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p-线性空间的不动点定理和非线性选择原理的建立

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数学学报（中文版） 2024年第5期67卷 962-986页

作者：袁先智重庆理工大学理学院重庆400054 成都大学商学院成都610106 四川大学数学学院成都610065 中山大学管理学院广州51027 华东理工大学商学院上海200237

本文的目标是在一般的p-线性空间和局部p-凸空间框架下建立针对单值和拟上半连续集值映射的不动点定理、最佳逼近定理、和对应的Leray-Schauder非线性(二择一)选择原理,这里p∈(0,1].我们建立的不动点定理是在p-线性空间和局部p-凸空间... 详细信息

本文的目标是在一般的p-线性空间和局部p-凸空间框架下建立针对单值和拟上半连续集值映射的不动点定理、最佳逼近定理、和对应的Leray-Schauder非线性(二择一)选择原理,这里p∈(0,1].我们建立的不动点定理是在p-线性空间和局部p-凸空间对Schauder猜想的肯定答复,对应的最佳逼近定理和Leray-Schauder选择原理也是非线性泛函分析的核心工具.这些新结果统一和推广了目前在数学文献中存在的理论成果,也是对作者最近工作([Fixed Point Theory Algorithms ***.,2022,2022:Paper Nos.20,26])的继续和深度发展.

关键词：非线性分析 p-线性空间局部p-凸空间(0Schauder猜想 Schauder不动点定理图逼近最佳逼近 Rothe型不动点 Leray-Schauder二择一原理拟上半连续(QUSC)

Key factors to prioritize when preparing for the Olympic Games

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Journal of Sport and Health Science 2024年第6期13卷 719-721页

作者： george P.Nassis Gregoire P.Millet Department of Physical Education College of EducationUnited Arab Emirates UniversityAl Ain 15551United Arab Emirates Institute of Sport Sciences University of LausanneLausanne 1015Switzerland

We need more research that will fulfill the needs of athletes and *** is a common statement,highly relevant nowadays only a few weeks before the commencement of the Paris 2024 Olympic *** fill this gap,we have identified 6 topics that we feel coaches and athletes would be interested in learning more to optimize their preparation for the *** topics are.

关键词： preparing statement interested

Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine

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Signal Transduction and Targeted Therapy 2024年第1期9卷 47-50页

作者： Mengyu Guo Mingjing Cao Jiufeng Sun Ziwei Chen Xin Wang Lianpan Dai george F.Gao Yuliang Zhao Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijingChina Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyBeijingChina

Dear editor,Vaccines are the most efficient and effective means to prevent infectious diseases,but improving the long-term protective efficacy is still a major challenge in contemporary vaccine development.1 The waning immunity varies depending on the diversification of the pathogen and the number of booster doses.1 Strategies to overcome this warrant is using adjuvants that amplify the immune response,and drive the production of memory B and T cells or long-lived plasma cells that recognize the pathogen for durable protection.2–4 Although existing adjuvants have achieved promising results,research on generating durable protective immunity is lacking in promoting vaccine development and staying ahead of global pandemics such as coronavirus disease 2019(COVID-19).The precisely designed nanoadjuvants can enhance lymph node targeting and increase antigenpresenting cell(APCs)uptake,achieving the co-delivery of adjuvants and antigens and activating innate and adaptive immune responses.5 Previously,we reported a manganese nanoadjuvant(MnARK)and receptor-binding domain(RBD)monomer antigen formulated nanovaccine.6 MnARK transported antigens to lymph nodes,activated the STING pathway,elicited strong neutralizing abilities and increased immune memory T cell percentage against the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).6 Regarding the long-term protection potential of MnARK for subunit vaccine development,we further explored the durable immune regulation abilities of MnARK to a SARS-CoV-2 RBD dimer antigen,which has been used in an approved COVID-19 subunit vaccine ZF2001 with aluminum adjuvant(alum).7,8 TEM result revealed that RBD dimer could interact with BSA on MnARK surface and epitope can be well preserved(Supplementary Fig.1a).The size and zeta potential of MnARK-RBD dimer nanovaccine was~58 nm and-14 mV,respectively(Supplementary Fig.1b,c).

