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Does orthotics use improve comfort,speed,and injury rate during running?A randomised control trial

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World Journal of Orthopedics 2023年第5期14卷 348-361页

作者： Alice e Fortune Jonathan M G Sims george Ampat School of Medicine University of LiverpoolLiverpool L693GEUnited Kingdom Research Unit Talita Cumi Ltd.SouthportPR83NSUnited Kingdom School of Medicine University of LiverpoolLiverpool L693GEMerseysideUnited Kingdom

BACKGROUND Running is a hugely popular ***,running-related injury(RRI)rates are high,particularly amongst amateur and recreational *** ways to reduce RRI rates and maximise comfort and performance for runners is *** regarding whether orthotics can successfully improve these parameters is limited and *** research is required to provide runners with clearer guidance on the usefulness of *** To investigate the effect of Aetrex Orthotics on comfort,speed and RRI rates during recreational *** One hundred and six recreational runners were recruited on a voluntary basis via running clubs and social media pages and randomised into either the intervention or control *** in the intervention group ran with Aetrex L700 Speed Orthotics inserted in their usual running shoes,whilst participants in the control group ran in their usual running shoes with no *** study ran for an 8-wk *** provided data relating to running comfort,distance,and time during weeks *** provided data relating to any RRIs they sustained during all 8 *** distance and time were used to calculate running speed in miles per hour(mph).For each outcome variable,95%confidence intervals and P values were calculated to assess the statistical significance between the *** comfort and speed data,univariate multi-level analysis was performed,and for outcome variables with significant between group differences,multi-level multivariate analysis was performed to evaluate any confounding effects of gender and *** Ninety-four participants were included in the final analysis(drop-out rate=11%).Comfort and speed from 940 runs and 978 injury data reports were *** who ran with orthotics reported,on average,speeds 0.30 mph faster(P=0.20)and comfort scores 1.27 points higher(P≤0.001)than participants who ran with no *** were also 2.22 times less

关键词： Running Foot orthoses Running related injuries Pain Patient comfort Athletic performance

Localized dissolution initiated at single and clustered intermetallic particles during immersion of Al-Cu-Mg alloy in sodium chloride solution

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Transactions of Nonferrous Metals Society of China 2016年第11期26卷 2800-2809页

作者：骆晨 Xiaorong ZHOU george e.THOMPSON 中航工业北京航空材料研究院航空材料先进腐蚀与防护航空科技重点实验室北京100095 School of Materials The University of Manchester

Aiming at understanding how intermetallic phases response when AA2024-T3 aluminium alloy is exposed to chloridecontainingaqueous medium, scanning electron microscopy was employed to provide morphological information on alloy surfacebefore and after corrosion testing. energy dispersive X-ray spectroscopy was carried out to determine compositional change inintermetallic particles. Atomic force microscopy was used to examine topographical variation introduced by the reactions ofintermetallic phases. Transmission electron microscopy combined with ultramicrotomy was carried out on dealloyed Al2CuMgparticles and their periphery region. It is found that dealloyed Al2CuMg particles exhibited porous, polycrystalline structurecomprised of body-centred cubic copper particles with sizes of 5 to 20 nm. Aluminium matrix started to trench in the periphery ofAl2CuMg particles at the early stage of dealloying. Development of trenching in ***.（Si） particle’s periphery was notuniform and took longer time to initiate than Al2CuMg dealloying. Localized corrosion at a cluster of Al2CuMg and Al2Cu particleswas mainly associated with Al2CuMg particles.

