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Is myopia a protective factor against central serous chorioretinopathy?

International journal of Ophthalmology(English edition) 2016年第2期9卷 266-270页

作者： george j.manayath Saurabh Arora Hardik Parikh Parag K.Shah Sarvesh Tiwari Venkatapathy Narendran Department of Retina and Ocular Oncology Aravind Eye Hospital

AIM： To evaluate if any association exists between central serous chorioretinopathy （CSCR） and the refractive status of the eye. METHODS： This retrospective, institutional, case control study included 499 patients, wherein 262 patients diagnosed as acute CSCR, were compared with an age and gender matched control group of 237 patients. All patients were evaluated with a detailed systemic and ocular history, objective and subjective refractions for both eyes and complete ocular examination by a retina specialist, at all visits. Optical coherence tomography confirmed the diagnosis of CSCR. ~ RESULTS： The mean age was found to be 40.7y in the study group （Group 1） compared to 38 10y in the control group （Group 2）. Most common refractive status in the study group, was emmetropia seen in 191 patients （72.9%）, followed by hypermetropia seen in 47 patients （17.9%） and astigmatism seen in 21 patients （8.0%）. Only 3 subjects （1.1%） had myopia, which was less than or equal to 1.0 D, compared to 70 subjects （29.5%） in the control group, suggesting a statistically significant lower incidence of CSCR among the myopic patients （P〈 0.0001）. With respect to the systemic factors, 26 （9.9%） patients were using systemic steroids in the study group （Group 1） compared to none in the control group （Group 2） suggesting a statistically significant association of CSCR with systemic steroid use （P〈0.05）. No other significant systemic risk factors were noted. CONCLUSION： Though CSCR is a multifactorial disease, myopia serves as a protective factor for CSCR. Thus, myopic eyes are less likely to develop CSCR. Since both retinal pigment epithelium （RPE） and choriocapillaris are postulated in the pathogenesis of CSCR, chorio-retinal thinning and atrophy seen in myopic eyes are less likely to cause CSCR.

关键词： central serous chorioretinopathy refractivestatus myopia

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan george jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Evaluation of alum-based water treatment residuals used to adsorb reactive phosphorus

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Water Science and Engineering 2020年第3期13卷 181-192页

作者： george Carleton Teresa j.Cutright Department of Civil Engineering The University of AkronAkronOH 44235-3905USA

Excess reactive phosphorus(PO4)in waterways can lead to eutrophication.A low-cost approach to reducing PO4 levels in surface water was evaluated using the alum-based water treatment residual(Al-WTR)or Al-WTR augmented with powdered activated carbon(PAC-WTR).Batch adsorption-desorption and continuous flow column experiments were performed to assess the specific adsorption capacities under various concentration and flow *** Al-WTR and PAC-WTR exhibited the ability to adsorb *** overall,cumulative sorbed amount after a 28-d desorption step for Al-WTR was 33.93 mg/kg,significantly greater than the PAC-WTR value of 24.95 mg/kg(p<0.05).The continuous flow column experiments showed a theoretical PO4 uptake of 9.00 mg/g for Al-WTR and 7.14 mg/g for PAC-WTR over 720 *** surface water was used,the Al-WTR and PAC-WTR columns removed 67.4%and 62.1%of the PO4,*** results indicated that Al-WTR was more effective for in-field evaluation.

关键词： Phosphorous Alum Water treatment residuals Adsorption Desorption Powered activated carbon

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Understanding Performance for Two 802.11 Competing Flows

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journal of Computer Science & Technology 2008年第3期23卷 365-376页

作者： Michael j.Feeley Brendan Cully Sharath j.george Department of Computer Science University of British ColumbiaVanconverCanada

It is well known that 802.11 suffers from both inefficiency and unfairness in the face of competition and interference. This paper provides a detailed analysis of the impact of topology and traffic type on network performance when two flows compete with each other for airspace. We consider both TCP and UDP flows and a comprehensive set of node topologies. We vary these topologies to consider all combinations of the following four node-to-node interactions：（1） nodes unable to read or sense each other, （2） nodes able to sense each other but not able to read each other＇s packets and nodes able to communicate with （3） weak and with （4） strong signal. We evaluate all possible cases through simulation and show that the cases can be reduced to 9 UDP and 10 TCP 802.11g models with similar efficiency/fairness characteristics. We also validate our simulation results with extensive experiments conducted in a laboratory testbed. These more detailed models improve on previous work such as hidden-/exposed-terminal categorization and are thus better suited as a basis for adaptive techniques to improve performance in 802.11 multi-hop WLAN or Mesh Networks.