关键词： manganese immunity protective

Robotic-assisted retroperitoneal lymph node dissection for stage II testicular cancer

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Asian Journal of Urology 2024年第1期11卷 121-127页

作者： george McClintock Ahmed S.Goolam Don Perera Ryan Downey Scott Leslie Peter Grimison Henry Woo Peter Ferguson Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaesthesia Chris O'Brien LifehouseSydneyNSWAustralia The University of Sydney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as well as early oncological outcomes of patients undergoing robotic retroperitoneal lymph node dissection for treatment of testicular ***:We conducted a prospective consecutive case series of patients undergoing robotic assisted retroperitoneal lymph node dissection for metastatic testicular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteristics,intraoperative and postoperative parameters,and functional and oncological *** statistics are ***:Nineteen patients were identified;18(94.7%)completed the procedure robotically and one was converted to open surgery;78.9%of patients had stage≥IIB and 12(63.2%)patients had undergone prior *** median operative time was 300(interquartile range[IQR]240-315)*** blood loss was 100(IQR 50-175)*** length of stay was 2(range 1-11)*** robotically completed patients commenced diet and passed flatus on Day 1 and were discharged by Day *** median lymph node yield was 40.5(IQR 38-51)*** patients undergoing nerve-sparing procedures recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous ascites requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months,one patient developed retroperitoneal recurrence,which was successfully treated with second-line chemotherapy;no other patients have had ***:Robotic retroperitoneal lymph node dissection is a safe and feasible alternative to open surgery in appropriately selected patients,offering low *** oncological outcomes are *** cohorts and longer follow-ups are required to validate our institution's findings.

关键词： Retroperitoneal lymph node dissection Robotic surgery Testicular cancer Retroperitoneal node dissection

A Dimensional Reduction Approach Based on Essential Constraints in Linear Programming

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American Journal of Operations Research 2024年第1期14卷 1-31页

作者： Eirini I. Nikolopoulou george S. Androulakis Department of Mathematics University of Patras Patras Greece Department of Business Administration University of Patras Patras Greece

This paper presents a new dimension reduction strategy for medium and large-scale linear programming problems. The proposed method uses a subset of the original constraints and combines two algorithms: the weighted average and the cosine simplex algorithm. The first approach identifies binding constraints by using the weighted average of each constraint, whereas the second algorithm is based on the cosine similarity between the vector of the objective function and the constraints. These two approaches are complementary, and when used together, they locate the essential subset of initial constraints required for solving medium and large-scale linear programming problems. After reducing the dimension of the linear programming problem using the subset of the essential constraints, the solution method can be chosen from any suitable method for linear programming. The proposed approach was applied to a set of well-known benchmarks as well as more than 2000 random medium and large-scale linear programming problems. The results are promising, indicating that the new approach contributes to the reduction of both the size of the problems and the total number of iterations required. A tree-based classification model also confirmed the need for combining the two approaches. A detailed numerical example, the general numerical results, and the statistical analysis for the decision tree procedure are presented.

关键词： Linear Programming Binding Constraints Dimension Reduction Cosine Similarity Decision Analysis Decision Trees

Differential Transcriptional Responses in Corneal and Lung Epithelial Cells to Seasonal Influenza With Potential Function of LGALS9

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Infectious Microbes & Diseases 2024年第3期6卷 141-151页

作者： Yang Han Ting Zhang Dan Bai Changcheng Wu Beiwei Ye Jianfang Zhou Yingze Zhao george F.Gao Jun Liu National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouChina State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)BeijingChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningChina National Key Laboratory of Intelligent Tracking and Forecasting for InfectiousDiseases(NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina

Seasonal flu,primarily caused by influenza A H1N1 and H3N2 subtype viruses or influenza B viruses,is the most prevalent respiratory tract infection globally and leads to substantial morbidity andmortality *** the influenza virus being initially recognized as a respiratory pathogenwithwell-characterized transmission through respiratory droplets,its impact on the ocular epithelium and associated gene expression remains relatively *** this study,we investigated the transcriptional profiles of immortalized human corneal epithelial cells(HCE-S)and A549 human lung epithelial cells infected with H1N1 and H3N2 influenza *** comparison with A549 cells,a reduced number of differentially expressed geneswas observed in HCE-S upon influenza virus ***,there was a significant upregulation of the genes IFI44L and OAS1,along with lower release of the CCL5/RANTES ***,our findings revealed uniquely upregulated LGALS9(encoding galectin-9)in HCE-S following infection with the 2009 pandemic H1N1 ***,targeted knockdown of LGALS9 in these cells resulted in a measurable decrease in viral infection,highlighting its role in the cellular responses to influenza virus and suggesting a novel avenue for antiviral ***,our findings provide insight into the distinct mechanisms of influenza virus interactions with different epithelial cells and underscore the importance of studying the ocular surface in understanding influenza pathogenesis.

