhai Bi College of life Science and Technology Xinjiang UniversityUrumchi830046China CAS key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing100101China Suzhou Center for Disease Control and Prevention Suzhou215004China Lafayette College EastonPA 18042USA University of Chinese Academy of Sciences Beijing100049China D.h.Chen School of Universal health Zhejiang UniversityHangzhou 310058China

Dear Editor,Influenza A virus(IAV)exhibits rapid mutability and antigenic *** the 20th century,IAV has caused at least four pandemics(Yang et al.,2022).Presently,seasonal h_(3)N_(2)and h1N1 are the prevailing human-adaptive IAV subvariants responsible for human *** implementation of public health interventions since the commencement of the COVID-19 pandemic has effectively curtailed global influenza circulation(Olsen et al.,2021).Following the downregulation of the prevention and control strategies against COVID-19,global influenza activity is showing a recovery.

关键词： influenza prevention h1N1

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A hybrid Signal Processing Method Combining Mathematical Morphology and Walsh Theory for Power Quality Disturbance Detection and Classification

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 584-592页

作者： Zhi Ding Tianyao Ji Mengshi li Q.h.Wu School of Electric Power Engineering South China University of Technology(SCUT)Guangzhou 510641China

In this paper, a novel signal processing method combining mathematical morphology (MM) and Walsh theory is proposed, which uses Walsh functions to control the structuring element (SE) and MM operators. Based on the Walsh-MM method, a scheme for power quality disturbances detection and classification is developed, which involves three steps: denoising, feature extraction and morphological clustering. First, various evolution rules of Walsh function are used to generate groups of SEs for the multiscale Walsh-ordered morphological operation, so the original signal can be denoised. Next, the fundamental wave of the denoised signal is suppressed by hadamard matrix;thus, disturbances can be extracted. Finally, the Walsh power spectrum of the waveform extracted in the previous step is calculated, and the parameters of which are taken by morphological clustering to classify the disturbances. Simulation results reveal the proposed scheme can effectively detect and classify disturbances, and the Walsh-MM method is less affected by noise and only involves simple calculation, which has a potential to be implemented in hardware and more suitable for real-time application.

关键词： hadamard matrix mathematical morphology morphological clustering power quality disturbance Walsh theory

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Efficient guiding and focusing of intense laser pulse using periodic thin slits

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Matter and Radiation at Extremes 2024年第4期9卷 29-39页

作者： L.Xu T.W.huang k.Jiang C.N.Wu h.Peng P.C.hen R.li h.B.Zhuo C.T.Zhou Shenzhen key Laboratory of Ultraintense Laser and Advanced Material Technology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been widely used in laser-plasma interactions as plasma optical components for generating high-harmonic light and controlling laser-driven particle ***,we propose and demonstrate that periodic thin slits can be regarded as a new breed of optical elements for efficient focusing and guiding of intense laser *** fundamental physics of intense laser interaction with thin slits is studied,and it is revealed that relativistic effects can lead to enhanced laser focusing far beyond the pure diffractive focusing *** addition,the interaction of an intense laser pulse with periodic thin slits makes it feasible to achieve multifold enhancement in both laser intensity and energy transfer efficiency compared with conventional *** results provide a novel method for manipulating ultra-intense laser pulses and should be of interest for many laser-based applications.

关键词： laser pulse intense

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