关键词： aluminium alloy intermetallic particle localized dissolution dealloying trenching

Cardiovascular physiology in the older adults

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Journal of Geriatric Cardiology 2015年第3期12卷 196-201页

作者： Xuming Dai Scott L Hummel Jorge B Salazar george e Taffet Susan Zieman Janice B Schwartz Division of Cardiology University of North Carolina at Chapel Hill Chapel Hill NC USA Division of Cardiovascular Medicine Department of Medicine University of Michigan Ann Arbor Ml Ann Arbor Veterans Affairs Health System Ann Arbor M1 USA Division of Cardiology Mayo Clinic Rochester MN USA Division of Geriatrics Geriatrics and Cardiovascular Sciences Houston Methodist Hospital Baylor College of'Medicine Houston TX USA Division of Geriatrics and Clinical Gerontology National Institute of Aging Bethesda ME) USA Divisions of Geriatrics and Clinical Pharmacology Department of Medicine University of California San Francisco CA USA

1 Introduction In an aging society with persistent high prevalence of cardiovascular disease （CVD） in the elderly population, the health care system is facing an increasing challenge to effectively care for these patients. However, due to the under-representation of CVD patients over 75 years of age in clinical trials, assessing safety and efficacy of diagnostic and therapeutic approaches, the evidence for managing elderly CVD patients is especially limited. Physiological changes of aging intertwined with pathophysiology of CVD, and comorbid conditions often complicate clinical management.

关键词： Aging Cardiovascular disease Left ventricular

Dynamical machine learning volumetric reconstruction of objects’ interiors from limited angular views

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Light(Science & Applications) 2021年第5期10卷 824-844页

作者： Iksung Kang Alexandre Goy george Barbastathis Department of electrical engineering and Computer Science Massachusetts Institute of Technology77 Massachusetts AveCambridgeMAUSA Department of Mechanical engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Singapore-MIT Alliance for Research and Technology(SMART)Centre 1 Create WaySingapore 117543Singapore Omnisens SA Morges 1110Switzerland

Limited-angle tomography of an interior volume is a challenging, highly ill-posed problem with practical implications in medical and biological imaging, manufacturing, automation, and environmental and food security. Regularizing priors are necessary to reduce artifacts by improving the condition of such problems. Recently, it was shown that one effective way to learn the priors for strongly scattering yet highly structured 3D objects, e.g. layered and Manhattan, is by a static neural network [Goy et al. Proc. Natl. Acad. Sci. 116, 19848–19856 (2019)]. Here, we present a radically different approach where the collection of raw images from multiple angles is viewed analogously to a dynamical system driven by the object-dependent forward scattering operator. The sequence index in the angle of illumination plays the role of discrete time in the dynamical system analogy. Thus, the imaging problem turns into a problem of nonlinear system identification, which also suggests dynamical learning as a better fit to regularize the reconstructions. We devised a Recurrent Neural Network (RNN) architecture with a novel Separable-Convolution Gated Recurrent Unit (SC-GRU) as the fundamental building block. Through a comprehensive comparison of several quantitative metrics, we show that the dynamic method is suitable for a generic interior-volumetric reconstruction under a limited-angle scheme. We show that this approach accurately reconstructs volume interiors under two conditions: weak scattering, when the Radon transform approximation is applicable and the forward operator well defined;and strong scattering, which is nonlinear with respect to the 3D refractive index distribution and includes uncertainty in the forward operator.

关键词： interior dynamical angular

Reducing strain on primary healthcare systems through innovative models of care:the impact of direct access physiotherapy for musculoskeletal conditions—an interrupted time series analysis

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Family Medicine and Community Health 2024年第3期12卷 1-12页