关键词： immortalized human corneal epithelial cell line human pulmonary epithelial cell line influenza A virus transcriptome sequencing LGALS9

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MULE转座子挖掘和转座活性验证

MULE转座子挖掘和转座活性验证

作者： Addy george Adinortey 扬州大学

学位级别：硕士

Post-operative protein supplementation following orthopaedic surgery: A systematic review

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Sports Medicine and Health Science 2024年第1期6卷 16-24页

作者： Andrew george Brendan M.Holderread Bradley S.Lambert Joshua D.Harris Patrick C.McCulloch Houston Methodist Orthopedics and Sports Medicine 6445 Main Street Suite 2300HoustonTX77030USA Houston Methodist Orthopedic Biomechanics Research Laboratory 6670 Bertner AveHoustonTX77030USA

Decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle *** purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery.A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and MetaAnalysis(PRISMA).PubMed(MEDLINE),Embase,Scopus,and Web of Science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic *** investigators independently conducted the search using relevant Boolean *** outcomes included functional or physiologic measures of muscle atrophy or *** studies including 611 patients(224 males,387 females)were *** studies evaluated protein supplementation after ACL reconstruction(ACLR),3 after total hip arthroplasty(THA),5 after total knee arthroplasty(TKA),and 3 after surgical treatment of hip *** supplementation showed beneficial effects across all types of *** primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional *** authors also demonstrated improved functional measures and quicker achievement of rehabilitation *** supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLR,THA,TKA,and surgical treatment of hip *** effects often correlate with improved functional measures and quicker achievement of rehabilitation *** research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.

关键词： Orthopaedic surgery Protein supplementation Systematic review Muscle atrophy

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共识博弈与区块链生态共识均衡

运筹学学报（中英文） 2024年第3期28卷 1-26页

作者：袁先智中山大学管理学院广东广州510275 华东理工大学商学院上海200237 重庆理工大学理学院重庆400054

本文的目的是建立刻画区块链生态系统行为表现的“共识博弈”的一般框架,并针对“矿池间隔博弈”的“共识均衡”的存在性进行刻画和解读。特别是通过引进共识博弈这个新概念作为出发点,尽管区块链平台生态本身会受到诸如挖矿间隔等行为... 详细信息

本文的目的是建立刻画区块链生态系统行为表现的“共识博弈”的一般框架,并针对“矿池间隔博弈”的“共识均衡”的存在性进行刻画和解读。特别是通过引进共识博弈这个新概念作为出发点,尽管区块链平台生态本身会受到诸如挖矿间隔等行为的干扰,我们证明了在合理的激励机制下一般区块链平台的共识博弈均衡点的存在性,从正面的角度回答了区块链生态本身发展是否稳定这个非常基本和核心的问题。这里,“间隔博弈”(不良)行为出现所在的区块链生态是指基于Nakamoto在2008年提出的遵循按照最长主链建设的“工作量证明”作为基本的共识原则的挖矿平台。特别地,本文首先在一般激励机制条件下,基于区块链生态中的共识博弈框架,在有挖矿间隔等不良行为出现的情况下,建立了在一般激励相容机制条件下的共识均衡点的存在性结果和对应区块链生态能够持续运转的稳定性解读;然后结合在“挖(币)矿”工作中涉及到的工作费用、奖励机制和挖矿能力这三类描述激励机制的核心要素,从挖矿工(组)收益的角度,针对不同嵌入场景对挖矿工(组)的“间隔博弈行为”可能产生的影响进行了解读和分析。本文的理论结果和案例分析表明,结合不同挖矿场景相合适的激励相容机制,共识博弈(均衡)这个概念可以在理论的层面(即,不需要情景数据模拟结果的支持),能够得到或形成针对不同场景下的挖矿行为的解释和解读。此外,我们有理由期待和相信,结合影响挖矿(组)收益相关的要素因子,共识博弈可以帮助我们构建对应的合适场景的激励相容机制,通过刻画挖矿工(组)出现的诸如“间隔行为”,“分叉链”,“矿池攻击”等(不良)行为,支撑数字经济的健康发展,并对共识经济学基础理论的发展能够起到推进作用。

关键词：共识博弈共识均衡合作与非合作博弈 Nakamoto共识工作量证明区块链生态区块链生态稳定性矿池博弈挖矿间隔博弈最长链规则区块链的分叉激励兼容性