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Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods：Association with particle constituents

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Journal of Environmental Sciences 2016年第9期28卷 201-210页

作者： Bin Wang Ning Li Furong Deng Nicholas Buglak george park Shu Su Aiguo Ren Guofeng Shen Shu Tao Xinbiao Guo Institute of Reproductive & Child Health/Ministry of Health Key Laboratory of Reproductive Health School of Public Health Peking University Beijing 100192 China Department of Pathobiology & Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing 48824 USA Department of Occupational & Environmental Health Sciences School of Public Health Peking University Beijing 100191 China Laboratory for Earth Surface Processes College of Urban & Environmental Sciences Peking University Beijing 100871 China Jiangsu Provincial Academy of Environmental Science Nanjing 210036 China

Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter（PM） *** presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM 〈 2.5 μm（PM2.5）pollution in China have led to serious concerns regarding the health effects of PM2.5during Asian *** investigated how changes in PM2.5composition,as the weather transitioned towards a sandstorm,affected human airway epithelial *** PM2.5samples covering two sandstorm events and their respective background and transition periods were collected in Baotou,an industrial city near the Gobi Desert in *** samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B,which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several *** PM samples potently increased the release of interleukin-6（IL-6） and interleukin-8（IL-8）.Endotoxin in all samples contributed significantly to the IL-6 response,with only a minor effect on *** was positively correlated with both IL-6 and IL-8 release,while Si was only associated with the increase of *** study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM.

关键词： Sandstorm particles Human bronchial epithelial cells Particle constituents Inflammation Local environmental surroundings

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Foreword to the Special Issue on Atomic and Close-to-Atomic Scale Metrology

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Nanomanufacturing and Metrology 2022年第2期5卷 81-82页

作者： Gaoliang Dai Daesung park Ndubuisi george Orji Physikalisch-Technische Bundesanstalt Bundesallee 10038116BrunswickGermany National Institute of Standards and Technology GaithersburgMD20899USA

Nanometrology covers a wide range of metrology techniques for enabling characterization and measurement of nanomaterials,structures,components,devices,and systems at the *** nanometrology is key to innovations in nanotechnology and nanoscience,such as understanding the interaction mechanism between atoms,controlling nanomanufacturing processes,optimizing nanoscale products,as well as preventing *** is closely related to industry sectors such as semiconductor,automotive,nanomaterial,and nanophotonics,and has major economic,environmental,and social impacts on our economy and daily lives.

关键词： metrology interaction mechanism

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2-D eddy resolving simulations of flow past a circular array of cylindrical plant stems

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Journal of Hydrodynamics 2018年第2期30卷 317-335页

作者： Kyoungsik Chang george Constantinescu Sanghyun park School of Mechanical Engineering Ulsan University Ulsan Korea Civil and Environmental Engineering Department IIHR-Hydroscience and Engineering Stanley Hydraulics Laboratory The University of Iowa Iowa City USA Korea Aerospace Research Institute Daejeon Korea

In the present study, 2-D large eddy simulations（LES） are conducted for flow past a porous circular array with a solid volume fraction（SVF） of 8.8%, 15.4% and 21.5%. Such simulations are relevant to understanding flow in natural streams and channels containing patches of emerged vegetation. In the simulations discussed in the paper, the porous cylinder of diameter D contains a variable number of identical solid circular cylinders（rigid plant stems） of diameter d= 0.048 D. Most of the simulations are conducted at a Reynolds number of 2 100 based on the diameter D and the velocity of the steady uniform incoming flow. Though in all cases wake billows are shed in the regions where the separated shear layers（SSLs） forming on the sides of the porous cylinder interact, the effect of these wake billows on the mean drag is different. While in the high SVF case（21.5%）, the total drag force oscillates quasi-regularly in time, similar to the canonical case of a large solid cylinder, in the cases with a lower SVF the shedding of the wake billows takes place sufficiently far from the cylinder such that the unsteady component of the total drag force is negligible. The mean amplitude of the oscillations of the drag force on the individual cylinders is the largest in a streamwise band centered around the center of the porous cylinder, where the wake to wake interactions are the strongest. In all cases the maximum drag force on the individual cylinders is the largest for the cylinders directly exposed to the flow, but this force is always smaller than the one induced on a small isolated cylinder and the average magnitude of the force on the cylinders directly exposed to the flow decreases monotonically with the increase in the SVF. Predictions of the global drag coefficients, Strouhal numbers associated with the wake vortex shedding and individual forces on the cylinders in the array from the present LES are in very good agreement with those of 2-D direct numerical simulations conduc

关键词： Vegetation eddy resolving simulation solid volume fraction porous cylinder bleeding flow

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Emerging resistance vs. losing response to immune check point inhibitors in renal cell carcinoma: two differing phenomena

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Cancer Drug Resistance 2023年第3期6卷 642-655页

