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Bioengineering strategies for the treatment of peripheral arterial disease

Bioactive Materials 2021年第3期6卷 684-696页

作者： Cui Li Oliver Kitzerow Fujiao Nie Jingxuan Dai Xiaoyan Liu Mark A.Carlson george p.casale Iraklis I.pipinos Xiaowei Li Mary&Dick Holland Regenerative Medicine program and Department of Neurological Sciences College of MedicineUniversity of Nebraska Medical CenterOmahaNE68198United States Department of Genetics Cell Biology and Anatomy College of MedicineUniversity of Nebraska Medical CenterOmahaNE68198United States Department of Surgery University of Nebraska Medical CenterOmahaNE68198United States Department of Genetics Cell Biology and AnatomyUniversity of Nebraska Medical CenterOmahaNE68198United States Omaha VA Medical Center OmahaNE68105United States

peripheral arterial disease(pAD)is a progressive atherosclerotic disorder characterized by narrowing and occlusion of arteries supplying the lower *** 200 million people worldwide are affected by *** current standard of operative care is open or endovascular revascularization in which blood flow restoration is the ***,many patients are not appropriate candidates for these treatments and are subject to continuous ischemia of their lower *** research in the therapy of pAD involves developing modalities that induce angiogenesis,but the results of simple cell transplantation or growth factor delivery have been found to be relatively poor mainly due to difficulties in stem cell retention and survival and rapid diffusion and enzymolysis of growth factors following injection of these agents in the affected ***,including hydrogels,have the capability to protect stem cells during injection and to support cell *** can also provide a sustained release of growth factors at the injection *** review will focus on biomaterial systems currently being investigated as carriers for cell and growth factor delivery,and will also discuss biomaterials as a potential stand-alone method for the treatment of ***,the challenges of development and use of biomaterials systems for pAD treatment will be reviewed.

关键词： Hydrogels Growth factors Cell transplantation peripheral arterial disease

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