关键词： 802.11 wireless unfairness two-flow competition network topology

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Instantaneous frequency and wave mode identification in a magnetosheath using few spatial points

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Chinese Physics B 2013年第8期22卷 496-501页

作者： Nathaniel E U Beloff N george N j Department of Physics Akwa Ibom State UniversityNigeria University of Sussex Brighton UK

Observational data such as those obtained from the magnetosheath in the downstream of Earth＇s bow shock have waveforms that differ from those of sinusoidal signals. In practice, they are not even aggregates of sinusoidal signals. Therefore, the frequency decomposition for the data requires technique that will account for the time-varying features of the data that will lead to deduction of physical meaning of the observations. The combination of empirical mode decompo- sition （EMD） and Hilbert transform has been used for extracting the various contributing oscillatory modes （EMDs） and the instantaneous frequency determination （Hilbert transform） of every physically meaningful mode called intrinsic mode func- tion （IMF）. The resulting instantaneous frequencies are used to determine instantaneous wave vectors. The combination of the instantaneous frequencies and wave vectors is useful in the identification of wave modes based on the characteristics of the waves. The results show that EMD-Hilbert can be more reliable than simple Hilbert transform alone.

关键词： EMD-Hilbert transform instantaneous frequency and wave vector

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Type 1 diabetes and associated autoimmune diseases

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World journal of Diabetes 2020年第11期11卷 527-539页

作者： Lara Frommer george j Kahaly Department of Medicine I Johannes Gutenberg Medical CenterMainz 55131Germany

BACKGROUND Common autoimmune diseases(AID)tend to occur together in the same individual and *** 1 diabetes(T1D)is caused by an autoimmuneinduced inflammatory destruction of the pancreatic tissue and clusters with several other *** To compare the demographic,clinical,and serological features of patients with single T1D vs those with T1D and associated *** From October 1999 to February 2020,a total of 665 patients with T1D and their first-degree relatives were *** Compared to patients with isolated T1D,those with T1D+AID were older and had a higher female:male *** patient age and age at disease onset were higher in T1D+AID vs T1D *** average time interval between T1D onset and the onset of a second glandular AID was markedly shorter than the time interval between T1D and the occurrence of a non-endocrine AID.T1Dspecific autoantibodies were more frequent in patients with T1D+AID and relatives vs those with T1D ***,the prevalence of AID and autoantibodies against various tissues were found to be higher in relatives of patients with T1D only compared to relatives of patients with T1D+*** Annual serological and subsequent functional screening for AID in patients with T1D and their first-degree relatives is recommended.

关键词： Type 1 diabetes Autoimmunity Serology Antibodies Autoimmune endocrine diseases Autoimmune non-endocrine disorders

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Mineral concentrations of chickpea and lentil cultivars and breeding lines grown in the *** Northwest

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The Crop journal 2018年第3期6卷 253-262页

作者： george j.VANDemark Michael A.Grusak Rebecca j.Mc Gee USDA-ARS Grain Legume Genetics and Physiology Research Unit USDA-ARS Red River Valley Agricultural Research Center

Diseases and health complications caused by mineral deficiencies afflict billions of people globally. Developing pulse crops with elevated seed mineral concentrations can contribute to reducing the incidence of these deficiencies. The objectives of this study were to estimate variance components conditioning seed mineral concentrations of chickpea and lentil grown in Washington and Idaho, determine correlations between different mineral concentrations and between mineral concentrations and yield, 100-seed weight, and days to flowering, and compare seed mineral concentrations between chickpeas and lentils grown in adjacent plots. Genotype effects, although significant in chickpea and lentil for all minerals except selenium, tended to be minimal compared to location, year, and their interaction effects. In both chickpeas and lentils high positive correlations were observed between seed concentrations of phosphorus and potassium, phosphorus and zinc, and potassium and zinc. Correlations between mineral concentration and yield, and mineral concentration and days to 50% flowering were similar for chickpeas and lentils across the majority of minerals. These results may reflect similarities between the two crops in physiological processes for mineral uptake and partitioning. Lentils had higher concentrations of iron and zinc than chickpea when the two crops were grown in adjacent plots,whereas chickpeas had higher concentrations of calcium and manganese. Plant genotypes that are more efficient at obtaining minerals from growing environments will be useful as parental materials to develop improved chickpea and lentil cultivars that have good yield potential coupled with high seed mineral concentrations.