作者： Arya Mariam Roy Saby george Division of Hematology and Oncology Department of Internal MedicineRoswell Park Comprehensive Cancer CenterBuffaloNY 14203USA

The introduction of immune checkpoint inhibitor (ICI) has revolutionized the treatment of metastatic renal cell carcinoma (mRCC) and has dramatically improved the outcomes of patients. The use of monotherapy or combinations of ICIs targeting PD-1/PD-L1 and CTLA-4, as well as the addition of ICIs with tyrosine kinase inhibitors, has significantly enhanced the overall survival of mRCC patients. Despite these promising results, there remains a subset of patients who either do not respond to treatment (primary resistance) or develop resistance to therapy over time (acquired resistance). Understanding the mechanisms underlying the development of resistance to ICI treatment is crucial in the management of mRCC, as they can be used to identify new targets for innovative therapeutic strategies. Currently, there is an unmet need to develop new predictive and prognostic biomarkers that can aid in the development of personalized treatment options for mRCC patients. In this review, we summarize several mechanisms of ICI resistance in RCC, including alterations in tumor microenvironment, upregulation of alternative immune checkpoint pathways, and genetic and epigenetic changes. Additionally, we highlight potential strategies that can be used to overcome resistance, such as combination therapy, targeted therapy, and immune modulation.

关键词： Renal cell carcinoma immunotherapy immune checkpoint inhibitors primary resistance acquired resistance immune exhaustion markers immunosuppressive tumor microenvironment

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Partitions with Initial Repetitions

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Acta Mathematica Sinica,English Series 2009年第9期25卷 1437-1442页

作者： george E.ANDREWS The Pennsylvania State University University Park

A variety of interesting connections with modular forms, mock theta functions and Rogers- Ramanujan type identities arise in consideration of partitions in which the smaller integers are repeated as summands more often than the larger summands. In particular, this concept leads to new interpretations of the Rogers Selberg identities and Bailey＇s modulus 9 identities.

关键词： partitions without gaps initial k-repetitions Glaisher's theorem Rogers-Selberg identities Bailey's modulus 9 identities

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Carbon nanotube and conducting polymer composites for supercapacitors

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Progress in Natural Science:Materials International 2008年第7期18卷 777-788页

作者： Daniel Jewell george Z. Chen School of Chemical and Environmental and Mining Engineering University of Nottingham University ParkNottingham NG7 2RD UK

Composites of carbon nanotubes and conducting polymers can be prepared via chemical synthesis, electrochemical deposition on pre- formed carbon nanotube electrodes, or by electrochemical co-deposition. The composites combine the large pseudocapacitance of the conducting polymers with the fast charging/discharging double-layer capacitance and excellent mechanical properties of the carbon nanotubes. The electrochemically co-deposited composites are the most homogeneous and show an unusual interaction between the polymer and nanotubes, giving rise to a strengthened electron delocalisation and conjugation along the polymer chains. As a result they exhibit excellent electrochemical charge storage properties and fast charge/discharge switching, making them promising electrode mate- rials for high power supercapacitors.

关键词： Supercapacitor Carbon nanotube Conducting polymer

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Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion

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Bone Research 2021年第4期9卷 571-581页

作者： Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim george Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun park-Min Arthritis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterNew YorkNYUSA Tissue Engineering Regeneration and RepairHospital for Special SurgeryNew YorkNYUSA Department of Cell and Developmental Biology Weill Cornell Medical CollegeNew YorkNYUSA BCMB allied program Weill Cornell Graduate School of Medical SciencesNew YorkNYUSA Hanyang University Institute for Rheumatology Research SeoulKorea Department of Rheumatology Hanyang University Hospital for Rheumatic DiseasesSeoulKorea Rheumatology College of MedicineKorea UniversitySeoulKorea Department of Medicine Weill Cornell Medical CollegeNew YorkNYUSA

Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone *** colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely ***,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)*** levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory ***,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis *** FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein ***,targeting the MNK1/2 pathway diminished arthritic bone *** results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion.

关键词： osteoclast stimulating 1/2

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β-LACTAMASE INHIBITORS

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中国抗生素杂志 1987年第3期12卷 171-180页

作者： george N.Rolinson Beecham Pharmaceuticals-Research Division Betchworth Surrey Brockham park Chemotherapeutic Research Centre England RH3 7AJ

It is now well established that among the penicillins and cephalosporins,one of the most important mechanisms of resistance is the production of theenzyme,β-*** enzyme is widely distributed among Gram-positiveand Gram-negative bacteria and in recent years the frequency of β-lactamaseproducing strains in many important pathogens bas increased *** 1 shows the frequency of penicillin-resistant Staphylococcusanreus in the Outpatients Department of one London hospital. It willbe seen that more than 80％ of these isolates are now penicillin-resistantwhich means they are also resistant to ampicillin,amoxycillin and to *** longer can we say that β-lactamase-producing *** confined to the hospital.