作者： James Henry Zouch Bjørnar Berg Are Hugo Pripp Kjersti Storheim Claire e Ashton-James Manuela L Ferreira Margreth Grotle Paulo H Ferreira Sydney Musculoskeletal Health Faculty of Medicine and HealthThe University of SydneySydneyNew South WalesAustralia Centre for Intelligent Musculoskeletal Health Oslo Metropolitan University Faculty of Health SciencesOsloNorway Oslo Metropolitan University Faculty of Health Sciences OsloNorway Oslo Centre of Biostatistics and epidemiology Oslo University HospitalOsloNorway Department of Rehabilitation Science and Health Technology Oslo Metropolitan University Faculty of Health SciencesOsloNorway Department of Research and Innovation Oslo University Hospital Division of Clinical NeuroscienceOsloNorway Sydney Medical School Kolling InstituteThe University of Sydney Faculty of Medicine and HealthSydneyNew South WalesAustralia The george Institute for Global Health SydneyNew South WalesAustralia Department of Research and Innovation Oslo University HospitalOsloNorway Department of Rehabilitation and Technology Oslo Metropolitan University Faculty of Health SciencesOsloNorway Charles Perkins Centre Sydney Musculoskeletal HealthThe University of Sydney Faculty of Medicine and HealthSydneyNew South WalesAustralia

Objectives To evaluate the longitudinal impact of introducing a national,direct access physiotherapy model of care on the rates of primary and secondary care consultations for musculoskeletal(MSK)*** Interrupted time series analysis using segmented linear *** Norway primary care Participants A cohort of 82072 participants was derived from 3 population-based health surveys conducted across separate geographical regions in *** participants surveyed were eligible for inclusion as a national representative sample of the Norwegian *** MSK consultations were linked to the Norwegian Control and Payment of Health Reimbursement database and the Norwegian Patient Register using the International Classification of Primary Care diagnostic medical codes L-chapter for MSK conditions and spine related International Classification of Diseases,10th Revision,*** Direct access to physiotherapy model of care introduced nationally in Norway in *** model allowed Norwegians to consult directly with qualified physiotherapists for MSK conditions(eg,back pain,knee osteoarthritis)without the need for a medical referral in order to claim a social security *** outcomes measured Rates of primary care consultations per 10000 population(general practitioner(GP)and physiotherapist consultations)and secondary care(specialist consultations and surgical procedures)measured from 2014 to *** The introduction of the direct access physiotherapy model was associated with an immediate stepped reduction of 391 general practice consultations per 10000 population,(95%CI:−564 to−216),without an associated change in physiotherapy *** analyses suggested there was an associated reduction in physiotherapy consultations for those in the lowest education group of 150 consultations per quarter(95%CI:−203 to−97),70 consultations per quarter in the intermediate education group(95%CI:−115 to−27)and a step

关键词： impact analysis strain

c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer

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World Journal of Gastroenterology 2014年第26期20卷 8458-8470页

作者： Daniel Delitto eva Vertes-george Steven J Hughes Kevin e Behrns Jose G Trevino Department of Surgery University of Florida-Gainesville Department of Pathology University of Florida-Gainesville

Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States. The majority of patients are candidates only for palliative chemotherapy, which has proven largely ineffective in halting tumor progression. One proposed mechanism of chemoresistance involves signaling via the mesenchymal-epithelial transition factor protein (MeT), a previously established pathway critical to cell proliferation and migration. Here, we review the literature to characterize the role of MeT in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of MeT as a therapeutic target in pancreatic cancer. In this review, we characterize the role of c-Met in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of c-Met as a therapeutic target in pancreatic cancer.

关键词： Pancreatic adenocarcinoma c-Met Chemoresistance Receptor tyrosine kinase

Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 393-398页

作者： Aristotelis Tsiakalos Gregorios Hatzis Ioannis Moyssakis Aggelos Karatzaferis Panayiotis D Ziakas george e Tzelepis Department of Pathophysiology Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Department of Cardiology Laikon General HospitalAthensGreece