关键词： Chickpea Lentil Mineral Nutrition Pulse

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Determination of selected semi-volatile organic compounds in water using automated online solid-phase extraction with large-volume injection/gas chromatography/mass spectrometry

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Frontiers of Environmental Science & Engineering 2011年第3期5卷 417-425页

作者： Yongtao LI Christina L.MCCARTY Ed j.george Drinking Water Quality Laboratory Underwriters Laboratories Inc.South BendIN 46617USA Chemical Analysis Bruker DaltonicsFremontCA 94538USA

A rapid,sensitive,and cost-effective analyticalmethod was developed for the analysis of selected semivolatileorganic compounds in *** method used anautomated online solid-phase extraction technique coupledwith programmed-temperature vaporization large-volumeinjection gas chromatography/mass *** samples were extracted by using a fully automatedmobile rack system based on x-y-z robotic techniquesusing syringes and disposable 96-well extraction *** method was validated for the analysis of 30 semivolatileanalytes in drinking water,groundwater,andsurface *** a sample volume of 10 mL,the linearcalibrations ranged from 0.01 or 0.05 to 2.5μg·L^(-1),and themethod detection limits were less than 0.1μg·L^(-1).For thereagent water samples fortified at 1.0μg·L^(-1)and2.0μg·L^(-1),the obtained mean absolute recoveries were70%-130%with relative standard deviations of less than20%for most *** the drinking water,groundwater,and surface water samples fortified at 1.0μg·L^(-1),theobtained mean absolute recoveries were 50%-130%withrelative standard deviations of less than 20%for *** new method demonstrated three advantages:1)no manipulation except the fortification of surrogatestandards prior to extraction;2)significant cost reductionassociated with sample collection,shipping,storage,andpreparation;and 3)reduced exposure to hazardous solventsand other *** a result,this new automatedmethod can be used as an effective approach for screeningand/or compliance monitoring of selected semi-volatileorganic compounds in water.

关键词： automated solid-phase extraction programmed-temperature vaporization large-volume injection gas chromatography/mass spectrometry semi-volatile organic compounds water analysis

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Analysis of High Frequency Data in Finance:A Survey

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2020年第2期15卷 141-166页

作者： george j.jiang Guanzhong Pan Department of Finance and Management Science College of BusinessWashington State UniversityPullmanWA 99164USA School of Finance Yunnan University of Finance and EconomicsKunming 650221China

This study examines the use of high frequency data in finance,including volatility estimation and jump *** frequency data allows the construction of model-free volatility measures for asset *** variance is a consistent estimator of quadratic variation under mild regularity *** variation concepts,such as power variation and bipower variation,are useful and important for analyzing high frequency data when jumps are *** frequency data can also be used to test jumps in asset *** discuss three jump tests:bipower variation test,power variation test,and variance swap test in this *** presence of market microstructure noise complicates the analysis of high frequency *** survey introduces several robust methods of volatility estimation and jump tests in the presence of market microstructure ***,some applications of jump tests in asset pricing are discussed in this article.

关键词： high frequency data quadratic variation(QV) realized variance(RV) power variation(PV) bipower variation jump tests market microstructure noise asset pricing

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Paleoecological Response of Corals to the End-Triassic Mass Extinction： An Integrational Analysis

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journal of Earth Science 2018年第4期29卷 879-885页

作者： george D Stanley jr Hannah M E Shepherd Autumn j Robinson University of Montana Paleontology Center Missoula MT 59812 USA

The end-Triassic （also Triassic-jurassic） mass extinction severely affected life on planet Earth 200 million years ago. Paleoclimate change triggered by the volcanic eruptions of the Central Atlantic Magmatic Province （CAMP） caused a great loss of marine biodiversity, among which 96% coral genera were get lost. However, there is precious little detail on the paleoecology and growth forms lost between the latest Triassic extinction and the Early jurassic recovery. Here a new pilot study was conducted by analyzing corallite integration levels among corals from the latest Triassic and Early jurassic times. Integration levels in corals from the Late Triassic and Early jurassic were determined through both the Paleobiology Database as well as from a comprehensive museum collection of fossil corals. Results suggest that in addition to a major loss of diversity following the end-Triassic mass extinction, there also was a significant loss of highly integrated corals as clearly evidenced by the coral data from the Early jurassic. This confirms our hypothesis of paleoecological selectivity for corals following the end-Triassic mass extinction. This study highlights the importance of assigning sim- ple to advanced paleoecological characters with integration levels, which opens a useful approach to understanding of mass extinction and the dynamics of the recovery.

关键词： coral loss integration level end-Triassic mass extinction paleoecology

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