关键词： LACTAMASE INHIBITORS acid than

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Systematic review and meta-analysis of the impact of deviations from a clinical pathway on outcomes following pancreatoduodenectomy

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World Journal of Clinical Cases 2021年第13期9卷 3024-3037页

作者： Monish Karunakaran Pavan Kumar Jonnada Savio george Barreto Department of Gastrointestinal Surgery Gastrointestinal Oncologyand Bariatric SurgeryMedanta Institute of Digestive and Hepatobiliary SciencesGurgaon 122001HaryanaIndia Department of Liver Transplantation and Regenerative Medicine Medanta-The MedicityGurgaon 122001HaryanaIndia Surgical Oncology Kidwai Memorial Institute of OncologyBengaluru 560029KarnatakaIndia Division of Surgery and Perioperative Medicine Flinders Medical CenterBedford Park 5042South AustraliaAustralia College of Medicine and Public Health Flinders UniversityBedford Park 5042South AustraliaAustralia

BACKGROUND Enhanced recovery after surgery is steadily gaining importance in patients undergoing pancreatic surgery,including pancreatoduodenectomy(PD).While clinical pathways targeting enhanced-recovery can achieve their intended outcome in reducing length of stay,compliance to these pathways,and their relevance is poorly *** aim of this systematic review was to assess the impact of deviations from/non-compliance to a clinical pathway on post-PD *** To assess the impact of deviations from/non-compliance to a clinical pathway on post-PD *** A systematic review of major reference databases was undertaken,according to preferred reporting items for systematic reviews and meta-analysis guidelines,between January 2000 and November 2020 relating to compliance with clinical pathways and its impact on outcomes in patients undergoing PD.A meta-analysis was performed using fixed-effects or random-effects *** Eleven studies including 1852 patients were *** overall compliance to all components of the clinical pathway was 65.7%[interquartile range(IQR):62.7%-72.3%]with median compliance to post-operative parameters of the clinical pathway being 44%(IQR:34.5%-52.25%).Meta-analysis using a fixed-effects model showed that≥50%compliance to a clinical pathway predicted significantly fewer post-operative complications[pooled odds ratio(OR):9.46,95%confidence interval(CI):5.00-17.90;P<0.00001]and a significantly shorter length of hospital stay[pooled mean difference(MD):4.32,95%CI:-3.88 to-4.75;P<0.0001].At 100%compliance which was associated with significantly fewer post-operative complications(pooled OR:11.25,95%CI:4.71-26.84;P<0.00001)and shorter hospital stay(pooled MD of 4.66,95%CI:2.81-6.51;P<0.00001).CONCLUSION Compliance to post-PD clinical pathways remains *** are associated with an increased risk of complications and length of hospital *** the relevance of deviations to clinical pathways post-

关键词： Outcomes Morbidity Mortality Quality Surgery Recovery

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Design and optimization of electrochemical cell potential for hydrogen gas production

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Journal of Energy Chemistry 2021年第1期30卷 421-427,I0013页

作者： Nawar KAl-Shara Farooq Sher Sania ZIqbal Oliver Curnick george ZChen Department of Chemical and Environmental Engineering Faculty of EngineeringUniversity of NottinghamUniversity ParkNottingham NG72RDUK School of Mechanical Aerospace and Automotive EngineeringFaculty of EngineeringEnvironmental and ComputingCoventry UniversityCoventry CV12JHUK Department of Biochemistry University of AgricultureFaisalabad 38000Pakistan Institute for Future Transport and Cities Coventry UniversityCoventry CV15FBUK Department of Chemical and Environmental Engineering Faculty of Science and EngineeringUniversity of Nottingham Ningbo ChinaUniversity ParkNingbo 315100China

This study deals with the optimization of best working conditions in molten melt for the production of hydrogen(H2) *** research has been carried out on how electrochemical process occurs through steam splitting via molten hydroxide.54 combinations of cathode,anode,temperature and voltage have been investigated for the optimization of best working conditions with molten hydroxide for hydrogen gas *** these electrochemical investigations were carried out at 225 to 300℃ temperature and 1.5 to 2.5 V applied voltage *** current efficiency of 90.5,80.0 and 68.6% has been achieved using stainless steel anodic cell with nickel,stainless steel and platinum working cathode *** nickel cathode,an increase in the current directly affected the hydrogen gas flow rate at *** can be hypothesized from the noted results that increase in current is directly proportional to operating temperature and applied *** values were noted when the applied voltages increased from 1.5 to 2.5 V at 300℃,the flow rate of hydrogen gas increased from 1.5 to 11.3 cm^(3) min^(-1),1.0 to 13 cm^(3) min^(-1) in case of electrolysis@stainless steel and@graphite anode *** is observed that the current efficiency of stainless steel anodic cell was higher than the graphite anodic ***,steam splitting with the help of molten salts has shown an encouraging alternate to current methodology for H2 fuel production.

关键词： Sustainable energy Splitting steam Electrolysis Hydrogen gas production Electrochemical cell and Variable cathodes

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