BACKGROUND:Cirrhosis is associated with several extrahepatic manifestations including portopulmonary hypertension (PPHT).Recent data suggest that endothelins (eTs) are related to the pathophysiology of *** study aimed to measure serum eT levels in hospitalized cirrhotic patients and to determine their association with PPHT and patient ***:Fifty-seven cirrhotic patients [43 males;median age 58 (28-87) years] underwent Doppler *** with systolic pulmonary arterial pressure ≥40 mmHg and pulmonary acceleration time ere deemed to have ***-1,2,and 3 serum levels were measured with an eLISA ***-cause mortality was recorded over a median period of 24 ***:Nine out of 57 patients (15.8%) had *** various clinical variables,only autoimmune hepatitis was associated with PPHT (OR=11.5;95% CI,1.58-83.4;P=0.01).eT-1 levels [9.1 (1.6-20.7) vs 2.5 (1.4-9.2) pg/mL,P=0.02] and the eT-1/eT-3 ratio [4.73 (0.9-22.4) vs 1.6 (0.3-10.7),P=0.02] were significantly higher in patients with PPHT than in those ***-2 and eT-3 levels did not differ between the two *** was no difference in survival between the two groups,although eT-1 levels were associated with an adverse outcome in Cox regression analysis (HR=1.11;95% CI,1.02-1.22;P=0.02 per unit increase in eT-1).CONCLUSION:Our data suggest that eT-1 and the eT-1/eT-3 ratio are elevated in patients with PPHT and that eT-1 is associated with a poor outcome irrespective of PPHT.

关键词： cirrhosis portopulmonary hypertension endothelin

Cardiac resynchronization therapy in the elderly heart failure patient

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Journal of Geriatric Cardiology 2005年第2期2卷 84-88页

作者： george e. Taffet Geriatrics and Cardiovascular Sciences Baylor College of Medicine HoustonTexas USA.

Ms. BP is an 83 year old white female with a long history of congestive heart failure (HF). She is now symptomatic with minimal exertion, has a left ventricular ejection fraction (LVeF) of 20%. Her CHF is due to hypertension (HTN) plus coronary artery disease (CAD) and she is on angiotensin converting enzyme inhibitor (ACeI), furosemide, digoxin,spironolactone, low dose beta blocker and nitrates. Her beta-natriuretic peptide (BNP) in clinic is 3030 pg/ml, heart rate (HR) 100, blood pressure (BP) 89/43.

关键词： CRT Cardiac resynchronization therapy in the elderly heart failure patient QRS CHF

effects of mycophenolate mofetil vs cyclosporine administration on graft survival and function after islet allotransplantation in diabetic rats

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World Journal of Gastroenterology 2005年第18期11卷 2733-2738页

作者： Constantin Fotiadis Paraskevi Xekouki Apostolos e Papalois PantelisT Antonakis Ioannis Sfiniadakis Dimitrios Flogeras eleutheria Karampela george Zografos 3~(rd) Department of Surgery Athens University Medical School Athens Greece experimentalResearch Unit eLPeN Pharma Athens Greece Department of Pathology Naval Hospital Athens Greece

AIM: To develop an experimental model of islet allotransplantation in diabetic rats and to determine the positive or adverse effects of MMF as a single agent. MeTHODS: Thirty-six male Wistar rats and 18 male Lewis rats were used as recipients and donors respectively. Diabetes was induced by the use of streptozotocin (60 mg/kg) intraperitoneally. Unpurified islets were isolated using the collagenase digestion technique and transplanted into the splenic parenchyma. The recipients were randomly assigned to one of the following three groups: group A (control group) had no immunosuppression; group B received cyclosporine (CsA) (5 mg/kg); group C receivedmycophenolate mofetil (MMF) (20 mg/kg). The animalswere killed on the 12th d. Blood and grafted tissues were obtained for laboratory and histological assessment. ReSULTS: Median allograft survival was significantly higher in the two therapy groups than that in the controls (10 and 12 d for CsA and MMF respectively vs 0 d for the control group, P＜0.01). No difference in allograft survival between the CsA and MMF groups was found. However,MMF had less renal and hepatic toxicity and allowed weight ***: Monotherapy with MMF for immunosu ppression was safe in an experimental model of islet allotransplantation and was equally effective with cyclosporine, with less toxicity.

关键词： Diabetes Islet transplantation Rats Mycophenolate mofetil Cyclosporine